cordycepin (OVI-123) / OncoVista - LARVOL DELTA

Clinical Study on the Application of Cordycepin in Combination with Anti-PD-1 for the Treatment of Non-Small Cell Lung Cancer (ChiCTR) - P=N/A | N=9 | Completed | Sponsor: Changzhou No.2 People’s Hospital; Changzhou No.2 People’s Hospital

New trial • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Predictive Modeling of Cordycepin Content in Cordyceps militaris Using Machine Learning Based on Cultivation Conditions. (PubMed, J Basic Microbiol) - "The developed GUI enables end-users to input cultivation conditions and receive immediate predictions, facilitating data-driven decision-making. This approach offers a scalable and interpretable framework for optimizing bioactive compound production in edible fungi, with potential application in smart bioprocessing and precision fermentation."

Journal

Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents. (PubMed, Int J Endocrinol) - "Moreover, CM increased uterine weight and serum superoxide dismutase in 17β-estradiol-treated OVX rats. These findings suggested that CM, particularly its component cordycepin, holds promise as a natural agent for mitigating weight gain, particularly in the context of postmenopausal obesity."

Journal • Preclinical • Cardiovascular • Genetic Disorders • Obesity • CDKN1A • CEBPA • CEBPB • CYP17A1 • FABP4 • LMNB1 • PPARG

Design, Synthesis, and Anti-Hepatic Fibrosis Evaluation of Cordycepin Derivatives. (PubMed, Molecules) - "The Western blotting result also indicated that 3a could activate the AMPK signaling pathway. Overall, these results suggest 3a may serve as a lead compound for further investigation."

Journal • Fibrosis • Hepatology • Immunology

Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model. (PubMed, Neurotox Res) - "CMWE mitigated cigarette smoke-induced behavioral and histological hallmarks of neurodegeneration in zebrafish, likely via synergistic antioxidant and anti-inflammatory mechanisms. These findings support the potential of C. militaris as a natural product-based therapeutic candidate for neurodegenerative disorders, warranting further studies on its individual constituents and mechanisms of action."

Journal • CNS Disorders • Inflammation

Cordycepin Suppressed Ferroptosis to Ameliorate Acute Kidney Injury Through Inhibiting the DNMT1/KLF15/FTH1 Axis. (PubMed, FASEB J) - "COR suppressed ferroptosis by regulating the DNMT1/KLF15/FTH1 axis, thereby improving AKI in vivo. COR suppressed ferroptosis in AKI by depressing DNMT1/KLF15/FTH1 axis."

Journal • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease • Reperfusion Injury • DNMT1 • KLF5

Multi-omics and compositional analysis of bidirectional solid fermentation products from Cordyceps militaris and Panax quinquefolius L. (PubMed, J Ginseng Res) - "This study demonstrates that co-culture of American ginseng with C. militaris enables bidirectional biotransformation: fungal enzymes convert ginsenosides into rare ginsenosides, while ginseng nutrients upregulate cordycepin biosynthesis. It offers a novel, eco-friendly approach for targeted transformation and enrichment of active ingredients."

Journal • RB1

RoCi-a single-step multi-copy integration system based on rolling-circle replication. (PubMed, Nucleic Acids Res) - "Using RoCi for cell factory construction resulted in a ∼10-fold increase in production of the specialized metabolite cordycepin and the enzyme β-glucuronidase compared to single-copy strains. Finally, we show that RoCi can also be applied in other fungi like the industrial workhorses A. niger and A. oryzae."

Journal

Cordycepin in cancer therapy: A bibliometric analysis and review of mechanisms. (PubMed, J Food Drug Anal) - "Future research should prioritize pharmacokinetic characterization, investigation of combinatorial therapeutic strategies, and pathways toward clinical translation. Intracellular exposure appears to be shaped by two complementary axes: interference with 3'end polyadenylation and ENT1/ENT2-mediated uptake with ADA-catalyzed deamination."

Journal • Review • Oncology • CDKN1A • SLC29A1

Combination treatment of cordycepin and radiation induces apoptosis accompanied by protective autophagy in TM3 mouse Leydig progenitor cells. (PubMed, J Food Drug Anal) - "Although apoptosis is eventually induced in TM3 cells, protective autophagy is also activated to mitigate the cytotoxic impact of the combination treatment. This finding may provide a reference for the development of safe therapeutic regimen for Leydig cell tumors."

