ibuprofen / Generic mfg. - LARVOL DELTA

REAL-WORLD RISK OF DRUG-INDUCED TUBULOINTERSTITIAL NEPHRITIS (ISN-WCN 2026) - "As shown in Figure 1a, 11 such drugs were identified: omeprazole, ibuprofen, pantoprazole, ciprofloxacin, pembrolizumab, nivolumab, vancomycin, carboplatin, pemetrexed, tacrolimus, and esomeprazole.The relationship between TIN and these suspected drugs is illustrated in the volcano plot (Figure 1a). Individuals aged over 60 years, male, or those who have taken 9 specific drugs including omeprazole are at a higher risk of developing DITIN. The findings of this study can provide important information for the early identification of drug-related acute interstitial nephritis and lay a foundation for future research on the pathogenesis of DITIN."

Clinical • Real-world • Real-world evidence • Immunology • Infectious Disease • Nephrology • Respiratory Diseases • Tuberculosis

Single-Cell Transcriptomics Reveals Biomarkers for NK Cell Dysfunction in Endometriosis-Associated Immune Dysregulation. (PubMed, Mediators Inflamm) - "This study highlights the central role of NK-cell dysfunction in EM pathogenesis and proposes GNLY, PRF1, and ENTPD1 as potential molecular diagnostic biomarkers. Notably, ENTPD1 appears to have dual functions, including immunomodulation and promotion of stromal cell migration, which promotes lesion formation. These findings provide a mechanistic rationale and actionable targets for earlier screening and targeted therapy in EM."

Biomarker • Journal • Endometriosis • Gynecology • Immunology • Women's Health • CD8 • ENTPD1 • PRF1

Early management of preterm infants in neonatal intensive care units (excluding respiratory diseases and ulcerative necrotizing enterocolitis) (PubMed, Rev Prat) - "Treatment includes medical (ibuprofen, para-cetamol), surgical, or percutaneous approaches...Diagnosis relies on blood cultures; treatment is empirical then targeted.Neurological:Common lesions include periventricular leukomalacia and intraventricular hemorrhage, with potential sequelae. Monitoring includes cranial ultrasound, EEG, MRI, and routine screening for hearing loss and retinopathy of prematurity."

Journal • Review • Candidiasis • Cardiovascular • Cholestasis • Critical care • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Infectious Disease • Orthopedics • Otorhinolaryngology • Respiratory Diseases • Retinal Disorders • Retinopathy of Prematurity • Ulcerative Colitis

Prevalence and predictors of analgesic use during early pregnancy in a Brazilian population. (PubMed, Front Pharmacol) - "Pregnant women up to 16 weeks of gestation (N = 275) were recruited in Curitiba, Brazil, and specifically asked about the use of paracetamol, dipyrone, ibuprofen, acetylsalicylic acid, and diclofenac, including common brand names and indications. Similarly, the use of pharmaceuticals other than analgesics was also positively associated with the heavy use of paracetamol (OR = 3.70; 95% CI = 1.08-12.74). Overall, the high prevalence of analgesic use during early pregnancy, particularly paracetamol and the combination of different analgesics, highlights the need for further research across different global regions and their potential implications for maternal and fetal health."

Journal • Pain

Renal Tubular Acidosis Leading to Severe Hypokalemia: An Uncommon Adverse Effect of Nonsteroidal Anti-inflammatory Drugs. (PubMed, Cureus) - "Her medical history was significant for osteoarthritis, for which her pain was controlled with ibuprofen and naproxen. This case emphasizes the importance of considering RTA in the differential diagnosis in the setting of unexplained hypokalemia and metabolic acidosis, especially in the absence of gastrointestinal losses or diuretic use. Discontinuation of NSAIDs with correction of electrolytes is crucial for recovery."

