labetalol / Generic mfg. - LARVOL DELTA

Impact of antihypertensive treatment on cardiovascular event reduction in patients with asymptomatic carotid artery stenosis: a systematic review and meta-analysis. (PubMed, Pan Afr Med J) - "The results reported that enalapril and fosinopril demonstrated dual benefits in blood pressure (BP) reduction and vascular remodeling, though meta-analysis showed statistically insignificant improvements in regional cerebral blood flow (CI: -0.84, 6.08, P = 0.14, I2= 94%). Similarly, isradipine, lacidipine, and amlodipine improved carotid hemodynamics and cerebral perfusion, with meta-analysis favoring calcium channel blocker intervention for blood pressure management (CI: -3.25 to 7.64, P = 0.43)...Moreover, beta-blockers showed specific benefits, with metoprolol improving plaque echogenicity (57.3 ± 16.8 vs. 51.8 ± 20.0, p = 0.006) and reducing cardiovascular events (17% vs. 37% placebo, p = 0.011), while labetalol effectively managed post-endarterectomy hypertension. In conclusion, antihypertensive treatments showed varying effectiveness in cardiovascular event reduction and improvements in vessel measures."

Clinical • Journal • Retrospective data • Review • Atherosclerosis • Cardiovascular • Hypertension

Effect of nifedipine combined with magnesium sulfate on gestational hypertension and its impact on blood lipids. (PubMed, Blood Press Monit) - "Nifedipine combined with magnesium sulfate is more effective in managing GH. This regimen better improves blood pressure, hemorheological parameters, lipid profiles, and pregnancy outcomes, with good safety."

Journal • Cardiovascular • Dyslipidemia • Hypertension

Acute cardiovascular complaints after recreational drug use (PubMed, Ned Tijdschr Geneeskd) - "For arrhythmia, labetalol, carvedilol, lidocaine and sodium bicarbonate can be considered. The use of beta-blockers is still under debate but should be considered in patients with heart failure with reduced ejection fraction. Therefore, always question patients with cardiovascular complaints about recreational drug use, know this changes management, and provide drug counselling."

Journal • Review • Acute Coronary Syndrome • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pain

Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2) (clinicaltrials.gov) - P3 | N=176 | Recruiting | Sponsor: Yonsei University | Trial completion date: Dec 2028 ➔ Dec 2029 | Trial primary completion date: Dec 2028 ➔ Dec 2029

Trial completion date • Trial primary completion date • Cardiovascular • Ischemic stroke

Intra-Arterial Vasodilators for Radial Artery Spasm and Occlusion Prevention in Trans-radial Coronary Procedures: A Network Meta-Analysis of Randomized Control Trials (AHA 2025) - "A random-effects model was used for outcomes with high heterogeneity. In the network meta-analysis, 21 clinical trials with 11010 patients comparing 10 treatments for the prevention of spasm (Placebo, Verapamil, Diltiazem, Molsidomine, Nitroglycerin, Nicorandil, ISDN, Labetalol, Magnesium, and Phentolamine) were included, forming a network centered on Verapamil and Placebo with multiple direct connections. Patients undergoing radial artery catheterization for coronary interventions, verapamil and molsidomine significantly reduced the risk of RAS relative to placebo."

Retrospective data

Risk of major congenital anomalies and beta-blockers: A comparative study from the EFEMERIS database. (PubMed, Br J Clin Pharmacol) - "This study found no increased risk of major congenital anomalies in women exposed to beta-blockers compared with those exposed to calcium channel blockers in early pregnancy."

Journal

Modulation of blood pressure in pregnant rats through probiotic-fermented buffalo milk, propionate-producing bacteria, and the phenylalanine metabolic pathway. (PubMed, J Hypertens) - "The blood pressure-lowering effect of PBM in PIH rats may be associated with the regulation of propionate-producing bacteria and their metabolic functions."

