methylprednisolone sodium succinate / Generic mfg. - LARVOL DELTA

REVIVES: The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA (clinicaltrials.gov) - P=N/A | N=1274 | Recruiting | Sponsor: National Taiwan University Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular

Atypical presentation of MOGAD-associated optic neuritis with premacular haemorrhage. (PubMed, BMJ Case Rep) - "Early intravenous methylprednisolone administration led to partial recovery; however, the right eye required pars plana vitrectomy for visual improvement. This case highlights that atypical ON associated with MOG antibodies can present with vascular complications such as premacular haemorrhage, likely due to inflammation-induced venous congestion. Prompt recognition, thorough evaluation and early intervention are key to optimising the visual outcomes in such atypical presentations."

Journal • Inflammation • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Solid Tumor

CLIPPERS syndrome following papillary thyroid carcinoma. (PubMed, BMJ Case Rep) - "High-dose intravenous methylprednisolone followed by a short taper induced rapid and sustained clinical and radiological remission. Serial neck ultrasound and serum thyroglobulin measurements confirmed no evidence of PTC recurrence. This case illustrates that CLIPPERS can precede, remit after and recur independently of cancer activity, highlighting the importance of comprehensive malignancy screening and long-term oncological surveillance."

Journal • Ataxia • Movement Disorders • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • TG

Effectiveness and safety of pirfenidone for radiation-induced lung injury in non-small cell lung cancer: a retrospective pilot study. (PubMed, BMC Cancer) - "Our findings provide preliminary evidence supporting the clinical benefit and tolerability of pirfenidone for RILI in NSCLC patients. These results warrant further investigation in prospective controlled trials to establish its role in routine clinical practice."

Journal • Retrospective data • Hematological Disorders • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pneumonia • Respiratory Diseases • Solid Tumor • Thoracic Cancer • Thrombocytopenia

Diagnosis and treatment of a patient with severe hepatitis and rash caused by toripalimab: A case report. (PubMed, Medicine (Baltimore)) - "This case proposes that clinician should comprehensively determine the risk of adverse reactions and strengthen medication monitoring to ensure patient safety."

Journal • Hepatology • Inflammation • Liver Failure • Nasopharyngeal Carcinoma • Oncology • Solid Tumor

Adrenal Crisis: From Perioperative Clinic to Diagnosis. (PubMed, Cureus) - "Persistent hypokalemia and hypoglycemia raised suspicion of adrenal insufficiency, prompting empiric intravenous (IV) methylprednisolone (75 mg), which rapidly resolved hypotension and obviated further inotropic support. The case underscores the importance of considering adrenal crisis in perioperative refractory hypotension, even without prior diagnosis. Early glucocorticoid administration, prior to confirmatory laboratory results, is critical to prevent mortality."

Journal • Endocrine Disorders • Hypoglycemia • Hypotension • Nephrology • Renal Disease

Hypokalemic Periodic Paralysis in a Patient With Primary Sjögren's Syndrome and Distal Renal Tubular Acidosis: A Case Report. (PubMed, Clin Med Insights Case Rep) - "Corrective measures included intravenous potassium chloride and sodium bicarbonate along with immunomodulation with intravenous methylprednisolone, followed by oral prednisolone...An accurate diagnosis of HPP secondary to dRTA and Sjögren's syndrome requires high clinical suspicion. Prompt recognition and intervention, including immunotherapy and balanced electrolyte replacement, can prevent profound neuromuscular complications and improve patient outcome."

Journal • Immunology • Metabolic Disorders • Nephrology • Pain • Sjogren's Syndrome

Presumed Cerebral Vasculitis Following Pneumococcal Meningitis: A Rare but Life-Threatening Complication. (PubMed, Case Rep Med) - "Despite appropriate antimicrobial therapy and intravenous (IV) dexamethasone, her mental status did not improve...High-dose IV methylprednisolone and a more prolonged taper of oral prednisone led to remission of her disease, with marked improvement in mental status and left-sided hemiparesis. Cerebral vasculitis is a rare but potentially lethal complication of pneumococcal meningitis that may be difficult to recognize and treat. The role of brain biopsy in diagnosis is unclear, and due to its rarity, management of this condition lacks conclusive evidence-based data."

Journal • CNS Disorders • Cognitive Disorders • Infectious Disease • Pneumococcal Infections • Septic Shock • Vasculitis

Efficacy and Safety of Sequential Hormone Therapy and Tetuzumab Therapy in Patients With Moderate to Severe TAO in the Active Stage After Glucocorticoid Treatment. (clinicaltrials.gov) - P4 | N=96 | Recruiting | Sponsor: Shanghai Changzheng Hospital

New P4 trial • Ophthalmology • Thyroid Eye Disease

The Safety and Efficacy of Sequential Hormone Therapy and IBI311 Therapy in Patients With Active Moderate to Severe TAO in the Initial Treatment. (clinicaltrials.gov) - P4 | N=64 | Recruiting | Sponsor: Shanghai Changzheng Hospital

New P4 trial • Ophthalmology • Thyroid Eye Disease

Association of different intra-orbital lymphocyte infiltrates with clinical phenotypes of thyroid eye disease (ATA 2025) - "OBJECTIVE Thyroid Eye Disease (TED) is characterized by an active inflammatory phase followed by an inactive fibrotic phase, treated with immunosuppressants (i.e. intravenous methylprednisolone, ivMP) and rehabilitative orbital surgery, respectively...CONCLUSIONDifferent TED phenotypes present distinct orbital lymphocyte infiltrates. Interestingly, inactive TED patients previously treated with ivMP (TED-I-MP) showed orbital-fat lymphocytic infiltration different from those never treated (TED-I-Naïve), but similar to patients with active DON.The degree of orbital lymphocyte infiltration correlated with TED activity and disease duration, supporting immunosuppressants therapy in the early active phases of disease.Extraocular muscle infiltration was markedly increased especially in DON patients, with acute inflammatory muscle enlargement causing optic nerve compression."

Clinical • Fibrosis • Ocular Inflammation • Ophthalmology • Optic Neuritis • Thyroid Eye Disease • CXCR5 • PTPRC

Isolated Angioedema Without Urticaria as a Rare Initial Manifestation of Newly Diagnosed Hashimoto's Thyroiditis: A Case Report (ATA 2025) - "Here is the case of a 64-year-old male with a past medical history significant for type 2 diabetes mellitus (on dapagliflozin and insulin glargine), seizure disorder, and stroke, who came from a nursing home with symptomatic hypoglycemia with blood glucose 38 mg/dL...His condition improved, and he was discharged on levothyroxine 75 mcg daily after 3 days of hospitalization...He was given epinephrine 0.5 mg intramuscularly, methylprednisolone 80 mg intravenously, and diphenhydramine 25 mg intravenously, with rapid clinical improvement and successful extubation on the following day...Although the underlying mechanism remains speculative, it is hypothesized that complement activation via the thyroperoxidase complement controller domain may release mediators, triggering angioedema. Therefore, clinicians should order thyroid function tests in idiopathic isolated angioedema, followed by TPO and thyroglobulin antibody testing when hypothyroidism is identified."

Case report • Clinical • Cardiovascular • CNS Disorders • Dermatology • Diabetes • Endocrine Disorders • Epilepsy • Heart Failure • Hereditary Angioedema • Hypoglycemia • Immunology • Metabolic Disorders • Type 2 Diabetes Mellitus • Urticaria

Persistent Diarrhea Following CAR-T Therapy for Multiple Myeloma: A Case of Immune Effector Cell-Associated Enterocolitis (ACG 2025) - "We highlight a case of immune effector cell (IEC) enterocolitis following CAR-T therapy.Case Description/ A 73-year-old female with a history of IgG kappa multiple myeloma status post CAR-T with ciltacabtagene autoleucel was hospitalized 170 days after treatment for acute onset non-bloody diarrhea with >4 L stool per day...She received IV methylprednisolone without significant improvement in her symptoms after 5 days, one dose of cyclophosphamide 1.5mg/m2, and given ongoing diarrhea, received two doses of vedolizumab 300mg IV, one week apart...This condition is treated with systemic corticosteroids, infliximab, or vedolizumab...25x pathology slide demonstrating increased intraepithelial lymphocytosis with most T-cells being CD4 positive with T-cell receptor (TCR) β-chain constant region 1 restriction. Polymerase chain reaction study for clonal T-cell gene rearrangement was positive."

