OPL-CXCL12-LPM / CoMentis - LARVOL DELTA

Blocking the CXCL12/CXCR4 pathway both radiosensitizes brain metastases in mice and protects against radiation-induced cognitive dysfunction following whole brain irradiation in rats (AACR-RM 2021) - "We have previously shown using an antagonist of CXCR4 (plerixafor) with brain implanted tumors in mice(1)or by blocking CXCL12 by olaptesed pegol (ola-peg) with chemically-induced brain tumors in rats(2) that the radiation response of the tumors is markedly enhanced by blocking the CXCL12/CXCR4 pathway. In the present study we aimed to test whether a similar radiation enhancement is produced in mice with multiple brain metastases, and in addition, in preparation for a clinical trial of whole brain irradiation (WBI) with plerixafor, we sought to determine whether blocking the CXCL12/CXCR4 pathway would affect the cognitive dysfunction of rats given WBI. In the brain metastasis study we produced multiple brain metastases by injection of the luciferase transduced brain-tropic human breast triple negative cancer cell line MDA-MB-231 B3 into the internal carotid artery of nude mice."