Journal • Preclinical • Oncology • ATG12 • ATG5 • BECN1

Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota. (PubMed, Biomed Pharmacother) - "Cordycepin exerts multi-target therapeutic effects in PH by inhibiting PASMC proliferation via the p53-CDK1/pTERT axis, modulating gut microbiota-linked immunometabolism and induces proinflammatory macrophage senescence. These findings support cordycepin as a promising candidate for PH therapies targeting the vascular, immune, and gut-lung axes."

Journal • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • CDK1 • CDKN2A • TERT

Evaluation of the Effect of Cordycepin on CD8+ Lymphocytopenia in Patients With Solid Tumors (clinicaltrials.gov) - P2 | N=127 | Recruiting | Sponsor: Second Affiliated Hospital of Soochow University | Not yet recruiting ➔ Recruiting

Enrollment open • Oncology • Solid Tumor • CD8

Cordycepin suppresses the progression of multiple myeloma by inducing ferroptosis through upregulating CLEC2. (PubMed, Cytotechnology) - "Collectively, COR inhibited MM progression by inducing ferroptosis through upregulating CLEC2. The online version contains supplementary material available at 10.1007/s10616-025-00886-5."

Journal • Hematological Disorders • Hematological Malignancies • Multiple Myeloma • Oncology • ACSL4 • GPX4 • HIF1A • SLC7A11

Cordycepin alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial oxidative stress and apoptosis through modulation of the PI3K/Akt/mTOR pathway. (PubMed, Cell Signal) - "COR mitigates inflammation, oxidative stress, and cardiomyocyte apoptosis in SICM via modulation of the PI3K/Akt/mTOR pathway, thereby attenuating myocardial injury and improving cardiac function. Collectively, these findings indicate that COR may serve as a potential novel therapeutic agent for the management of SICM."

IO biomarker • Journal • Cardiomyopathy • Cardiovascular • Infectious Disease • Inflammation • Septic Shock • BAX • BCL2 • CASP3 • CASP9

Pheromone-mediated quorum sensing enables dynamic regulation of cordycepin biosynthesis in Cordyceps militaris. (PubMed, Bioresour Technol) - "Through 2A-peptide-mediated multigene co-expression and precursor supply engineering (co-expression of cns1 and nt5e), the cordycepin yield was further elevated to 447.9 mg/L, marking a 445.3 % improvement. This work provides a novel dynamic regulation strategy for efficient cordycepin biosynthesis in C. militaris and lays the groundwork for the development of synthetic biology tools in medicinal fungi."

Journal • CD73 • NT5E

An Immunomodulatory Mushroom, Cordyceps militaris, and Its Constituents: A Review of In Vitro/In Vivo Studies and Clinical Trials. (PubMed, Phytother Res) - "They enhance innate and cell-mediated adaptive immunity not only under normal conditions but also in immunosuppressed states induced by cyclophosphamide, interleukin-4, tumor culture supernatant, methotrexate, cancer cell-line-xenografts, influenza virus, and severe acute respiratory syndrome coronavirus 2. This study reviewed recent and notable literature evaluating the immunomodulatory potentials of CM extract, cordycepin, and polysaccharides. In vitro, in vivo, and clinical trial results indicate that CM is safe for administration and shows promise for developing functional foods having various efficacies such as immunomodulation, anti-tumor, and neuroprotection."

Journal • Preclinical • Review • Genetic Disorders • Immunology • Infectious Disease • Influenza • Novel Coronavirus Disease • Obesity • Oncology • Respiratory Diseases • Solid Tumor • IL4

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient-Gene-Disease Interaction. (PubMed, Immun Inflamm Dis) - "CS alleviates COPD symptoms by suppressing inflammation, apoptosis, and oxidative stress, suggesting novel therapeutic strategies."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Oncology • Pulmonary Disease • Respiratory Diseases • HMOX1 • MMP1 • PTGDR • PTGDR2

Comparative chemical profiles of fruiting bodies and mycelia of Cordyceps cicadae and Ophiocordyceps sobolifera, and Immunometabolic modulation by liquid-fermented mycelia. (PubMed, Fitoterapia) - "Cordycepin was detected only in artificially cultivated C. cicadae...Meanwhile, O. sobolifera may be explored for GLP-1-related benefits. Overall, this study provides a molecular and functional basis to differentiate the two species and highlights their distinct potential in health applications."

