AC-501 / TWi Biotechnology - LARVOL DELTA

Specific enhancement of the translation of thermospermine-responsive uORF-containing mRNAs by ribosomal mutations in Arabidopsis thaliana. (PubMed, Plant Signal Behav) - "Our results showed that these alleles enhanced GUS activity in SAC51 and SACL3 5'-fusion constructs but had no effect on other 5'-fusion constructs unrelated to thermospermine response. This suggests that these ribosomal proteins are specifically involved in the thermospermine-mediated regulation of mRNA translation."

Journal • RACK1 • RPL10

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity. (PubMed, Cell Discov) - "Meanwhile, CoVac501 elicited the increase of memory T cells, antigen-specific CD8 T-cell responses, and Th1-biased CD4 T-cell immune responses in NHPs. Notably, at an extremely high SARS-CoV-2 challenge dose of 1 × 10 TCID, CoVac501 provided near-complete protection for the upper and lower respiratory tracts of cynomolgus macaques."

IO biomarker • Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CD4 • CD8

"Volunteer with me and @YPACS501 and @AmericanCancer at 2019 Little Rock Marathon! https://t.co/g4t6X9wEgG #HappyVolunteering #LRMarathon #givingback" (,@AlexanderWinans)