haloperidol / Generic mfg. - LARVOL DELTA

Investigating Metabotropic Glutamate Receptor 4/7 Heterodimers as a Novel Drug Target for Parkinson’s Disease (Neuroscience 2026) - "mGlu4 positive allosteric modulators (PAMs) show antiparkinsonian efficacy in preclinical models such as haloperidol-induced catalepsy (HIC), and one mGlu4 PAM is currently in Phase II clinical trials for PD...Using these pharmacological tools with Grm7 (mGlu7) knockout mice in the HIC model, we are testing the in vivo behavioral relevance of these findings. Together, this work may elucidate the biological mechanisms of mGlu4 PAM efficacy and guide the development of mGlu heterodimer-informed therapeutic strategies for PD."

CNS Disorders • Movement Disorders • Parkinson's Disease

Chronic haloperidol-induced dopamine supersensitivity in Disc1 mutant mice (Neuroscience 2026) - "Wild-type (WT) and Disc1 Het mice of both sexes received an amphetamine (Amph; 2.5 mg/kg, i.p.) challenge to assess locomotor activity as a behavioral readout of dopamine reactivity...Pretreatment with the dopamine D2 receptor (D2R) antagonist sulpiride reduced Amph-induced locomotor responses in HAL-treated mice, supporting the involvement of D2R-mediated mechanisms...Together, these findings suggest that chronic antipsychotic-induced dopamine supersensitivity involves both dopaminergic and structural adaptations in the striatum, and these changes are influenced by biological sex and Disc1 mutation. This model offers a valuable tool for investigating the interaction between genetic vulnerability and chronic antipsychotic exposure in the emergence of dopamine supersensitivity, with implications for developing more personalized treatment strategies in schizophrenia."

Preclinical • CNS Disorders • Schizophrenia • DRD2

Haloperidol suppresses accumbens core D2-MSN activity in-vivo (Neuroscience 2026) - "These findings identify a rapid, cell-type-specific neuronal response to haloperidol, in which D2 receptor blockade in the NAcc suppresses D2-MSN activity in vivo. This suppression, rather than D2 receptor blockade alone, may represent a key circuit mechanism through which haloperidol alters psychomotor output."

Preclinical • CNS Disorders • Psychiatry • Schizophrenia

Intravenous Lipid Emulsion Attenuates Hepatic, Renal, Cerebral and Testicular Histopathological Injury but Not Renal Dysfunction or Cardiac Histological Change in an Acute Haloperidol Overdose Model in Rats: Implications for Veterinary Toxicology. (PubMed, Vet Sci) - "Given the analytical uncertainty and the limited sample size, these indices provided no usable surrogate information about organ-level injury in this model. These findings define which organ systems respond and require confirmation in target veterinary species before informing clinical practice."

Journal • Preclinical • CNS Disorders • Hepatology • Inflammation • Liver Failure • Nephrology • Renal Disease

Multi criteria evaluation of schizophrenia drugs: DFT, ADMET, and molecular docking investigations. (PubMed, Comput Biol Chem) - "Global reactivity descriptors indicated a higher oxidative stability in aripiprazole, opposite to the marked reactivity sensitivity of haloperidol...Structural divergence was observed in Olanzapine and Haloperidol...Risperidone showed the highest affinity (-10.0 kcal/mol) due to strong electrostatic interactions with the primary anchoring residue Asp474 and hydrophobic stabilisation through Tyr142, Trp322 and Pro383...The MEP maps confirmed that the binding affinity to GlyT1 is the large negative potential localisation around the hydrogen-bond accepting heteroatoms, as well as the large electrochemically neutral hydrophobic regions. These insights provide a crucial integrated framework for optimising the next generation antipsychotic drug design."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Orchiectomy increases sensitivity to effort-related costs and alters mesoaccumbal circuit function in male mice. (PubMed, Horm Behav) - "Dopamine-related function was probed using systemic haloperidol administration and high-performance liquid chromatography to measure dopamine and its metabolites, while whole-cell recordings assessed the intrinsic excitability of NAc spiny projection neurons (SPNs)...Although similar behavioral phenotypes emerged following pre- and postpubertal ORX, distinct neurochemical and cellular adaptations suggest that timing may shape the neural response to ORX. These results provide insight into the circuit mechanisms that may underlie altered motivation following testicular hormone loss."

Journal • Preclinical • Endocrine Disorders • Fatigue

Rumination Syndrome in a Young Male Without Classic Risk Factors Initially Misdiagnosed as Refractory Gastroparesis (ACG 2026) - "Symptoms progressed despite proton pump inhibitor therapy and metoclopramide, with frequent daily episodes of effortless regurgitation intermixed with forceful vomiting, often without preceding nausea...Multiple therapies including ondansetron, haloperidol, nortriptyline, and mirtazapine, provided minimal or transient relief...Delayed recognition led to extensive diagnostic testing, prolonged hospitalization, severe malnutrition, and temporary enteral feeding support. Earlier recognition may help avoid unnecessary interventions and improve outcomes."

Clinical • CNS Disorders • Depression • Diabetes • Fibromyalgia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Musculoskeletal Pain • Obesity • Rare Diseases

The Contemporary "Balloon Man" Phenotype: A Giant Fecaloma in a Patient on Chronic Antipsychotics (ACG 2026) - "Psychiatry transitioned him from clozapine and olanzapine to haloperidol without breakthrough psychosis. He was discharged on prucalopride, polyethylene glycol, bisacodyl, and lactulose...Figure: Fig 2. Prior flexible sigmoidoscopy showing 2-3 cm clean-based rectosigmoid ulcers, consistent with chronic stercoral pressure injury from recurrent fecal loading."

Clinical • Acute Kidney Injury • CNS Disorders • Constipation • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Mental Retardation • Nephrology • Renal Disease • Schizophrenia

Anti-psychotic therapeutics modify gut microbial metabolism and modulate susceptibility to gastrointestinal infection in mice. (PubMed, bioRxiv) - "Using a murine model, we evaluated haloperidol, olanzapine, risperidone, and quetiapine through longitudinal microbiome profiling, untargeted metabolomic fingerprinting, behavioral testing, and enteric infection challenge. Although microbial compositional changes did not fully account for functional outcomes, their integration with metabolomics data revealed disrupted bacterial taxa-metabolite networks and loss of homeostatic metabolic modules. These results provide a potential mechanistic link between the disruptive effects of antipsychotics on the microbiome and impaired colonization resistance."

Journal • Preclinical • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Zuclopenthixol acetate for acute schizophrenia and similar major mental illnesses. (PubMed, Cochrane Database Syst Rev) - "Based on the evidence in this review, there may be no difference between zuclopenthixol acetate and standard medications in the management of acute psychiatric symptoms, tranquillisation and adverse events. Zuclopenthixol acetate was probably associated with a greater degree of sedation at 24 and 48 hours of administration. The use of zuclopenthixol acetate may be associated with a lower requirement for adjunctive benzodiazepines, but this is uncertain. Doses of zuclopenthixol acetate of 25 mg to 50 mg per injection may be as effective as doses of 50 mg to 100 mg per injection (very low-certainty evidence). Recommendations favouring zuclopenthixol acetate over standard medications for the management of acute behavioural disturbance should be interpreted with caution, given the methodological limitations of most included studies."

Clinical • Journal • Review • Anesthesia • CNS Disorders • Psychiatry • Schizophrenia

Comparative efficacy of antipsychotics for reducing aggression in schizophrenia: systematic review and network meta-analysis. (PubMed, Br J Psychiatry) - "Antipsychotics reduced hostility and aggressive behaviour in predominantly short- to medium-term studies. Clozapine, paliperidone and olanzapine appeared most effective, although low-certainty evidence limits conclusions about differences between antipsychotics. Further trials with aggressive behaviour as the primary outcome and longer follow-up are needed."

