metoclopramide / Generic mfg. - LARVOL DELTA

Effect of Multiple Pharmacological Interventions and Magnetic Control on Capsule Endoscopy Gastrointestinal Transit Time and Diagnostic Yield: A Systematic Review and Meta-Analysis. (PubMed, JGH Open) - "Erythromycin and magnetic guidance were consistently associated with faster gastric passage, while lubiprostone and polyethylene glycol (PEG) shortened SBTT compared with control groups. For improving overall completion, metoclopramide remains a dependable option. These findings support individualized preparation strategies tailored to the specific diagnostic goals of CE."

Journal • Retrospective data

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study. (PubMed, BMC Med) - "This large-scale study found no association between antiemetic exposure during pregnancy and the risk of neurodevelopmental disorders or delays in children, providing reassurance for the use of antiemetics in pregnancy to treat nausea and vomiting. However, the slightly elevated risks observed in certain subgroups warrant further investigation. Meanwhile, these findings may assist in guiding decisions when considering antiemetic treatment during pregnancy."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • Cerebral Palsy • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Movement Disorders • Pediatrics • Psychiatry

Earmuff and eye mask in the treatment of acute primary headache in emergency department: a randomized controlled open label study. (PubMed, BMC Emerg Med) - P=N/A | "Earmuffs combined with sleep eye masks as an adjunct to metoclopramide significantly enhance early headache relief in the emergency department and represent a safe, low-cost complementary therapy. Participants were not blinded to the intervention due to practical constraints, and for the same reason, placebo control was not used."

Clinical • Journal • CNS Disorders • Migraine • Pain • Sleep Disorder

Causality, severity and avoidability of adverse drug reactions in children: An 11-year review. (PubMed, Br J Clin Pharmacol) - "Our study shows that one in six paediatric ADRs were potentially avoidable, highlighting the need for improved ADR documentation, pharmacovigilance and clinician education."

Adverse drug reaction • Journal • Allergy • Immunology • Pain • Pediatrics

Preoperative Aprepitant Decreases Postoperative Nausea After Laparoscopic Sleeve Gastrectomy. (PubMed, R I Med J (2013)) - "The addition of preoperative aprepitant to a multimodal protocol can reduce nausea after laparoscopic sleeve gastrectomy."

Journal • Retrospective data • Gastrointestinal Disorder

BAGI-assessed green GC-MS method for rapid analysis of paracetamol/metoclopramide in pharmaceuticals and plasma. (PubMed, Sci Rep) - "Greenness assessment via three metrics, including the BAGI tool (score: 82.5), confirmed its environmental superiority over conventional methods. With high sensitivity, accuracy, and a 5-minute runtime, this approach is ideal for routine quality control and pharmacokinetic studies."

Journal

The Importance of Medication Reconciliation in a Patient with Parkinson's Disease. (PubMed, Sr Care Pharm) - "His carbidopa/levodopa dose was titrated back to the previous regimen, metoclopramide was discontinued, and his symptoms significantly improved. This case highlights the importance of best practices in medication reconciliation for patients with Parkinson's disease, the impact of drug-disease interactions, and emphasizes the critical role of ambulatory care pharmacists in geriatric patient care."

Journal • CNS Disorders • Geriatric Disorders • Infectious Disease • Movement Disorders • Parkinson's Disease • Pneumonia • Respiratory Diseases

Tirzepatide: Failing the Acid Test (KIDNEY WEEK 2025) - "Case Description A 34-year-old female with class 3 obesity presented with multiple episodes of vomiting and nausea for 4 days...She was started on metoclopramide and required multiple substantial potassium and phosphorus repletion...She was profoundly malnourished with lab values indicating refeeding syndrome only 12 hours after treatment. This case highlights the potential of life-threatening starvation ketoacidosis induced by the tirzepatide."

