Exparel (bupivacaine liposome injectable suspension) / Pacira - LARVOL DELTA

Biphasic Brachial Plexus Blockade Following Interscalene Administration of Liposomal Bupivacaine (Exparel): A Case Report. (PubMed, A A Pract) - "To our knowledge, this represents one of the earliest documented recurrences of dense motor blockade after brachial plexus block with Exparel. Potential mechanisms, including delayed drug release, inflammatory-mediated nerve compression, and anatomical variations, are discussed."

Journal • Orthopedics

Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine (clinicaltrials.gov) - P3 | N=96 | Completed | Sponsor: The University of Hong Kong | Active, not recruiting ➔ Completed

Trial completion • Musculoskeletal Diseases • Orthopedics • Pain

A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery (clinicaltrials.gov) - P2 | N=96 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

NCI-2018-01124: Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery (clinicaltrials.gov) - P3 | N=101 | Active, not recruiting | Sponsor: M.D. Anderson Cancer Center | Recruiting ➔ Active, not recruiting

Enrollment closed • Hepatology • Pain

Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population (clinicaltrials.gov) - P2 | N=100 | Recruiting | Sponsor: Texas Scottish Rite Hospital for Children | Not yet recruiting ➔ Recruiting

Enrollment open • Pain • Pediatrics

Intraoperative Liposomal Bupivacaine Is Not Associated with Reduced Opioid Use Following Total Hip Arthroplasty (AAOS 2026) - "Intraoperative administration of Exparel in primary THA was not associated with reduced opioid utilization at any postoperative timepoint. Exparel use correlated with modestly increased NSAID and gabapentin prescriptions, suggesting a potential shift in analgesic modality rather than a net reduction in analgesic burden. These findings do not support routine use of Exparel in THA for opioid-sparing purposes."

Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Diabetes • Heart Failure • Immunology • Metabolic Disorders • Orthopedics • Respiratory Diseases

Comparison between bupivacaine liposome injectable suspension and ropivacaine as local anesthetics for transversus abdominis plane block in postoperative pain management after laparoscopic sleeve gastrectomy: a randomized controlled trial. (PubMed, Eur J Med Res) - P=N/A | "BLIS offers prolonged analgesic effects, extending up to 72 h, and significantly reduces the reliance on additional analgesics, making it a valuable option in multimodal pain management for LSG. However, its impact on enhancing ERAS-related outcomes requires further investigation. Trial registration registration number ChiCTR2500104979, registration date 2025-06-26 00:00:00 (retrospectively registered)."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • Gastrointestinal Disorder • Genetic Disorders • Pain

Transversus Abdominis Plane Blocks with Liposomal Bupivacaine: A New Standard of Care in Abdominal Wall Cryoablation" AND "Laparoscopicassisted Cryoablation of Abdominal Wall Tumors (SIO 2026) - "TAP blocks with bupivacaine liposome injectable suspension were hypothesized to provide effective pain relief, reduce opioid consumption, and improve patient-reported outcomes... Ultrasound-guided TAP blocks with bupivacaine liposomal suspension are effective and safe for providing regional anesthesia in patients undergoing abdominal wall tumor ablation. They significantly reduce pain scores and opioid consumption during the early post-procedure period at a time when many patients struggle with pain following multi-needle cryoablation involving the parietal peritoneum, enhancing patient comfort and recovery. Further randomized controlled studies are warranted to confirm these findings and optimize block techniques."

Desmoid Tumors • Endometriosis • Fibrosis • Gynecology • Oncology • Solid Tumor • Women's Health

Exparel® (Bupivacaine Liposome Injectable Suspension) as Adjunctive Pain Control in Adult Tonsillectomy: Reducing Post-Operative Opioid Use. (PubMed, Ann Otol Rhinol Laryngol) - "Use of Exparel® in adult tonsillectomy may decrease post-operative opioid use compared to standard of care treatment. These findings may serve as guidance for best practices in adult tonsillectomy."

Journal • Pain

Endoscopic transnasal sphenopalatine ganglion block for chronic craniofacial pain. (PubMed, Eur Arch Otorhinolaryngol) - No abstract available

Journal • Pain

Efficacy of EXPAREL vs. Bupivacaine (clinicaltrials.gov) - P3 | N=104 | Recruiting | Sponsor: Emory University | Not yet recruiting ➔ Recruiting

Enrollment open • Orthopedics

Comment on "Surgical site injection of liposomal bupivacaine reduces 90-day incidence of major complications after hip fracture: a nonrandomized trial". (PubMed, Int J Surg) - No abstract available

Journal • Musculoskeletal Diseases • Orthopedics

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain (clinicaltrials.gov) - P2/3 | N=150 | Enrolling by invitation | Sponsor: Rutgers, The State University of New Jersey | Recruiting ➔ Enrolling by invitation | Trial completion date: Apr 2025 ➔ Apr 2027 | Trial primary completion date: Jan 2025 ➔ Jan 2027