Journal • Retrospective data • Review • CNS Disorders • Psychiatry • Schizophrenia

Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats. (PubMed, Methods Protoc) - "The training set, relative to which the effects of the pharmacological agents from the test set were classified, were the matrices of effects of 12 pharmacological agents: the NMDA antagonist dizocilpine, the D2/D3 antagonists haloperidol and sulpiride, the M-anticholinergic tropicamide, the H1/5HT2A receptor blocker hydroxyzine, the acetylcholinesterase inhibitor galantamine, the alpha-2 adrenergic agonist dexmedetomidine, the alpha-2 adrenergic antagonist atipamezole, the adenosine receptor blocker caffeine and the GABA-mimetics aminophenylbutyric acid (phenibut), bromdihydrochlorophenylbenzodiazepine (phenazepam) and 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione. The test set included various drugs with tropism for the targets of the training set drugs: dopamine receptor antagonists chlorpromazine, droperidol, tiapride and raclopride, H1-histamine blockers diphenhydramine and promethazine, 5-HT2-receptor blockers ritanserin and glemenserin, acetylcholinesterase..."

Journal • Preclinical • Pain

Epilepsy After Antipsychotic Prescription in Survivors of Traumatic Brain Injury: A Population-Based Cohort Study. (PubMed, Crit Care Med) - "We found no clear signal of a differential risk of epilepsy when comparing new prescriptions for haloperidol or risperidone with quetiapine among survivors of TBI. Nonetheless, high mortality limited comparability across groups, CIs were wide, and additional studies should confirm our findings."

Journal • CNS Disorders • Epilepsy • Vascular Neurology

Drugs for acute treatment of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

BASAL RELEASE OF 6-CYANODOPAMINE AND 6-NITRODOPAMINE FROM RAT ISOLATED AORTA AND THEIR ROLE IN VASCULAR RELAXATION. (PubMed, Eur J Pharmacol) - "Vascular reactivity was assessed in U-46619-precontracted rings with intact or removed endothelium and after pharmacological inhibition with Nω-nitro-L-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), indomethacin, SQ-22536, SCH-23390, and haloperidol...SQ-22536 also attenuated forskolin- and iloprost-induced relaxation, supporting involvement of adenylyl cyclase/cAMP signaling in 6-CYD responses...Rat thoracic aorta basally releases 6-CYD and 6-ND, and although both act as potent vasodilators, they have distinct mechanisms of action. These findings shed new light on mechanisms by which the vascular endothelium regulates vascular tone."

Journal • Preclinical • Cardiovascular • Hypertension

Neuroprotective and Antiparkinsonian Effects of Green-Synthesized Silver Nanoparticles from Eclipta prostrata in a Haloperidol-Induced Murine Model (MDS Congress 2026) - No abstract available

Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease

Compromised striatal structure and function in mouse models of RARB-related disorder. (PubMed, Brain) - "Furthermore, RARB-RD mice showed partial resistance to the cataleptic effects of haloperidol, a D2R-specific antagonist...Progressive emergence of most neurologic deficits highlights a potential therapeutic window. Our results support the development of strategies aimed at silencing RARB-RD alleles."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Developmental Disorders • Dystonia • Huntington's Disease • Movement Disorders • Ophthalmology • DRD1 • DRD2 • RARB

Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients-A Post Hoc Bayesian Analysis of the AID-ICU Trial. (PubMed, Acta Anaesthesiol Scand) - P4 | "Compared with placebo, haloperidol was associated with moderate to high probabilities of benefit in both hypoactive and hyperactive delirium, with moderate probabilities of greater effects in hyperactive delirium. Further research is warranted to confirm these results."

Clinical • Journal • Retrospective data • CNS Disorders

Recurrent hypothermia associated with atypical antipsychotics: a diagnostic challenge in a medically complex patient. (PubMed, Arch Clin Cases) - "We report the case of a 55-year-old woman with tuberous sclerosis, epilepsy, intellectual disability, and chronic kidney disease who developed recurrent episodes of hypothermia in temporal association with risperidone and subsequently olanzapine, with several episodes also accompanied by bradycardia, hypotension, and AKI...Recurrent episodes with a consistent clinical pattern resolved following substitution of atypical antipsychotics with haloperidol, supporting a probable drug-induced etiology...This report highlights the importance of recognizing this rare adverse effect and ensuring careful monitoring and timely adjustment of psychotropic treatment. The temporal association with AKI also raises the possibility of a bidirectional interaction, although the underlying mechanisms remain incompletely understood."

Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Developmental Disorders • Endocrine Disorders • Epilepsy • Hypoglycemia • Hypotension • Infectious Disease • Mental Retardation • Nephrology • Renal Disease

Biased μ-opioid receptor agonist tegileridine for postoperative analgesia after gynecologic laparoscopy or abdominal surgery: a prospective, double-blind, randomized controlled trial (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: Maternal and Child Health Hospital of Jiangxi Province; Maternal and Child Health Hospital of Jiangxi Province

New trial

How Often Do QT-prolonging Drugs Really Prolong QT? A Systematic Review. (PubMed, J Psychiatr Pract) - "Drug-induced QTc prolongation is not uncommon across a range of widely used medications, especially in psychiatric care, yet its monitoring and risk remain inconsistently assessed, particularly in outpatient settings. While TdP was rarely reported, QTc >500 ms occurred with notable frequency. Significant heterogeneity in QTc definitions, study populations, and ECG methodologies limits cross-study comparability, underscoring the need for greater standardization."

Journal • Review • Cardiovascular • CNS Disorders • Psychiatry

Employment trajectories following the diagnosis and after long-acting injectable antipsychotic treatment in patients with schizophrenia: A nationwide study. (PubMed, Aust N Z J Psychiatry) - "Employment outcomes in schizophrenia appear shaped by diagnostic and treatment-related transitions rather than static disease status. Stabilization after long-acting injectable initiation may be linked to incremental improvements in employment trajectories for some subgroups, but optimizing long-term vocational outcomes likely requires integrated psychosocial and vocational support."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Clozapine-Induced Gastrointestinal Hypoperfusion Leading to Bowel Ischemia and Secondary Atrial Fibrillation: A Case Report. (PubMed, Case Rep Psychiatry) - "His psychiatric management was shifted to haloperidol and olanzapine, and he returned close to his psychiatric baseline over time. This case emphasizes the importance of monitoring for rare gastrointestinal complications associated with clozapine, including hypoperfusion-mediated bowel ischemia, and supports early recognition and prompt discontinuation to reduce morbidity and mortality."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Pain • Psychiatry • Schizophrenia

Dissecting affinity determinants of benzotriazine-based ligands at sigma-1 receptor: a multilevel molecular dynamics analysis. (PubMed, Bioorg Chem) - "In this work, we computationally re-examine a representative set of benzotriazine derivatives previously synthesized and pharmacologically characterized by Fabio Sparatore and coworkers, integrating their published experimental binding affinities with newly generated molecular dynamics simulations to investigate subtle structure-affinity relationships within the series, using haloperidol as a reference S1R antagonist...Collectively, these results demonstrate that S1R affinity in this series is not dictated by static binding motifs alone, but by the joint stabilization of specific local interaction networks and receptor-bound conformational ensembles. This integrated dynamic framework extends the interpretation of S1R structure-affinity relationships beyond static pharmacophore models and provides a computational basis for the rational optimization of future benzotriazine-based ligands."

Journal • Oncology

Electroconvulsive Therapy Refusal in Severe Psychosis: Navigating Capacity, Surrogate Decision-Making, and Ethical Duty. (PubMed, Cureus) - "She was partially compliant with psychotropic therapy, including haloperidol, lorazepam, and lurasidone, but demonstrated limited improvement. This case highlights the enduring clinical and ethical complexities surrounding the use of ECT. It underscores the importance of evaluating capacity, engaging families in shared decision-making, and balancing the principles of autonomy and beneficence in the treatment of severe psychiatric illness."

Journal • Cardiovascular • CNS Disorders • Depression • Dyslipidemia • General Anxiety Disorder • Hypertension • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia