labetalol / Generic mfg. - LARVOL DELTA

Preclinical Evaluation of Labetalol for Cutaneous Melanoma Drug Repurposing: Cytotoxic Activity in A375 Cells and Mitochondria-Associated Apoptotic Signaling. (PubMed, Medicina (Kaunas)) - "These findings provide preliminary evidence supporting further investigation of LB within a melanoma-directed drug-repurposing strategy. Additional studies are required to establish receptor dependence, achievable local exposure, safety, and translational relevance."

Journal • Preclinical • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor • CASP3 • CASP7 • CASP9

Labetalol-Associated Drug-Induced Liver Injury: A Case Report (ACG 2026) - "The patient was managed with ursodeoxycholic acid and hydroxyzine, with continued improvement noted on follow-up. Baseline liver function test levels were obtained on day of initiation (day 0). Labetalol was discontinued on the day of admission to the hospital (day 60)."

Case report • Clinical • Cardiovascular • Fibrosis • Genetic Disorders • Hepatology • Hypertension • Immunology • Inflammation • Liver Failure • Obesity

Oral antihypertensive agents in hypertensive pregnancies and adverse maternal and perinatal outcomes: study protocol for a target trial emulation using Dutch electronic health record data. (PubMed, BMJ Open) - "International guidelines vary in their treatment recommendations and preferences for methyldopa, labetalol and nifedipine. The Medical Research Ethics Committee of the University Medical Centre Utrecht (NedMec, 23-092/DB) confirmed that formal ethical approval was not required. Study findings will be disseminated through publication in peer-reviewed scientific journals."

Clinical protocol • Journal • Acute Kidney Injury • Cardiovascular • Critical care • Gynecology • Hematological Disorders • Hypertension • Hypoglycemia • Nephrology • Obstetrics • Renal Disease • Small for Gestational Age

Hospital readmissions and blood pressure management in the early postpartum period following hypertensive disorders of pregnancy. (PubMed, Pregnancy Hypertens) - "Postnatal hypertension following HDP is common and remains a major driver of re-attendance. Differences in BP profiles by discharge medication suggest that antihypertensive choice influences early postnatal outcomes. Prospective studies and trials are needed to inform prescribing practices and to reduce morbidity."

Journal • Cardiovascular • Hypertension

Venoarterial extracorporeal membrane oxygenation for peripartum cardiomyopathy complicated by severe preeclampsia: a case report with 5-year follow-up. (PubMed, Front Med (Lausanne)) - "Labetalol, magnesium sulfate, and furosemide were administered, followed by emergency cesarean delivery of a 2,880-g male infant (Apgar scores, 8 and 10). This case provides rare 5-year documentation of sustained myocardial recovery after VA-ECMO in PPCM with severe preeclampsia. In peripartum patients with severe hypertension and respiratory symptoms, an LVEF below 45% should prompt evaluation for PPCM; timely echocardiography, multidisciplinary care, and early VA-ECMO may bridge refractory hemodynamic instability to recovery, followed by prolonged cardiac surveillance."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Cough • Gynecology • Heart Failure • Hypertension • Pulmonary Disease • Respiratory Diseases

Acute aortic dissection masquerading as large bowel obstruction: a case report. (PubMed, Egypt Heart J) - "In the setting of acute abdomen and severe hypertension, imaging to probe the vascular integrity of the aorta is essential to avoid life-threatening, inappropriate surgical interventions. The primary "take-away" lesson is the need for high suspicion of AD in hypertensive patients with abdominal symptoms."

Journal • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypertension • Pain

Medical Management of Aortic Emergencies in Critical Care Transport. (PubMed, Prehosp Emerg Care) - "We observed a similar odds of achieving HR and SBP targets regardless of medication used in a large sample of patients with aortic emergencies. While a combination of beta and calcium channel blockers may be optimal medical therapy, treatment with esmolol, labetalol, or nicardipine as single agents may be reasonable to achieve HR and SBP goals."

Journal • Cardiovascular • Critical care • Hypotension

Construction of a human placental brush border membrane vesicle model for evaluating the effect of antenatal drugs on OCTN1/2 transport function. (PubMed, Chem Biol Interact) - "Substrate uptake experiments with ergothioneine and L-carnitine revealed classical saturable concentration-dependent kinetics, which were substantially suppressed by verapamil...However, metformin, glibenclamide, and labetalol moderately inhibited OCTN2, which could hinder placental L-carnitine uptake. Notably, fluoxetine exerted inhibitory effects on both OCTN1 and OCTN2, implying elevated risks of impaired placental antioxidant defense and energy substrate transfer. These findings elucidate the transport characteristics of placental OCTN1/2 and identify unintended inhibitory effects of common antenatal drugs, providing critical experimental references for rational clinical medication during pregnancy."

