ibuprofen / Generic mfg. - LARVOL DELTA

Pain Reduction Caused by the Combined Treatment of Physiotherapy, Oral Gabapentin and Oral Ibuprofen Arginine. (clinicaltrials.gov) - P4 | N=129 | Completed | Sponsor: Universidad Europea de Madrid | N=35 ➔ 129

Enrollment change • Musculoskeletal Pain • Pain

Encapsulation-based enhancements in modern drug delivery systems. (PubMed, Int J Pharm) - "In addition, the pharmaceutical industry has commercialized many encapsulated drugs, such as anti-inflammatory (ibuprofen, dexamethasone), high blood pressure drugs (valsartan, azilsartan), proton pump inhibitors (lansoprazole), anti-cancer (carboplatin, carmustine, cisplatin, trastuzumab, cytarabine, paclitaxel, doxorubicin (DOX), vincristine) antiparasitic (amphotericin), antifungal (clotrimazole), and hormonal (melatonin (MLT))). It can render drugs more convenient and user-friendly for various therapeutic purposes and help to enhance their performance, functionality, and effectiveness. This comprehensive review examines the encapsulation technologies employed in the pharmaceutical industry, highlighting notable examples of encapsulated drugs that demonstrate their mechanism of action and potential therapeutic effects in vitro, in vivo, and through clinical trials, with relevance to various diseases."

Journal • Review • Cardiovascular • Hypertension • Oncology

Ibuprofen and Neural Mobilization Treatment in Carpal Tunnel Syndrome. (clinicaltrials.gov) - P4 | N=123 | Completed | Sponsor: Universidad Europea de Madrid | N=44 ➔ 123

Enrollment change • Musculoskeletal Pain • Pain

Ibuprofen Arginine and Neural Mobilization Versus Ibuprofen Arginine in the Treatment of Carpal Tunnel Syndrome (clinicaltrials.gov) - P4 | N=76 | Completed | Sponsor: Universidad Europea de Madrid | N=27 ➔ 76

Enrollment change • Musculoskeletal Pain • Pain

Acute Viral-Induced Myopathy Following Covid-19. (PubMed, Eur J Case Rep Intern Med) - "Coronavirus disease 2019 can cause acute, self-limiting viral myopathy that mimics autoimmune myositis with positive anti-Mi-2 even in previously healthy individuals.Careful exclusion of neuropathic and autoimmune causes prevents misdiagnosis, overtreatment, and avoiding unnecessary invasive tests.Supportive management with hydration, analgesia, and physiotherapy leads to full recovery."

Journal • CNS Disorders • Fatigue • Immunology • Infectious Disease • Musculoskeletal Pain • Myositis • Novel Coronavirus Disease • Pain • Pulmonary Disease • Respiratory Diseases • Urinary Incontinence • Urology • CHD4 • MB

Bifunctionalized Polyethyleneimine-Based Sponge for Adsorption of Ibuprofen from Aqueous Solution. (PubMed, Polymers (Basel)) - "After eight cycles of use, the adsorption efficiency decreased by only 4%. These findings suggest that the synthesized dendritic anion exchange adsorbent represents a promising candidate for the removal of IBU from contaminated water sources."

Journal

Transdermal diclofenac versus oral paracetamol-ibuprofen combination for postoperative pain following surgical extraction of mandibular third molar: a randomized controlled trial. (PubMed, Ann Med Surg (Lond)) - "Both the transdermal diclofenac patch and the oral combination of paracetamol and ibuprofen are effective in managing postoperative pain following mandibular third molar extraction. However, the transdermal diclofenac patch has significantly fewer gastrointestinal side effects, making it a preferable option for patients at risk of gastric irritation."

Journal • Pain

Role of Alprazolam in Management of Post Endodontic Pain After Single Visit Root Canal Treatment. To Compare Mean Pain Score Between Two Group of Participants Undergoing Post Operative Pain Management After Single Visit Root Canal Treatment: NSAIDs Alone and a Combination of NSAIDs and Alprazolam. (clinicaltrials.gov) - P=N/A | N=110 | Not yet recruiting | Sponsor: Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi

New trial • Pain

Pain Reduction and Changes in Upper Limb Function Produced by Different Treatments in Carpal Tunnel Syndrome (clinicaltrials.gov) - P4 | N=196 | Completed | Sponsor: Francisco Unda Solano | N=87 ➔ 196

