Twinrix (inactivated hepatitis A and recombinant hepatitis B) / GSK - LARVOL DELTA

Adult immunization. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Measles • Meningococcal Infections • Pertussis • Pneumococcal Infections • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus • Varicella Zoster

Comparison chart: Some vaccines for adults. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Infectious Disease • Inflammation • Influenza • Measles • Meningococcal Infections • Pertussis • Pneumococcal Infections • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus

Long-Term Persistence of Hepatitis A Virus Immunity in Healthcare Workers Upto 25 Years After Vaccination. (PubMed, J Viral Hepat) - "We conducted a prospective cohort study among healthcare personnel and medical students vaccinated with either a monovalent HAV vaccine (Havrix, Avaxim) or a combined HAV/HBV vaccine (Twinrix) between 1996 and 2003 at Bari University Hospital, Italy. These findings demonstrate that protective HAV antibody levels persist for more than two decades after vaccination. Both monovalent and bivalent vaccines confer durable immunity, supporting the continued inclusion of HAV vaccination in national immunisation programs and occupational health strategies."

Journal • Infectious Disease • Inflammation

Immunogenicity of two versus three doses of hepatitis B vaccine when administered to children aged 2-18 months: a randomized clinical trial. (PubMed, J Infect Dis) - "The anamnestic response three years after two- (2, 12 months) and three-dose (2, 4, 18 months) hepatitis B vaccination schedules was similar. The heterologous two-dose schedule was more immunogenic and less reactogenic than the homologous two-dose schedule."

Clinical • Journal • Hepatitis B • Infectious Disease • Inflammation

Hepatitis B Vaccine Compliance and Seroresponse Rates Among Solid Organ Transplant Recipients Receiving Recombinant versus Adjuvanted HBV Vaccine (WTC 2025) - "Subjects that received Engerix-B (GSK) or Recombivax-HB (Merck) were categorized as recombinant HBV vaccine, while those who received Heplisav-B (Dynavax) were categorized as adjuvanted HBV vaccine...HBV vaccine type was unknown for 23.2% (n=92), while 4.5% (n=18) received Twinrix (Hep A/B)... HBV vaccination rates remain suboptimal in SOTR. There was a trend towards higher HBV vaccine completion rates with adjuvanted HBV vaccine. While there was no difference in seroresponse between adjuvanted and recombinant HBV vaccination, seroresponse rates to adjuvanted HBV vaccine were lower in this cohort than those achieved in phase 3 clinical trials (over 90%)."

Clinical • Compliance • Hepatitis B • Hepatology • Infectious Disease • Inflammation • Solid Organ Transplantation • Transplantation

Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively (clinicaltrials.gov) - P=N/A | N=0 | Withdrawn | Sponsor: Karolinska University Hospital | N=250 ➔ 0 | Suspended ➔ Withdrawn

Enrollment change • Trial withdrawal • Cystic Fibrosis • Fibrosis • Genetic Disorders • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Is it time to rethink our strategy in Hepatitis B virus (HBV) booster vaccination? (APASL 2024) - " Case Report and Literature Review In December 2018, the patient received 3-dose Twinrix vaccination series after negative testing for HBsAg, Anti-HBs and antiHBcoreAb... This patient developed acute HBV despite being vaccinated 3 years prior with a positive anti-HBs titre. This raises the question of the need for serial anti-HBs testing post vaccination, and whether there is a role of booster vaccines for patients with early decline in anti-HBs titres. If adapted, this may lead to significant changes in public health strategies against HBV."

Hepatitis B • Hepatology • Infectious Disease • Inflammation • CD4

Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial. (PubMed, Lancet Infect Dis) - P1 | "Pfs230D1 but not Pfs25 vaccine induces durable serum functional activity in Malian adults. Direct skin feed assays detect parasite transmission to mosquitoes but increased event rates are needed to assess vaccine effectiveness."

Journal • P1 data • Allergy • Immunology • Infectious Disease • Malaria

Adult immunization. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Hepatology • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Meningococcal Infections • Pneumococcal Infections • Respiratory Diseases • Tetanus • Varicella Zoster

Expanded table: Some vaccines for adults. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Hepatology • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Meningococcal Infections • Pertussis • Respiratory Diseases • Tetanus • Varicella Zoster

Impacts of Systematically Screening All Blood Donations for Parvovirus B19 and Hepatitis A Using Nucleic Acid Tests (AABB 2022) - "Neither of them had travelled nor had risk factors for hepatitis A. They all had a recent history of hepatitis A vaccination in the days prior to the donation (Havrix: 2 days and 1 day, Twinrix: 6 days). The rate of parvovirus B19 positivity was much lower than expected, possibly because of the sanitary measures during the SARS-CoV-2 pandemic. The three individuals who tested positive for hepatitis A were presumably false positives due to recent vaccination with inactivated viral strains. We introduced a seven-day deferral after HAV vaccination to minimize the negative impacts of false-positive results."

Genetic Disorders • Hematological Disorders • Hepatology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • Sickle Cell Disease

A three-antigen hepatitis B vaccine (PreHevbrio). (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Hepatology • Infectious Disease • Inflammation

Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively (clinicaltrials.gov) - P=N/A | N=250 | Suspended | Sponsor: Karolinska University Hospital | Enrolling by invitation ➔ Suspended

Trial suspension • Cystic Fibrosis • Fibrosis • Genetic Disorders • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • Tuberculosis

A Prospective Study of HBV Immunity and HBV Vaccination in Patients With NAFLD in Canada (clinicaltrials.gov) - P=N/A; N=82; Completed; Sponsor: University of Calgary; Active, not recruiting ➔ Completed; N=300 ➔ 82

Clinical • Enrollment change • Trial completion • Hepatitis B • Hepatology • Infectious Disease • Inflammation • Non-alcoholic Fatty Liver Disease • CD4

Autoimmune Hepatitis, Primary Biliary Cholangitis or Overlap? A Case Beyond the Single Diagnosis (ACG 2021) - "Medical history included atrial fibrillation and current medications were Eliquis and metoprolol...Hepatitis serologies showed HAV and HBV non-immunity with Twinrix vaccination underway and a negative HCV antibody...Treatment focused on the predominant pattern of PBC and ursodiol 13-15 mg/kg/daily was initiated...B. Trichrome stain demonstrating dense periportal and sinusoidal fibrosis with non-bridging fibrous septa, suggestive of AIH."

Clinical • Atrial Fibrillation • Cardiovascular • Fibrosis • Hepatology • Hypertension • Immunology • Inflammation • Oncology • Pain • Portal Hypertension • Primary Biliary Cholangitis • MRI

[VIRTUAL] Hepatitis B vaccine NON-RESPONDERS show higher frequencies of REGULATORY B CELLS, but lower levels of IL-10 expression compared to responders (EASL-ILC 2021) - "The current study aimed to investigate the role of regulatory B cells (Breg) in hepatitis B vaccine non-responsiveness after immunization with second- (Twinrix®) or third-generation (Sci-B-VacTM) hepatitis B vaccines... Here we report significantly higher frequencies of CD24highCD38high Breg in parallel with significantly lower IL-10 expression levels of CD24+CD27+ and CD24highCD38high Breg in 2nd HBvac NR compared to 2nd HBvac R. Anti-HBs seroconversion accompanied by a decrease of Breg numbers after booster immun- ization with a third-generation hepatitis B vaccine could indicate a positive effect of third-generation hepatitis B vaccines on Breg mediated immunomodulation in hepatitis B vaccine non-responders."

IO biomarker • Hepatitis B • Hepatology • Immune Modulation • Infectious Disease • Inflammation • CD24 • CD27 • IL10