bupivacaine implant (ATX-101)
/ Allay Therap
- LARVOL DELTA
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November 05, 2025
SPARK 2: Study Assessing Pain Relief After Replacement of the Knee
(clinicaltrials.gov)
- P2 | N=226 | Completed | Sponsor: Allay Therapeutics, Inc. | Active, not recruiting ➔ Completed
Trial completion • Orthopedics • Pain
September 10, 2025
SPARK 2: Study Assessing Pain Relief After Replacement of the Knee
(clinicaltrials.gov)
- P2 | N=226 | Active, not recruiting | Sponsor: Allay Therapeutics, Inc. | Recruiting ➔ Active, not recruiting
Enrollment closed • Orthopedics • Pain
January 29, 2025
SPARK 2: Study Assessing Pain Relief After Replacement of the Knee
(clinicaltrials.gov)
- P2 | N=200 | Recruiting | Sponsor: Allay Therapeutics, Inc.
New P2 trial • Orthopedics • Pain
June 26, 2024
SPARK: Study Assessing Pain Relief After Replacement of the Knee
(clinicaltrials.gov)
- P2 | N=112 | Terminated | Sponsor: Allay Therapeutics, Inc. | N=305 ➔ 112 | Trial completion date: Aug 2025 ➔ Jan 2024 | Active, not recruiting ➔ Terminated | Trial primary completion date: Aug 2025 ➔ Jan 2024; Based on positive data from the dose-ranging portion of the study, Sponsor decided as of May 28, 2024 not to move forward with the previously designed global ATX101-TKA-003 study.
Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Orthopedics • Pain
January 09, 2024
SPARK: Study Assessing Pain Relief After Replacement of the Knee
(clinicaltrials.gov)
- P2 | N=305 | Active, not recruiting | Sponsor: Allay Therapeutics, Inc. | Recruiting ➔ Active, not recruiting | Phase classification: P2b ➔ P2 | Trial completion date: Jun 2024 ➔ Aug 2025 | Trial primary completion date: Jun 2024 ➔ Aug 2025
Enrollment closed • Phase classification • Trial completion date • Trial primary completion date • Orthopedics • Pain
February 08, 2023
Study Assessing Pain Relief After Replacement of the Knee
(clinicaltrials.gov)
- P2b | N=305 | Recruiting | Sponsor: Allay Therapeutics, Inc. | Trial completion date: Jun 2023 ➔ Jun 2024 | Trial primary completion date: Jun 2023 ➔ Jun 2024
Trial completion date • Trial primary completion date • Orthopedics • Pain
June 10, 2022
ATX-101 for Post-surgical Pain Following Total Knee Arthroplasty
(clinicaltrials.gov)
- P2b | N=345 | Recruiting | Sponsor: Allay Therapeutics, Inc. | Not yet recruiting ➔ Recruiting
Enrollment open • Orthopedics • Pain
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