raltegravir / Generic mfg. - LARVOL DELTA

A 48-week, Randomized Controlled Trial of Doravirine for Individuals with HIV and Obesity on Integrase Inhibitors and Tenofovir Alafenamide: The Do IT Study (ACTG A5391). (PubMed, Clin Infect Dis) - P4 | "In people with HIV and obesity, switching from an INSTI+TAF/FTC regimen to DOR/FTC with either TAF or TDF did not produce clinically meaningful differences in weight change or metabolic health after 48 weeks."

Journal • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Obesity

Prioritization of adverse events related to integrase inhibitors and NNRTIs: a disproportionality analysis using data from the FAERS database. (PubMed, J Antimicrob Chemother) - "This study provides a systematic framework for evaluating post-marketing AEs of INSTIs and NNRTIs using a semi-quantitative scoring system. Our findings identified five high-priority AEs that require clinical validation and further investigation."

Adverse events • Journal • Eosinophilia • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Liver Failure

Pharmacovigilance study of INSTIs associated with weight gain and glucose/lipid metabolism adverse events based on the FDA adverse event reporting system. (PubMed, HIV Med) - "This study identified metabolic AEs associated with INSTIs, with agent-specific differences in risk and timing, highlighting the need for regular monitoring and individualized management during INSTI-based ART."

Adverse events • Journal • Dyslipidemia • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders

HIV-1 integrase resistance in the context of antiretroviral therapy in paediatric patients ‒ Northeast Brazil. (PubMed, Braz J Infect Dis) - "A high frequency of INSTI resistance-associated mutations was identified, indicating the need for continued surveillance in this population."

Journal • Human Immunodeficiency Virus • Infectious Disease • Pediatrics • CD4 • CD8

Antiretroviral Raltegravir, a Selective Human Immunodeficiency Virus Type 1 Integrase Inhibitor, Shows Anti-Alzheimer's Potential against Amyloid-Beta1-42-Induced Neurodegeneration. (PubMed, Mech Ageing Dev) - "Additionally, raltegravir significantly attenuated IL-1β production, likely through the downregulation of the NLRP3-inflammasome signaling pathway, indicating an important anti-inflammatory activity. Collectively, our in vitro findings are preliminary mechanistic observations that support raltegravir's repurposing for AD, thus soliciting further complementary research, especially in relevant animal models of AD, to accelerate the translation of these findings into the clinical setting."

Journal • Alzheimer's Disease • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Aβ42 • CD163 • CD86 • IL1B • NLRP3

HIV and Pregnancy in Türkiye: Gaps and Gains in the Era of Modern ART: A Multicenter Cohort Study. (PubMed, AIDS Behav) - "The most chosen ART combination during pregnancy was tenofovir/emtricitabine+raltegravir...Regarding newborn prophylaxis, 137 (88.4%) received zidovudine and 34 received nevirapine...The findings highlight that the absence of ART and breastfeeding remain critical risk factors for perinatal HIV transmission. This large real-world cohort, reflecting Turkish clinicians' practices, helps define major gaps in MTCT prevention in the modern ART era and provides valuable evidence to inform clinicians, policy makers, and public health strategies."

Journal • Human Immunodeficiency Virus • Infectious Disease

First characterization of insertions in the HIV-1 integrase-coding region from people with HIV. (PubMed, J Antimicrob Chemother) - "Our study has revealed that the mutations observed in people living with HIV-1 do not confer resistance to anti-integrase compounds but are detrimental to viral replication."

Journal • Human Immunodeficiency Virus • Infectious Disease

Safety and Tolerability of Raltegravir in a Premature Neonate: A Case Report. (PubMed, Pediatr Infect Dis J) - No abstract available

Journal

Efavirenz-Induced Hepatitis Mimicking Autoimmune Hepatitis: A Case Report. (PubMed, Cureus) - "A multidisciplinary team suspected efavirenz-related liver injury, and the drug was replaced with Raltegravir while the rest of the antiretroviral therapy (ART) regimen was maintained. Following Efavirenz withdrawal, liver enzymes, IgG, and ANA levels normalized, and liver stiffness on FibroScan improved. This case highlights the challenge of distinguishing autoimmune hepatitis from drug-induced liver injury when autoimmune markers are present and emphasizes the importance of considering late ART toxicity, as timely drug withdrawal can lead to full recovery without immunosuppression."

Journal • Autoimmune Hepatitis • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Liver Failure

Real-Life Long-Term Weight Trends After Switching to INSTI-Based Therapy in People Living with HIV: A 12-Year Retrospective Cohort Study. (PubMed, New Microbiol) - "Switching from PI- to INSTI-based cART in virologically suppressed PLWH is associated with modest but sustained increases in body weight and BMI over time, without evident deterioration in metabolic health. These results support the favourable safety profile of INSTIbased regimens while underscoring the need for routine anthropometric monitoring and preventive lifestyle interventions during long-term therapy."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease

Despite increasing use of integrase inhibitors to treat HIV infection, resistance to this class remains stable. (PubMed, J Antimicrob Chemother) - "Although the use of INSTIs has increased over time with differences in the duration of use, we did not observe a corresponding increase in the proportion of ARV-treated PLWHIV who experienced virological failure with INSTI-resistant viruses during the study period."

Journal • Human Immunodeficiency Virus • Infectious Disease

Graft-versus-HIV-reservoir reactivity: Long term HIV remission after allogeneic stem cell transplantation from a donor with active CCR5 (ASH 2025) - "Three years after alloSCT (September 2017), the patientdiscontinued antiretroviral therapy (Raltegravir and Abacavir/Lamivudine). This is the first case of HIV cure via alloSCT from a donor with active CCR5 and provides compellingevidence that "graft-versus-reservoir" reactivity is the key driver of viral reservoir clearance.For alloSCT recipients living with HIV and their caregivers, these data demonstrate the possibility of HIVcure even when no HIV resistant (CCR5 Δ32/ Δ32) alloSCT donor can be identified. Outside the alloSCTfield, our data builds the underlying rationale for HIV cure strategies based on effective viral reservoirreductions."

Clinical • Acute Graft versus Host Disease • Graft versus Host Disease • Human Immunodeficiency Virus • Immunology • Infectious Disease • Transplantation • CCR5 • CD4 • CXCR4 • FLT3

Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy. (PubMed, Open Forum Infect Dis) - "Among 529 persons with HIV (median age: 50 years, 29% non-Hispanic Black, 22% female), 62% were overweight or obese at integrase strand transfer inhibitor switch, and 62% switched to raltegravir. In adjusted linear models, three variants were associated (P < .05) with weight change after switch in all participants or in prespecified subgroups. These exploratory findings are consistent with the role of melanocortins in appetite and weight and suggest a neuroendocrine contribution to integrase inhibitor-related weight gain."

Clinical • Journal • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Obesity • MC4R

Efficacy of raltegravir in achieving virological suppression at delivery in HIV-positive pregnant women: a systematic review and meta-analysis. (PubMed, BMC Pregnancy Childbirth) - "It concluded that RAL is effective for achieving virological suppression at delivery in HIV-positive pregnant women, and possibly contribute to the prevention of mother-to-child HIV transmission."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease

Deep sequencing reveals underestimated burden of integrase inhibitor resistance mutations in people living with HIV: a global individual patient data meta-analysis. (PubMed, Emerg Microbes Infect) - "IPD analysis of 394 mutation-positive individuals revealed 8.52% low-frequency resistance to dolutegravir and bictegravir in treatment-naïve populations, while treated patients exhibited significantly increased intermediate/high-level resistance to first-generation INSTIs, including raltegravir and elvitegravir. Although second-generation INSTIs maintain lower resistance rates, cross-resistance risks necessitate clinical vigilance. Optimized resistance surveillance strategies incorporating low-frequency mutation detection offer critical evidence for advancing global HIV control efforts."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease

Prevalence of primary HIV-1 drug resistance among antiretroviral-naïve individuals in Togo in 2023: a national study. (PubMed, Front Public Health) - "However, accessory mutations (genetic changes that do not confer significant resistance by themselves) as E157Q/E157EQ (43/57) and T97A/T97TA (14/57) associated with resistance against first-generation integrase inhibitors (INIs) as raltegravir, elvitegravir were found in 17.2% of samples. The dominant subtypes were CRF02_AG (64.8%) and CRF06_cpx (12.8%). These results support the continued use of dolutegravir-based regimens in Togo and call for continued monitoring of primary resistance to maintain the effectiveness of therapeutic strategies in Togo."

Journal • Human Immunodeficiency Virus • Infectious Disease

Effects of Dolutegravir (DTG) and Raltegravir (RAL) on Brain function and Behavioral study. A Model for Cognitive disorder and Motor Function in C57 Black Mice. (Neuroscience 2025) - "The reduced locomotor activity and the marker protein changes showed new model for motor function/ cognitive function due to the effect of DTG and RAL. Our findings therefore highlight the potential of ART to be harmful to the brain and as such these drugs may contribute the development of HIV associated neurocognitive disorder."

Preclinical • CNS Disorders • Cognitive Disorders • Psychiatry

Tenofovir Alafenamide Fumarate-Associated Fanconi Syndrome (KIDNEY WEEK 2025) - "The patient had been stable on darunavir, ritonavir, and raltegravir, but this was changed to a combined bictegravir-emtricitabine-tenofovir alafenamide for simplicity just prior to his presentation. His development of acute and severe electrolyte disturbances after initiation of TAF is concerning for acute worsening of preexisting Fanconi syndrome. This case highlights that while TAF is generally considered safer, there is still risk of renal toxicity, particularly when renal tubular dysfunction is already present."

Chronic Kidney Disease • Fatigue • Human Immunodeficiency Virus • Infectious Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease

Beyond General HIV Risk: Insights on Antiretroviral Agents, Immune Status, and Cardiovascular Disease Progression in a Vulnerable Urban Cohort (AHA 2025) - "After adjustment, tenofovir use was associated with decreased CAD progression (aOR 0.14, 95% CI 0.03–0.69, p<0.05), while raltegravir (aOR 49.40, CI 1.84–1326.57, p<0.05), cobicistat (aOR 23.57, CI 1.31–425.58, p<0.05), cocaine use (aOR 13.52, CI 2.09–87.60, p<0.01), male sex (aOR 8.55, CI 1.24–59.12, p<0.05), and obstructive sleep apnea (aOR 25.23, CI 2.15–296.64, p<0.05) were associated with increased risk. Specific ART agents and CD4 count were independently associated with distinct CVD outcomes alongside traditional cardiovascular risk factors in this cohort. These insights support considering individual ART and immune status for tailored CVD risk assessment in vulnerable populations with HIV."

Cardiovascular • Coronary Artery Disease • Human Immunodeficiency Virus • Infectious Disease • Myocardial Infarction • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • CD4

Integrase Strand Transfer Inhibitors for Treatment-experienced Young Adults With Perinatal HIV in the US: Immunologic, Virologic, and Anthropometric Outcomes. (PubMed, Clin Infect Dis) - "Individual INSTI-based regimens among treatment-experienced AYAPHIV had moderate effectiveness with respect to viral suppression. Continued average weight gain across INSTIs raises concerns about long-term cardiometabolic sequalae."

Journal • Human Immunodeficiency Virus • Infectious Disease • Obesity • Pediatrics • CD4

Differences in ART regimen initiation among people with recently acquired HIV: 2015-2021 (EACS 2025) - "INSTIs were classified as first-generation (raltegravir, elvitegravir) or second-generation (dolutegravir, bictegravir). However, women and individuals from Africa remain less likely to receive these regimens despite early care engagement. Qualitative research with prescribers is needed to understand these disparities to inform more equitable ART initiation."

Human Immunodeficiency Virus • Infectious Disease • CD4

Nucleocapsid mutations at time of virological failure with an integrase inhibitor (EACS 2025) - "Results : Sequences were available for 61 PLWH-1 receiving either elvitegravir (n=3), raltegravir (n=4), cabotegravir (n=4), dolutegravir (n=18), or bictegravir (n=32). Conclusions : Our study confirms that mutations in the nucleocapsid are observed in a small number of individuals with VF with an INSTI-based regimen. Phenotypic data are needed to decipher the impact of the new mutations (F16Y, N27D, and N27H), and the frequency of nucleocapsid mutations should be explored in larger cohorts."

Human Immunodeficiency Virus • Infectious Disease

Antiretroviral therapy in people with HIV and TB in France: a nationwide retrospective study between 2010 and 2023 (EACS 2025) - "Purpose : Since 2014, following EACS guidelines, raltegravir (RAL) and then dolutegravir (DTG) are proposed as alternatives to efavirenz (EFV)-based ART in people with HIV (PWH) treated for TB...First ART following the TB index date was used to classify ART as 2 NRTIs plus a boosted protease inhibitor (PI/r), an INSTI (RAL, DTG, or bictegravir [BIC]), EFV, or other combinations...​ Conclusions : In this French nationwide cohort, TB and HIV were diagnosed concomitantly in 40% of cases. DTG-based regimens have replaced EFV- and PI/r-based regimens over the past decade, representing half of ART prescriptions in PWH treated for TB in 2023."

Retrospective data • Human Immunodeficiency Virus • Infectious Disease • Tuberculosis

Virological Outcomes in People Living With HIV on INSTI-based cART Receiving Paclitaxel for Kaposi Sarcoma: A Retrospective Cohort Study (EACS 2025) - "INSTI-based regimens included Dolutegravir (DTG): n=7, Raltegravir (RAL): n=8, Bictegravir (BIC): n=4, and Cabotegravir/Rilpivirine (CAB/RPV): n=1. The null clinical impact reflects Paclitaxel’s transient enzyme induction. These findings support co-administration safety with standard dose second-generation INSTIs but warrant: (1) therapeutic drug monitoring and (2) evaluation of long-acting CAB/RPV and oral INSTI-based two drug regimens with chemotherapy where resistance risks may differ."

Retrospective data • Human Immunodeficiency Virus • Infectious Disease • CYP3A4 • UGT1A1

Unconventional DORAVIRINE antiretroviral regime: a single-center experience (EACS 2025) - "1,2 Available in a once-daily combination with tenofovir-disoproxil/lamivudine (TDF/3TC), DOR showed versatility in more unconventional combinations, especially in dual-therapy with dolutegravir (DTG) 1,3 or 3TC...Twenty-two were dual-therapy with DOR+darunavir/cobicistat (DRV/c) (9/30; 30%) and DOR+DTG (7/30; 23%) being the most common...DOR+ARV ensured good immunovirological control and neutral impact on cholesterol and BMI as already reported 1,3,4 with high tolerability, having only one person/30 discontinuing DOR. Conclusions : Unconventional DOR combinations in dual-therapy including those with DRV/c or raltegravir are effective and well-tolerated options among others for multi-treated PLWH experiencing aging and comorbidities."

Clinical • Human Immunodeficiency Virus • Infectious Disease