allopurinol / Generic mfg. - LARVOL DELTA

POTENTIAL NEPHROPROTECTION WITH NOVEL URAT1 INHIBITOR DOTINURAD: A SYSTEMATIC REVIEW OF KIDNEY FUNCTION CHANGES (ISN-WCN 2026) - "Unlike traditional agents such as allopurinol or febuxostat, preliminary clinical observations suggest dotinurad may offer unique renoprotective properties beyond urate reduction. Dedicated randomized controlled trials with eGFR as the primary endpoint are urgently needed, particularly with CKD stage-stratified analyses, long-term outcomes (>1 year), and establishment of optimal patient selection criteria. This review provides crucial preliminary evidence to inform such trial designs."

Review • Chronic Kidney Disease • Inflammation • Renal Disease

TUMOUR LYSIS SYNDROME IN ACUTE LEUKEMIA: THE ROLE OF EARLY RENAL REPLACEMENT THERAPY (ISN-WCN 2026) - "She received IV dexamethasone 4 mg and IV rasburicase 3 mg while on oxygenation support for respiratory distress...She was also started on allopurinol 300 mg daily along with aggressive hydration.Results Despite optimal medical therapy, her potassium level rose to 7.1 mmol/L with persistent TLS features...CVVHDF provides effective and stable correction of refractory electrolyte disturbances while maintaining hemodynamic stability. Multidisciplinary collaboration among oncology, nephrology, and critical care teams is essential to achieve optimal patient outcomes."

Acute Kidney Injury • Acute Lymphocytic Leukemia • CNS Disorders • Endocrine Disorders • Epilepsy • Hematological Malignancies • Hepatology • Infectious Disease • Leukemia • Lymphoma • Metabolic Disorders • Nephrology • Oncology • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases • T Acute Lymphoblastic Leukemia

A RANDOMIZED CONTROLLED TRIAL OF ALLOPURINOL FOR CARDIOVASCULAR DISEASE IN CHRONIC KIDNEY DISEASE: BASELINE CHARACTERISTICS OF THE STUDY POPULATION (ISN-WCN 2026) - "Histories of hypertension, diabetes, renal stone disease, coronary artery disease and smoking were present in 82%, 27%, 18%, 7% and 18% of patients, respectively (Table 1). Baseline mean serum creatinine, eGFR and uric acid were 3 ± 1 mg/dl, 26 ± 9 and 8 ± 1 mg/dl (Table 2).Conclusion This multi-centre trial represents the largest study evaluating allopurinol's effect on cardiovascular outcomes in CKD patients with hyperuricemia."

Clinical • Cardiovascular • Chronic Kidney Disease • Coronary Artery Disease • Diabetes • Diabetic Nephropathy • Gout • Hepatology • Hypertension • Immunology • Inflammatory Arthritis • Metabolic Disorders • Nephrology • Renal Calculi • Renal Disease

Population Pharmacokinetic Models of Oxypurinol in Adults: A Systematic Review. (PubMed, Curr Drug Metab) - "Further research involving larger, more diverse cohorts is needed to refine therapeutic drug monitoring and identify potential covariates across different populations to optimize allopurinol therapy."

Journal • PK/PD data • Gout • Inflammatory Arthritis • Rheumatology

Leishmania infantum in red foxes (Vulpes vulpes): from clinical findings to cytokine expression. (PubMed, Parasit Vectors) - "The present study confirmed a high L. infantum prevalence of infection in red foxes from southern Italy. Serological findings herein and in the literature, together with in vitro cytokine gene expression, suggested that most foxes may remain subclinically infected. The high molecular positivity and the synanthropic nature of red foxes reinforce their role as reservoirs of L. infantum in endemic areas."

Journal • Hematological Disorders • Infectious Disease • IFNG • IL10 • IL12A • IL4 • IL6 • TNFA

The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome. (PubMed, Cureus) - "The findings indicate that allopurinol-induced DRESS most often presents with cutaneous manifestations and systemic involvement, most commonly affecting the liver and kidneys, and is associated with considerable morbidity and mortality despite treatment. These results emphasize the importance of early recognition, prompt drug discontinuation, and cautious prescribing of allopurinol, particularly in high-risk populations."

