umbilical cord mesenchymal stem cells / Vinmec - LARVOL DELTA

Mesenchymal Stem/Stromal Cell Therapy in the Treatment of Frailty (clinicaltrials.gov) - P1/2 | N=158 | Active, not recruiting | Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology | Recruiting ➔ Active, not recruiting | N=44 ➔ 158 | Trial completion date: Nov 2023 ➔ Dec 2024

Enrollment change • Enrollment closed • Stroma • Trial completion date

Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Bronchopulmonary Dysplasia (clinicaltrials.gov) - P1 | N=10 | Completed | Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology | Unknown status ➔ Completed

Trial completion • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases • Transplantation

Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease (clinicaltrials.gov) - P1/2 | N=40 | Completed | Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology | Recruiting ➔ Completed

Stroma • Trial completion • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases • Transplantation

Mesenchymal Stem/Stromal Cell Therapy in the Treatment of Frailty (clinicaltrials.gov) - P1/2 | N=44 | Recruiting | Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology | Not yet recruiting ➔ Recruiting | Trial completion date: Nov 2022 ➔ Nov 2023 | Trial primary completion date: Nov 2021 ➔ Sep 2022

Enrollment open • Stroma • Trial completion date • Trial primary completion date • CDKN2A

Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes. (PubMed, Front Immunol) - "Moreover, TGFβ-primed UCMSCs secreted EVs that could upregulate the expression of chondrogenesis markers (COL2 and ACAN) and downregulate fibrotic markers (COL1 and RUNX2) in chondrocytes. Hence, priming UCMSCs with cytokines can deliver selective therapeutic effects of EV treatment in OA and chondrocyte-related disorders."

Journal • Fibrosis • Immunology • Oncology • Osteoarthritis • Pain • Rheumatology • ACAN • IFNA1 • MIR181B1 • MIR320A • RUNX2 • TGFB1 • TNFA

Effects of Extracellular Vesicles Secreted by TGFβ-Stimulated Umbilical Cord Mesenchymal Stem Cells on Skin Fibroblasts by Promoting Fibroblast Migration and ECM Protein Production. (PubMed, Biomedicines) - "On the contrary, the protein levels of total collagen and elastin released by fibroblasts were greater in the cell groups treated with EVs compared to EV-depleted conditions; particularly elastin associated with TGFβ-stimulated UCMSCs. These data indicate the potential roles of EVs from UCMSCs in protecting skin from aging by promoting ECM protein production."

Journal • Immunology • FGF2 • TGFB1

Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti-N-Methyl-d-Aspartate Receptor Encephalitis: First Case Report. (PubMed, Cell Transplant) - "Cerebral atrophy was reduced on brain magnetic resonance imaging (MRI). Overall, the outcomes of this patient suggest a potential cell therapy for autoimmune encephalitis and its neurological consequences."

Journal • CNS Disorders • Immunology

Umbilical Cord-derived Mesenchymal Stem Cell Infusion in the Management of Adult Liver Cirrhosis (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology

New P1 trial • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis

Mesenchymal Stem/Stromal Cell Therapy in the Treatment of Frailty (clinicaltrials.gov) - P1/2; N=44; Not yet recruiting; Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology

Clinical • New P1/2 trial • CDKN2A

Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease (clinicaltrials.gov) - P1/2; N=40; Recruiting; Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology; Trial primary completion date: Nov 2020 ➔ Jul 2021

Clinical • Trial primary completion date • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases • Transplantation

Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease (clinicaltrials.gov) - P1/2; N=40; Recruiting; Sponsor: Vinmec Research Institute of Stem Cell and Gene Technology

Clinical • New P1/2 trial • Chronic Obstructive Pulmonary Disease • Respiratory Diseases • Transplantation