27 / Hanmi - LARVOL DELTA

Association of the triglyceride-glucose index with cardiovascular outcomes across cardiovascular-kidney-metabolic syndrome stages. (PubMed, Korean J Intern Med) - "The TyG index independently predicted cardiovascular risk across the CKM syndrome stages. Its integration into routine clinical assessments could enhance early risk stratification and guide preventive strategies, particularly for patients in the early stages of CKM syndrome."

Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Metabolic Disorders • Myocardial Infarction • Nephrology • Renal Disease

Cardiorenal outcomes and safety of SGLT2 inhibitors in patients with diabetes secondary to disorders of the exocrine pancreas: a nationwide population-based study. (PubMed, Diabetes Metab) - "SGLT2 inhibitors were associated with a reduced risk of adverse cardiorenal outcomes and all-cause mortality and were safely used in patients with DEP."

Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hypoglycemia • Infectious Disease • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • Oncology • Pancreatic Cancer • Pancreatitis • Renal Disease • Solid Tumor

Combined impact of prediabetes and fatty liver index on cardiometabolic outcomes and mortality in middle aged adults: a nationwide cohort study. (PubMed, Cardiovasc Diabetol) - "The coexistence of prediabetes and FLI ≥ 60, which is a surrogate marker of hepatic steatosis, demonstrated a combined effect, additively increasing the risk of incident DM, composite MACE, and all-cause mortality in middle-aged adults."

Journal • Cardiovascular • Metabolic Disorders

Cancer risk in patients with systemic sclerosis: A nationwide cohort study in South Korea 2004-2021. (PubMed, Arthritis Care Res (Hoboken)) - "In this study, we revealed that the incidence of cancer is higher in patients with SSc in South Korea compared to general population. The strong association between SSc and cancer occurrence prompts clinicians to conduct careful cancer screening for SSc patients."

Journal • Fibrosis • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Laryngeal Cancer • Lymphoma • Multiple Myeloma • Myelodysplastic Syndrome • Oncology • Scleroderma • Solid Tumor • Systemic Sclerosis

Prevalence and Incidence of Ethambutol-Induced Optic Neuropathy and Its Risk Factors in Korea: A Nationwide Population-Based Study. (PubMed, J Korean Med Sci) - "The cumulative incidence of EON was 0.9%. The prevalence and incidence rates of EON were higher among women than men. Age, diabetes, renal diseases, and duration of EMB prescription were risk factors for developing EON. These findings could be valuable for the prevention or early management of EON patients."

Journal • Retrospective data • Cardiovascular • Chronic Kidney Disease • Diabetes • Hypertension • Metabolic Disorders • Nephrology • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Renal Disease

Do circular innovations and carrying capacity of natural environment enhance circular economy in the European Union? Evidence from simulation and machine learning methods. (PubMed, J Environ Manage) - "This study analyses the impact of circular innovations and the carrying capacity of the natural environment on the circular economy for 27 European Union countries...Furthermore, the European Union must limit the use of naturally occurring endowments and increase the use of recycled resources. Concludingly, this study provides unique insight into the sustainable and circular landscape in the European Union."

Journal

Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults. (PubMed, Cardiovasc Diabetol) - "Prediabetes and hepatic steatosis additively increased the risk of cardiometabolic outcomes in young adults. These findings hold significance for physicians as they provide insights into assessing high-risk individuals among young adults with prediabetes."

Journal • Cardiovascular • Hepatology • Metabolic Disorders • Myocardial Infarction

Pirfenidone and risk of lung cancer development in IPF: a nationwide population-based study. (PubMed, Eur Respir J) - "Pirfenidone use may be associated with a reduced lung cancer risk in patients with IPF."

Journal • Idiopathic Pulmonary Fibrosis • Immunology • Lung Cancer • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Income-Related Disparities in Mortality Among Young Adults With Type 2 Diabetes. (PubMed, JAMA Netw Open) - "Data were analyzed between January 1, 2023, and August 27, 2024...In this cohort study of 1 240 780 individuals aged 20 to 79 years, the risk of mortality with low income was most prominent among individuals with T2D aged 20 to 39 years. These findings highlight the need for socioeconomic support to reduce income-related health disparities in younger individuals."

Journal • Retrospective data • Cardiovascular • Diabetes • Metabolic Disorders • Oncology • Type 2 Diabetes Mellitus

Efficacy and diabetes risk of moderate-intensity statin plus ezetimibe versus high-intensity statin after percutaneous coronary intervention. (PubMed, Cardiovasc Diabetol) - "In patients undergoing PCI, moderate-intensity statin plus ezetimibe demonstrated a similar risk of MACCEs but a lower risk of new-onset DM than high-intensity statin. Early combination treatment of moderate-intensity statin and ezetimibe may be a useful and safe lipid-lowering strategy after PCI."

Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Dyslipidemia • Ischemic stroke • Metabolic Disorders

Effects of gamification on academic motivation and confidence of undergraduate nursing students: A systematic review and meta-analysis. (PubMed, Nurse Educ Today) - "This review provides convincing evidence for the positive effects of gamification interventions on academic motivation and confidence among undergraduate nursing students. However, the limited number of RCTs and moderate-to-low certainty of the evidence underscore the need for additional research."

Journal • Retrospective data • Review

A phase I, open-label, multicenter, dose escalation and expansion study of HM97662 (EZH1/2 dual inhibitor) as a single agent in patients with advanced or metastatic solid tumors (ESMO 2024) - P1 | "EZH1/2 repress the transcription of target genes by triggering tri-methylation of the lysine 27 residue of histone H3 (H3K27me3). Dose expansion part is designed to assess and confirm the efficacy, safety, pharmacokinetics, and pharmacodynamics of HM97662 with specific target disease determined by available preclinical study results and clinical outcomes. The final analysis will be performed once or separately for each part based on study progression."

Clinical • Metastases • Oncology • Solid Tumor • EZH2

On the issue of comparing the immobilization characteristics of matrix materials based on Nb-Ta-Ti-oxides of the types AB2O6 and A2B2O7. (PubMed, Sci Rep) - "It is concluded that the difference in the relative content of uranium (27.3 wt% in polycrase and 31.6 wt% in betafite) cannot be the only reason for the complete oxidation of uranium in betafite, given that in polycrase 30% of uranium is preserved in the tetravalent state...This allows us to consider minerals of the euxenite group to be quite promising as matrix materials for the immobilization of actinides. At the same time, an opinion was expressed on the advisability of further comparative studies of Nb-Ta-Ti-oxides of the mineral groups AB2O6 and A2B2O7 for their use at the final stage of the nuclear fuel cycle."

Journal

Body mass index is associated with clinical outcomes in idiopathic pulmonary fibrosis. (PubMed, Sci Rep) - "Based on BMI, 3.1%, 32.8%, 27.8%, and 36.4% were classified as underweight, normal, overweight, and obese, respectively...Spline HR curve analysis adjusted for all covariates revealed a non-linear relationship between BMI and mortality in patients with IPF. Our data suggest that BMI is associated with clinical outcomes in patients with IPF."

Clinical data • Journal • Retrospective data • Fibrosis • Genetic Disorders • Idiopathic Pulmonary Fibrosis • Immunology • Obesity • Pulmonary Disease • Respiratory Diseases

The association between body mass index and osteoporosis in a Taiwanese population: a cross-sectional and longitudinal study. (PubMed, Sci Rep) - "Participants were categorized into four BMI groups: underweight (BMI < 18.5 kg/m2), normal weight (18.5 kg/m2 ≤ BMI < 24 kg/m2), overweight (24 kg/m2 ≤ BMI < 27 kg/m2), and obese groups (BMI ≥ 27 kg/m2)...In addition, underweight is an independent risk factor for developing osteoporosis. These findings highlight the importance of maintaining normal weight for optimal bone health."

Journal • Observational data • Obesity • Osteoporosis • Rheumatology

Synthetic lethal strategy of an EZH1/2 dual inhibitor, HM97662, for the treatment of ARID1A-mutated solid cancers (AACR 2024) - "Enhancer of zeste homolog 2 (EZH2), an enzymatic subunit of polycomb repressive complex 2 (PRC2), is known to catalyze tri-methylation of histone H3 at lysine 27 (H3K27me3), leading to repression of the transcription of its target genes involved in cell cycle regulation, cell proliferation, cell differentiation, and tumor suppression. In conclusion, these preclinical studies demonstrated that HM97662 as an EZH1/2 dual inhibitor, holds promising therapeutic potential for ARID1A-mutated solid cancers. It is crucial to evaluate the effectiveness of HM97662 in subsequent clinical trials."

Synthetic lethality • Bladder Cancer • Gastric Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Lung Cancer • Oncology • Ovarian Cancer • Prostate Cancer • Small Cell Lung Cancer • Solid Tumor • ARID1A • EZH2 • PBRM1 • SMARCA4

INCREASED RISK OF DEMENTIA AFTER TRANSIENT GLOBAL AMNESIA: A NATIONWIDE POPULATION-BASED, LONGITUDINAL FOLLOW-UP STUDY IN SOUTH KOREA (ADPD 2024) - "Cumulative incidence curve was plotted to compare the incidence rate of dementia between the TGA (G 45.4; n=10,276) and the non-TGA (n=27,389) groups determined using a 1:3 propensity score matching... Our results suggest the longitudinal association of TGA with incident dementia."

Clinical • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Depression • Diabetes • Metabolic Disorders • Mood Disorders • Psychiatry

Percutaneous coronary intervention versus medical therapy in stable angina: a matched cohort study. (PubMed, Heart) - "PCI plus OMT was associated with higher rate of primary endpoint of MI, stroke, cardiac death as compared with OMT alone in patients with pure stable angina at 9.3-year follow-up in large population."

Journal • Cardiovascular • Myocardial Infarction

No association between cholecystectomy and risk of colorectal cancer: a meta-analysis of cohort studies. (PubMed, Int J Colorectal Dis) - "No clear evidence to support the association between cholecystectomy and an increased risk of colorectal cancer. For patients with valid indications, timely cholecystectomy could be performed without the risk of colorectal cancer."

Journal • Retrospective data • Colon Cancer • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of the novel long-acting glucagon analogue HM15136 in overweight and obese patients with co-morbidities. (PubMed, Diabetes Obes Metab) - "This study of HM15136 provides a preliminary safety and tolerability profile with initial insights into its efficacy profile."

Journal • PK/PD data • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Hypoglycemia • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus