cefprozil / Generic mfg. - LARVOL DELTA

Urticaria-Like Hypersensitivity Reaction Following Botulinum Toxin Injection: A Case Report of Possible Interaction with β-Lactam Antibiotics. (PubMed, Int Med Case Rep J) - "The treatment was performed after the patient had taken cefprozil for an upper respiratory tract infection. Subsequently, the patient developed urticaria-like symptoms that completely resolved within 24 hours after administration of antihistamines. This case emphasises the need for careful medication history review before botulinum toxin administration, especially in patients receiving β-lactam antibiotics, as hypersensitivity reactions may occur."

Journal • Allergy • Dermatology • Immunology • Infectious Disease • Respiratory Diseases • Urticaria

Evaluating the effectiveness and outcomes of oral cephalosporin drug allergy assessment (AAAAI-WAO 2025) - "The most common culprit cephalosporins were cephalexin (38), cefaclor (24), and cefprozil (14). Conclusions A single-day cephalosporin OC is safe following careful risk assessment, and skin testing may not always be necessary. These findings suggest that streamlined diagnostic approaches could remove cephalosporin allergy labels, thereby reducing unnecessary avoidance of potentially first-line treatment."

Allergy • Immunology

Safety of Direct Cephalosporin Oral Challenges in Children (AAAAI-WAO 2025) - "There is much data regarding direct amoxicillin challenges; however, published reports of pediatric direct cephalosporin challenges are limited...Results A total of 194 oral challenges were completed - 146 cefdinir, 39 cephalexin, 5 cefprozil, 3 cefixime, and 1 cefuroxime...Conclusions Direct oral cephalosporin challenges can be safe to use in children without a history of anaphylaxis or SCAR. Oral challenges can be an excellent tool for those with CAL to delabel and allow for optimal care."

Clinical • Dermatology • Immunology • Pediatrics • Urticaria

Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP (clinicaltrials.gov) - P4 | N=236 | Recruiting | Sponsor: Medical College of Wisconsin | Not yet recruiting ➔ Recruiting

Enrollment open • Head-to-Head • Infectious Disease • Pneumonia • Respiratory Diseases

Microwave Synthesis of Fluorescent Carbon Quantum dots from Araucaria Heterophylla Gum: Application in Drug Detection. (PubMed, J Fluoresc) - "Moreover, we present here for the first time that the synthesized CQDs demonstrate a rapid, exceptionally sensitive, and discerning fluorescence quenching phenomenon (IFE) concerning Cefprozil (CPR)...The limit of detection for relationships for CPR was 2.51 µM. This study provides novel opportunities for producing high-quality luminescent CQDs that meet the requirements for various biological and environmental applications."

Journal

Cotton Ball Aspiration Leading to Pulmonary Complications in a Child. (PubMed, Am J Case Rep) - "Laboratory findings indicated an elevated white blood cell; therefore, cefprozil was given as anti-infective treatment...CONCLUSIONS For children with unclear history of foreign body aspiration, bronchoscopy is recommended if there is recurrent pulmonary infection, low auscultation breath sounds, or abnormal imaging. The choice of surgical method depends on the location and type of foreign body and the experience of the surgeon, which is also very important."

Journal • Hematological Disorders • Infectious Disease • Respiratory Diseases

Evaluation of Cross-Reactivity Between Penicillins and Cephalosporins in Children with a History of Cephalosporin Allergy. (PubMed, Sisli Etfal Hastan Tip Bul) - "The children had used 5.14±4.91 (1-15) times any beta-lactam antibiotic in the previous year and the most common cephalosporins accused were ceftriaxone (42.92%), and cefuroxime, cefazolin, cefixime, cefprozil and cefotaxime (9.5% each). There seems to be a high risk of adverse reactions to penicillins and other cephalosporins in children with a history of type I hypersensitivity reaction to cephalosporins. Therefore, skin testing with both cephalosporins and penicillins should be performed in patients with a history of cephalosporin allergy."

Journal • Allergy • Immunology

Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP (clinicaltrials.gov) - P4 | N=236 | Not yet recruiting | Sponsor: Medical College of Wisconsin

Head-to-Head • New P4 trial • Infectious Disease • Pneumonia • Respiratory Diseases

A CASE OF MULTIDRUG-RESISTANT PSEUDOMONAS PUTIDA URINARY TRACT INFECTION IN AN IMMUNOCOMPENTENT MALE INFANT WITH VESICOURETERAL REFLUX (ESPID 2024) - "The patient presented with febrile illness while receiving oral cefprozil for an upper respiratory tract infection. Urinalysis revealed 50-60 leukocytes and 5-8 erythrocytes per high power field, bacteria, nitrires, protein 2+, ph 6. Urinary culture, obtained by clean-catch mid-voided urine, was positive for Pseudomonas putida > 10 5 cfu/ml, resistant to all penicillins but meropenem (sensitive), intermediately sensitive to piperacillin/tazobactam, imipenem, ceftazidime, sensitive to gentamicin and resistant to quinolones, tetracyclines, glycopeptides, nitrofurantoin, trimethoprim/sulfamethoxazole, fosfomycin. The patient was initially administered intravenous ceftriaxone, which was modified to ceftazidime accordingly, for 10 days."

Clinical • Cognitive Disorders • Infectious Disease • Nephrology • Pediatrics • Respiratory Diseases • CRP

Differences in Anaphylaxis Reporting Among Cephalosporins: Analysis of the FDA Adverse Event Reporting System Database (AAAAI 2024) - "Top parenteral cephalosporins associated with anaphylaxis were cefazolin (n=346;PRR=55.65), cefoxitin (37;36.67), cefuroxime (423;31), ceftriaxone (367;13.13), and cefotaxime (34;8.96) and top oral cephalosporins were cefadroxil (n=29;PRR=27.03), cefuroxime-axetil (136;26.22), cefaclor(46;18.64), cephalexin (188;12.20) and cefprozil (8;11.75). In our review of FAERS data, we uncovered important themes and trends in reports of cephalosporin-associated anaphylaxis. Intravenous cephalosporins are disproportionately reported to be associated with anaphylaxis compared to oral cephalosporins and may therefore, represent a higher priority for standardized testing approaches."

Adverse events • Allergy • Immunology

Identification and characterization of domain-specific inhibitors of DENV NS3 and NS5 proteins by in silico screening methods. (PubMed, J Biomol Struct Dyn) - "Our comprehensive analysis identified tolcapone, cefprozil, delavirdine and indinavir as potential inhibitors of NS5 MTase, NS5 RdRp, NS3 protease and NS3 helicase functions, respectively. These high-confidence candidate molecules will be useful for developing effective anti-DENV therapy to combat dengue infection.Communicated by Ramaswamy H. Sarma."

Journal • Dengue Fever • Infectious Disease

Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections. (PubMed, Ther Deliv) - "Aim: The study aimed to develop and evaluate an aquasome drug-delivery system for controlled drug delivery of cefprozil monohydrate... It showed particle size of 2791.9 nm, zeta potential of -0.3 mV with good stability, and 99.08% of drug loading and drug release were controlled and prolonged, achieving 56% within 8 h and possessing potential for 100% release beyond 12 h. An aquasome drug-delivery system was developed for novel controlled drug delivery for pharmaceutical antibiotic therapeutics."

Journal • Infectious Disease

Assessing Pediatric Cephalosporin Allergic Reactions Through Direct Graded Oral Challenges. (PubMed, J Allergy Clin Immunol Pract) - "Direct GOCs are safe and effective for diagnosing pediatric cases who report non-vesicular skin-limited symptoms while treated with cephalosporins."

Journal • Allergy • Dermatology • Food Hypersensitivity • Immunology • Pediatrics

Pharmacokinetic and Bioequivalence Evaluation of Two Cefprozil Dispersible Tablets in Healthy Chinese Volunteers. (PubMed, Clin Pharmacol Drug Dev) - "The test and the reference cefprozil were bioequivalent in healthy Chinese volunteers, and there was no significant food effect in individuals receiving either formulation. No serious adverse event was recorded, and no volunteers withdrew from the study."