Journal • Review • Eosinophilia • Immunology • Steven-Johnson Syndrome

Prevention of Recurrent Nephrolithiasis in Adults and Children : A Systematic Review. (PubMed, Ann Intern Med) - "For adults with calcium oxalate or phosphate stones, increased water intake; a diet with normal to high calcium, low protein, and low sodium; thiazides; alkali treatment; and allopurinol may reduce stone recurrence (low SOE)...75Q80120D00007/75Q80124F32010). (PROSPERO: CRD42024617257)."

Journal • Review • Infectious Disease • Nephrology • Renal Calculi • Septic Shock

Economic Evaluation of Pre-emptive Pharmacogenetic Panel Testing versus No Genetic Testing in a Multi-ethnic Asian Population. (PubMed, Pharmacoeconomics) - "Pre-emptive PGx panel testing is economically viable when panel design, variant prevalence, drug costs, and local prescribing patterns are carefully considered. As more data become available, the model can be tailored to evaluate additional drug-gene pairs and their downstream consequences."

Biomarker • HEOR • Journal • CYP2C19 • DPYD • HLA-B

A treat-to-target strategy versus symptom-driven management of gout in the Netherlands (GO TEST Overture): a multicentre, open-label, pragmatic, superiority, randomised controlled trial. (PubMed, Lancet Rheumatol) - P4 | "A treat-to-target strategy was associated with improved long-term disease control compared with symptom-driven care, without evidence of increased adverse events. These findings provide support for the use of systematic serum urate-guided urate-lowering therapy titration in the routine management of gout."

Head-to-Head • Journal • Gout • Inflammatory Arthritis • Pain • Rheumatology

Association between HLA alleles and adverse drug reactions. Mechanisms involved. (PubMed, Adv Lab Med) - "A division by groups of drugs is established (antiretrovirals, aromatic antiepileptics, allopurinol, antibiotics and other drugs), indicating for each of them the HLA involved, the proposed mechanism, ethnicity in which the association was described and the degree of association. A table is included to facilitate consultation of key information. HLA alleles play a critical role in the pathogenesis of numerous ADRs, and further studies are needed to clarify HLA-ADRs associations and the mechanisms involved."

Adverse drug reaction • Journal • Review • Immunology

Single-cell-based identification of drug synergy with immunotherapy via tumor microenvironment remodeling. (PubMed, J Immunother Cancer) - "This work provides a robust framework for assessing TME remodeling that uncovers genes and compounds that significantly modulate immunotherapeutic efficacy."

Biomarker • Journal • Gout • Inflammatory Arthritis • Oncology • Rheumatology

Iatrogenic Triggers of Granuloma Annulare Reflect Disease Pathophysiology (AAD 2026) - "Immune checkpoint inhibitors accounted for 12 patients, predominantly PD-1 blockade (pembrolizumab n=7, nivolumab n=3). Cytokine-targeted biologics included TNF-α inhibitors (n=14, most often adalimumab), IL-17A inhibitors (n=6, most often secukinumab), IL-6 inhibition (n=3), and dupilumab (n=2). Additional triggers included BRAF inhibitors, topiramate, allopurinol, and other agents...The strong representation of Th1-skewing therapies highlights GA as a Th1-predominant dermatosis, while additional cases suggest contributions from other immune pathways. Thus, iatrogenic cases highlight clinically important drug- and vaccine-related associations while providing insight into the immune pathways driving GA."

Immune Modulation • Immunology • Infectious Disease • Novel Coronavirus Disease • Rare Diseases • Respiratory Diseases • IL17A

Challenges in culprit drug identification in DRESS syndrome (AAD 2026) - "Antibiotics accounted for the majority of DRESS cases (63.2%), followed by anticonvulsants (19.9%), with anticancer therapies and allopurinol each responsible for 7.0%... Culprit medication cessation is necessary in the treatment of DRESS; however, in nearly half of DRESS cases, a single causative medication could not be identified, unaided by pre-existing reported medications allergies. Dermatologists would benefit from updated diagnostic tools to aid in the identification of most common and likely DRESS triggers."

Eosinophilia • Immunology

Reported Patterns and Outcomes of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Associated with Novel Antineoplastic Therapies: A Retrospective Pharmacovigilance Analysis (AAD 2026) - "Introduction: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, life-threatening drug reaction traditionally linked to anticonvulsants and allopurinol...Positive signals for DRESS were observed with several drugs, including imatinib, vemurafenib, thalidomide, brentuximab vedotin, and temozolomide. In contrast, drugs like nivolumab, rituximab, and denosumab showed negative signals... Our findings describe an emerging association of DRESS syndrome with novel antineoplastic therapies. The varied risk of DRESS across agents within the same class suggests that it is not necessarily a class-wide hypersensitivity. This highlights the need for increased clinician awareness to aid early recognition and prompt drug withdrawal to improve patient outcomes."

Adverse events • Retrospective data • Eosinophilia • Immunology

Outbreak of Stevens-Johnson syndrome/Toxic epidermal necrolysis in Singapore secondary to illicit, off-label use of Armodafanil: A report of 5 cases (AAD 2026) - "Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are rare severe cutaneous adverse reactions that are traditionally caused by a few high notoriety drugs such allopurinol...In 2 patients who denied prior drug intake, toxicology analysis revealed urinary presence of Armodafinil & Modafinil...Ciclosporine (n=4) and Etanercept (n=1) was administered along with supportive care...Our reported 5 cases is likely a harbinger: Their popularity as a lifestyle biohack, property as a “less potent” drug of abuse, as well as their availability from unlicensed sources and online will likely fuel the increase. Lastly, toxicology studies are useful in elucidating causality in cases of SJS/TEN which may be otherwise classified as “idiopathic”."

Clinical • Narcolepsy • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • Steven-Johnson Syndrome

Application of risk priority number of failure mode and effects analysis to drug-variant pairs for severe cutaneous adverse reactions in Korean and American populations. (PubMed, Pharmacogenet Genomics) - "Drug-variant pairs with high RPN scores can be prioritized in clinical strategies to prevent SCARs in Korean and American populations. Incorporating these findings into clinical practices could ultimately contribute to the safe use of drugs."

Journal • Allergy • Immunology • HLA-B

Allopurinol and Febuxostat Hypersensitivity in a Patient with Young Onset Gout: A Case Report. (PubMed, Acta Med Philipp) - "This case report describes a patient with young-onset, tophaceous gout who developed severe hypersensitivity reactions to both allopurinol and febuxostat - an unusual and challenging therapeutic dilemma. The case highlights the need for individualized management strategies, including the consideration of drug desensitization, in patients with limited urate-lowering options."

Journal • Allergy • Gout • Immunology • Inflammation • Inflammatory Arthritis • Rheumatology

Development and optimization of Fe₃O₄@SiO₂-xanthine oxidase magnetic nanoparticles for rapid screening of XOD inhibitors from Trichosanthes anguina (snake gourd) with molecular docking approach. (PubMed, Int J Biol Macromol) - "The immobilized enzyme retained over 65% of its activity after eight reuse cycles and exhibited high specificity toward active ligands as validated using allopurinol...Overall, the Fe₃O₄@SiO₂-XOD NPs platform provides an efficient and reusable strategy for screening natural XOD inhibitors. Trichosanthes anguina was confirmed as a rich source of anti-hyperuricemic flavonoids, supporting its further exploration for gout management."

Journal • Gout • Inflammatory Arthritis • Rheumatology

ABCG2 and allopurinol response: when pharmacogenetics collides with fixed-dose practice. (PubMed, Pharmacogenomics) - No abstract available

Biomarker • Journal • Gout • Inflammatory Arthritis • Rheumatology • ABCG2

Do people with tophaceous gout require more allopurinol for good clinical outcomes? Analysis of two randomized controlled trials with allopurinol dose escalation. (EULAR 2026) - No abstract available

Clinical • Clinical data • Gout • Inflammatory Arthritis • Rheumatology

Rapidly Evolving AKI after CAR-T therapy: A Case for Clinical Vigilance and Timely Renal Support (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 34-year-old male diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) with relapse was admitted for CAR-T therapy with brexucabtagene autoleucel...Four doses of tocilizumab and dexamethasone were given for neurotoxicity...Rasburicase and allopurinol were given due to concern for TLS...Clinicians must maintain high clinical vigilance with close and proactive monitoring of AKI and prompt response. Early initiation of renal replacement therapy in this clinical setting may provide both organ support and mitigate inflammation-related injury."