Clinical • IO biomarker • Acute Kidney Injury • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Lymphoma • Multiple Myeloma • Nephrology • Renal Disease • T Cell Non-Hodgkin Lymphoma • CD4

ICI-Mediated Lymphocytic Colitis in a Patient with Metastatic BRAF-Mutant Malignant Melanoma (ACG 2025) - "This case highlights the diagnostic approach and management of an emerging subset of ICI colitis – ICI-mediated lymphocytic colitis – in a patient with advanced BRAF-mutant melanoma.Case Description/ A 72-year-old male with a history of metastatic BRAF-mutant malignant melanoma (on encorafenib, binimetinib, and Opdualag) presented with two weeks of severe nausea, vomiting, and diarrhea. The patient also had a prior history of ICI-associated acute interstitial nephritis (AIN), for which he was tapering off prednisone.Upon presenting to the emergency department (ED), the patient was hemodynamically stable...The patient was started on intravenous methylprednisolone 80 mg daily, which was later increased to 160 mg daily due to inadequate symptom resolution...The patient's symptoms improved with corticosteroids, budesonide, and infliximab, emphasizing the importance of early recognition and treatment. This case contributes to the growing body of evidence supporting the..."

Clinical • IO biomarker • Metastases • Gastroenterology • Gastrointestinal Disorder • Immunology • Melanoma • Nephrology • Solid Tumor • BRAF

Late Onset Immune Mediated Hepatitis Emerging After Pembrolizumab: A Case Report (ACG 2025) - "ICIs include CTLA-4 inhibitors (ipilimumab) and the PD-1 and PD-L1 inhibitors (nivolumab and pembrolizumab)...Solu-Medrol started in the emergency room...We discharged her on oral prednisone for 2 weeks...Hepatotoxicity is not uncommon secondary to ICI treatment. It can occur 8-12 weeks after the initiation of ICI and presents with elevation of transaminases."

Case report • Clinical • Fatigue • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Hepatology • Immunology • Inflammation • Liver Failure • Renal Cell Carcinoma • Solid Tumor

Mistaken for Infection: Delayed Recognition of Pyoderma Gangrenosum in a Crohn's Flare (ACG 2025) - "Azathioprine was discontinued, and IV methylprednisolone (40 mg daily) was started for a severe Crohn's flare.General surgery was consulted early and performed multiple drainages of the thigh lesion, but the wound continued to enlarge and remained painful despite broad-spectrum antibiotics (cefepime and daptomycin). Treatment includes corticosteroids, immunosuppressants, or biologics. In this case, steroids and vedolizumab led to near-complete resolution, highlighting the need for early diagnosis.Figure: Pyoderma Gangrenosum Lesions"

Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

A Rare Case of Chronic Lymphocytic Leukemia Complicated by Myasthenia Gravis. (PubMed, J Community Hosp Intern Med Perspect) - "He was admitted for treatment with intravenous immune globulin, pyridostigmine, and intravenous solumedrol...He was given the first dose of rituximab during the hospital admission after which his dysphagia clinically improved.Outpatient management included obinutuzumab and Ventoclax for CLL control, resulting in gradual resolution of MG symptoms over a few months...Conversely, symptoms like ptosis in chronic lymphocytic leukemia (CLL) should prompt MG assessment. Early CLL treatment, as seen in this case, can resolve neurological symptoms and achieve remission, highlighting the need for a timely diagnosis and intervention to enhance patient outcomes."

Journal • Chronic Lymphocytic Leukemia • CNS Disorders • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Myasthenia Gravis

Ulcerative Colitis Unmasked by a Clostridioides difficile Infection: A Case Report (ACG 2025) - "Symptoms began after completing a 7-day course of Cefdinir...There was no prior history of IBD, IBS, celiac disease, or pancreatitis.He initially tested positive for C. difficile and was treated with a 2-week course of oral vancomycin, with only brief symptom improvement...Biopsies showed active colitis with chronic architectural changes.He was started on IV methylprednisolone, transitioned to a prednisone taper, and initiated on vedolizumab...Early colonoscopy is essential when symptoms persist. The patient improved with corticosteroids and vedolizumab, aligning with standard UC therapy.Figure: Colonoscopy images #1Figure: Colonoscopy images #2"

Case report • Clinical • Anemia • Celiac Disease • Colorectal Cancer • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Pancreatitis • Type 2 Diabetes Mellitus • Ulcerative Colitis

Pembrolizumab-Induced Immune Checkpoint Inhibitor Colitis (ACG 2025) - "His outpatient oncologist started him on prednisone 50mg once daily, but eventually presented to the ED after his symptoms failed to resolve...The patient was started on methylprednisolone 120 mg IV daily, and after 5 days, his symptoms improved...The rapid response to high-dose corticosteroids supports the current guidelines of using corticosteroids in moderate to severe cases of ICI-induced colitis. This case highlights the utility of promptly identifying ICI-induced colitis and the need for multidisciplinary coordination in the management of such cases to prevent long-term oncologic or gastrointestinal complications, while also balancing the patient's cancer treatment goals."

