KIND T / University of California - LARVOL DELTA

Pathways to Self-Compassion: The Effects of Self-Kind Behaviors and Self-Kind Thoughts on Self-Compassion and Well-Being. (PubMed, Affect Sci) - "Further research is needed to test cognitive self-compassion as an especially useful tool to bolster Latinx and first-generation college student well-being. The online version contains supplementary material available at https://doi.org/10.1007/s42761-026-00379-4."

Journal • Cognitive Disorders

Prospective randomised double-blind trial: holmium laser lithotripsy with vs without Moses™ 2.0. (PubMed, BJU Int) - "Our study evaluated the impact of Moses 2.0 technology on high-powered renal stone dusting, constituting the largest double-blind trial of its kind to date. There was insufficient evidence to suggest any difference in operative times or clinical outcomes when using Moses 2.0 compared to standard laser lithotripsy. Moses 2.0 was associated with reduced surgeon workload, which has implicit impact on surgeon wellness."

Journal • Nephrology • Renal Calculi

PNOC018: Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma (clinicaltrials.gov) - P1 | N=4 | Terminated | Sponsor: University of California, San Francisco | N=12 ➔ 4 | Trial completion date: Aug 2029 ➔ Jan 2026 | Active, not recruiting ➔ Terminated | Trial primary completion date: Aug 2029 ➔ Jan 2026; Logistical issues

Enrollment change • First-in-human • Trial completion date • Trial primary completion date • Trial termination • Brain Cancer • Diffuse Midline Glioma • Glioma • Oncology • Solid Tumor

Spiritual care for Latinx youth with type 1 diabetes (T1D) and their caregivers: qualitative analysis of focus groups. (PubMed, Diabetol Metab Syndr) - "Latinx youth and caregivers described deep emotional experiences related to living with T1D and self-management practices, which can be viewed and addressed through the lens of spiritual care. Our research is the first-of-its-kind to identify specific unmet needs in T1D care that could benefit from chaplaincy as part of the multidisciplinary team. Spiritual struggle related to managing T1D (e.g., isolation from others with T1D, negative self-image, grief) warrants specialized support. Further investigation should examine preferences of youth with T1D and their caregivers, specifically for spiritual care services as part of their T1D care, and integration of professional chaplain support in T1D care."

Journal • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Metasurface-enabled astronomical polarimetry. (PubMed, Sci Adv) - "Here, we present the Solar Imaging Metasurface Polarimeter (SIMPol), a first-of-its-kind telescope for snapshot imaging polarimetry of the sun enabled by a high-performance metasurface polarization-analyzing grating, which provides for single element, snapshot imaging polarimetry. We demonstrate SIMPol's integration into a major observatory telescope facility and the characterization of Zeeman signatures of solar magnetism. This work-among the first to demonstrate an advantage presented by metasurface optics to a real application in astronomical instrumentation-heralds the application of metasurfaces and emergent nanophotonic technologies in astronomy more broadly."

Journal

Anti-Latine bias and drug-induced homicide law support: Evidence from a nationally diverse, randomized survey experiment in the United States. (PubMed, Int J Drug Policy) - "This is the first study of its kind to consider the Latine community as a target of punitive drug policy bias. These results suggest that race- and ethnicity-based assumptions continue to influence public opinion about drug policy, echoing the punitive racialization patterns of past "wars" on drugs."

Journal

Child Protective Service Interactions in Children with Cardiac Conditions (PAS 2026) - "13,750 pediatric cardiology patients were included. 54% were male, 42% Hispanic, 36% White, 16% Asian, 4% Black, and 0.4% Native I/A. 41% had public insurance."

Clinical • Cardiovascular

PNOC018: Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma (clinicaltrials.gov) - P1 | N=12 | Active, not recruiting | Sponsor: University of California, San Francisco | Recruiting ➔ Active, not recruiting

Enrollment closed • First-in-human • Brain Cancer • Diffuse Midline Glioma • Glioma • Oncology • Solid Tumor

Dense sampling for mapping pituitary growth dynamics before, during, and after pregnancy. (PubMed, J Neuroendocrinol) - "In contrast, no significant volumetric changes in the posterior lobe were detected across the observation period (pnon-linear = 0.79). In one of the first studies of its kind to leverage a dense sampling approach in multiple pregnant women, non-linear analyses revealed rapid, reversible anterior pituitary hypertrophy across human pregnancy consistent with lactotrope expansion and heightened endocrine load."