Adverse events • Journal • Fatigue • Immunology • Metabolic Disorders • Osteoarthritis • Pain • Rheumatology

Engineered MnO2/UiO-66-x Heterostructure with Tailored Interfaces for Efficient Capture of NSAIDs: Performance and Mechanistic Insights. (PubMed, Langmuir) - "Structure-activity relationships indicated that NSAIDs adsorption efficiency (naproxen ≈ ibuprofen ≈ ketoprofen > indomethacin > paracetamol) was governed by molecular structure, size, and pKa values. This study establishes a new paradigm for metal-organic-framework-based adsorbent design through precise control of metal-organic interfaces and defect engineering. With 87% capacity retention after 5 regeneration cycles, MnO2/UiO-66-x shows strong potential for practical water remediation applications."

Journal

PCB-KinD: Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement (clinicaltrials.gov) - P2 | N=76 | Not yet recruiting | Sponsor: Rush University Medical Center

New P2 trial • Pain

Ibuprofen Challenge or Desensitisation in Myo-Pericardial Disease: A Case Series (EAACI 2026) - No abstract available

Clinical • Allergy • Immunology

Novel stirring method for small-scale dissolution test: Rotating vessel method. (PubMed, ADMET DMPK) - "The dissolution and bulk-phase precipitation tests were performed for ibuprofen sodium (IBU Na) and carbamazepine (CBZ), respectively, using RV-μDISS and MSB-μDISS, as well as ORP with the conventional vessel (500 mL, for IBU Na) (CV) or the mini-vessel (50 mL, for CBZ) (MV). The precipitation profile in RV-μDISS was close to those in ORP-CV and ORP-MV. RV-μDISS would be a useful tool for the assessment of the precipitation profiles of drugs."

Journal

Quantum Insights into IR Spectral Density of Hydrogen-Bonded Cyclic Dimers: RS-Ibuprofen and RS-Ketoprofen as Model Systems. (PubMed, J Phys Chem A) - "This suggests that the synergistic effects of these mechanisms, within the framework of linear response theory, can be regarded as the primary dependable cause of the unconventional IR spectral properties observed. It is anticipated that this innovative algorithm will minimize the discrepancies between the experimental and simulated spectra and may facilitate the computation of spectra in more intricate hydrogen-bonded systems."

Journal

Mutual solubilization of rosiglitazone and ibuprofen: Investigation and mechanistic insight. (PubMed, PLoS One) - "The observed mutual solubilization is attributed to specific intermolecular interactions and enhanced solvent compatibility. These findings offer a simple, formulation-free strategy for improving the dissolution of poorly water-soluble drugs."

Journal

Responses to Ibuprofen after Neonatal Hypoxic-Ischemic Brain Injury Vary by Genetic Background. (PAS 2026) - No abstract available

CNS Disorders • Vascular Neurology

Two-year outcomes of a randomized controlled trial of nonintervention versus oral ibuprofen for patent ductus arteriosus in premature infants (PAS 2026) - No abstract available

Clinical • Cardiovascular

Racial and Ethnic Differences in Patent Ductus Arteriosus Treatment Response to Indomethacin and Ibuprofen in Very-Low-Birthweight Infants: A 12-Year Longitudinal Cohort Study (PAS 2026) - No abstract available

Cardiovascular

WHEN IMAGING THE ABDOMEN REVEALS THE HEART: MALIGNANT PERICARDIAL EFFUSION IN VULVAR CANCER (ACC 2026) - "Case: A 51-year-old woman with vulvar SCC treated with radiation and cisplatin presented with dyspnea...She was discharged on colchicine and ibuprofen with plans for pembrolizumab, paclitaxel, and carboplatin, but before initiation died from acute pulmonary embolism... This case represents the first cytology-proven malignant pericardial effusion from vulvar SCC, underscoring that even rare cancers may reach the heart."

Gynecologic Cancers • Kidney Cancer • Oncology • Pulmonary Disease • Pulmonary Embolism • Renal Cell Carcinoma • Respiratory Diseases • Solid Tumor • Squamous Cell Carcinoma • Vulvar Cancer • TP63

Personalized 3D-Printed Finger Splints Derived from CT Data Incorporating Multi-Drug Bilayer Nanofiber Delivery Systems. (PubMed, AAPS PharmSciTech) - "Ex vivo porcine skin permeation studies showed significantly enhanced drug delivery compared with pure drug controls, with cumulative permeation values of 155.52 ± 19.97 µg/cm2 for ibuprofen and 74.38 ± 2.18 µg/cm2 for hydrocortisone at 24 h. These findings demonstrate the feasibility of CT-based personalized finger splints that integrate structural support with localized multidrug delivery, highlighting a promising platform for next generation, patient-tailored fracture management."