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Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence. (PubMed, Tissue Cell) - "Furthermore, LBL administration altered semen parameters including abnormal head, tail, and mid-piece region of sperms thereby suggesting direct testicular toxicity. Collectively, these observations underscore the pronounced testiculotoxic capacity of LBL, highlighting the interplay of oxidative injury, inflammatory mediators, apoptotic processes, and severe histomorphological disruption as principal determinants of its pathogenic effects."

Journal • Cardiovascular • Hypertension • Inflammation • AR • BCL2 • CASP9 • CREM • DAZL • ER • IL1B • IL6 • TNFA

Inhibition of either the sympathetic or parasympathetic nervous system increases tonic immobility duration in laying hens. (PubMed, Poult Sci) - "In experiment 1, sixteen Dekalb White hens (43 weeks of age) were given 0.1 mL/kg of either saline as a control (CON), labetalol (5 mg/mL) to inhibit the SNS (LAB), or glycopyrrolate (0.2 mg/mL) to inhibit the PNS (GLY)...For experiment 2, the CON2 group was also quicker to right than DRUG (p = 0.052). These results indicate that both the PNS and SNS play a role in TI recovery, however further studies need to be undertaken to better understand the neurobiology of tonic immobility."

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Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study. (PubMed, Hypertens Res) - "The most used drugs were intravenous furosemide, nitroglycerin, clonidine and labetalol for HE. Finally, regarding the exploratory analysis, BP at ED admission and its management didn't present significant association with in-hospital mortality. In conclusions, our study demonstrated that adherence to guidelines in the management of HE/UH could be further improved."

Journal • Retrospective data • Acute Coronary Syndrome • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Intraoperative Hemodynamic Management and Cerebral Protection During Awake Craniotomy: Evidence-Based Approaches. (PubMed, Anesthesiol Res Pract) - "Preventive strategies, such as scalp blocks, individualized blood pressure targets, and the use of dexmedetomidine and midazolam, improved intraoperative stability, while short-acting agents, including esmolol and labetalol, were preferred for rapid control. Looking ahead, advanced monitoring and emerging AI systems may provide new opportunities to enhance cerebral protection and optimize patient safety. This review summarizes evidence on intraoperative hemodynamic control in awake craniotomy, emphasizing strategies that enable maximal safe resection while preserving neurological function."

Journal • Review • Anesthesia • Brain Cancer • Cardiovascular • Glioma • Hypertension • Hypotension • Oncology • Pain • Solid Tumor

Postpartum Thrombotic Thrombocytopenic Purpura With Coexisting Preeclampsia With Severe Features (ASA 2026) - "Initial treatment included labetalol, nifedipine, and magnesium. She was treated with plasma exchange, high-dose corticosteroids, rituximab, and caplacizumab with platelet recovery after 7 days. This case highlights TTP as a critical diagnostic consideration in postpartum patients with apparent preeclampsia."

Gynecology • Hematological Disorders • Hypertension • Thrombocytopenia • Thrombocytopenic Purpura • HP

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

Neuraxial Management in a High-Risk Obstetric Patient with VACTERL Association and Prior Tethered Cord Release (ASA 2026) - "A 25-year-old primigravida at 32 weeks with VACTERL association, tethered cord syndrome with surgical release, GERD with Nissen fundoplication, repaired tracheoesophageal fistula, and chronic hypertension with superimposed preeclampsia on labetalol presented for labor analgesia...Bilateral T10 level was maintained across 12 hours of labor before conversion to surgical anesthesia for non-reassuring fetal heart tones and urgent cesarean delivery, without general anesthesia. We discuss anesthetic and perioperative challenges of neuraxial management in pregnant patients with VACTERL association and prior tethered cord release."

Clinical • Cardiovascular • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Gynecology • Hypertension • Obstetrics

Severe Hemodynamic Instability After Pneumoperitoneum in a Patient With Recent Phentermine Use and Chronic Labetalol Therapy (ASA 2026) - "After targeted medication reconciliation and extended phentermine discontinuation, repeat surgery proceeded uneventfully. The patient recovered well with an undetectable PSA."

Clinical • Hypotension

Compounding Anesthetic Risks in Fulminant Eclampsia: HELLP Syndrome, PRES, and Seizure-Related Airway Trauma (ASA 2026) - "Severe hypertension (>200 mmHg) required labetalol and magnesium...Cesarean delivery proceeded uneventfully; however, persistent encephalopathy required prolonged postoperative ventilation and 3-day ICU admission for neurologic and blood pressure management. This case highlights anesthetic challenges of managing a high-risk obstetric patient with fulminant eclampsia."

Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders • Hypertension • Mood Disorders • Obstetrics • Thrombocytopenia

Reducing Anesthetic Drug Utilization in Electroconvulsive Therapy (ASA 2026) - "In response to pandemic-related drug shortages, we removed the precurarizing dose of rocuronium and withheld glycopyrrolate, labetalol, ketorolac and ondansetron if deemed unnecessary. Although case duration increased slightly, median times remained stable. This suggests that reducing anesthetic drugs can influence case efficiency, though further matching of allocated times is needed to balance medication reductions with overall system performance and productivity within ECT."

Impact of chronic beta-blocker versus renin-angiotensin inhibitor use on outcomes after blunt pelvic trauma. (PubMed, Surgery) - "Prior use of β-blockers is correlated with significantly worse rates of hemorrhage, infection, and thromboembolic events after a traumatic pelvic fracture when compared with renin-angiotensin system inhibitors. This could be due to renin-angiotensin system inhibitors attenuating the post-traumatic inflammatory response system by blocking angiotensin II, which causes inflammation, oxidative stress, endothelial dysfunction, and vasoconstriction. These findings suggest that chronic cardiovascular therapy type may influence post-pelvic trauma outcomes, underscoring the need for further investigation."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Septic Shock

Comparison of Labetalol With Versus Without Magnesium Sulfate on Intraoperative Blood Pressure Variability During Cesarean Delivery in Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study. (PubMed, Ann Ital Chir) - "For HDP patients undergoing cesarean delivery, the perioperative application of a combined regimen of labetalol and magnesium sulfate, compared with labetalol alone, was associated with more stable intraoperative blood pressure, reduced variability under surgical stress, and improved early neonatal outcomes. This combined regimen provides valuable clinical reference for optimizing perioperative blood pressure management during cesarean delivery."

Clinical • Journal • Retrospective data • Cardiovascular • Critical care • Hypertension • Hypotension

Impact of labetalol versus nifedipine treatment on readmission risk in postpartum hypertension: A randomized controlled trial. (PubMed, Pregnancy (Hoboken)) - "Primary outcome was statistically significant and consistent with observational data. Our findings support nifedipine as the first-line agent for treatment of postpartum hypertension."

Journal • Cardiovascular • Gynecology • Hypertension • Obstetrics

Hypertension-related morbidity after delivery discharge: A comparison of nifedipine versus labetalol. (PubMed, Pregnancy (Hoboken)) - "Individuals on nifedipine were less likely to return to the hospital in the 30 days following discharge (4.6% vs. 12.7%; aOR, 0.3; 95% CI, 0.1-0.7) and less likely to have a hospital return lasting ≥24 h (1.7% vs. 6.8%; OR, 0.2; 95% CI, 0.07-0.8). Among individuals on antihypertensive monotherapy at delivery discharge, nifedipine was associated with significantly reduced odds of post-discharge morbidity compared to labetalol."

Journal • Acute Kidney Injury • Cardiovascular • CNS Disorders • Congestive Heart Failure • Gynecology • Heart Failure • Hematological Disorders • Hypertension • Myocardial Infarction • Obstetrics • Renal Disease • Respiratory Diseases • Vascular Neurology

β2-Adrenergic receptor antagonists are not protective against spinal cord injury-induced bone loss. (PubMed, Bone) - "Moving in vivo, we utilized a novel intraosseous catheter for targeted delivery of labetalol (mixed α- and β-AR antagonist) and butoxamine (selective β-AR antagonist) directly into the sublesional (below the level of injury) bone marrow space for 28 consecutive day, beginning 24 h post-injury...These findings demonstrate that while blocking β2-ARs is sufficient to reduce NE-driven osteoclastogenesis, excessive NE does not fully explain SCI-induced bone loss. Local AR antagonists do not appear to be a viable therapeutic strategy to mitigate SCI-induced osteoporosis."

Journal • CNS Disorders • Orthopedics • Osteoporosis • Rheumatology

Labetalol, Nifedipine, and Methyldopa for the Management of Hypertensive Disorders in Pregnancy in Iran: A Cost-Effectiveness Analysis. (PubMed, Health Sci Rep) - "From the perspective of Iranian healthcare payers, labetalol is a cost-saving and dominant option compared to methyldopa. However, it is not cost-effective when compared to nifedipine at a willingness-to-pay threshold of $18,261 per QALY in managing hypertensive disorders during pregnancy."

Clinical • HEOR • Journal • Cardiovascular • Hypertension

Green Spectrofluorometric Method for Labetalol Determination Based on Electron Transfer Inhibition With Density Functional Theory Validation and Statistical Design Optimization. (PubMed, Luminescence) - "Furthermore, successful applications to pharmaceutical formulations and biological samples (plasma) demonstrated recoveries ranging from 96.36% to 104.97%. The developed PET-blocking approach provides an environmentally sustainable alternative for labetalol determination, eliminating toxic derivatization reagents while maintaining analytical reliability and sensitivity."

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