Journal

Radiation and Busulfan-Free Hematopoietic Stem Cell Transplantation Using Briquilimab (JSP191) Anti-CD117 Antibody-Conditioning, Transient Immunosuppression and TCRαβ+ T-Cell/CD19+ B-Cell Depleted Haploidentical Grafts in Patients with Fanconi Anemia (ASH 2023) - "Objective: To reduce acute and long-term treatment-related toxicities, we have developed a first of its kind treatment intended to improve the safety of allo-HSCT through: 1) a TBI- and busulfan-free conditioning regimen consisting of briquilimab, rabbit ATG (rATG - Thymoglobulin), fludarabine, cyclophosphamide and rituximab - briquilimab (formerly called JSP191) is a monoclonal antibody (mAb) that targets human CD117 to deplete host HSCs enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection; 2) transplantation of TCRαβ+ T-cell/CD19+ B-cell hematopoietic grafts - a stem cell therapy that enhances donor hematopoietic and immune reconstitution while decreasing GvHD; and 3) a pre- and post-transplant monitoring protocol to maximize engraftment. All three patients in the Phase 1b portion of the study show early safety and efficacy of this approach. Briquilimab was..."

Clinical • Acute Graft versus Host Disease • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Immunology • Transplant Rejection • Transplantation • CD34 • KIT • NCAM1

The Impact of an Adaptive mHealth Intervention on Improving Patient-Provider Health Care Communication: Secondary Analysis of the DIAMANTE Trial. (PubMed, JMIR Mhealth Uhealth) - "While our study found no significant changes in patient-provider communication by RCT arm, the temporal implications of the COVID-19 pandemic during the DIAMANTE study period remain unclear and should be further studied. This study is the first of its kind to examine the influence of an adaptive mHealth intervention on patient-reported health care communication, with insights that may be important as digitally-enabled chronic care management rapidly expands."

Clinical • Journal • CNS Disorders • Depression • Diabetes • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Psychiatry • Type 2 Diabetes Mellitus

Identification of novel electrophysiologic biomarkers of cognition in glioma-infiltrated cortex. (ASCO 2025) - "This study is the first of its kind to identify unique electrophysiological biomarker differences (at resting state) for oligodendroglioma and astrocytoma speech cortex. It has two key implications. First, clinically, the identification of electrophysiologic biomarkers may improve direct cortical stimulation (DCS) mapping: It can make surgeries faster by identifying cortex critical for cognition (speech) based on these biomarkers, safer by helping neurosurgeons avoid resecting critical regions, and more accessible."

Biomarker • Astrocytoma • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Oligodendroglioma • Oncology • Solid Tumor

HIV prevention and crack harm reduction using projection mapping in Mexico City. (PubMed, Health Educ J) - "The Tirando Esquina: Interviniendo Muros de Salud (TE:IMS) project uses projection-mapping technology and is the first of its kind to reach and provide health education at an individual and community level to at-risk crack smoking populations in Mexico City...TE: IMS was successful in providing health education and harm reduction strategies at a community level to at-risk crack smoking populations in Mexico City. These findings provide evidence for the initial effectiveness of innovative education and harm reduction efforts in this population."

Journal • Hepatitis C • Human Immunodeficiency Virus • Infectious Disease • Inflammation

Prophylactic Nimodipine for Hearing Preservation in Vestibular Schwannoma: A Retrospective Cohort Study (ARO 2025) - "This study, the largest of its kind to date, provides compelling evidence for the efficacy of prophylactic nimodipine in preserving hearing in patients undergoing vestibular schwannoma surgery. While our results highlight nimodipine's potential clinical benefits, the retrospective design limits the ability to assess long-term hearing outcomes. Future prospective studies are necessary to confirm these findings and further elucidate nimodipine's role in otologic surgery."

Retrospective data • Brain Cancer • CNS Disorders • Depression • Hematological Disorders • Oncology • Otorhinolaryngology • Psychiatry • Solid Tumor • Subarachnoid Hemorrhage

Patriarchy, Fertility and Excess Female Child Mortality in India. (PubMed, Spat Demogr) - "This study is the first of its kind to examine the association of a novel measure of patriarchy with TFR and excess female child mortality. As patriarchy is deep-rooted in Indian society, a great deal of effort is needed to shift these traditionally held social norms and practices."

Journal

Self-Compassion (AACAP 2024) - "Sponsored By Wellness Programs Description: Sometimes we are just not kind to ourselves when we should be practicing self-compassion...Participants have the opportunity to participate in exercises to help reinforce the components of self-compassion, create their own self-compassion affirmation, and learn about and try out self-compassion strategies in small groups. Participants discuss barriers to self-compassion and learn different ways to practice self-compassion daily."

