amisulpride / Generic mfg. - LARVOL DELTA

Effectiveness of amisulpride augmentation versus other antipsychotics in clozapine-treated adolescents: a real-world retrospective study. (PubMed, BMC Psychiatry) - "Clozapine augmentation with amisulpride was not superior to augmentation with other antipsychotics in our sample. Treatment response appears to be driven more by clozapine dose and baseline severity. In addition, high standardized doses of adjunctive agents may counterproductively limit negative symptom recovery, perhaps due to secondary negative symptoms caused by excessive D2 receptor blockade."

Clinical • Journal • Real-world evidence • Retrospective data • CNS Disorders • Psychiatry • Schizophrenia

Olfactory Reference Syndrome Responding to Amisulpride. (PubMed, Prim Care Companion CNS Disord) - No abstract available

Journal

A TiO2@MWCNTs-based dispersive solid-phase extraction method for mitigating matrix effects in plasma LC-MS/MS analysis. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "The matrix effects of representative small-molecule drugs, including metformin, amisulpride, and aripiprazole, were compared across TiO2@MWCNTs-based d-SPE, protein precipitation, and traditional solid-phase extraction. The validated method was also successfully applied to a pharmacokinetic study of metformin with pharmacokinetic parameters comparable to those reported previously. This study shows that the dispersive solid-phase extraction method based on TiO2@MWCNTs could act as a simple, rapid, low-cost and reliable pretreatment strategy to mitigate matrix effects for small-molecule analytes with low lgP in rat plasma as a proof-of-concept attempt."

Journal

A pH-mediated stacking CE-MS method for the sensitive determination of clozapine and amisulpride drugs in high ionic strength biomatrices. (PubMed, J Chromatogr A) - "Analysis of patient plasma samples yielded relative differences of 0.9% (clozapine) and 2.8% (amisulpride) compared with UHPLC-MS/MS, confirming good agreement between the two methods. These results indicate that pH-mediated stacking CE-MS provides a practical alternative to UHPLC-MS/MS for therapeutic drug monitoring, with comparable sensitivity, minimal sample consumption, and requiring only liquid-liquid extraction without additional offline enrichment."

Journal • CNS Disorders

Amisulpride-induced toxic epidermal necrolysis: A clinician's alert. (PubMed, Ind Psychiatry J) - No abstract available

Journal • Steven-Johnson Syndrome

Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery (clinicaltrials.gov) - P2 | N=276 | Active, not recruiting | Sponsor: Instituto do Cancer do Estado de São Paulo | Recruiting ➔ Active, not recruiting

Enrollment closed • Gynecology

Risk Factors for Amisulpride-Associated Hyperprolactinemia: Gender-Specific Plasma Concentration Cutoffs Derived from ROC Analysis. (PubMed, Drug Des Devel Ther) - "Daily amisulpride dose was positively correlated with plasma drug concentration (p < 0.001); multivariable analysis identified sex, plasma amisulpride concentration, and concomitant idebenone or lorazepam use as independent risk factors for amisulpride-induced prolactin elevation (p < 0.05). Plasma amisulpride concentration cutoffs were higher in women (317.8 ng/mL) than in men (294.2 ng/mL), suggesting greater tolerance to higher plasma concentrations among women and confirming significant sex differences in susceptibility to amisulpride-induced prolactin elevation. Clinically, 28 ng/mL can be adopted as the screening cutoff value for elevated prolactin levels in patients treated with amisulpride, we advocate for sex-dependent plasma concentration management for personalized therapeutic drug monitoring to effectively prevent and control amisulpride-associated HPRL."

Journal • Retrospective data

Temporal mapping of radiation-induced neural injury and mitigation in human cortical organoids. (PubMed, Stem Cells Transl Med) - "Human cortical organoids recapitulate key features of radiation-induced neural injury, recovery, and therapeutic modulation, providing a robust, scalable, and human-relevant platform for studying CNS radiation biology and preclinical screening of candidate radiation mitigators."

Journal • Brain Cancer • Oncology

Baseline inflammatory profile is associated with short-term antipsychotic-induced weight gain in first-episode psychosis: results from the OPTiMiSE study. (PubMed, Schizophr Res) - "A lower baseline inflammatory profile, captured by a sparse principal component, was associated with greater weight gain following antipsychotic initiation. This profile was characterized by relatively lower levels of several predominantly T cell-related immune markers, suggesting that baseline immune-related variation may be associated with individual susceptibility to AIWG."

