ibuprofen / Generic mfg. - LARVOL DELTA

Dinuclear Platinum(II) Complexes Targeting DNA and Human Serum Albumin: Electrostatic Binding and Apoptosis-Driven Antiproliferative Activity. (PubMed, J Med Chem) - "Fluorescence quenching confirmed static binding to HSA, while ibuprofen/warfarin displacement indicated binding outside Sudlow site II...Although Pt1 and Pt2 were generally less cytotoxic than established reference drugs, particularly cisplatin, Pt2 showed reduced toxicity toward noncancerous mMSCs. In CT26 cells, Pt2 induced apoptosis, increased Bax/Bcl-2 and Bax/Bcl-xL ratios, activated caspase-3, reduced Ki-67, altered cell-cycle distribution, increased p27 and p53, and suppressed AKT/mTOR signaling. These findings support further evaluation of Pt2 as a selective anticancer candidate with a mechanistic profile linking DNA interaction, apoptosis, checkpoint regulation, and impaired survival signaling within colorectal carcinoma cells."

Journal • Breast Cancer • Colorectal Cancer • Oncology • Solid Tumor • BAX • BCL2 • BCL2L1 • CASP3

Low-Dose Mitomycin-C for Mucosal Overgrowth Treatment in Boston Type 1 Keratoprosthesis With Autologous Buccal Mucosa Overlay in a Patient With Severe Stevens-Johnson Syndrome. (PubMed, Cornea) - "Mucosal overgrowth is a frequent complication after B1KProM, particularly in eyes with Stevens-Johnson syndrome. This report provides initial evidence that the complication could be successfully treated with mucosal excision and a lower dose of MMC, to prevent recurrence, avoiding side effects, and to improve prosthesis retention, usually shorter in patients with autoimmune disease."

Journal • Immunology • Infectious Disease • Steven-Johnson Syndrome

Fe (III)-Aminopolycarboxylate Complexes Enhance Photo-Fenton-Like UV/Sodium Percarbonate Process for Pharmaceutical Degradation. (PubMed, Water Environ Res) - "This study evaluated a batch-scale ultraviolet/sodium percarbonate/Fe (III)-aminopolycarboxylate system for ibuprofen degradation under near-neutral conditions...Liquid chromatography-tandem mass spectrometry tentatively identified eight transformation products. The system also degraded structurally diverse pharmaceuticals in mineral and surface water matrices, supporting its potential for further development."

Journal

Evaluating the impact of cannabinoid extracts on chronic pain and quality of life in endometriosis patients - a pilot study. (PubMed, PLoS One) - "Pain intensity decreased markedly (p = 0.0004), accompanied by reductions in the number of pain days and analgesic use, including both NSAIDs (e.g., ibuprofen, diclofenac) and opioid analgesics (e.g., tramadol, tilidin, oxycodone) (p < 0.001). Although limited by its single-center design, lack of placebo control, and short follow-up, this study provides preliminary evidence that oral CBMPs may represent a safe and effective adjunct therapy for managing pain and related symptoms in women with endometriosis. Larger randomized controlled trials are warranted to confirm these findings and establish optimal dosing strategies."

Clinical • HEOR • Journal • Endometriosis • Fatigue • Gynecology • Mood Disorders • Musculoskeletal Pain • Pain • Psychiatry • Women's Health

KYNA-3M: Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Plovdiv Medical University | Initiation date: Sep 2019 ➔ Oct 2017

Biomarker • Trial initiation date • Inflammation • Pain • Psychiatry

Comparing paracetamol, ibuprofen and celecoxib for reducing inflammation and supporting wound healing in children with burn injuries: a pilot randomised controlled trial (ANZCTR) - P2 | N=60 | Not yet recruiting | Sponsor: Griffith University

New P2 trial • Inflammation

Systematic allergological evaluation enables NSAID allergy delabeling and identification of safe alternatives in adults. (PubMed, Allergol Immunopathol (Madr)) - "Nearly half of adults labeled as NSAID-allergic were not truly hypersensitive. These prospective Mexican data demonstrate the clinical impact of systematic evaluation in reducing overdiagnosis and improving therapeutic access."

Journal • Allergy • Cardiovascular • Dermatology • Immunology • Pain • Urticaria

Association of genetic polymorphisms with response to preoperative NSAIDs in endodontic postoperative pain: a randomized double-blind placebo-controlled clinical trial. (PubMed, Odontology) - "To evaluate the effects of single nucleotide polymorphisms in the CYP2C8, CYP2C9, and UGT2B7 genes on postoperative pain intensity and analgesic response in patients receiving preoperative ibuprofen or diclofenac before endodontic treatment...These findings provide preliminary evidence that genetic variation in CYP2C8 may influence the analgesic response to diclofenac following endodontic treatment. However, these exploratory findings require confirmation in larger, independent studies before their clinical relevance can be established."

