Exparel (bupivacaine liposome injectable suspension) / Pacira - LARVOL DELTA

A Study of TLC590 for Postsurgical Pain Following Bunionectomy (clinicaltrials.gov) - P3 | N=300 | Recruiting | Sponsor: TLC Biopharmaceuticals, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

CALMS-1: Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1 (clinicaltrials.gov) - P=N/A | N=300 | Not yet recruiting | Sponsor: University of Texas Southwestern Medical Center

New trial • Lung Cancer • Oncology • Pain • Solid Tumor

IPP Placement & Intracavernosal Block (clinicaltrials.gov) - P4 | N=100 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences

New P4 trial • Anesthesia • Erectile Dysfunction

Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine (clinicaltrials.gov) - P3 | N=96 | Active, not recruiting | Sponsor: The University of Hong Kong | Completed ➔ Active, not recruiting | Trial completion date: May 2025 ➔ Feb 2026 | Trial primary completion date: Feb 2025 ➔ Nov 2025

Enrollment closed • Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

R.E.C.K vs Exparel in Robotic Nephrectomy (clinicaltrials.gov) - P3 | N=170 | Recruiting | Sponsor: Wake Forest University Health Sciences | Not yet recruiting ➔ Recruiting

Enrollment open • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor

Study recruitment challenges when conducting a randomized controlled trial comparing long- and short-acting local anesthetics for pain control after penile prosthesis. (PubMed, J Sex Med) - No abstract available

Journal • Anesthesia • Erectile Dysfunction • Pain

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties (clinicaltrials.gov) - P4 | N=56 | Recruiting | Sponsor: Melinda Seering | Phase classification: P=N/A ➔ P4 | Trial completion date: Jan 2026 ➔ Jan 2027 | Trial primary completion date: Oct 2025 ➔ Oct 2026

Phase classification • Trial completion date • Trial primary completion date • Anesthesia • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology

A solvent-free ropivacaine-loaded composite hydrogel assembled from pH-sensitive micelles and a thermosensitive injectable hydrogel for prolonged local anesthesia. (PubMed, Acta Biomater) - "The effective analgesic time of Rop-micelles@HPCH (20.3 h) or Rop-micelles@HPCH-Dex with only a small fraction (<one thousandth) of adjuvant dexmedetomidine (29.1 h) was evidently longer than those of the free Rop HCl (4.2 h) and the commercial EXPAREL® injection (4-6 h) groups in the rat sciatic nerve model. In this study, we develop the ropivacaine-loaded pH-sensitive micelles/hydrogel composite via a solvent-free process based on pH-sensitive and biodegradable polymeric micelles and thermosensitive and injectable hydroxypropyl chitin for postoperative pain management. The drug-loaded micelles/hydrogel composite exhibited sustained drug release in vitro and in vivo, displaying a much longer effective analgesic time than that of the free ropivacaine injection and the commercial EXPAREL® injection in the rat sciatic nerve blockade model."

Journal • Anesthesia • Pain

Laparoscopic Transversus Abdominis Plane (TAP) Block to Reduce Post-operative Opioids (clinicaltrials.gov) - P2/3 | N=0 | Withdrawn | Sponsor: Baylor Research Institute | N=165 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal

Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: University of Cincinnati | Not yet recruiting ➔ Recruiting

Enrollment open • Breast Cancer • Oncology • Solid Tumor

Nanotechnology for pain management in orthopedic surgery. (PubMed, World J Orthop) - "This narrative review evaluated the potential of nanotechnology platforms (DepoFoam bupivacaine®, DepoDur®, Exparel®, Zynrelef®, NeuroCuple™) in the control of postoperative pain following orthopedic procedures...All EREM dosages diminished the mean fentanyl usage vs placebo and delayed the median time to first dose of fentanyl...Opioid consumption was reduced by 37% in the Zynrelef® PR cohort vs 25% in the bupivacaine HCl cohort. In individuals experiencing total knee arthroplasty and total hip arthroplasty, the use of a nanotechnology-based NeuroCupleTM device diminished postoperative pain at rest by 34% and reduced pain with movement by 18%."

Journal • Review • Anesthesia • Orthopedics • Pain

Study on the Application of Bupivacaine Liposome Injection in the Fast Track Recovery after Open Ovarian Cancer Surgery (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Liuzhou Workers' Hospital; Liuzhou Workers' Hospital

New trial • Oncology • Ovarian Cancer • Solid Tumor

The Efficacy and Safety of Bupivacaine Liposomes in Lower Extremity Debridement Following Burn Injuries (ChiCTR) - P1 | N=116 | Not yet recruiting | Sponsor: Chinese People's Liberation Army Northern Theater Command General Hospital; Chinese People's Liberation Army Northern Theater Command General Hospital

New P1 trial

The efficacy and safety of bupivacaine liposome injection for postoperative pain treatment after minimally invasive cardiac surgery: A single-center, prospective, randomized, single-blind, controlled trial (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Fuwai Huaxin Cardiovascular Hospital; Fuwai Huaxin Cardiovascular Hospital

New P4 trial • Cardiovascular • Pain

Study on the effectiveness of local infiltration anesthesia in the posterior joint capsule during TKA (ChiCTR) - P=N/A | N=66 | Not yet recruiting | Sponsor: West China Hospital of Sichuan University; West China Hospital of Sichuan University

New trial • Anesthesia • Immunology • Osteoarthritis • Pain • Rheumatology

A Phase 3 Study on TLC590 for Managing Postsurgical Pain Following Bunionectomy (clinicaltrials.gov) - P3 | N=300 | Not yet recruiting | Sponsor: TLC Biopharmaceuticals, Inc.

New P3 trial • Pain

Single Shot Exparel vs Catheters in Lower Extremity Trauma (clinicaltrials.gov) - P4 | N=90 | Recruiting | Sponsor: George Washington University

New P4 trial • Musculoskeletal Diseases • Orthopedics

Vaginal Cuff Exparel—A Game Changer in Postoperative Pain Management? (ESGE 2025) - "Conclusions Adjunctive vaginal cuff Exparel injection in addition to QL block may enhance postoperative pain management in RALH. Further prospective studies are needed to confirm these findings and explore the benefits of localized long-acting anesthetic strategies."

Anesthesia • Gynecology • Pain

Pacira BioSciences Notified of Abbreviated New Drug Application Filing from Qilu Pharmaceutical (Hainan) Co., Ltd. for EXPAREL (GlobeNewswire)

ANDA • Pain

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery (clinicaltrials.gov) - P3 | N=100 | Recruiting | Sponsor: University of North Carolina, Chapel Hill | Trial completion date: May 2026 ➔ Oct 2026 | Trial primary completion date: May 2026 ➔ Oct 2026

Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics

A NEAR-FATAL CASE OF LOCAL ANESTHETIC SYSTEMIC TOXICITY: RAPID RECOGNITION AND SUCCESSFUL RESUSCITATION (CHEST 2025) - "Preoperative cardiac evaluation deemed her low risk, with a normal She received epidural injections of Liposomal Bupivacaine and Ropivacaine during the Surgery...She was extubated on postoperative day (POD) 1 and weaned off Epinephrine by POD 2...Severe toxicity remains a concern, particularly with bupivacaine, a racemic mixture known for its high cardiac and CNS toxicity compared to ropivacaine or levobupivacaine [2].LAST occurs when local anesthetics reach systemic circulation, leading to sodium channel blockade in the heart and CNS... This case underscores the importance of vigilance when using local anesthetics, particularly in high-risk populations, and highlights lipid emulsion therapy as a life-saving intervention."

Clinical • Anesthesia • Cardiovascular • CNS Disorders • Epilepsy • Hepatitis C • Hepatology • Hypertension • Hypotension • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics

Surgical site injection of liposomal bupivacaine reduces 90-day incidence of major complications after hip fracture: a nonrandomized trial. (PubMed, Int J Surg) - "With surgical site injection of LB, patient might have reduced incidence of major complications. The benefits of LB regarding all-cause mortality and delirium were not observed in this study, possibly due to insufficient power. Future randomized clinical trials with larger sample size were warranted by the current study."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Infectious Disease • Musculoskeletal Diseases • Myocardial Infarction • Orthopedics • Pain • Pneumonia • Respiratory Diseases • Septic Shock • Venous Thromboembolism

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine (clinicaltrials.gov) - P=N/A | N=128 | Recruiting | Sponsor: Boston Children's Hospital | Not yet recruiting ➔ Recruiting | Trial primary completion date: Aug 2026 ➔ Aug 2027

Enrollment open • Trial primary completion date • Pain

RCT to Test Regional Anesthesia Effect on Decreased Opiate Use (clinicaltrials.gov) - P3 | N=50 | Enrolling by invitation | Sponsor: United States Naval Medical Center, Portsmouth | Trial completion date: Sep 2025 ➔ Sep 2026 | Trial primary completion date: Aug 2025 ➔ Aug 2026

Trial completion date • Trial primary completion date • Anesthesia • Pain

Pediatric Anesthetic Management of a Patient With Warburg Micro Syndrome, a Rare Autosomal Recessive Genetic Disorder. (PubMed, Clin Case Rep) - "Warburg micro syndrome is an extremely rare autosomal recessive genetic disorder with only 100 families documented worldwide. We present a safe and successful anesthetic management of a pediatric patient with Warburg micro syndrome utilizing total intravenous anesthesia (TIVA) and incisional Exparel."

Journal • Anesthesia • Genetic Disorders • Pediatrics