Addiction (Opioid and Alcohol) • Genetic Disorders • Metabolic Disorders • Musculoskeletal Pain • Obesity • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

Therapeutic potential of Codonopsis lanceolata peel extract in premenstrual syndrome: insights into hormonal, immune, and microbial interactions. (PubMed, Food Sci Biotechnol) - "In a metoclopramide (MCP)-induced hyperprolactinemia mouse model, CPE decreased serum prolactin, PGE2, and inflammatory cytokines, while increasing PGE1 and FSH levels...Overall, these findings suggest that CPE alleviates PMS symptoms by modulating endocrine function and regulating gut microbiota. The online version contains supplementary material available at 10.1007/s10068-025-02003-w."

Journal • Gynecology • IL6 • PRL • TNFA

Two cases of MACS due to PBMAH associated with an in vivo aberrant response to LHRH treated with leuprolide acetate. (PubMed, Endocrinol Diabetes Metab Case Rep) - "In both patients, morning serum cortisol levels remained elevated following 1 mg dexamethasone suppression test (DST) and 4 mg intravenous DST, while basal adrenocorticotropic hormone (ACTH) levels were suppressed...The first case involved a 69-year-old woman who exhibited significant increases in cortisol in response to luteinizing hormone-releasing hormone (LHRH; +142%), vasopressin (+66%) and metoclopramide (+98%)...In patients with MACS who have an aberrant cortisol response following LHRH stimulation, the long-acting GnRH agonist leuprolide acetate can be used to suppress endogenous LH production and improve hypercortisolism. A greater increase in cortisol secretion following LHRH stimulation and small response to the other stimuli could potentially be predictive of a better response to treatment with leuprolide acetate."

Journal • Preclinical • Endocrine Disorders

Which Analgesic Should We Use to Relieve Pain After Knee or Hip Arthroplasty? A Systematic Review and Network Meta-analysis of RCTs. (PubMed, Clin Orthop Relat Res) - "For knee arthroplasty, local levobupivacaine appeared to be the most effective option. For hip arthroplasty, local ropivacaine combined with ketorolac and adrenaline appeared the best. In terms of functional improvement, nerve-block levobupivacaine combined with dexmedetomidine (used under monitored conditions) appeared the most effective after knee arthroplasty. Although most interventions had similar safety profiles, intravenous tramadol combined with metoclopramide decreased the risk of nausea. Clinicians should integrate these results with known safety profiles and patient-specific factors to guide individualized postoperative pain management after knee and hip arthroplasties."

Journal • Retrospective data • Musculoskeletal Pain • Orthopedics • Pain

Evaluation of factors associated with clinically problematic hiccups in cisplatin-containing treatment with dexamethasone and neurokinin 1 receptor antagonists. (PubMed, Int J Clin Oncol) - "Our study revealed that male sex, hypoalbuminemia, and concomitant bevacizumab use were significant risk factors for clinically problematic hiccups in patients receiving CDDP-containing treatment along with dexamethasone and NK1 receptor inhibitors for thoracic cancer."

Journal • Oncology • Thoracic Cancer

The Use of Gastrointestinal Reflux and Pro-Motility Medications in Hospitalized Infants with Congenital Heart Disease using the Pediatric Acute Care Cardiology Collaborative Registry (AHA 2025) - "Groups were compared based on the use of the following medications at discharge: histamine H2 antagonists, proton pump inhibitors, antacids, metoclopramide, erythromycin ethylsuccinate, or amoxicillin/clavulanic acid. Patients with SV CHD, those on elemental formula, tube assisted feeding and those with longer length of stays are more likely to be discharged on anti-reflux or pro-motility medications. An interesting finding is the positive association of the use of these medications with growth velocity prior to discharge specifically among SV patients. This suggests that these infants may have additional benefit from utilization of these medications at discharge."

Clinical • Cardiovascular • Gastroenterology • Gastroesophageal Reflux Disease • Heart Failure • Pediatrics

The Impact of Chewing Gum on Intestinal Activity in Patients After Esophageal Cancer Radical Surgery: A Randomized Controlled Study (ChiCTR) - P1 | N=50 | Not yet recruiting | Sponsor: The Third Affiliated Hospital of Sun Yat-sen University; The Third Affiliated Hospital of Sun Yat-sen University

New P1 trial • Esophageal Cancer • Oncology

An Intriguing Case of Hypermobile Ehlers-Danlos Syndrome Presenting With Severe Gut Dysmotility and Refractory Gastroparesis (ACG 2025) - "Full-thickness biopsy via laparoscopic gastric pacemaker placement revealed fibrosis of the myenteric plexus with sparse ganglion cells. Despite trials of metoclopramide, erythromycin, domperidone, and prucalopride, the patient exhibited minimal clinical improvement. Early recognition, combined with integrative care, is critical. As awareness of hEDS-related GI dysfunction grows, more systematic investigation is needed to inform targeted therapies and long-term outcomes."

