MP-157 / Tanabe Pharma - LARVOL DELTA

Photochemical probe identification of a small-molecule inhibitor binding site in Hedgehog acyltransferase (HHAT). (PubMed, Angew Chem Int Ed Engl) - "Topology and homology data suggested a potential mechanism for HHAT inhibition which was confirmed via kinetic analysis. Our results provide an optimal HHAT tool inhibitor IMP-1575 ( K i  = 38 nM) and a strategy for mapping small molecule interaction sites in MBOATs."

Journal • Genetic Disorders • Obesity • Oncology

Molecular Characterization of an IncFII Plasmid Co-harboring bla and tet(A) Variant in a Clinical Klebsiella pneumoniae Isolate. (PubMed, Front Microbiol) - "The plasmid pIMP1572 was apparently originated from a tet(A)-carrying IncFII plasmid but with a deletion length of 6,216-bp and a multiple drug resistance region (MDRR) insertion of 25,259 bp. The plasmid pIMP1572 in the present study represents the first report of the IncFII plasmid co-carrying bla and tet(A) variant, which should be monitored."

Clinical • Journal • Infectious Disease • Pneumonia • Respiratory Diseases

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