Journal • CNS Disorders • Inflammation • Psychiatry • Schizophrenia • CSF2 • IFNG • IL15 • IL16 • IL17A • IL7 • TNFA

WS-23 Pharmacological Optimization in Schizophrenia: From Neurobiological Hypotheses to Clinical Polypharmacy (WFSBP 2026) - "We will specifically examine the use of clozapine and amisulpride within the context of combined antipsychotic therapy. Finally, we invite participants to share clinical insights on optimizing therapy. Our goal is to foster a productive dialogue on pharmacological optimization in schizophrenia and facilitate an exchange of expertise among all attendees."

Clinical • CNS Disorders • Psychiatry • Schizophrenia

Case report of S-ketamine as treatment option for suicidal ideation and treatment-resistant depression in adolescents with early-onset psychosis. (PubMed, Neuropsychiatr) - "This case suggests that intranasal S‑ketamine may be a safe and effective augmentation strategy for TRD and suicidality in stable adolescent early-onset psychosis, highlighting the need for further research in this high-risk population."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry • Schizophrenia • Suicidal Ideation

Occurrence, temporal variation and environmental fate of psychoactive substances in wastewater treatment plant and receiving river | Poster Board #1509 (ACS-Fall 2026) - "Among antidepressants, venlafaxine, desvenlafaxine and amisulpride were the dominant compounds, with mean concentrations 575.98, 532.03 and 490.85 ng/L. Sulpiride and amisulpride were the main antipsychotic drugs...The consumption pattern of methamphetamine, MDA, ketamine and codeine shows a significant weekend effect. In the downstream receiving river, the concentrations of most PSs showed a decreasing trend with increasing distance from the WWTP effluent, whereas the concentrations of norketamine, benzoylecgonine and desvenlafaxinesome increased, indicating that bio-transformation and abiotic transformation processes occurred during the transport of pollutants in the aquatic environment."

CNS Disorders

Incorporation of PO Antiemetics in the Perioperative Space: Colorectal Surgery (ASA 2026) - "Preoperative oral ondansetron has been shown to be as effective as intraoperative intravenous administration in preventing post-operative nausea and vomiting (PONV), a key factor in prolonged recovery stays. In the first Plan-Do-Study-Act (PDSA) cycle, we targeted the colorectal surgery service, who had a high rate of intravenous medication use and low utilization of oral premedication. We will track intraoperative intravenous administrations, targeting a 15% reduction over three months, and track postoperative amisulpride doses to ensure clinical efficacy is not impacted."

Surgery

SINGLE CENTRE, DOUBLE BLIND, RANDOMIZED, PARALLEL GROUP STUDY TO EVALUATE EFFECTIVENESS OF AMISULPRIDE TO PREVENT POST OPERATIVE NAUSEA AND VOMITING IN FEMALE PATIENTS UNDERGOING BREAST SURGERY (ASA 2026) - "Abstract is embargoed at this time."

Clinical • Surgery

Zuclopenthixol and clozapine-induced neutropenia. (PubMed, BMJ Case Rep) - "We highlight a case of zuclopenthixol-induced neutropenia, a rarely reported adverse effect (AE), and subsequent susceptibility to clozapine-induced neutropenia. Investigations excluded infective, autoimmune, nutritional and primary haematological causes.The patient was subsequently established on amisulpride and lithium, with recovery of ANC. This case highlights the potential susceptibility to antipsychotic-induced neutropenia and the consideration of lithium for augmentation of ANC in future therapy."

Journal • CNS Disorders • Eosinophilia • Hematological Disorders • Immunology • Neutropenia • Psychiatry • Schizophrenia

Dopaminergic modulation of social reward anticipation in depression: neural effects of amisulpride versus placebo. (PubMed, Neuropsychopharmacology) - "Within the MDD-amisulpride group, exploratory analyses revealed positive associations between anhedonia severity and activity in the putamen, VTA, and anterior insula, and higher striatal activity correlated with faster responses to highly rewarding cues. These findings suggest that while amisulpride enhances VTA activity during the anticipation of social rewards, core striatal deficits in MDD remain, underscoring both the potential and limitations of dopaminergic modulation in addressing social anhedonia."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Evolving patterns of antipsychotic use and polypharmacy for schizophrenia in Hong Kong: a 21-year longitudinal study. (PubMed, Psychiatry Res) - "Over the last two decades, overall antipsychotic use in schizophrenia remained stable in Hong Kong, though patterns shifted between agents. Antipsychotic polypharmacy became more prevalent, emphasising the need for further research on their safety and effectiveness."

