ISM3312
/ Insilico Medicine
- LARVOL DELTA
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May 16, 2025
A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro.
(PubMed, Nat Commun)
- "Furthermore, ISM3312 shows significant inhibitory effects against Nirmatrelvir-resistant Mpro mutants, suggesting ISM3312 may contribute to reduced viral escape in these settings. Incorporating ISM3312 and Nirmatrelvir into antiviral strategy could improve preparedness and reinforce defenses against future coronavirus threats."
Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases
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