haloperidol / Generic mfg. - LARVOL DELTA

Reciprocal Paracrine Signaling and Dynamic Coordination of Transitional States in the Alveolar Epithelial Type 2 Cells and Associated Alveolar Lipofibroblasts During Homeostasis, Injury and Repair. (PubMed, Cells) - "Candidate therapeutics including metformin, haloperidol and FGF10 show promise in reprogramming fibroblast and epithelial states through metabolic and signaling modulation. Integrating WI-38-based assays, alveolosphere co-cultures, and multi-omics profiling offers a translational framework for identifying interventions that halt fibrosis and actively induce lung regeneration. This review highlights a unifying framework in which epithelial and mesenchymal plasticity converge to define repair outcomes and identifies actionable targets for promoting alveolar regeneration in chronic lung disease."

Journal • Review • Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • FGF10

Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity. (PubMed, Mol Psychiatry) - "Notably, chronic antagonism of both D1 and D2 receptors using selective antagonists, as well as long-term treatment with first- and second-generation antipsychotics haloperidol, chlorpromazine, olanzapine, clozapine, and aripiprazole, promoted robust synaptic upscaling. These findings reveal a novel mechanism of action for antipsychotic medications and suggest that antipsychotics do not solely act on counteracting hyperdopaminergia, but also tune glutamatergic neurotransmission by activating homeostatic plasticity mechanisms."

Journal • CNS Disorders

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention. (PubMed, Am J Hum Genet) - "Analyzing >3.5 million electronic health records, we conducted analyses of emulated trials for 11 drugs across 290 comparisons and identified three drugs significantly associated with reduced colorectal cancer risk: caffeine vs. paroxetine (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.41-0.64), haloperidol vs. prochlorperazine (HR, 0.47; 95% CI, 0.33-0.68), and trazodone hydrochloride vs. paroxetine (HR, 0.49; 95% CI, 0.38-0.63). Conversely, caffeine was associated with increased cancer risk in comparison with finasteride (colorectal cancer) and fluoxetine (breast cancer). Meta-analysis identified six drugs significantly associated with cancer risk, including acetazolamide, which was associated with reduced colorectal cancer risk (HR, 0.79; 95% CI, 0.72-0.87). This study identifies previously unreported protein biomarkers and candidate drug targets across six major cancer types and highlights several approved drugs with potential chemopreventive effects."

Biomarker • Journal • Breast Cancer • Colorectal Cancer • Genito-urinary Cancer • Oncology • Pancreatic Cancer • Prostate Cancer • Solid Tumor

Peripheral IV Catheter-Associated Upper Extremity Deep Vein Thrombosis in a Patient with Psychiatric Illness: A Case Report and Literature Review. (PubMed, Int Med Case Rep J) - "We report a 44-year-old man with bipolar affective disorder on haloperidol, promethazine, and carbamazepine...The patient was initially started on low molecular weight heparin, later transitioned to apixaban...Antipsychotics, such as haloperidol and chlorpromazine, may further elevate thrombosis risk. Clinicians must maintain vigilance for UEDVT in patients with unilateral arm swelling post-cannulation, recognizing that prompt ultrasound evaluation and guideline-based anticoagulation are essential to prevent complications."

Journal • Bipolar Disorder • Cardiovascular • CNS Disorders • Hematological Disorders • Mental Retardation • Pain • Psychiatry • Thrombosis • Venous Thromboembolism • Venous Ulcer

Haloperidol versus Ketamine for Managing Acute Agitation in the Emergency Department: A Randomized Clinical Trial. (PubMed, Bull Emerg Trauma) - "Ketamine demonstrated a faster onset of action in managing acute agitation than haloperidol. These findings suggested that ketamine might represent a viable first-line therapeutic option for acutely agitated patients, particularly in clinical scenarios where rapid symptom control is critical."

Clinical • Journal • Anesthesia • CNS Disorders • Psychomotor Agitation

Fecal incontinence in hospitalized bipolar disorder patients: prevalence, gender disparities, and associations with demographic and pharmacological factors. (PubMed, BMC Psychiatry) - "This study reveals an exceptionally high prevalence of fecal incontinence in hospitalized bipolar disorder patients, with demographic factors proving more predictive than broad medication classes. The profound gender disparity and medication-specific risk profiles necessitate systematic continence screening protocols and individualized pharmacological selection strategies. These findings highlight the critical need for multidisciplinary care approaches integrating psychiatric treatment with specialized continence management to address this previously underrecognized complication affecting nearly half of hospitalized bipolar patients."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Acute confusional migraine in adults – A case report (EHF-EHC 2025) - "Diazepam, haloperidol, and chlorpromazine were administered, but agitation persisted...Lumbar puncture was performed, and empiric antibiotics plus acyclovir were started but discontinued within hours after normal CSF and negative viral PCR...Although self-limiting, no abortive treatment is available; however, valproic acid and topiramate may be used to treat and prevent recurrences. The absence of formal criteria and the diagnosis being one of exclusion hinder clinical recognition."

Case report • Clinical • Cardiovascular • CNS Disorders • Hypertension • Migraine • Pain

Haloperidol-induced liver injury in pregnancy: A rare case report and review of drug-induced hepatitis. (PubMed, Radiol Case Rep) - "Haloperidol was discontinued and replaced with Chlorpromazine, leading to normalization of liver function within 1 month and favorable maternal and fetal outcomes. This case highlights the diagnostic challenges of idiosyncratic DILI during pregnancy and underscores the importance of regular liver function monitoring in patients on long-term antipsychotics, as well as careful multidisciplinary management when hepatic adverse effects occur."

Journal • CNS Disorders • Hepatology • Inflammation • Liver Failure • Psychiatry • Schizophrenia

Exploration of neural mechanisms underlying antidepressant-like property of Ziziphora clinopodioides Lam. essential oil using mouse forced swimming test: Involvement of the monoaminergic systems. (PubMed, Curr Res Physiol) - "Moreover, naloxone (non-selective antagonist for opioid receptor subtypes, 1 mg/kg), prazosin (α1-adrenergic receptor antagonist, 1 mg/kg), yohimbine (α2-adrenergic receptor antagonist, 1 mg/kg), propranolol (β-adrenergic receptor antagonist, 2 mg/kg), WAY100635 (selective 5-HT1A receptor antagonist, 0.1 mg/kg), ondansetron (5-HT3 receptor antagonist, 1 mg/kg), haloperidol (non-selective dopamine receptor blocker, 0.2 mg/kg), SCH23390 (selective dopamine D1 receptor blocker, 0.05 mg/kg), sulpiride (selective dopamine D2 receptor blocker, 50 mg/kg) and flumazenil (GABAA/BDZ receptor antagonist, 10 mg/kg) were used to ascertain the neural pathways implicated in the antidepressant-like response of EOZC. However, this effect remained unaffected by naloxone, propranolol and flumazenil. These findings indicate that EOZC elicits antidepressant-like response, which relies on its interaction with noradrenergic, serotonergic and..."

Journal • Preclinical • Addiction (Opioid and Alcohol) • DRD2

Dual one-step LC-MS/MS methods for hair analysis in drug-facilitated crime: application to an alleged Fraud-Related case. (PubMed, Forensic Sci Med Pathol) - "This study aimed to develop and validate two simplified, one-step extraction methods coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous segmental analysis of psychoactive substances, specifically doxylamine (DOX), haloperidol (HAL), citalopram (CTP), sildenafil (SDF), and common illicit drugs in hair samples. Segmental hair analysis provided critical retrospective evidence, reinforcing its value in complex DFC investigations. The interpretation remained confined to analytical evidence, without inferring intent."

Journal • CNS Disorders • Psychiatry

Clinical and sociodemographic characterization of Patients with Psychiatric Disorders and Epilepsy admitted to a reference psychiatric hospital (AES 2025) - "Among antiseizure medications, valproate (20.2%), carbamazepine (14.6%), and phenobarbital (12.4%) were most frequently prescribed. The most utilized psychiatric medications were risperidone (18%), haloperidol (15.73%), levomepromazine (9%), and sertraline (9%)... The findings indicate a high prevalence of psychiatric and behavioral comorbidities among institutionalized individuals with epilepsy, emphasizing the significant use of psychoactive substances and aggressive manifestations. The medication profile underscores the necessity for integrated clinical and psychiatric management, highlighting the importance of multidisciplinary approaches to optimize seizure control, reduce complications, and enhance quality of life."

Clinical • Late-breaking abstract • Behavior Disorders • CNS Disorders • Depression • Epilepsy • Insomnia • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia • Sleep Disorder • Suicidal Ideation

CH2O: Comparing Haloperidol to Olanzapine in the Treatment of Suspected Cannabinoid Hyperemesis in the Emergency Department (clinicaltrials.gov) - P3 | N=114 | Recruiting | Sponsor: Mercy Bon Secours Saint Vincent Medical Center

New P3 trial

Preoperative Aprepitant Decreases Postoperative Nausea After Laparoscopic Sleeve Gastrectomy. (PubMed, R I Med J (2013)) - "The addition of preoperative aprepitant to a multimodal protocol can reduce nausea after laparoscopic sleeve gastrectomy."

Journal • Retrospective data • Gastrointestinal Disorder

Impact of antipsychotics, antiparkinsonian drugs, and anthraquinone stimulant laxatives on severe constipation in patients with schizophrenia. (PubMed, PCN Rep) - "High dosages of clozapine (odds ratio [OR]: 8.688; 95% confidence interval [CI]: 1.926-39.186; p = 0.005), haloperidol (OR: 1.987; 95% CI: 1.093-3.610; p = 0.024), anthraquinone stimulant laxatives (OR: 1.769; 95% CI: 1.337-2.340; p < 0.001), antiparkinsonian drugs (OR: 1.641; 95% CI: 1.280-2.104; p < 0.001), and female sex (OR: 1.318; 95% CI: 1.097-1.582; p = 0.003) were found to be significantly associated with this condition. On the other hand, high-dosage risperidone was associated with a reduced risk (OR: 0.688; 95% CI: 0.508-0.932; p = 0.016). These findings highlighted the need for careful monitoring of constipation and for optimizing antipsychotic drug regimens. The use of antiparkinsonian drugs and anthraquinone stimulant laxatives should be limited to the short term."

Journal • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Movement Disorders • Parkinson's Disease • Psychiatry • Schizophrenia

Mass Spectrometric Study of Heterogeneous Reactions of Transformations of Molecules of Butyrophenone Derivatives During Adsorption on a Hot Surface of Tungsten Oxide. (PubMed, J Mass Spectrom) - "The results of the mass spectrometric studies of heterogeneous transformations of molecules of psychotropic drugs-piperidine and piperazine derivatives of butyrophenone haloperidol, trifluperidol, droperidol, and azaperone during adsorption on a hot surface of tungsten oxide-have been presented...At relatively high emitter temperatures (from 800 K), current lines of monomolecular decays of metastable parent ions have been detected. When using the surface of tungsten oxide as a positive ion converter, a high efficiency (up to 98%) of surface ionization of desorbed radicals has been established, making it possible to trace the complete picture of the heterogeneous reactions occurring in the adsorbed layer."

Heterogeneity • Journal

Brexpiprazole does not adversely impact neurobehavior following preclinical traumatic brain injury (Neuroscience 2025) - "Contrary to our hypothesis, brexpiprazole did not improve outcomes relative to vehicle (p>0.05), but it also did not worsen. This finding suggests that brexpiprazole may be a safer option for managing TBI-induced agitation without the negative cognitive effects associated with traditional APDs with D2 antagonist actions like haloperidol and risperidone."

Preclinical • CNS Disorders • Vascular Neurology

Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications. (PubMed, Mol Psychiatry) - "Haloperidol, amisulpride, and aripiprazole significantly increased PSD protein expression in the striatum. Acute olanzapine increased PSD molecules levels in striatal regions, reducing Arc expression in frontal cortex (SMD [95%CIs]=-2.15 [-2.7;-1.61], p < 0.0001); chronic treatment had opposite effects. Clozapine increased Homer1a levels in dorsal (1.13 [0.41;1.86], p = 0.002) and ventral striatum (1.48 [0.72;2.24], p = 0.0001), and cingulate cortex (2.12 [1.12;3.12], p < 0.0001), as well as increased NMDAR subunits levels in frontal cortex."

Journal • Preclinical • Retrospective data • Review • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry • Schizophrenia • DRD2

QT interval prolongation in acute antipsychotic poisoning: systematic review and recommendations. (PubMed, Clin Toxicol (Phila)) - "Individual medication recommendations were made for amisulpride (15 articles), thioridazine (11 articles), ziprasidone (eight articles) and quetiapine (13 articles), whilst consensus statements based on limited data were made for acute ingestions of clozapine, haloperidol, iloperidone, pimozide, pipamperone, olanzapine and risperidone (14 articles in total). The QT Interval Prolongation in Clinical Toxicology Workgroup suggests the same approach for patients with overdoses of haloperidol, iloperidone, pipamperone and pimozide. The risk of torsade de pointes is likely overstated for acute antipsychotic medication overdose as a general class group, and concern should rather focus on a few specific medications."

Journal • CNS Disorders

Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy (clinicaltrials.gov) - P2/3 | N=42 | Recruiting | Sponsor: M.D. Anderson Cancer Center | N=30 ➔ 42

Enrollment change • CNS Disorders • Epilepsy

Transition rates to schizophrenia and early intervention effectiveness in substance-induced and brief psychotic disorders: a randomized controlled trial. (PubMed, Sci Rep) - "TAU included standard antipsychotic treatment (primarily risperidone or haloperidol), monthly psychiatric follow-ups, and case management without structured psychosocial components. The study highlights the substantial risk of schizophrenia following a first psychotic episode, especially in the context of substance use. A comprehensive, multi-component early intervention appears effective in reducing transition rates, underscoring the importance of targeted preventive strategies."

Clinical • Journal • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Experience of Neuroleptic Malignant Syndrome After Operation:Total Arch Replacement for Stanford Type A Acute Aortic Dissection:Report of a Case (PubMed, Kyobu Geka) - "We discontinued haloperidol and started dantrolene. Neuroleptic malignant syndrome after aortic dissection surgery is very rare and includes numerous differential diagnoses. However, prompt action is important because delays in diagnosis and treatment can lead to deterioration in the general condition of the patient."

Journal • Cardiovascular • Infectious Disease

ECG Changes Associated With Antipsychotic Use: A Case Vignette From the Emergency Department. (PubMed, Adv Emerg Nurs J) - "First- and second-generation antipsychotics, including the commonly used haloperidol and ziprasidone, are known to cause QTc prolongation, the most clinically significant ECG abnormality. Effective management requires individualized assessment, vigilant ECG and electrolyte monitoring, and informed antipsychotic selection. This case study highlights the clinical presentation and potential ECG changes associated with antipsychotic medication use in the ED."

Journal • Cardiovascular • CNS Disorders • Mental Retardation • Psychiatry • Ventricular Tachycardia

A novel homecage operant task reveals dopaminergic modulation of social motivation in mice (Neuroscience 2025) - "Blocking dopamine D2 receptors with haloperidol reduced social seeking, overall activity, and feeding (n = 14, all p<0.05, Bonferroni-corrected), suggesting that blocking D2 receptors causes a general reduction in behavior that was not specific to social seeking...This means that mice first addressed their caloric needs each day, and then focused on socializing. Overall, our homecage-based social motivation task offers a new way for studying social motivation, which may be particularly valuable for studying disorders that involve both social and circadian disruptions."

Preclinical • CNS Disorders • Psychiatry

Mouse touchscreen methods for assessing effort-based decision making based on physical effort: the role of individual differences in modulating drug effects (Neuroscience 2025) - "Following this FR2/pellet choice training, mice were tested for the effects of the DA D2 antagonist haloperidol (vehicle, 0.05, 0.1, and 0.15 mg/kg IP). Only the high-performance group showed the classic shift from high-effort to low-effort behavior commonly seen in rodent studies after administration of DA antagonists (i.e., decreased panel pressing/increased pellet intake). Ongoing studies are using these methods to assess additional mouse strains (e.g., C57BL6), and other pharmacological interventions."

Preclinical • CNS Disorders • Depression • Movement Disorders • Parkinson's Disease • Psychiatry • Schizophrenia

Spatiotemporal DA Coordination as a Target of Antipsychotic Action (Neuroscience 2025) - "We further test whether various antipsychotic medications (including Haloperidol, Clozapine, Xanomeline) restores normal DA dynamics that are essential for behavioral flexibility. Ultimately, our findings suggest that DA wave coordination is a vulnerable substrate for cognitive dysfunction in psychosis and a functional readout for evaluating the efficacy of antipsychotic interventions. This framework shifts focus from bulk DA levels in restricted striatal domains towards studying the complexity of spatiotemporal organization of DA signals in the striatum, offering a novel window into the circuit-level mechanisms through which novel antipsychotic medications alleviate classes of cognitive symptoms."

CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia