bupivacaine implant (ATX-101) / Allay Therap - LARVOL DELTA

SPARK 2: Study Assessing Pain Relief After Replacement of the Knee (clinicaltrials.gov) - P2 | N=226 | Completed | Sponsor: Allay Therapeutics, Inc. | Active, not recruiting ➔ Completed

Trial completion • Orthopedics • Pain

SPARK 2: Study Assessing Pain Relief After Replacement of the Knee (clinicaltrials.gov) - P2 | N=226 | Active, not recruiting | Sponsor: Allay Therapeutics, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed • Orthopedics • Pain

SPARK 2: Study Assessing Pain Relief After Replacement of the Knee (clinicaltrials.gov) - P2 | N=200 | Recruiting | Sponsor: Allay Therapeutics, Inc.

New P2 trial • Orthopedics • Pain

SPARK: Study Assessing Pain Relief After Replacement of the Knee (clinicaltrials.gov) - P2 | N=112 | Terminated | Sponsor: Allay Therapeutics, Inc. | N=305 ➔ 112 | Trial completion date: Aug 2025 ➔ Jan 2024 | Active, not recruiting ➔ Terminated | Trial primary completion date: Aug 2025 ➔ Jan 2024; Based on positive data from the dose-ranging portion of the study, Sponsor decided as of May 28, 2024 not to move forward with the previously designed global ATX101-TKA-003 study.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Orthopedics • Pain

SPARK: Study Assessing Pain Relief After Replacement of the Knee (clinicaltrials.gov) - P2 | N=305 | Active, not recruiting | Sponsor: Allay Therapeutics, Inc. | Recruiting ➔ Active, not recruiting | Phase classification: P2b ➔ P2 | Trial completion date: Jun 2024 ➔ Aug 2025 | Trial primary completion date: Jun 2024 ➔ Aug 2025

Enrollment closed • Phase classification • Trial completion date • Trial primary completion date • Orthopedics • Pain

Study Assessing Pain Relief After Replacement of the Knee (clinicaltrials.gov) - P2b | N=305 | Recruiting | Sponsor: Allay Therapeutics, Inc. | Trial completion date: Jun 2023 ➔ Jun 2024 | Trial primary completion date: Jun 2023 ➔ Jun 2024

Trial completion date • Trial primary completion date • Orthopedics • Pain

ATX-101 for Post-surgical Pain Following Total Knee Arthroplasty (clinicaltrials.gov) - P2b | N=345 | Recruiting | Sponsor: Allay Therapeutics, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Orthopedics • Pain