staccato prochlorperazine (AZ -001) / Ferrer International - LARVOL DELTA

Inhaled Drug Therapy Development for the Treatment of Migraine. (PubMed) - Expert Opin Pharmacother - "Inhaled DHE offers rapid absorption with a pharmacokinetic profile similar to IV administration. Improved side effect profile results from more selective binding at anti-migraine serotonergic receptors 5-HT1B and 5-HT1D. Inhaled prochlorperazine is rapidly absorbed and resulted in statistically significant migraine pain relief at 2 hours compared to placebo but is not currently being pursued by the manufacturer as a potential migraine abortive. Inhaled loxapine is also rapidly absorbed into systemic circulation but Phase IIb trials did not show statistically improved pain relief or pain freedom compared to placebo. Inhaled therapy clearly offers rapid systemic absorption but this route of delivery may not be appropriate for every drug. MAP0004 will likely provide a good alternative to patients seeking rapid relief without the need for injection or other invasive routes."

Journal • Biosimilar • Migraine • Pain

Semi-Mechanistic Modeling Platform to Assess Cardiac Contractility and Hemodynamics in Preclinical Cardiovascular Safety Profiling of New Molecular Entities. (PubMed, Br J Pharmacol) - "The contractility and hemodynamics semi-mechanistic modeling platform accounts for diurnal variation, drug induced changes and inter-animal variation. The model can be used to hypothesize and evaluate pharmacological effects and to provide a holistic cardiovascular safety profile for new molecular entities."

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