ibuprofen / Generic mfg. - LARVOL DELTA

Evaluating adverse events reported for non-steroidal anti-inflammatory drugs in osteoarthritis: a real-world pharmacovigilance study. (PubMed, Inflammopharmacology) - "This study complementing evidence from clinical trials and epidemiological research, by detecting potential adverse reaction signals not fully captured or reflected in approved product information, thus providing a pharmacovigilance perspective grounded in real-world data."

Adverse events • Journal • Real-world evidence • Cardiovascular • CNS Disorders • Depression • Dermatology • Dyspepsia • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammation • Ischemic stroke • Musculoskeletal Diseases • Musculoskeletal Pain • Osteoarthritis • Pain • Peptic Ulcer • Psychiatry • Respiratory Diseases • Rheumatology • Vascular Neurology

TRANSIENT ACUTE MYOCARDIAL INJURY DURING G-CSF MOBILIZATION IN HEALTHY PERIPHERAL STEM CELL DONORS: A CASE SERIES (EBMT 2026) - " We retrospectively collected data of 3 healthy donors (2 related and 1 unrelated) who developed acute myocardial injury during PBSC mobilization with biosimilar filgrastim (10 μg/kg/day for 5 consecutive days), observed at our Department between January 2024 and December 2025...In the 21-year-old female donor TTE showed preserved biventricular function and mild pericardial effusion that was treated with a short ibuprofen therapy... This is among the first reports of transient myocardial injury in healthy PBSC donors after receiving G‑CSF, suggesting a possible association. Cardiovascular adverse events should be considered in the differential diagnosis of donors reporting chest pain during HSCs mobilization, leading to prompt cardiological evaluation. Careful clinical monitoring and multidisciplinary management are crucial."

Clinical • Cardiovascular • Hypertension • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Myocardial Infarction • Obesity • Vasculitis

Efficacy of Herbaceous Apiaceae Plants in Primary Dysmenorrhea: A Systematic Review and Meta-analysis of RCTs. (PubMed, Ann Pharm Fr) - "Apiaceae plants are potentially effective adjunct therapies for dysmenorrhea, though further high-quality trials are warranted to confirm these findings. PROSPERO Registration number: CRD42024538888."

Journal • Retrospective data • Review • Women's Health

MOTION: Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries (clinicaltrials.gov) - P4 | N=60 | Enrolling by invitation | Sponsor: State University of New York at Buffalo

New P4 trial • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Protein engineering of a genetically encoded biosensor for wastewater detection of profen NSAIDs. (PubMed, bioRxiv) - "The resulting sensor, PYR NSAID , has a nanomolar limit of detection for ketoprofen and panoprofen, and µM sensitivity to the NSAIDs ibuprofen, fenoprofen, tolmetin and diclofenac. We also demonstrated dose responsive-activity of our sensor in simulated wastewater matrices containing the common wastewater contaminants sulfamethoxazole, caffeine, acetaminophen, and 2,4, dichlorophenol using a split Nanoluc luminescence assay. PYR NSAID is the first step towards a scalable, cost-effective alternative for real-time monitoring of pharmaceutical pollution."

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Unveiling the Uncommon: A Rare IgE-Mediated Presentation of Multiple Drug Hypersensitivity Syndrome. (PubMed, Cureus) - "Although it is commonly associated with delayed reactions, we report a rare case of immediate IgE-mediated MDHS in a 30-year-old female who reacted to levofloxacin and ibuprofen. Both reactions were confirmed through drug challenges, while acetylsalicylic acid was tolerated, excluding COX-1 cross-reactivity. This case highlights the importance of recognizing IgE-mediated MDHS and performing thorough allergy diagnostic workups to ensure accurate management and patient safety."

Journal • Allergy • Immunology

Patient-Reported Symptom Relief and Use of Analgesics After Open Release of Trigger Finger: A Prospective, Multicenter Cohort Study With 6 Months Follow-Up. (PubMed, J Hand Surg Am) - "Open release is an effective treatment for trigger finger with limited need for nonprescription drugs, since almost all patients reported full resolution of triggering within 6 weeks, and analgesic use was minimal. However, 23% of the patients reported persisting pain and 33% residual stiffness at 6 weeks, indicating that the recovery process is longer than expected."

Journal • Inflammation • Pain

A Ru(ii)-arene complex with promising anti-Aβ activity. (PubMed, RSC Adv) - "Lastly, RuPA also demonstrated exceptional biocompatibility towards two neuronal cell lines and displayed a lower affinity to human serum albumin in comparison to ibuprofen. Taken together, the primary amine groups on the phen ligand enhanced the anti-Aβ ability of the complex, which is an important structure-activity relationship."

Journal • Alzheimer's Disease • CNS Disorders

Acute Exacerbation of Chronic Periapical Pathology in a Dentist: An Autobiographical Case Report. (PubMed, Cureus) - "Self-medication began with paracetamol, escalating to ibuprofen, aceclofenac, and etoricoxib, when pain worsened. Amoxicillin and metronidazole were also taken for infection control...Timely endodontic intervention remains the cornerstone of treatment for acute periapical abscesses. Analgesic prescribing should be individualized and symptom-based rather than fixed-duration, with rotation considered selectively."

Journal • Anesthesia • Infectious Disease • Mood Disorders • Pain

Single-Cell Transcriptomics Reveals Biomarkers for NK Cell Dysfunction in Endometriosis-Associated Immune Dysregulation. (PubMed, Mediators Inflamm) - "In silico analyses also nominated candidate agents targeting this pathway, including resveratrol, ibuprofen, and danazol. Notably, ENTPD1 appears to have dual functions, including immunomodulation and promotion of stromal cell migration, which promotes lesion formation. These findings provide a mechanistic rationale and actionable targets for earlier screening and targeted therapy in EM."

Biomarker • Journal • Endometriosis • Gynecology • Immunology • Women's Health • CD8 • ENTPD1 • PRF1

A Widespread Pruritic Blistering Eruption in a Young Female. (PubMed, Int J Dermatol) - "Serology identified high-titre antibodies directed against the NC16A domain of BP180 by enzyme-linked immunosorbent assay (ELISA), and histopathological examination demonstrated a subepidermal blister with an eosinophil-rich infiltrate, together with linear IgG and C3 deposition along the basement membrane zone on direct immunofluorescence. This case illustrates an uncommon autoimmune blistering disorder presenting in a young adult, potentially triggered by viral infection and ibuprofen exposure, achieving sustained remission with rituximab."

Journal • Eosinophilia • Immunology • Infectious Disease

Addressing the Challenge of Wastewater Upcycling Through Cavitation-Plasma Synergy: From Pilot to Semi-Industrial Scale. (PubMed, ChemSusChem) - "The effective exploitation of HC/ED plasma synergy led to the process achieving the quantitative degradation of model pollutants, specifically ibuprofen and diclofenac (10 mg/L), in competitive times (13 passes) and without detectable byproducts, thereby validating the process' robustness and successful scale-up. Although current wastewater treatment plants (WWTPs) recover nutrients from sludge, biologically treated effluents still contain pharmaceutical residues. This work therefore, potentially solves this issue by providing a sustainable strategy for complete wastewater upcycling in WWTPs, delivering safe regenerated water for agricultural and irrigation reuse, while closing the water cycle."

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Thermo-Regenerable Anion-Exchange Composites for the Removal of Diclofenac and Ibuprofen. (PubMed, ACS Appl Mater Interfaces) - "At the optimal p(AA-co-AM) loading (26-37 wt%), diclofenac desorption reached 92.2% and ibuprofen desorption reached 96.0% at 50 °C, representing 1.7- and 1.8-fold that of 25 °C, respectively. By circumventing chemical-intensive regeneration protocols, this work highlights an innovative strategy for stimuli-responsive adsorbent design with excellent regeneration capabilities."