Enrollment change • Musculoskeletal Pain • Pain

Pain Reduction Produced by Different Treatments in Carpal Tunnel Syndrome (clinicaltrials.gov) - P4 | N=117 | Completed | Sponsor: Francisco Unda Solano | N=79 ➔ 117

Enrollment change • Musculoskeletal Pain • Pain

Response to Wang et al. "Comparative analysis of continuous pericapsular nerve group block and supra-inguinal fascia iliaca compartment block for postoperative analgesia in total hip arthroplasty: a randomized controlled trial". (PubMed, J Orthop Surg Res) - "In terms of analgesic protocol, every patient received scheduled intravenous administration of the non-steroidal anti-inflammatory drug ibuprofen and patient-controlled analgesia with tramadol...Although the difference in opioid use was slightly below the minimal clinically important difference, it was accompanied by lower pain scores and less need for rescue medication. We acknowledge the absence of patient-reported outcomes as a limitation and encourage their inclusion in future research."

Clinical • Journal • Anesthesia • Orthopedics • Pain

Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen (clinicaltrials.gov) - P4 | N=200 | Recruiting | Sponsor: University of Chicago | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial completion date • Trial primary completion date

Opportunities and challenges for the implementation of pharmacogenomics in supportive care for gastrointestinal cancer patients in Zimbabwe. (PubMed, Pharmacogenomics) - "PGX guidelines were fully implemented for tramadol, codeine, omeprazole, and ondansetron; partially for ibuprofen and celecoxib; and unimplementable for amitriptyline. There is an opportunity to improve supportive care in gastrointestinal cancer patients through pharmacogenomics though some specific medicines challenges to full implementations are due to limited registered medicines."

Biomarker • Journal • Gastrointestinal Cancer • Oncology • Solid Tumor

The Association Between Common NSAID Use and Early Dental Implant Failure: A Large-Scale Retrospective Cohort Study. (PubMed, J Stomatol Oral Maxillofac Surg) - "The use of Ibuprofen and, to a lesser extent, Naproxen, is associated with a significantly increased risk of early dental implant failure, independent of other patient risk factors. Clinicians should consider these findings when formulating post-operative analgesic plans, particularly for patients with complex medical histories."

Journal • Retrospective data • Diabetes • Metabolic Disorders • Osteoporosis • Pain • Rheumatology

Bullous fixed drug eruption associated with ibuprofen. (PubMed, CMAJ) - No abstract available

Journal

Pediatric Epididymitis With Atypical Evolution: A Case of Testicular Necrosis and Review of Management Strategies. (PubMed, Pediatr Emerg Care) - "Testicular necrosis is an exceedingly uncommon but serious complication of AOE in children. Persistent pain, increasing testicular size, or poor clinical response should prompt early Doppler reassessment and consideration of surgical exploration. Recognition of TCS as a possible pathophysiological mechanism may help guide timely diagnosis and intervention to prevent irreversible ischemic injury."

Journal • Dermatology • Pain • Pediatrics • Respiratory Diseases • Urology

Impacts of the 2024 flash flood on water quality, pathogenic bacteria and organic contaminant risks in the Albufera wetland (Valencia, Spain). (PubMed, Environ Res) - "Comparison with pre-flood data revealed significant concentration increases for PPCPs, PFAS, PAHs, and OPFRs, attributed to wastewater treatment failures and urban/industrial chemical mobilization. Several pollutants were found to exceed established ecological protection thresholds, with the most significant risks identified for ibuprofen, PFOS, and fluoranthene in water samples, along with 13 sediment-associated contaminants (including PFOS and several PESTs and PPCPs), which require further monitoring and investigation."

Journal

Closing Data Gaps for LCA of Pharmaceutical Production: Estimating Energy Usage by Upscaling Laboratory Data. (PubMed, ACS Sustain Chem Eng) - "The application of this method to six pharmaceuticals resulted in total energy estimates exceeding those of the existing methods by over 102% for Lidocaine, Diclofenac, Paracetamol, and Ibuprofen...We conclude that our method improves the estimation of industrial energy usage for pharmaceutical production and reduces the risk of impact underestimation. It enables LCA practitioners to conduct more reliable assessments, supporting sustainability decisions."