Journal • Preclinical • Cardiovascular • Hypertension

Aetiology and Long-Term Outcome of Hypertension Emergencies in Children (KIDNEY WEEK 2025) - "Labetalol and nitro-glycerine infusion were used to control BP. Conclusion Hypertensive emergency in children is mostly due to RPD. Significant proteinuria, dialysis dependency at 2 weeks, Hb < 7.5 gm% and uncontrolled BP at 2 weeks were predictive of dialysis dependency,"

Clinical • Cardiovascular • Glomerulonephritis • Hypertension • IgA Nephropathy • Lupus Nephritis • Nephrology • Pulmonary Disease • Renal Disease

Polypharmacy Screen of the Thiazide-Sensitive Sodium Chloride Cotransporter (NCC) (KIDNEY WEEK 2025) - "10 compounds were selected for further study: atenolol, furosemide, bendroflumethiazide, dapagliflozin, empagliflozin, labetalol, ramiprilat, metolazone, amlodipine and indapamide. Conclusion Potentially significant interactions between the site of known NCC inhibition and three compounds known to exert diuretic effects (dapagliflozin, empagliflozin and furosemide) have been identified in this computational screening study. A selection of docked conformations from a virtual polypharmacy screen of NCC."

Cardiovascular • Hypertension

Pheo-Nominal Finds: Using Point-of-Care Ultrasonography (POCUS) to Detect Hemorrhagic Postpartum Pheochromocytoma (KIDNEY WEEK 2025) - "She reported severe intermittent headache and labile home blood pressure despite treatment with labetalol...Diagnostic delays can lead to prolonged symptom burden, psychologic stress, and a 27-fold increased risk of gestational complications for patients. POCUS offers a key diagnostic adjunct to rapidly screen for adrenal masses and potentially decrease time-to-treatment of pheochromocytoma."

Cardiovascular • Gynecology • Hematological Disorders • Hypertension • Neuroendocrine Tumor • Solid Tumor

Hemodialysis Initiation During Pregnancy for Advanced CKD Due to ANCA-Associated Glomerulonephritis (KIDNEY WEEK 2025) - "Pre-pregnancy medications included rituximab (for RA) and losartan, both stopped at pregnancy diagnosis...Her blood pressure was 125/79 mmHg on nifedipine and labetalol...However, most patients in these studies were on dialysis before conception, with limited data on those who initiated dialysis during pregnancy. More research is required to guide timing and intensity of dialysis initiation during pregnancy."

Metastases • Cardiovascular • Chronic Kidney Disease • Glomerulonephritis • Gynecology • Hypertension • Immunology • Inflammatory Arthritis • Lupus Nephritis • Nephrology • Rheumatoid Arthritis • Rheumatology

Hyperkalemic? Don't Miss the Mag! (KIDNEY WEEK 2025) - "After initial improvement on oral labetalol, systolic blood pressure rose to 180 mm Hg on post-op day 4, prompting pre-eclampsia concerns...Even mild CKD is a critical risk factor for iatrogenic hypermagnesemia. Symptoms are nonspecific and require close monitoring and high index of suspicion."

Chronic Kidney Disease • Constipation • Gastroenterology • Gastrointestinal Disorder • Gynecology • Hypotension

Postpartum Health-Care Utilization and Blood Pressure Control by Antihypertensive Agent in Hypertensive Disorders of Pregnancy. (PubMed, Am J Obstet Gynecol MFM) - "Discharge on labetalol was associated with an increased odds of postpartum hospital readmission following a HDP compared with discharge on nifedipine. Our findings suggest this may be driven by more severe hypertension on home monitoring by each day postpartum in the first ten days postpartum."

HEOR • Journal • Cardiovascular • Gynecology • Hypertension

Probiotic-fermented milk alleviates hypertension in preeclampsia rats and is associated with increases in branched fatty acid esters of hydroxy fatty acids. (PubMed, Nutr Res) - "Probiotic-fermented milk substantially attenuated hypertension in PE rats, with an efficacy comparable to that of labetalol (4 mg/kg)...These results indicate that probiotic-fermented milk alleviates hypertension in PE rats, potentially mediated by FAHFAs. This study provides foundational evidence for the antihypertensive mechanism of probiotic-fermented milk in preeclampsia and supports the development of novel strategies for its prevention and treatment."