Journal

TREATMENT METHODS AND ATTITUDES TOWARDS PRIMARY DYSMENORRHEA AMONG CROATIAN STUDENTS: A CROSS-SECTIONAL STUDY. (PubMed, Acta Clin Croat) - "The most common drug used to treat painful menstruation was ibuprofen (84.7%)...Our study found that Croatian students were more likely to self-medicate than to seek advice from a health professional regarding painful menstruation. They use both pharmacological and non-pharmacological methods."

Journal • Observational data • Pain • Women's Health

A green and sustainable approach using Thuja occidentalis-mediated Fe3O4 QDs decorated on rGO NSs for enhanced photocatalytic degradation of antibiotics. (PubMed, RSC Adv) - "Under visible-light irradiation, the Fe3O4 QDs-rGO NSs demonstrated superior photocatalytic performance toward pharmaceutical contaminants, achieving degradation efficiencies of 94.5% for ciprofloxacin (CIP), 76.2% for ibuprofen (IBU), and 90.7% for tetracycline (THC) within 120 min at an optimum catalyst dose of 5 mg and neutral pH ≈ 7. The enhanced activity is attributed to the synergistic interaction between Fe3O4 QDs and rGO, which promotes efficient charge carrier separation and radical generation. These results highlight the potential of bioinspired Fe3O4 QDs-rGO NSs as an efficient, sustainable photocatalyst for wastewater remediation applications."

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Injectable chitosan-based hydrogel via in situ gelation modulates the inflammatory microenvironment and facilitates minimally invasive repair of peripheral nerve injury. (PubMed, Mater Today Bio) - "In vivo, perineural injection results in sustained ibuprofen release, accompanied by accelerated recovery of gait and nerve conduction, better preservation of gastrocnemius muscle mass and architecture, and more organized axon regeneration. These data suggest that the IBU-CS-GP hydrogel is a promising minimally invasive local therapy for non-transecting peripheral nerve injuries, as it enables near-neutral-pH in situ gelation and modulates the post-injury microenvironment."

Journal • Inflammation

NSAID Use Is Not Associated With Persisting Symptoms in Adolescent Concussion. (PubMed, Clin J Sport Med) - "In adolescents, NSAID use was associated with more severe symptoms but not PSaC. To optimize clinical guidance, future research should further evaluate the role of NSAIDs in concussion recovery."

Journal • CNS Disorders • Pediatrics • Vascular Neurology

A multicenter, randomized controlled clinical study on the efficacy and safety of right-handed ibuprofen oral suspension in treating acute respiratory infections with fever. (ChiCTR) - P4 | N=260 | Not yet recruiting | Sponsor: Affiliated hangzhou first people's hospital, zhejiang university school of medicine; Affiliated hangzhou first people's hospital, zhejiang university

New P4 trial • Infectious Disease • Respiratory Diseases

Paracetamol versus ibuprofen as required for fever or pain in the first year of life and the risk of eczema and bronchiolitis at age 1 year in New Zealand (PIPPA Tamariki): a multicentre, open-label, parallel-group, superiority, randomised controlled trial. (PubMed, Lancet Child Adolesc Health) - P4 | "There was no evidence of an important difference between paracetamol and ibuprofen in the risk of eczema or bronchiolitis at age 1 year."