Journal • IL33

The Velvet protein vea: a key positive regulator of growth and cordycepin biosynthesis in Cordyceps militaris. (PubMed, Microb Cell Fact) - No abstract available

Journal

Multi-pathway therapeutics in colorectal cancer: Targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal. (PubMed, J Drug Target) - "Natural compounds (neferine, ajoene, baicalein, isoliensinine, curcumin analogs) and synthetic drugs (5-FU, oxaliplatin, irinotecan, norcantharidin, cordycepin) modulate EMT and trigger ferroptosis, cuproptosis, paraptosis, and autophagy...Simultaneous targeting of EMT, CR-CSC maintenance, and chemoresistance using multifunctional natural and synthetic agents represents a promising strategy in CRC therapy. Induction of alternative cell death pathways may improve response, minimize relapse, and enable combinatorial regimens for resistant tumors."

Journal • Review • Colorectal Cancer • Oncology • Solid Tumor • CDH17 • CTNNB1 • ERCC1 • FOS • GPX4 • HUWE1 • JAK2 • NANOG • POU5F1 • SOX2 • TGFB1

Integrated multi-omics and machine learning elucidate the pathogenic role of mitophagy in osteoarthritis and identify novel therapeutic strategies. (PubMed, Int Immunopharmacol) - "Our findings establish mitophagy impairment as a critical factor in OA pathogenesis and present cordycepin as a promising therapeutic option that targets mitochondrial quality control. This study lays the groundwork for future precision therapies aimed at degenerative joint disorders."

Journal • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • ATG12 • MAP1LC3B

Noncovalent and precise loading of small molecule drugs on DNA nanocarriers. (PubMed, Nanoscale Horiz) - "As a proof of principle, we successfully loaded cordycepin into aptamer-functionalized DNA nanoparticles and achieved a significant therapeutic effect in melanoma-bearing mice. This approach expands the range of small molecule drugs that can be loaded onto DNA nanostructures, particularly benefiting the synergistic therapy that combines small molecule drugs with nucleic acid drugs."

Journal • Melanoma • Oncology • Solid Tumor

Study on the potential mechanism of Cordyceps militaris in chronic obstructive pulmonary disease via integrating metabolomics and network pharmacology. (PubMed, J Pharm Pharmacol) - "This study suggested that CM could ameliorate COPD by modulating linoleic acid metabolism and influencing IDH1 and CYP19A1, which would provide a scientific basis for the treatment of COPD with CM."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases • CYP19A1 • IDH1

Associations of hypoglycemic medications, cordycepin and vaccination with clinical outcomes in diabetic kidney disease patients with COVID-19. (PubMed, Ren Fail) - "Among 642 DKD patients with COVID-19, 66.8% were treated with sodium-glucose cotransporter-2 inhibitors (SGLT2i) at baseline, 36.9% with dipeptidyl peptidase-4 inhibitors (DPP4i), 30.8% with metformin, and 36.4% with cordycepin. Compared with unvaccinated patients, multiple-dose COVID-19 vaccination was associated with reduced risks of adverse outcomes, including prolonged COVID-19 symptoms, pneumonia, decreased eGFR, and elevated blood glucose and HbA1c levels. In conclusion, pretreatment with SGLT2i, cordycepin, and multiple-dose COVID-19 vaccination was associated with reduced adverse outcomes among DKD patients with COVID-19."

Clinical data • Journal • Retrospective data • Diabetic Nephropathy • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pneumonia • Renal Disease • Respiratory Diseases

Cordycepin Mitigates Sepsis-Associated Encephalopathy by Promoting Microglial M2 Polarization via the IL-17a/IL-17RA/NF-κB Axis. (PubMed, Mol Neurobiol) - "Furthermore, it promoted polarization of microglia toward the anti-inflammatory M2 phenotype. Collectively, these findings suggest that cordycepin alleviates SAE by modulating the gut-immune-brain axis, suppressing IL-17a/IL-17RA/NF-κB signaling, and enhancing microglial M2 polarization, thereby offering a promising therapeutic strategy for sepsis-related cognitive impairment."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Infectious Disease • Inflammation • Septic Shock • IL17A • IL17RA