Journal • PK/PD data

Heterologous expression, purification, and characterization of thermo- and alkali-tolerant laccase-like multicopper oxidase from Bacillus mojavensis TH309 and determination of its antibiotic removal potential. (PubMed, Arch Microbiol) - "BmLMCO reduced the antibacterial activity of cefprozil, gentamycin, and erythromycin by 72.3 ± 1.5%, 79.6 ± 6.4%, and 19.7 ± 4.1%, respectively. This is the first revealing shows the recombinant production of laccase-like multicopper oxidase from any B. mojavensis strains, its biochemical properties, and potential for use in bioremediation."

Journal

A Multicenter Evaluation of Antimicrobial Resistance and Trends in Escherichia coli (E. coli) Urinary Isolates among Female Outpatients in the U.S.: Comparison of Facility Reported Results versus Results Re-interpreted with Current Clin. and Lab. Standards Inst. (CLSI) Breakpoints (ASM Microbe 2023) - "To assess the potential impact of the CLSI changes in minimum inhibitory concentration breakpoints, AMR (defined as non-susceptible intermediate or resistant results) prevalence trends were assessed over the study period for cefazolin, ciprofloxacin, and levofloxacin for facility reported results and results re-interpreted using current CLSI breakpoints, including surrogate testing of cefazolin to predict results for cefaclor, cefdinir, cefpodoxime, cefprozil, cefuroxime, cephalexin and loracarbef. Rates of ciprofloxacin and levofloxacin AMR were higher using current CLSI breakpoints compared to facility reported results for the study period. AMR rates to cefazolin and levofloxacin increased 2011-2021 in E. coli urinary isolates among US female outpatients. Table."

Clinical • Infectious Disease • Nephrology

A Multicenter Evaluation of Antimicrobial Resistance and Trends in Klebsiella pneumoniae (K. pneumoniae) Urinary Isolates among Female Outpatients in the U.S.: Comparison of Facility Reported Results versus Results Re-Interpreted with Current Clin. and Lab. Standards Inst. (CLSI) Breakpoints (ASM Microbe 2023) - "To assess the potential impact of the CLSI changes in minimum inhibitory concentration breakpoints, AMR (defined as non-susceptible intermediate or resistant results) prevalence trends were assessed over the study period for cefazolin, ciprofloxacin, and levofloxacin for facility reported results and results re-interpreted using current CLSI breakpoints, including surrogate testing of cefazolin to predict results for cefaclor, cefdinir, cefpodoxime, cefprozil, cefuroxime, cephalexin and loracarbef. Rates of ciprofloxacin and levofloxacin AMR were higher using current CLSI breakpoints than facility reported results for the study period. AMR rates to cefazolin, ciprofloxacin and levofloxacin increased 2011-2021 in K. pneumoniae urinary isolates among US female outpatients. Table."

Clinical • Infectious Disease • Nephrology • Pneumonia

A MONTH-LASTING HIGH-GRADE INTERMITTENT DAILY FEVER ASSOCIATED WITH SPLENOMEGALY, LYMPHADENOPATHIES AND CYTOPENIAS IN AN OTHERWISE HEALTHY 10-YEARS-OLD BOY WITH A MISDIAGNOSED COMMON PEDIATRIC VIRAL INFECTION (ESPID 2023) - "Cefprozil and clarithromycin were ineffective. Laboratory tests excluded EBV and Group-A Streptococcus infections, showing mildly increased phlogosis indexes; the child was discharged with oral prednisone with subsequent 48-hours lasting defervescence...Learning Points/ Parvovirus is a potential cause of FUO with hematotropism. Molecular infectivological analysis on bone marrow aspirate should be considered in case of serological-molecular inconclusive results on peripheral blood."

Clinical • Anemia • Cognitive Disorders • Hematological Disorders • Hepatitis B • Infectious Disease • Leukopenia • Lyme Disease • Musculoskeletal Pain • Pediatrics • Rheumatology

Measuring Adherence to First-Line Antimicrobial Treatment for Presumed Urinary Tract Infections in the Pediatric Emergency Department (PAS 2023) - "Cephalexin and cefprozil were considered appropriate for children < 12 years, and cephalexin and nitrofurantoin for children 12 years or older. A total of 1461 eligible encounters were included, with 1060 (72.6%) prescribed antibiotics considered inappropriate by hospital guidelines. Among those patients, the vast majority (88%) were prescribed cefdinir (Table 1). For patient characteristics, older age was associated with appropriate prescribing and Hispanic/Latino race was associated with inappropriate."

Adherence • Clinical • Infectious Disease • Nephrology • Pediatrics

Characterization of vancomycin-resistance vanD gene clusters in the human intestinal microbiota by metagenomics and culture-enriched metagenomics. (PubMed, JAC Antimicrob Resist) - "Stool samples were collected before and after 7 days of cefprozil β-lactam antibiotic exposure of 18 participants and six control participants who were not exposed to the antibiotic at the same time points. This study showed that culture-enriched metagenomics allowed detection of vanD genes not detected by direct metagenomics and revealed collateral enrichment of bacteria containing vancomycin-resistance vanD genes following exposure to β-lactams, with a higher prevalence of the most likely gut commensal anaerobes carrying vanD. These commensal anaerobes could be the reservoir of vanD genes carried by enterococci."

Journal

Assessing Allergic Reactions to Cephalosporins in Children (AAAAI 2023) - "Cefprozil represented the most common cephalosporin antibiotic exposure (61.9% of cases)...Direct GOC is an effective, safe, and appropriate tool for diagnosing cephalosporin allergies in children."

Clinical • Allergy • Dermatology • Immunology • Pediatrics

Quantification of sixteen cephalosporins in the aquatic environment by liquid chromatography-tandem mass spectrometry. (PubMed, J Sep Sci) - "Moreover, seven cephalosporins, including cefuroxime, ceftazidime, cefradine, cefprozil, cefixime, cefalexin, and cefadroxil (0.68-105.45 ng/L) were determined in the aquatic environment. The overall findings showed that the effluent from the wastewater treatment plants that receive wastewater from pharmaceutical factories had a higher detected amount of cephalosporins than that of domestic sewage. Moreover, seven cephalosporins, including cefuroxime, ceftazidime, cefradine, cefprozil, cefixime, cefalexin, and cefadroxil (0.68-105.45 ng/L) were determined in the aquatic environment."

Journal • Infectious Disease • Novel Coronavirus Disease

Proteomic analysis of Penicillin G acylases and resulting residues in semi-synthetic β-lactam antibiotics using liquid chromatography - tandem mass spectrometry. (PubMed, J Chromatogr A) - "In total nine batches of five types of SSBAs (amoxicillin, cephalexin, cefprozil, cefdinir and cefaclor) from eight manufacturers were selected for investigation. Moreover, it could provide in-depth analysis of amino acid sequences and signature peptides contributing to assignment of the strain sources of PGAs. This method could become a promising and powerful tool to monitor enzymatic process robustness and reliability of this kind of SSBAs manufacturing."

Journal • Allergy

Lipophilicity study of different cephalosporins: Computational prediction of minimum inhibitory concentration using salting-out chromatography. (PubMed, J Pharm Biomed Anal) - "The chromatographic and lipophilicity characters of seven cephalosporins of different four classes (cephradine, cefaclor, cefprozil, cefixime, cefotaxime, ceftazidime and cefepime) were examined by salting out thin-layer chromatography (SOTLC). The developed SOTLC method can be considered as a good start alternative to reversed phase thin layer chromatography (RP-TLC) for prediction of the lipophilic properties of examined cephalosporins. Moreover, the proposed NP-TLC densitometric method can be easily applied for quality control analysis of the chosen drugs and other structurally related components."

Journal

Pharmacokinetic comparison with different assays for simultaneous determination of cis-, trans-cefprozil diastereomers in human plasma. (PubMed, J Pharm Anal) - "Comparison of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state, which may affect clinical dose and usage settings. Furthermore, we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans."

Journal • PK/PD data