Journal • Musculoskeletal Diseases • Orthopedics • Pain

nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential and anticancer activity. (PubMed, J Inorg Biochem) - "Furthermore, the nido-carborane conjugates with ibuprofen, flurbiprofen or fenoprofen incorporating propylene spacers 3b, 6b, and 9b, respectively, displayed the most potent activity against A549 lung cancer cells and in comparison to other tested molecules exhibited better selectivity towards malignant cells, as evidenced by selectivity index values. The main mechanism of action of these NSAID conjugates includes caspase dependent apoptosis synchronized by inhibited cell division and hyperproduction of superoxide anions, hydrogen peroxide and peroxynitrites."

Journal • Lung Cancer • Oncology • Solid Tumor

Impact of Postnatal Changes in Creatinine Levels on Plasma Gentamicin Concentrations in Neonates. (PubMed, Pharm Res) - "PMA-based dosing appears to be preferable for determining initial GM dosing on postnatal day 0, whereas Cr-based renal function parameters may be more effective for guiding maintenance dosing."

Journal • Infectious Disease

Validation of the DIOAC-GIB Model for Predicting Gastrointestinal Bleeding in Anticoagulated Patients: Comparison to the Alfalfa Models for Warfarin and DOACs (THSNA 2026) - "While they account for nonsteroidal anti-inflammatory drugs (NSAIDs) use, they do not differentiate between specific NSAIDs such as ibuprofen and ketoprofen...Predictor variables included age; comorbidities; history of prior GIB or major bleeding; renal and hepatic impairment; thrombocytopenia; alcohol use; and medication exposures, including NSAIDs, serotonin/norepinephrine reuptake inhibitors (SSRI/SNRI), systemic corticosteroids, aspirin and antiplatelet agents, and gastrointestinal protective agents... The DIOAC-GIB model demonstrated stable predictive performance and clinically meaningful risk stratification. By incorporating detailed medication-specific risk coefficients—including individual NSAIDs, SSRIs, antiplatelets, corticosteroids, and gastroprotective therapy, DIOAC-GIB provides a nuanced, medication-responsive framework for estimating GIB risk in anticoagulated patients. No part of this publication may be reproduced, distributed, or transmitted in any form..."

Clinical • Gastroenterology • Hematological Disorders • Hepatology • Thrombocytopenia

Development of injectable ibuprofen and resveratrol co-loaded mesoporous silica nanoparticle-based hydrogels for sustained delivery in osteoarthritis management. (PubMed, J Pharm Sci) - "Myeloperoxidase activity also declined markedly. Overall, M41IFRSG displayed greater therapeutic potential than S15IFRSG, effectively mitigating inflammation, oxidative stress, and joint degeneration associated with OA."

Journal • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • IL1B • MPO • TNFA

Adverse events related to drug-drug interactions in tocilizumab combination therapy: a retrospective analysis and clinical implications. (PubMed, Front Med (Lausanne)) - "The most significant DDI-related AEs identified for specific TCZ drug combinations were as follows: with DMARDs (e.g., methotrexate, hydroxychloroquine, and leflunomide), occurrence of anti-cyclic citrullinated peptide (CCP) positivity, hand deformity, and pemphigus were observed; with glucocorticoids (specifically prednisone), pemphigus, hand deformity, glossodynia, and pericarditis should be monitored; with NSAIDs (specifically diclofenac), heightened vigilance is warranted for anti-CCP positive, rheumatic fever, duodenal ulcer perforation, and Helicobacter infections. Age and sex influence DDI risks: adults (≥18 years) were more susceptible to infusion reactions with TCZ + hydroxychloroquine or TCZ + sulfasalazine, and to joint swelling with TCZ + naproxen. Male patients demonstrated a higher incidence of stomatitis with TCZ + methotrexate, and of joint swelling with TCZ + ibuprofen or TCZ + naproxen. Female patients were more susceptible to infusion-related reactions..."

