trandolapril/verapamil / Generic mfg. - LARVOL DELTA

Higher Blood Pressure Time-in-Target Range May Improve Primary Cardiovascular Outcome in Patients with Hypertension and Coronary Artery Disease (AHA 2025) - "However, the prognostic value of BP-TTR among patients with hypertension (HTN) and coronary artery disease (CAD) remains unclear.Research Question: Is higher BP-TTR over a 6-month period associated with a reduced risk of primary cardiovascular outcome (composite all-cause mortality, nonfatal myocardial infarction, nonfatal stroke) among patients with HTN+CAD? In this post-hoc analysis of the randomized INternational VErapamil-trandolapril STudy (INVEST), we pooled patients (aged ≥50 years with HTN+CAD) randomized to a calcium antagonist or non-calcium antagonist strategy, which had equivalent outcomes in INVEST... In patients with HTN+CAD, higher BP-TTR at the target of <140/90 mmHg may be associated with a reduced risk of the composite outcome of all-cause mortality, nonfatal myocardial infarction, and nonfatal stroke, though statistical significance was not reached after adjustment. As a next step, we plan to conduct additional analyses applying alternative BP..."

Clinical • Cardiovascular • Coronary Artery Disease • Hypertension • Myocardial Infarction

Use of Intravenous Lipid Emulsion Therapy and Insulin in a Case of Tarka Intoxication. (PubMed, WMJ) - "ILE is an alternative treatment method for acute lipophilic drug intoxications, such as Tarka."

Journal • Cardiovascular • Diabetes • Hypotension • Metabolic Disorders

LEVERAGING MACHINE LEARNING TO ILLUMINATE PREDICTORS OF LONG-TERM MORTALITY: AN IN-DEPTH ANALYSIS OF HYPERTENSIVE PATIENTS WITH CAD (ACC 2024) - "We utilized machine learning methods (MLM) to analyze predictors of long-term mortality. We used data from the US cohort of the INternational VErapamil SR-Trandolapril Study (INVEST), a randomized controlled trial of hypertensive patients ≥50 years old with CAD evaluating a calcium antagonist vs β blocker strategy. In a machine learning model applied to a large population of older hypertensive patients with CAD, the top contributors to long-term outcomes were age, race, diabetes, and BP variability."

Clinical • Machine learning • Diabetes • Metabolic Disorders

MELANOMA AND DYSPLASTIC NEVI DEVELOPMENT AFTER RANITIDINE/RILMENIDINE/МOXONIDINE, LERCANIDIPINE, ROSUVASTATIN AND VERAPAMIL/TRANDOLAPRIL - NEW DATA/CASE SERIES. THE POTENTIAL ROLE OF NITROSAMINE/NDSRIS CONTAMINATION IN POLYMEDICATION AS SUBSTANTIAL SKIN CANCER TRIGGERING FACTOR. (PubMed, Georgian Med News) - "In the last decade, melanoma has been described repeatedly in the medical literature as a possible side-effect within the intake of possibly with nitrosamines contaminated medications such as: Valsartan, Hydrochlorothiazide, Amlodipine, Nebivolol, Bisoprolol and Perindopril. Ingredients that are present in drug preparations, identified as availability and as carcinogenic potency, but not yet reflected in packaging or prescriptions. The question remains: why?"

Journal • Cutaneous Melanoma • Genetic Disorders • Melanoma • Oncology • Skin Cancer • Solid Tumor

MACHINE LEARNING PREDICTION MODEL OF BLOOD PRESSURE VARIABILITY (ACC 2022) - "We investigated predictors of higher BP variability in International Verapamil SR-Trandolapril Study (INVEST) patients aged ≥50 years with hypertension and CAD and treated with a calcium antagonist vs β-blocker strategy. We used XGBoost machine learning algorithm based on the gradient boosting framework to identify predictors of higher BP variability. In a large population of older patients with CAD, age, baseline & mean BP and sex were the strongest predictors of BP variability. Efforts to identify and minimize visit-to-visit systolic BP variability and its etiology may improve outcomes in this population."