Enrollment status • Trial completion date • Trial primary completion date • Cardiovascular • Heart Failure • Pain

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy (clinicaltrials.gov) - P2 | N=78 | Recruiting | Sponsor: Masonic Cancer Center, University of Minnesota | Trial completion date: Jan 2026 ➔ Jan 2028 | Trial primary completion date: Jan 2026 ➔ Jan 2027

Head-to-Head • Trial completion date • Trial primary completion date • Oncology • Pain • Pancreatic Cancer • Small Intestinal Carcinoma • Solid Tumor

EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (clinicaltrials.gov) - P2 | N=80 | Active, not recruiting | Sponsor: M.D. Anderson Cancer Center | Recruiting ➔ Active, not recruiting

Enrollment closed • Anesthesia • Oncology

Comparing Bupivacaine Liposomes with Conventional Bupivacaine for Paracervical Nerve Block in the Treatment of Acute Herpes Zoster Neuralgia (ChiCTR) - P4 | N=80 | Recruiting | Sponsor: Affiliated Hospital of Guangdong Medical University; Affiliated Hospital of Guangdong Medical University

New P4 trial • Herpes Zoster • Neuralgia • Pain • Varicella Zoster

Comparison of Bupivacaine Liposome and Modified Cocktail Formulation for Local Infiltration Anesthesia and Analgesia in Promoting Rapid Recovery after Anal Fistula Surgery: A Prospective, Double-Blind, Randomized Controlled Clinical Study Protocol (ChiCTR) - P4 | N=360 | Not yet recruiting | Sponsor: Sichuan University, West China Hospital; Sichuan University, West China Hospital

New P4 trial • Anesthesia • Gastrointestinal Disorder

The application of bupivacaine liposome combined with posterior branch block of spinal nerve in minimally invasive spinal surgery (ChiCTR) - P4 | N=104 | Recruiting | Sponsor: Affiliated Hospital of Guangdong Medical University; Affiliated Hospital of Guangdong Medical University

New P4 trial

Effect of Liposomal Bupivacaine Combined with Ultrasound-Guided Fascia Iliaca Compartment Block on Postoperative Analgesia and Enhanced Recovery in Elderly Patients Undergoing PFNA Internal Fixation: A Randomized Double-Blind Controlled Trial (ChiCTR) - P=N/A | N=48 | Not yet recruiting | Sponsor: people's hospital of wenjiang; Wenjiang District People's Hospital of Chengdu City

New trial • Musculoskeletal Diseases • Orthopedics

Comparison of the effects of different doses of liposomal bupivacaine on sciatic nerve block on foot and ankle function after total knee arthroplasty (TKA) (ChiCTR) - P=N/A | N=90 | Completed | Sponsor: Foshan Fosun Chancheng Hospital; Foshan Fosun Chancheng Hospital

New trial • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology

Efficacy and safety of bupivacaine liposome injection combined with routine treatment in early postoperative analgesia in patients undergoing lumbar surgery: a single center, prospective cohort study (ChiCTR) - P=N/A | N=74 | Not yet recruiting | Sponsor: Hospital of Chengdu University of Traditional Chinese Medicine; Hospital of Chengdu University of Traditional Chinese Medicine

New trial • Pain

Safety and Efficacy of Bupivacaine Liposome Injection for Postoperative Pain Management in Pediatric Congenital Heart Disease Surgeries: A Single-Center, Prospective, Observational Study (ChiCTR) - P=N/A | N=90 | Not yet recruiting | Sponsor: Fuwai Central China Cardiovascular Hospital; Fuwai Central China Cardiovascular Hospital

New trial • Cardiovascular • Heart Failure • Pain • Pediatrics

The effect of liposomal bupivacaine and bupivacaine hydrochloride on postoperative pain during laparoscopic repair of inguinal hernia in children with transverse abdominis muscle plane nerve block: a randomized, Open-label, parallel controlled clinical study (ChiCTR) - P=N/A | N=200 | Not yet recruiting | Sponsor: Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine; Shanghai Children's Medical Center Affiliated to Sha

New trial • Gastroenterology • Pain

Clinical study on the application of levobupivacaine liposome injection for upper trunk brachial plexus block in postoperative analgesia after shoulder arthroscopy: A single-center randomized controlled prospective study (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Zhongnan Hospital of Wuhan University; Zhongnan Hospital of Wuhan University

New trial • Orthopedics

Comparison of Bupivacaine Liposome with Modified Cocktail Formula for Local Infiltration Anesthesia and Analgesia in Promoting Rapid Recovery after Hemorrhoid Surgery: A Prospective, Double-Blind, Randomized Controlled Clinical Study Protocol (ChiCTR) - P=N/A | N=360 | Not yet recruiting | Sponsor: Sichuan University, West China Hospital; Sichuan University, West China Hospital

New trial • Anesthesia • Gastroenterology • Gastrointestinal Disorder