Journal • Observational data • CNS Disorders • Psychiatry • Schizophrenia

Seizures associated with clozapine augmentation by other antipsychotics: a pharmacovigilance-pharmacodynamic analysis using VigiBase. (PubMed, Ther Adv Psychopharmacol) - "Among antipsychotics classified under ATC code N05A, DDIs with clozapine were detected for amisulpride, chlorpromazine, haloperidol, lurasidone, olanzapine, penfluridol, risperidone, sulpiride, zotepine, and zuclopenthixol. These findings suggest a potential role of dopamine D4 receptor occupancy in seizures associated with clozapine augmentation by other antipsychotics. Further large-scale epidemiological studies are needed to validate these findings."

Adverse events • Journal • PK/PD data • CNS Disorders • Epilepsy • Psychiatry • Schizophrenia

Impact of nutritional factors on the pharmacokinetics of antipsychotics - a systematic review. (PubMed, Psychiatry Res) - "Nutritional factors are a significant source of PK variability in antipsychotic treatment. The results underscore the necessity of standardized administration guidelines (e.g., "take with food" for ziprasidone or "fasted" for amisulpride) to ensure predictable plasma levels and optimize therapeutic outcomes in clinical practice."

Journal • PK/PD data • Review • CNS Disorders • Psychiatry

The efficacy and safety of paliperidone palmitate injection(II) as a replacement for oral medication in the treatment of schizophrenia (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Nanjing Brain Hospital; Nanjing Brain Hospital

New P4 trial • CNS Disorders • Psychiatry • Schizophrenia

Population pharmacokinetic modeling of amisulpride drug interactions and a transporter binding analysis. (PubMed, Eur J Clin Pharmacol) - "This study provides the first clinical indication of a potential drug-drug interaction between amisulpride and metformin. We provide model‑informed dosing references stratified by CLcr, along with recommendations for dose reduction and heightened vigilance for interaction-related adverse effects in patients receiving combination therapy. Molecular docking offers a structural hypothesis regarding binding at OCT2 and MATE1 to support further mechanistic investigation."

Journal • PK/PD data • CNS Disorders • Psychiatry • Schizophrenia

Competing value signals impair reward-learning via dopaminergic mechanisms and increase exploration. (PubMed, PLoS Biol) - "Finally, pharmacological attenuation of dopaminergic signaling via the D2/3 receptor antagonist amisulpride abolished both the increased exploration and the interference with reward learning. These findings suggest that punishment-history interference during reward learning is dopamine-modulated and associated with increased exploration, with individual differences in this exploration linked to loss aversion, providing a mechanistic account of how the brain resolves competing value signals and informing dopamine-related learning disturbances in neuropsychiatric conditions."

Journal • Cognitive Disorders • Psychiatry

Clinical Study of Amisulpride for the Prevention of Postoperative Nausea and Vomiting (ChiCTR) - P=N/A | N=1600 | Not yet recruiting | Sponsor: Shandong Provincial Hospital; Shandong Provincial Hospital

New trial

Adsorption outweighs biodegradation: Organic micropollutants exhibit compound-specific temperature responses in biologically active granular activated carbon filters. (PubMed, Water Res) - "Furthermore, laboratory tests show that an adapted microbial community in GAC filters especially improves the biodegradation of diclofenac, clarithromycin and amisulpride, compared to an activated sludge system. Especially for 1H-benzotriazole, elevated temperatures lead to increased effluent concentrations in the pilot scale GAC filters which can be explained that exothermic adsorption behaviour outweighs potentially increased biodegradation. With the exception of 1H-benzotriazole and ∑4-/5-methylbenzotriazole, all OMPs examined exhibit the opposite behaviour, namely a decrease in wastewater concentrations with increasing temperature."

Journal

Neuroleptic malignant syndrome occurring with amisulpride after lithium toxicity in a patient. (PubMed, Dusunen Adam) - No abstract available

Journal