Journal

Degradation of organic contaminants by non-thermal plasma: Unraveling the pH-dependent mechanism based on experiment, density functional theory analysis and machine learning. (PubMed, Environ Res) - "When pH=3.1, methyl orange (MO) and ibuprofen (IBP) showed a high degradation rate, but the degradation effect was poor under alkaline conditions. Bisphenol A (BPA), sulfamethoxazole (SMX), ciprofloxacin (CIP) and tetracycline (TC) showed excellent removal efficiency at pH=10.6...Finally, by innovatively integrating interpretable machine learning with feature engineering, this study successfully identified key molecular descriptors-such as pKa and the Highest Occupied Molecular Orbital (HOMO) energy level-that substantially influence degradation efficiency under varying pH conditions. These findings provide crucial theoretical insights and practical guidance for the targeted optimization of pollutant degradation processes."

Journal

Case Report: Severe thrombocytopenia in the context of concomitant tirofiban and ibuprofen use: does ibuprofen matter? (PubMed, Front Cardiovasc Med) - "Alternative analgesics (e.g., acetaminophen/paracetamol) may be considered when pain management is required. If concurrent administration is unavoidable, intensive platelet count monitoring (e.g., every 6-12 h) is imperative during the first 24 h of therapy."

Journal • Cardiovascular • Hematological Disorders • Pain • Thrombocytopenia • Thrombosis

Effect of ibuprofen on the pharmacokinetics of intravenous flucloxacillin in healthy adults. (PubMed, Int J Antimicrob Agents) - "Orally administered ibuprofen had no measurable effect on plasma flucloxacillin PK in healthy adults. Given the lack of drug-drug interaction, there is no benefit to prescribe ibuprofen alongside flucloxacillin to increase flucloxacillin exposure."

Journal • PK/PD data • Infectious Disease • Pain

Charting the Undiscovered Metabolome with Synthetic Multiplexing. (PubMed, bioRxiv) - "Through improvements in the construction of the computational infrastructure that enables pan repository-scale MS/MS comparisons, searching this biologically inspired MS/MS library increased the overall reference-based match rate by 17.4%, yielding over 60 million new matches and raising the global pan-repository MS/MS annotation rate to 8.1%. By facilitating structural hypotheses for previously uncharacterized MS/MS data, this framework expands the accessible detectable biochemical landscape across human, animal, plant, and microbial systems, revealing previously undescribed metabolites such as ibuprofen-carnitine and 5-ASA-phenylpropionic acid conjugates arising from drug-host and host-microbiome co-metabolism."

Journal

Protonated epichlorohydrin-crosslinked chitosan beads for ibuprofen removal from water: Insights into adsorption mechanisms, isotherms, kinetics, and reusability. (PubMed, J Contam Hydrol) - "Leaching tests revealed no detectable release of potentially toxic epichlorohydrin into the water. These findings suggest that PECBs are effective adsorbents for removing anionic contaminants, such as IBP, from aqueous environments."

Journal

2025 guideline update to acute treatment of migraine for adults in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies. (PubMed, Headache) - "Prochlorperazine IV and GONB must be offered to eligible adults presenting to the ED with a migraine attack for treatment of headache requiring parenteral therapy (level A - must offer) in those without contraindications, while hydromorphone IV must not be offered (level A - must not offer). Treatments that should be offered when appropriate (level B - should offer) include dexketoprofen IV, ketorolac IV, metoclopramide IV, sumatriptan SC, and SONB. Chlorpromazine IV, dexamethasone IV, and valproate IV may be offered (level C - may offer). Paracetamol IV may not be offered (level C - should not offer). Eptinezumab should be offered (level B) only for patients matching the clinical trial population but is rated level U - no recommendation for an ED-specific population. Additional evidence is needed for caffeine, granisetron, ibuprofen, ketamine, lidocaine, normal saline, propofol, and SPG blocks, all currently rated level U - no recommendation."

Journal • CNS Disorders • Migraine • Pain

Case report: Retinal involvement in recurrent painful ophthalmoplegic neuropathy with reversible color vision impairment (EHF-EHC 2025) - "Acute treatments (rizatriptan, ibuprofen, loxoprofen, rimegepant) failed; only indomethacin provided relief. Interictal IV nitroglycerin failed to induce migraine-like headache...By inhibiting cyclooxygenase (COX), indomethacin suppresses prostaglandin synthesis, reducing prostaglandin-mediated sensitization of trigeminovascular afferents, suggesting trigeminovascular afferent sensitization in RPON. Furthermore, RPON pathophysiology may involve retinal neuronal networks beyond the oculomotor nerve, supported by PERG amplitude changes implicating inner retinal layer pathology, indicating pathogenesis distinct from classical cranial neuropathies."

Case report • Clinical • CNS Disorders • Migraine • Neuralgia • Ophthalmology • Pain