Human Papillomavirus (HPV) Vaccination Rates Among U.S. Military Veteran Females and Males and Non-Veterans in the National Health Interview Survey. (PubMed, Mil Med) - "Veterans of both sexes are more likely to be vaccinated than their non-Veteran civilian counterparts. However, vaccination rates overall remain low. To our knowledge, ours is the first study of its kind to establish HPV vaccination rates among female Veterans. These findings underscore the important role of DoD and VA health care systems in improving HPV vaccine uptake and mitigating HPV-associated cancer risk among Veterans."

Interview • Journal • Human Papillomavirus Infection • Infectious Disease • Oncology

A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation. (PubMed, Front Cell Neurosci) - "To our knowledge, this is the first study of its kind that compares the presentation of siblings each with a KCNB1 disorder. Our study demonstrates that Kv2.1-S114R has profound cellular and phenotypic consequences. Understanding the mechanisms underlying KCNB1-linked disorders aids clinicians in diagnosis and treatment and provides potential therapeutic avenues to pursue."

Journal • Absence Seizure Disorder • Autism Spectrum Disorder • Behavior Disorders • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Infectious Disease • Mental Retardation • Psychiatry

An Analysis of Trainee Salaries Offered in Nurse Practitioner and Physician Assistant/Associate Postgraduate Residency and Fellowship Programs in the United States. (PubMed, Cureus) - "Conclusion To the best of our knowledge, this national study is the first of its kind to examine and summarize APP postgraduate trainee annual salaries across multiple specialties. Additional studies are needed to clarify the relationships between trainee salaries and other variables."

Journal • Psychiatry

Identification of gaps in the delivery of high-quality care of patients with eosinophilic esophagitis. (PubMed, Dis Esophagus) - "This is the first study of its kind to utilize these previously established QIs to objectively identify care gaps that exist in EoE amongst several institutions. These findings also highlight the importance of QIs and standardization of management of complex chronic diseases like EoE to help bridge these gaps and provide a framework to measure adherence to these best practices."

Clinical • Journal • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Immunology

Compass Rose™ Implementation in a Large Academic Medical Center. (PubMed, Explor Res Clin Soc Pharm) - "To the best of our knowledge, this is the first study of its kind to discuss the implementation of Compass Rose™...Compass Rose™ implementation had no significant impact on staff satisfaction, patient satisfaction, or overall refill documentation time. Prescription turnaround time increased, which could be due to significant workflow changes with Compass Rose™ or several other contributing factors such as increased prescription volume and training new staff during this period.Benefits of Compass Rose™ included standardization of workflow, ability to quantify staff performance and clinical impact, and increased transparency regarding care provided by the specialty pharmacy team."

Journal

Age-related brain atrophy and the positive effects of behavioral enrichment in middle-aged beagles. (PubMed, J Neurosci) - "We show increased hippocampal volumes across all dogs, even control placebo dogs, compelling evidence for a strong enrichment-related benefit on hippocampal structural integrity. Our findings are the first of its kind to demonstrate benefits of behavioral intervention on longitudinal structural brain changes in a higher mammalian model of aging and AD."

Journal • Alzheimer's Disease • CNS Disorders • NFATC1

"Resilience?" perspectives from adults living with sickle cell disease. (PubMed, J Natl Med Assoc) - "This study suggests that current definitions of resilience used in validated survey measures do not match how adults living with SCD define resilience. Our results expand the understanding of resilience as a dynamic process, more about the process of "not giving up." These findings suggest that providers may find it productive to facilitate conversations with adults living with SCD around "how" they approach challenges. This study is also the first of its kind to examine resilience in a community living with SCD."

Journal • Genetic Disorders • Hematological Disorders • Sickle Cell Disease

PNOC018: Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: University of California, San Francisco | Not yet recruiting ➔ Recruiting

Enrollment open • Brain Cancer • CNS Tumor • Diffuse Midline Glioma • Glioma • Oncology • Solid Tumor

PNOC018: Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: University of California, San Francisco | Trial completion date: Dec 2028 ➔ Aug 2029 | Initiation date: May 2023 ➔ Aug 2023 | Trial primary completion date: Dec 2028 ➔ Aug 2029

Trial completion date • Trial initiation date • Trial primary completion date • Brain Cancer • CNS Tumor • Diffuse Midline Glioma • Glioma • Oncology • Solid Tumor