Clinical • Acute Kidney Injury • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • CNS Disorders • Hematological Malignancies • Hypotension • Leukemia • Nephrology • Renal Disease

Vancomycin-Induced DRESS Syndrome Presenting With Shock and Multiorgan Involvement (SCCM 2026) - "The patient improved with IV hydrocortisone, was extubated on ICU day 4, and transitioned to high-dose oral prednisone with a 12-week taper. She resumed levetiracetam at discharge after neurology review. DRESS syndrome is a severe cutaneous adverse reaction characterized by delayed onset (2–6 weeks), eosinophilia, and systemic organ involvement. While classically linked to anticonvulsants, sulfonamides, and allopurinol, vancomycin is increasingly recognized as a cause, with over 50 cases now described...Treatment includes systemic corticosteroids for severe cases and supportive care. This case reinforces the importance of recognizing delayed hypersensitivity reactions even after completion of therapy, and highlights vancomycin as a high-risk agent for DRESS."

CNS Disorders • Dermatitis • Eosinophilia • Epilepsy • Immunology • Infectious Disease • Inflammation • Septic Shock • Steven-Johnson Syndrome

Testicular Pain and Swelling as Initial Sign of Desmoplastic Small Round Cell Tumor in Adolescent (SCCM 2026) - "He had clinical and laboratory findings consistent with tumor lysis syndrome (TLS) and acute kidney injury (AKI), initially treated with hyperhydration, rasburicase and allopurinol. ACS has also been linked to DSRCT, typically occurring in patients with extensive intra-abdominal disease or rapid tumor progression. It is essential to consider malignancy as a differential diagnosis of testicular pain and ensure close follow-up for complete symptom resolution."

Acute Kidney Injury • Back Pain • Cardiovascular • Hypertension • Musculoskeletal Pain • Nephrology • Oncology • Pain • Peritoneal Cancer • Renal Disease • Sarcoma • Soft Tissue Sarcoma • Solid Tumor

The Diagnostic Blind Spot of Light's Criteria: A Misclassified Case of Gouty Pleuritis (SCCM 2026) - "The patient was initiated on colchicine and corticosteroids while diuretics were tapered, resulting in clinical improvement. He was discharged on allopurinol for long-term management. Gouty pleuritis is a rare cause of exudative pleural effusion...Persistent effusions with transudative profiles but unexplained symptoms warrant further workup including crystal analysis and potential pleural biopsy. Integrating clinical, biochemical, and procedural findings is essential to diagnose atypical and unresponsive effusions, enabling targeted therapy."

Clinical • Cardiovascular • Congestive Heart Failure • Gout • Heart Failure • Inflammatory Arthritis • Pulmonary Disease • Respiratory Diseases

An Unusual Presentation of Multiple Myeloma with Spontaneous Subarachnoid Hemorrhage from Skull Base Involvement and Thrombocytopenia: Case Report and Literature Review (THSNA 2026) - "Initial therapy with dexamethasone and allopurinol was followed by outpatient initiation of daratumumab-VRd. Clinicians should maintain a high index of suspicion for plasma cell neoplasms in patients presenting with pancytopenia, renal dysfunction, and spontaneous intracranial hemorrhage. Early diagnosis and prompt initiation of anti-myeloma therapy, even in the setting of hemorrhagic complications, can lead to favorable outcomes. This case provides insight into the intersection of hemostasis and plasma cell malignancy and is relevant for thrombosis and hemostasis-focused discussions."

Case report • Clinical • Review • Cerebral Hemorrhage • CNS Disorders • Heart Failure • Hematological Malignancies • Leukemia • Monoclonal Gammopathy • Multiple Myeloma • Nephrology • Plasma Cell Leukemia • Plasmacytoma • Renal Disease • Subarachnoid Hemorrhage • Thrombocytopenia • Thrombosis