Hypertension • Nephrology • Renal Disease

[VIRTUAL] ASSOCIATION BETWEEN SHORT-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND LONG-TERM MORTALITY AMONG PATIENTS WITH CORONARY ARTERY DISEASE (ACC 2021) - "Its early measurement may identify those at increased mortality To investigate the influence of short term (1 year) visit-to-visit systolic (S) and diastolic BP variability on long term mortality we used the US cohort of INternational VErapamil SR-Trandolapril Study (INVEST)... Minimizing visit-to-visit SBP variability may be important in reducing excess mortality later in life"

Clinical • Cardiovascular • Coronary Artery Disease

Valproic acid for myoclonic epilepsy in POLG1 carriers can be fatal. (PubMed, Folia Neuropathol) - "With interest we read the article by Tarka et al...It was concluded that pancreatitis prior to liver failure is unusual [1]. The study is appealing but raises comments and concerns."

Journal • CNS Disorders • Epilepsy • Hepatology • Liver Failure • Mental Retardation • Metabolic Disorders • Pancreatitis

Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease: A Post Hoc Analysis of a Randomized Clinical Trial. (PubMed, JAMA Netw Open) - P4 | "The study evaluated a calcium antagonist (sustained-release verapamil plus trandolapril) vs β-blocker (atenolol plus hydrochlorothiazide) treatment strategy. Efforts to identify and minimize visit-to-visit SBP variability may be important in reducing excess mortality later in life. ClinicalTrials.gov Identifier: NCT00133692."

Clinical • Journal • Retrospective data • Cardiovascular • CNS Disorders • Coronary Artery Disease • Hypertension

Optimal systolic blood pressure and reduced long-term mortality in older hypertensive women with prior coronary events - An analysis from INVEST☆. (PubMed, Int J Cardiol Hypertens) - "We analyzed long-term all-cause mortality data from the International Verapamil SR/Trandolapril Study (INVEST), stratified by risk attributable to clinical severity of CAD (women with prior coronary events of myocardial infarction or revascularization considered high risk, all others at low risk) and by age group (50-64 or ≥65 years)...A similar pattern was observed among low-risk women ≥65 and <65 years old. Among women ≥65 years old with hypertension and prior coronary events, in-trial SBP between 130 and 139 mmHg was associated with lower mortality over the long term versus SBP <130 mmHg."

Clinical • Journal • Cardiovascular • Coronary Artery Disease • Heart Failure • Hypertension • Myocardial Infarction

A Prospective Noninterventional, Observational Study to Describe the Effectiveness and Safety of Trandolapril and Verapamil Single-Pill Combination in the Management of Patients with Hypertension and Type 2 Diabetes Mellitus: A Harvest TR Study. (PubMed, Biomed Res Int) - P | "The trandolapril/verapamil combination was evaluated as being safe and well-tolerated following a treatment period of 8 weeks. This trial was registered with NCT02298556."

Clinical • Journal • Observational data • Diabetes • Hypertension • Metabolic Disorders • Type 2 Diabetes Mellitus

"Tarka daal for the win 😋" (@MadihaRaeesMD)

Risk and Blood Pressure Control Rates Across the Spectrum of Coronary Artery Disease in Hypertensive Women: An Analysis from The INternational VErapamil SR-Trandolapril STudy (INVEST). (PubMed, J Womens Health (Larchmt)) - "In a prospective, multinational cohort of hypertensive women with CAD, those with prior MI or revascularization comprised a group at higher risk for death, nonfatal MI, and nonfatal stroke, and were less likely to have their BP controlled, despite more aggressive therapy. The feasibility and benefit of reducing BP to <130/80 mmHg in women, particularly with more severe CAD, warrant further investigation."

Clinical • Journal • Cardiovascular • Coronary Artery Disease • Hypertension • Myocardial Infarction

Univariate calibrations with or without chemometric assistance for determination of drugs lacking peak maxima in their zero-order profiles. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "...In this manuscript, several univariate and multivariate spectrophotometric methods were developed and validated for determination of Trandolapril (TR) and Verapamil (VR) combination...Moreover, a statistical comparison between the developed methods and a reference method was done. Also, One-way ANOVA statistical test was done between all the proposed univariate and multivariate spectrophotometric methods."

Journal • Biosimilar

Variability of radon and thoron equilibrium factors in indoor environment of Garhwal Himalaya. (PubMed) - "The annual average equilibrium factors for radon and thoron have been found to vary from 0.23 to 0.80 with an average of 0.42 and from 0.01 to 0.29 with an average of 0.07, respectively. The detailed discussion of the measurement techniques and the explanation for the results obtained is given in the paper."

Journal • Biosimilar

Starka incitament för att avbryta införandet av värdebaserad vård. (PubMed) - Lakartidningen - No abstract available.

Journal • Biosimilar

"So impressed. My wife loves tarka dhal!! Making one from scratch is on my to do list! Any recipe recommendations?" (@drkeithsiau)

PAIT-Survey Follow-Up: Changes in Albuminuria in Hypertensive Diabetic Patients with Mild-Moderate Chronic Kidney Disease. (PubMed, High Blood Press Cardiovasc Prev) - "The treatments decrease the prevalence of subjects with albuminuria, showing a significant difference among the different drug combinations, favoring the use of new dihydropyridine calcium channel blockers, such as lercanidipine, combined with RAAS inhibitors, to control albuminuria in diabetic hypertensive patients."

Clinical • Journal

Genome-wide association analysis of common genetic variants of resistant hypertension. (PubMed, Pharmacogenomics J) - "We conducted a genome-wide association analysis in 1194 White and Hispanic participants with hypertension and coronary artery disease from the INternational VErapamil-SR Trandolapril STudy-GENEtic Substudy (INVEST-GENES)...Participants with the highest number of risk alleles were at increased risk of RHTN compared to participants with a lower number (p-trend = 1.8 × 10). Overall, we identified and replicated associations with RHTN in the MSX2, IFLTD1, and PTPRD regions, and combined these associations to create a genetic risk score."

Journal

Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure. (PubMed, ESC Heart Fail) - "In patients with CAD, a physician diagnosis of HF at baseline portended a higher risk for death, MI, or stroke than in those without an HF history. Achieving SBP of 120-140 mmHg and heart rate < 85 b.p.m. was associated with a better outcome in patients with known HF and CAD."

Clinical • Journal

One-year persistence of fixed-dose combinations of angiotensin-converting enzyme inhibitor and calcium channel blocker in hypertensive patients (PubMed, Orv Hetil) - "The authors demonstrated that the one-year persistence of ACEI/CCB FDCs was significantly different in hypertensive patients. Ramipril/amlodipine FDC was more advantageous for patient adherence. Orv Hetil. 2019; 160(9): 343-348."

Clinical • Journal

Do hypertensive women with coronary artery disease benefit from lowering systolic blood pressure under 130 mmHg? Long-term mortality in the INternational VErapamil SR-trandolapril STudy (INVEST) (ESC 2019) - "In women =65 yo with hypertension and prior myocardial infarction and/or coronary revascularization enrolled in INVEST, a SBP between 130 to <140 mmHg was associated with lower all-cause, long-term mortality versus SBP <130 mmHg."

Clinical

Prevalence of Trachoma and Access to Water and Sanitation in Benue State, Nigeria: Results of 23 Population-Based Prevalence Surveys. (PubMed, Ophthalmic Epidemiol) - "There is a need for public health-level interventions against trachoma in three LGAs of Benue State."

Clinical • Journal