Clinical • Fibrosis • Gastrointestinal Disorder • Genetic Disorders • Immunology • Rheumatology

No Light at the End of the Tunnel: Closing a Mucosal Defect from Inside the Tunnel During G-POEM Procedure (ACG 2025) - "We report a case of gastric POEM (GPOEM) with a mucosal defect closure from inside the tunnel due to difficult luminal side closure.Case Description/ A 48-year-old female with gastroparesis (gastric emptying study with 68% retention at 4 hours) with abdominal pain after eating, epigastric fullness, early satiety, bloating, nausea with rare vomiting, not feeling hungry, and 60 lbs weight loss over two years underwent GPOEM due to concern about long term neurological side effects with metoclopramide in the setting of lamotrigine use for bipolar disorder. Panel C: closure of the mucosal defect from inside the tunnel using two clips. Panel D: abdominal X-ray 3 months later showing only one clip in the gastric outlet/duodenal bulb area."

Bipolar Disorder • CNS Disorders • Gastrointestinal Disorder • Infectious Disease • Psychiatry

Endoscopic-Guided Gastric Fundal Botulinum Injection for Intractable Hiccups Secondary to GERD and Esophagitis (ACG 2025) - "Patient was further trialed on baclofen, gabapentin, metoclopramide, and chlorpromazine; all had only offered transient symptom relief...Throughout the perioperative period and preceding diagnostic EGD, the patient continued to experience frequent hiccups, which abruptly ceased 1 minute and 30 seconds after the first Botox injection...In patients with intractable hiccups refractory to standard medical therapy, endoscopic-guided injection of botulinum toxin targeting the diaphragm may offer an effective therapeutic option. Figure: Figure A-D demonstrating endoscopic-guided botulinum toxin injection to gastric fundus and gastroesophageal junction."

Anorexia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder

A Complex Case of Idiopathic Gastroparesis Presenting With Recurrent Hypoglycemia (ACG 2025) - "Initial management comprised of symptom control with PPI, metoclopramide, and ondansetron, as well as dietary modifications...Trial of botox injection 100units/2ml normal saline improved symptoms...G-POEM has emerged as a highly effective intervention for gastroparesis secondary to pyloric dysfunction, with long-term success rates reported to be as high as 100% in select populations. This highlights its growing role in the therapeutic arsenal for patients with refractory gastroparesis."

Clinical • Cardiovascular • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hypertension • Hypoglycemia • Metabolic Disorders • Myositis • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

Administration of Metoclopramide Prior to Endoscopy for Acute Upper Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis (ACG 2025) - "A total of 7 studies were included, resulting in a pooled analysis of 665 patients. Metoclopramide significantly increases the Endoscopic Visualization Score of the Fundus (SMD=0.30, 95% CI: [0.12,0.47 ]; p=0.0008; I²=0%), Endoscopic Visualization Score Body (SMD=0.25, 95% CI: [0.07,0.42 ]; p=0.006; I²=0%), Endoscopic Visualization Score Antrum (SMD=0.23, 95% CI: [0.05,0.40 ]; p=0.01; I²=0%), and Endoscopic Visualization Score Total (SMD=0.32, 95% CI: [0.15,0.50 ]; p=0.0003; I²=0%). Outcomes such as length of hospital stay (p=0.73), re-endoscopy (p=0.53), RBC transfusion units (p=0.42), second look endoscopy(p=0.44), duration of endoscopy (p=0.82), and mortality (p=0.86) showed insignificant results. In conclusion, metoclopramide usage improved the endoscopic visualization, but it showed no significant results when evaluated for the secondary outcomes."

Retrospective data • Review • Gastroenterology

Gastroparesis Following Ablation for Atrial Fibrillation (ACG 2025) - "The patient was trialed on metoclopramide 10 mg daily, pantoprazole 40 mg daily and famotidine 20 mg daily to alleviate her symptoms. Treatment modalities for gastroparesis include dietary modification and initiation of prokinetic agents. This case underscores the importance to acknowledge gastroparesis as a possible adverse clinical sequela to radiofrequency ablation in the setting of atrial fibrillation."

Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Diabetes • Dyslipidemia • Gastrointestinal Disorder • Heart Failure • Hypertension • Metabolic Disorders

Comparative Analysis of Medication Use and Healthcare Utilization in Gastroparesis and Functional Dyspepsia: A Propensity-Matched Cohort Study (ACG 2025) - "We identified 7,329 patients with GP (mean age 47.1±17.6 years; 72.7% female) and 3,950 with FD (mean age 44.7±20.3 years; 69.2% female). After 1:1 matching, 3,420 patients per group were followed for 5 years. GP patients had significantly higher use of metoclopramide (RR 3.4, 95% CI 3.02–3.84, P-value< .0001), erythromycin (RR 2.7, 95% CI 2.24–2.92, P-value< .0001), and antiemetics including ondansetron, promethazine, prochlorperazine, and diphenhydramine (all P-value< .0001)."

HEOR • Dyspepsia • Gastrointestinal Disorder

Looking Deeper: A Case of Double HIT Gastric Lymphoma Masquerading as Gastroparesis (ACG 2025) - "A gastric emptying study showed delayed gastric emptying, which was attributed to long-standing diabetes, and he was started on metoclopramide...EGD findings.Figure: Figure 2. EGD Biopsy findings."

Clinical • Anemia • B Cell Lymphoma • Cardiovascular • Colorectal Cancer • Diabetes • Diffuse Large B Cell Lymphoma • Fatigue • Gastrointestinal Disorder • Hematological Malignancies • High-grade B-cell lymphoma • Hypertension • Lymphoma • Metabolic Disorders • Non-Hodgkin’s Lymphoma • BCL2

Multifactorial Shock in Patient With Hiatal Hernia Causing Cardiac Compression (ACG 2025) - "She was started on vancomycin, cefepime, azithromycin, and a heparin infusion and admitted to the intensive care unit. The presence of PE, therapeutic anticoagulation and hemodynamic instability meant that any surgical intervention would have been deemed high-risk for complications. Given the elevated procedural risk, conservative management with metoclopromide and dietary changes were utilized to address the underlying physiology without exposing the patient to excessive risk.Figure: Transthoracic echocardiogram - parasternal long axisFigure: CT angiography chest"

Clinical • Breast Cancer • Cardiomyopathy • CNS Disorders • Esophageal Cancer • Gastroenterology • Gastrointestinal Disorder • Hypotension • Infectious Disease • Movement Disorders • Parkinson's Disease • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Septic Shock • Solid Tumor • Thrombosis

Dystonia in a Dose: Recognizing a Class Effect in Susceptible Patients (ACG 2025) - "This case report describes a young patient who has extrapyramidal side effects to multiple anti-emetics (metoclopramide, promethazine, and prochlorperazine), all of which triggered dystonic reactions, rendering only trimethobenzamide and ondansetron as viable treatment options.Case Description/ A 32-year-old male was admitted to hospital with viral gastroenteritis due to coronavirus infection...The healthcare team promptly responded, and given characteristic dystonic presentation, prior history of dystonia with other medications, and temporal relation with metoclopramide administration, the reaction was identified as a medication-induced extrapyramidal side effect and diphenhydramine was administered...This case emphasizes the need for healthcare providers to be vigilant and proactive when choosing antiemetic agents, particularly for patients with a history of extrapyramidal symptoms. Further research into strategies to prevent medication-related adverse effects,..."

Clinical • CNS Disorders • Dystonia • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Movement Disorders • Novel Coronavirus Disease • Respiratory Diseases