Head-to-Head • Journal • Asthma • Atopic Dermatitis • Dermatology • Immunology • Pain • Pulmonary Disease • Respiratory Diseases

Seasonal and spatial dynamics of organic micropollutants in a Mediterranean river: implications for environmental risk assessment. (PubMed, Environ Geochem Health) - "Among the 27 tested pharmaceuticals, ibuprofen (4.7 µg/L), caffeine (23.6 µg/L), telmisartan (833.5 ng/L), carbamazepine (658.5 ng/L), gemfibrozil (71.0 ng/L), mefenamic acid (64.7 ng/L), and diphenhydramine (65.9 ng/L) were the most frequently detected, with some reaching notably high concentrations in the µg/L range in surface water. Sediments revealed ubiquitous contamination by ibuprofen, telmisartan, climbazole, diphenhydramine, and azithromycin...The findings from this study contribute to the state of knowledge of pollution levels of emerging contaminants in a major Mediterranean river and permit to inform and guide future mitigation and management strategies. The environmental risk assessment applied in this study enabled the translation of measured concentrations into ecologically meaningful indicators allowing the identification of priority contaminants and high-risk locations."

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Population developmental hazard of over-the-counter NSAIDs. (PubMed, Folia Med Cracov) - "Same epidemiological studies show that OTC antipyretics and painkillers may increase risk of spontaneous abortion, intrauterine growth retardation, preterm constriction of ductus arteriosus with secondary persistent pulmonary hypertension, reduced fetal renal perfusion that leads to oligohydramion, prolonged pregnancy, as well as selected congenital anomalies, including orofacial cleft, cardiovascular (i.e. ventricular septal defect, pulmonary valve stenosis) and neural tube defects (i.e., anophthalmia/microphthalmia, encephalocele, spina bifida), amniotic bands/limb body wall defects, and transverse limb deficiencies. However, other reports prove high prenatal tolerability or even beneficial effect in case of selected maternal sicknesses, especially influenza or disease with fever and thrombotic complications. The best advice for pregnant women is to avoid any xenobiotic, especially multidrug therapy, but in case OTC NSAIDs are needed they should be ingested in lowest..."

Journal • Review • Anesthesia • Cardiovascular • CNS Disorders • Genetic Disorders • Hematological Disorders • Hypertension • Infectious Disease • Influenza • Ophthalmology • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Preemptive Analgesia for Pain and Anxiety Control in Children With MIH (clinicaltrials.gov) - P=N/A | N=46 | Recruiting | Sponsor: October University for Modern Sciences and Arts

New trial • Mood Disorders • Pain • Psychiatry

Predictive models for the removal efficiency of emerging organic contaminants based on conventional water quality parameters in horizontal subsurface flow constructed wetlands. (PubMed, Sci Total Environ) - "To bridge this gap, compound specific predictive models of six PhCs (acetaminophen, diclofenac, erythromycin, ibuprofen, ketoprofen and naproxen) and two PCPs (tonalide and triclosan) are developed underpinned by the principal component, correlation and multiple linear regression analyses conducted using a dataset compiled from peer-reviewed publications. These novel models can serve as a screening tool to support assessment for making predictions for a number of EOCs. The new approach and resulting model developed in this study offer a robust framework for preliminary assessment of EOC removal under data limited situations alongside guiding research and optimizing HFCW design and operation."

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The effects of therapeutic drugs on brain development in infants with fetal growth restriction. (PubMed, J Physiol) - "We will describe the status for the antenatal use of magnesium sulphate for neuroprotection associated with preterm birth, sildenafil citrate to improve fetal growth and melatonin as a neuroprotectant in FGR, together with the postnatal administration of the neuroprotective agents ibuprofen, nanoparticles or cell therapies. Understanding drug treatment effects on the developing brain is critical, and this is particularly the case for FGR, where new therapies are needed but the implications for brain structure and function must be characterised."

Journal • Review

A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma. (PubMed, Sci Transl Med) - "Our laboratory recently identified the actin-binding protein advillin (AVIL) as being overexpressed, oncogenic, and necessary for tumorigenesis in GBM. Here, we further examined AVIL expression in GBMs and found that it was enriched across molecular subtypes and states, including GBM stem cells and temozolomide-resistant samples...In summary, we have identified an efficacious first-in-class compound targeting an oncogene in GBM. Further optimization of the molecule may offer an effective therapeutic intervention for GBM."

Journal • Preclinical • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • FOXM1 • LIN28B