Clinical • Journal • Pain • CYP2C9

Effect of Occlusal Reduction on Pain in Posterior Teeth with Necrosis and Apical Periodontitis: A Randomized Controlled Trial. (PubMed, Int J Clin Pediatr Dent) - "Patients were prescribed Ibuprofen 400 mg to be consumed 8 hourly, if required...Sangwan P, Saini HR, Sangwan A. Effect of Occlusal Reduction on Pain in Posterior Teeth with Necrosis and Apical Periodontitis: A Randomized Controlled Trial. Int J Clin Pediatr Dent 2026;19(8):957-962."

Journal • Dental Disorders • Pain • Periodontitis

Suspected NIUAA after indobufen in a patient with ibuprofen allergy: a case report suggesting possible cross-reactivity. (PubMed, Front Pharmacol) - "Subsequent continued use of other concomitant medications, along with antiplatelet therapy with clopidogrel and cilostazol, did not elicit any allergic reactions; this case suggests indobufen as a possible culprit allergen, and its shared COX-1 inhibitory mechanism with ibuprofen-despite their different chemical groups-raises the possibility of cross-reactive hypersensitivity between the two agents, although this inference remains to be confirmed. Although allergic reactions to indobufen are rare in clinical practice, clinicians should remain vigilant about the potential risk of cross-reactivity when prescribing indobufen to patients with a history of NSAID hypersensitivity."

Journal • Allergy • CNS Disorders • Dermatology • Immunology • Pruritus

Safety of short-term non-steroidal anti-inflammatory drug use in the postoperative setting in paediatric patients with chronic kidney disease: protocol for a randomised, placebo-controlled trial. (PubMed, BMJ Open) - P4 | "Patients aged >18 months will be randomised 1:1 to receive ketorolac/ibuprofen or placebo for ≤5 days postoperatively...Secondary outcomes are postoperative pain scores and opioid use (reported as morphine equivalents/kg/day)...Study findings will be disseminated through presentation at scientific meetings and publications in peer-reviewed journals. NCT06860711."

Clinical protocol • Journal • Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Pain • Pediatrics • Renal Disease • Urology

Novel Use of Synthetic Peptide Hydrogel to Improve Outcomes in Adult Tonsillectomy: A Pilot Study (AAO-HNSF 2026) - "They also required ibuprofen for significantly fewer days (p=0.026). In adult tonsillectomy, intraoperative application of RADA-16 significantly decreased post-operative pain and quickened recovery."

Clinical • Hematological Disorders

Novel Use of Synthetic Peptide Hydrogel to Improve Outcomes in Adult Tonsillectomy: A Pilot Study (AAO-HNSF 2026) - "They also required ibuprofen for significantly fewer days (p=0.026). In adult tonsillectomy, intraoperative application of RADA-16 significantly decreased post-operative pain and quickened recovery."

Clinical • Hematological Disorders

STRIDE-NSAID: The immediate effects of ibuprofen compared to placebo on knee pain and knee joint loading during running in runners with patellofemoral pain (ANZCTR) - P4 | N=100 | Not yet recruiting | Sponsor: La Trobe University

New P4 trial • Musculoskeletal Pain • Pain

Bilateral Bloody Pleural Effusions With Discordant Cellular Patterns: A Case of Concurrent Parapneumonic Effusion and Dressler Syndrome. (PubMed, Respirol Case Rep) - "Both effusions were bloody, an appearance possibly exacerbated by the concomitant use of a direct oral anticoagulant and aspirin. The left effusion recurred months later but significantly improved following ibuprofen treatment, supporting an immune-mediated aetiology. This case highlights that bilateral effusions can arise from different aetiologies and that pneumonia-induced inflammation may trigger a latent immune response related to prior cardiac surgery."

Journal • Pleural effusion • Cardiovascular • Cough • Infectious Disease • Inflammation • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Association between spinal manipulative therapy and cervical artery dissection in patients with neck pain or headache: a retrospective cohort study. (PubMed, Chiropr Man Therap) - "This study found no evidence of an increased risk of CeAD after chiropractor-administered cervical SMT compared with ibuprofen prescription in adults seeking care for new episodes of neck pain or headache. Despite the rarity of these events, all clinicians, including chiropractors, should maintain vigilance for CeAD symptoms. Additional multidisciplinary research is warranted to further address potential confounding and examine patient subgroups (e.g., migraine) and stroke."

Journal • Retrospective data • Cardiovascular • CNS Disorders • Migraine • Musculoskeletal Pain • Pain • Vascular Neurology

2026 Taiwan guidelines for the acute pharmacologic treatment of migraine in adults. (PubMed, J Chin Med Assoc) - "Non-specific agents include acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs: diclofenac, ibuprofen, naproxen). Injectable prochlorperazine is also strongly recommended. Ergotamine/caffeine combinations are less effective and are second-line agents, while high-dose aspirin is limited by gastrointestinal risk. Considering the potential risk of dependency, tramadol or tramadol/paracetamol combinations should be reserved until all other agents fail, and should be limited to oral forms. Other opioids, such as morphine, butorphanol, etc., lack evidence and are not recommended...Acetaminophen remains first-line for children and pregnant women. To prevent medication-overuse headache, acute treatments, including NSAIDs, acetaminophen, triptans, ergot derivatives, and combination analgesics, should not exceed two days per week, probably with the exception of rimegepant."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Migraine • Pain

Comparative effectiveness of therapeutic ultrasound and pharmacotherapy in the management of muscular temporomandibular disorders: a randomized clinical trial. (PubMed, Front Oral Health) - "Group A received ibuprofen (400 mg), paracetamol (325 mg), and chlorzoxazone (250 mg) twice daily for seven days...Both treatments were effective for muscular temporomandibular disorders; however, therapeutic ultrasound was associated with greater short-term improvements in pain intensity and maximum mouth opening than pharmacotherapy under the conditions of this study. https://ctri.nic.in/Clinicaltrials/login.php, identifier CTRI/2024/12/077788."

Clinical • HEOR • Journal • Musculoskeletal Diseases • Pain

Small Bowel Neuroendocrine Tumor Presenting as Overt Gastrointestinal Bleeding (ACG 2026) - "Case Description/ A 59-year-old man with obesity on tirzepatide, pre-diabetes, hypertension, recent left total knee arthroplasty on aspirin and ibuprofen presented to the hospital with syncope, shortness of breath and dark stools...Congested Mucosa at Terminal Ileum Figure: Figure 2. Grade 1 Well-differentiated Neuroendocrine Tumor of Small Intestine"

Cardiovascular • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Gastrointestinal Neuroendocrine Tumor • Genetic Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Neuroendocrine Tumor • Obesity • Oncology • Orthopedics • Small Intestinal Carcinoma • Solid Tumor

Paediatric Posterior Reversible Encephalopathy Syndrome (PRES) Induced by Ibuprofen Intake: A Case Report. (PubMed, J Paediatr Child Health) - No abstract available

Journal • CNS Disorders • Pediatrics

Association of Common Anti-Inflammatory Medications with Reduced Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes. (PubMed, Ophthalmology) - "Cetirizine, ibuprofen, and prednisone were associated with reduced incidence of DME and PDR in adults with T2DM, with effect sizes comparable to those of the fenofibrate positive control. These findings support prospective evaluation of anti-inflammatory medications for the prevention of vision-threatening diabetic retinopathy."

Journal • Diabetes • Diabetic Macular Edema • Diabetic Retinopathy • Metabolic Disorders • Ophthalmology • Retinal Disorders • Type 2 Diabetes Mellitus

Disseminated meningococcal infection presenting with constrictive pericarditis and bilateral septic arthritis without meningitis: A case report. (PubMed, SAGE Open Med Case Rep) - "The patient was successfully treated with intravenous ceftriaxone, colchicine, ibuprofen, pericardiocentesis, and bilateral knee washout, followed by oral ciprofloxacin. This case adds to the limited literature describing concurrent cardiac and musculoskeletal manifestations of invasive meningococcal disease without meningitis and shows the importance of early recognition, comprehensive investigation and multidisciplinary management of these uncommon presentations."

Journal • Cardiovascular • CNS Disorders • Cough • Fatigue • Immunology • Infectious Disease • Meningococcal Infections • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Pulmonary Disease • Respiratory Diseases • Rheumatology

Structure-driven photocatalytic degradation pathways of organic contaminants of emerging concern over TiO₂/CeO₂/g-C₃N₄: A molecular reactivity and life cycle perspective. (PubMed, J Hazard Mater) - "Herein, we investigate structure-reactivity-sustainability relationships in visible-light-driven photocatalytic degradation of indigo carmine (IC), tetracycline (TTC), and ibuprofen (IBU) using a recyclable TiO₂/CeO₂/g-C₃N₄ (TiCe-gCN) heterojunction photocatalyst. Beyond degradation performance, life cycle assessment (LCA) was conducted to evaluate the environmental sustainability of the TiCe-gCN system, identifying electricity consumption during catalyst synthesis as the dominant burden across all impact categories. Projected grid decarbonization could reduce global warming potential (GWP) by 54.9% by 2040, highlighting the critical role of energy infrastructure in determining the sustainability of photocatalytic water treatment."

Journal

Detection of Crystalline Ibuprofen Components in Ibuprofen-Loaded SBA-15 Mesoporous Silica Using Time-Domain NMR. (PubMed, Chem Pharm Bull (Tokyo)) - "The signal proportions of these NMR relaxation components increased with increasing ibuprofen loading and showed trends consistent with the apparent crystallinity estimated by DSC. These results suggest that TD-NMR, particularly T2 relaxation analysis, may serve as a complementary, nondestructive, and rapid method for evaluating the appearance and increase of crystalline ibuprofen components in mesoporous silica formulations and for monitoring changes in crystallinity."

Journal

Avoiding Breakthrough Pain Following Dental Implant Surgery. (PubMed, Compend Contin Educ Dent) - "Because dental implant post-surgical pain is mainly driven by inflammation, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (eg, Advil'ae, Motrin'ae IB) or naproxen sodium (Aleve'ae) are logical choices to address it. Implant surgeons must be able to identify those patients in whom a short course of NSAIDs can be used safely and employ dosing strategies that provide optimal analgesic efficacy while limiting untoward events. This article discusses current recommendations for postoperative pain management in dental implant patients, emphasizing the role of NSAIDs while addressing patient-specific safety considerations."

Journal • Review • Anesthesia • Inflammation • Pain