Adverse events • Journal • Retrospective data • Cardiovascular • Dental Disorders • Immunology • Infectious Disease • Musculoskeletal Diseases • Peptic Ulcer • Rheumatology • Stomatitis

CARDIORENAL SAFETY OF NSAIDS IN PATIENTS WITH ARTHRITIS: A NETWORK METANALYSIS (ACC 2026) - " We included 23 studies (19 RCTs, 4 cohort) with 1245,108 patients,NSAIDs evaluated were Naproxen (n=69,209),Ibuprofen(n=535,651), Celecoxib(n=107,493),oral Diclofenac (n=335,154),Rofecoxib (n=105,102), Nabumetone (n=507),Valdecoxib (n=5,075), Meloxicam (n=27,713),Piroxicam (n=14,585),Mefenamic acid (n=13,856),Indomethacin (n=26,254),placebo (n=4192), Acetaminophen (n=287),and Amtolmetin guacil (n=30).Compared to placebo, Valdecoxib had highest odds of MACE [OR: 2.96 (95%CI:1.80-4.85)] and Rofecoxib highest odds of renal AEs [OR: 5.11 (95%CI: 2.58-10.10)].League tables showed no differences between different NSAIDs, SUCRA rankings identified Celecoxib with highest MACE and Rofecoxib with highest renal risk (Figure). Valdecoxib and Rofecoxib confer the highest cardiorenal risks. SUCRA rankings ranked Celecoxib as highest for MACE risk and Rofecoxib for renal risk, underscoring the importance of NSAID-specific safety profiles to guide arthritis treatment decisions."

Clinical • Cardiovascular • Immunology • Rheumatology

ECPELLA SUPPORT IN FULMINANT VIRAL MYOCARDITIS: A BRIDGE IN CARDIOGENIC SHOCK (ACC 2026) - "Case: A 34-year-old previously healthy male was diagnosed with viral pericarditis after coxsackievirus infection and treated with ibuprofen and colchicine...Despite inotropic support with milrinone, he progressed to advanced cardiogenic shock...He developed sustained ventricular tachycardia (VT) requiring intravenous amiodarone, lidocaine, and temporary transvenous pacing at 90 bpm for overdrive suppression. He also received pulse intravenous methylprednisolone for 3 days and intravenous immunoglobulin (IVIG)... This case underscores the rapid progression from outpatient viral myocarditis to fulminant myocarditis with cardiogenic shock requiring VA-ECMO and Impella support. EMB excluded acute inflammatory myocarditis, highlighting the role of biopsy, vigilance in follow-up, and multidisciplinary coordination to bridge young patients toward recovery or advanced heart failure therapies."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Infectious Disease • Inflammation • Pulmonary Disease • Sarcoidosis • Ventricular Tachycardia

FROM NECROTIZING LYMPHADENITIS TO ACUTE PERICARDITIS: A CASE OF TUBERCULOSIS (ACC 2026) - "He improved on ibuprofen and colchicine and remained asymptomatic on follow-up...Management emphasized NSAID and colchicine with dose adjusted for rifampin... TB pericarditis, though uncommon, requires early recognition. ECG staging, TTE surveillance, and drug adjustment are key to prevent effusive constrictive progression."

Clinical • Cardiovascular • Infectious Disease • Respiratory Diseases • Tuberculosis

ATYPICAL PERI MYOCARDITIS WITH DISCREPANT BIOMARKERS: A DIAGNOSTIC CHALLENGE (ACC 2026) - "She was treated with colchicine, prednisone, and ibuprofen, but she was still complaining of chest pain. This case highlights the importance of a meticulous and comprehensiveapproach to biomarker interpretation in similar clinical scenarios. The elevated HsTI, despite normal troponin T and CKMB and unremarkable imaging findings, suggests the possibility of false-positive HsTI results, likely due to heterophile antibodies or macro troponins."

Biomarker • Cardiovascular • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pulmonary Embolism • Respiratory Diseases