Journal • Preclinical • Cardiovascular • Genetic Disorders • Gynecology • Hypertension • Obesity

Evaluation of the clinical application of information-motivation-behavior model care combined with labetalol pharmacotherapy for patients with hypertensive disorders of pregnancy: a randomized controlled study for improving pregnancy outcomes. (PubMed, Front Med (Lausanne)) - "The IMB care model combined with labetalol medication had a positive impact on blood pressure control and pregnancy outcomes in patients with HDP, providing data support and theoretical basis for the application of this care model in HDP. However, the study also pointed out its limitations, such as single-centre design and limited sample size, and more comprehensive studies are needed to further validate these findings in the future."

Journal • Hypertension

Effectiveness of Nifedipine Versus Labetalol for Postpartum Hypertension Control: A Systematic Review and Meta-analysis (AHA 2025) - "A p-value of less than 0.05 was considered statistically significant.Results Nifedipine significantly reduced the risk of readmission compared to labetalol (RR = 0.40, 95% CI [0.31, 0.52]; P < 0.00001). No significant differences were found in time to blood pressure control (MD = –0.68, 95% CI [–2.20, 0.84]; P = 0.38), discharge on initial medication (RR = 0.78, 95% CI [0.45, 1.34]; P = 0.37), or incidence of adverse effects.ConclusionNifedipine was associated with lower readmission risk than labetalol, with comparable efficacy and safety in postpartum hypertension management.Keywords:Nifedipine, Labetalol, Postpartum hypertension, Oral antihypertensive"

Retrospective data • Review • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypertension • Respiratory Diseases

Idiosyncratic Drug-Induced Liver Injury From Labetalol in a Pregnant Patient (ACG 2025) - "Her medications included prenatal vitamins, progesterone vaginal cream, and a new prescription of labetalol 200mg BID for palpitations three months prior. Labetalol is a commonly used first-line medication for hypertension in pregnancy, with only a handful of cases of DILI from Labetalol in the literature. This case aims to highlight the importance of early recognition of DILI from labetalol use to prevent severe adverse outcomes.Figure: Histopathology ImagesFigure: Liver Enzymes Graph and Table"

Clinical • Cardiovascular • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Failure • Obesity • Thrombosis

Purtscher-Like Retinopathy as an Unusual Initial Manifestation of Acute Pancreatitis in a Postpartum Patient (ACG 2025) - "She was diagnosed with pre-eclampsia, for which she was started on labetalol and underwent an uncomplicated cesarean section...In this case, the initial manifestation of pancreatitis was visual disturbances, which underscores the importance of a multidisciplinary approach in evaluating atypical presentations. Early identification and treatment of pancreatitis is critical to prevent severe complications.Figure: Fundus photograph of the left and right eye with peripapillary retinal whitening consistent with Purtscher flecken."

Clinical • Anemia • Cardiovascular • Genetic Disorders • Gynecology • Hematological Disorders • Hypertension • Obesity • Pancreatitis • Retinal Disorders

Tachycardia-Induced Cardiomyopathy Due to Atrial Tachycardia During Pregnancy. (PubMed, J Cardiothorac Vasc Anesth) - "At 28 weeks of gestation, an electrocardiogram indicated sinus tachycardia, and treatment with labetalol was ineffective in controlling the heart rate...During the procedure, the patient experienced 2 episodes of cardiac arrest and underwent cardiopulmonary resuscitation. This case serves as a critical reminder that persistent, unexplained sinus tachycardia in pregnancy may mask underlying focal atrial tachycardia and portend a high risk for rapidly deteriorating tachycardia-induced cardiomyopathy, demanding vigilant evaluation and preemptive management strategies."

Journal • Review • Cardiomyopathy • Cardiovascular

PARTIAL MOLE PRESENTING AS EARLY PREGNANCY HYPERTENSIVE EMERGENCY (CHEST 2025) - "Postoperative blood pressure control was achieved with oral labetalol... Accurately distinguishing between disorders and complications of pregnancy can be challenging due to atypical presentations and overlapping features between gestational disorders and exacerbations of chronic diseases. Preeclampsia typically occurs after 20 weeks of gestation, and early onset of preeclamptic features should prompt further investigation into precipitating factors including gestational trophoblastic disorders."

Cardiovascular • CNS Disorders • Endocrine Disorders • Epilepsy • Gestational Trophoblastic Neoplasia • Gynecology • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Obstetrics • Renal Disease

AORTIC TIME BOMB: INCIDENTAL DIAGNOSIS OF CHRONIC TYPE A DISSECTION IN A YOUNG PATIENT (CHEST 2025) - "A labetalol infusion was initiated for heart rate and blood pressure control... Chronic AD can remain undiagnosed for years, necessitating careful evaluation. This case underscores the importance of family history in identifying at-risk patients, even in the absence of known connective tissue disorders. Early diagnosis and tailored management, including genetic counseling, medical therapy, and surgical intervention, are essential to preventing life-threatening complications."

Clinical • Cardiovascular • Otorhinolaryngology • Rheumatology

HYPERTENSIVE EMERGENCY DUE TO RESISTANT HYPERTENSION REQUIRING SEVEN MEDICATIONS (CHEST 2025) - "The patient was eventually weaned off labetalol infusion and transitioned to oral medications which were up-titrated to maximum doses of carvedilol, chlorthalidone, clonidine, nifedipine, spironolactone, hydralazine and valsartan before nicardipine infusion was weaned off improving systolic BP (SBP) to 130s mmHg before discharge. HE should be treated immediately with intravenous antihypertensives to avoid further end-organ damage."

Addiction (Opioid and Alcohol) • Cardiovascular • Cerebral Hemorrhage • Chronic Kidney Disease • CNS Disorders • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Hematological Disorders • Hypertension • Ischemic stroke • Nephrology • Nicotine Addiction • Ophthalmology • Renal Disease • Respiratory Diseases • Subarachnoid Hemorrhage

ACUTE ENCEPHALOPATHY DUE TO ANTIDEPRESSANT DISCONTINUATION SYNDROME: A CASE REPORT (CHEST 2025) - "Ceftriaxone was started while awaiting bacterial culture results, and amlodipine with lisinopril was advised to manage hypertensive urgency. Since the patient refused all oral and home medications, IV enalapril was initiated, with hydralazine and labetalol given as needed. Bacterial culture revealed UTI due to Aerococcus sanguinicola, and the patient was started on a 7-day course of IV ampicillin...Following improvement in her mental status with resolution of the encephalopathy and UTI, the patient was discharged with improved mental status on venlafaxine, valproate, amlodipine, trazodone, atorvastatin, lisinopril, and mirtazapine following a 10-day hospitalization... Antidepressant discontinuation syndrome may predispose patients of advanced age with multiple medical conditions to developing acute encephalopathy."

Case report • Clinical • Cardiovascular • CNS Disorders • Depression • Dyslipidemia • Hypertension • Infectious Disease • Insomnia • Mood Disorders • Nephrology • Psychiatry • Sleep Disorder

COMPLEX CARDIOVASCULAR MANIFESTATIONS IN OSTEOGENESIS IMPERFECTA: A CASE REPORT OF SEVERE LVH, RIGHT VENTRICULAR COLLAPSE, AND PERICARDIAL EFFUSION IN A 54-YEAR-OLD FEMALE (CHEST 2025) - "She was treated with Lasix and labetalol. Osteogenesis imperfecta is associated with a high incidence of valvular heart disease, particularly aortic and mitral regurgitation. While only nine cases of valvular insufficiencies and aortic dissection were documented in OI, this is the first study that may have suggested that OI may have contributed to right ventricular collapse in diastole, exacerbating the pericardial effusion, a complication not commonly associated with the condition."

Case report • Clinical • Cardiovascular • Genetic Disorders • Heart Failure • Hematological Disorders • Hypertension • Musculoskeletal Diseases • Orthopedics • Pulmonary Embolism • Respiratory Diseases

P-PAT: Preeclampsia Postpartum Antihypertensive Treatment (clinicaltrials.gov) - P3 | N=300 | Active, not recruiting | Sponsor: Medical College of Wisconsin | Trial completion date: Jun 2025 ➔ Dec 2025

Trial completion date • Cardiovascular • Gynecology • Hypertension