Checkpoint inhibition • Endocrine Disorders • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Pneumonia • Solid Tumor

A Rare Presentation of Anorectal Melanoma Presenting as Hemorrhoidal Discomfort and Rectal Bleeding (ACG 2025) - "Therapy was discontinued and patient was treated with IV solumedrol. Subsequently, patient was treated with imatinib but it was discontinued due to the development of a severe erythrodemic rash...Anorectal mucosa is vascular and has great lymphatic supply, causing fast growth and metastatic spread. Prognosis is worse with delayed diagnosis."

Anal Carcinoma • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Melanoma • Mucosal Melanoma • Myositis • Solid Tumor • SOX10

A Rare Case of Palbociclib-Induced Pancolitis: Clinical Insights and Literature Review (ACG 2025) - "Colitis presents a diagnostic challenge due to symptom overlap with infectious and inflammatory bowel diseases.Case Description/ A 65-year-old woman with metastatic HR+ breast cancer on palbociclib, fulvestrant, and denosumab for five months developed a two-week history of severe watery diarrhea and abdominal cramping...Palbociclib was held, and intravenous methylprednisolone was initiated for suspected drug-induced colitis, leading to rapid symptom improvement...While GI side effects such as diarrhea are more commonly associated with abemaciclib, severe colitis with palbociclib has been reported in fewer than five cases in the literature...This case underscores the importance of clinician vigilance for rare toxicities, prompt withdrawal of the offending agent, and judicious use of immunosuppressive therapy. Early recognition and multidisciplinary management are key to optimizing outcomes.Figure: Image 1: Colonoscopy findings showing pancolitis"

Clinical • Review • Breast Cancer • Gastroenterology • Gastrointestinal Disorder • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Immunology • Infectious Disease • Inflammatory Bowel Disease • Solid Tumor • HER-2

Checkpoint Inhibitor Hepatotoxicity Unresponsive to Steroids: A Case for Ursodiol (ACG 2025) - "Ursodiol, a bile acid commonly used in primary biliary cholangitis, is not a standard DILI treatment but may be beneficial in select cases.Case Description/ A 74-year-old woman with a history of endometrial cancer completed three cycles of carboplatin, paclitaxel, and pembrolizumab...The patient was treated with IV methylprednisolone over six months without improvement in LFTs...Recognition of atypical treatment responses is critical, especially as ICI use expands in oncology. Liver biopsy played a key role in identifying the pattern of injury and guiding management."

Checkpoint inhibition • Clinical • Endometrial Cancer • Fibrosis • Hepatology • Immunology • Liver Failure • Oncology • Primary Biliary Cholangitis • Solid Tumor

Checkpoint and Checkmate: Concurrent Immune-Mediated Hepatitis and HBV Reactivation in a Cancer Patient (ACG 2025) - "She was receiving Pembrolizumab and Lenvatinib for her RCC...She was started on treatment for hepatitis B reactivation with Tenofovir and N-Acetylcysteine (NAC)...After a multidisciplinary discussion, she was initiated on Solumedrol 1 g/kg in addition to continuing her Tenofovir. Thereafter, the patient's LFTs and INR rapidly improved, and she was transitioned to oral prednisone taper...Therefore, it is imperative to check hepatitis B serologies before immunosuppression and initiate antiviral prophylaxis when indicated. Unfortunately, our patient did not have her serologies checked before starting treatment.Figure: Figure 1, H&E image showing acute hepatitis pattern of injury with lobular disarray, inflammation, hepatocyte swelling, and many acidophil bodiesFigure: Figure 2, Hepatitis B stain image showing the positive staining for hepatitis B (brown color in the hepatocytes)"

Clinical • Genito-urinary Cancer • Hepatitis B • Hepatitis C • Hepatology • Infectious Disease • Liver Failure • Oncology • Renal Cell Carcinoma • Solid Tumor

A Case of Decompensated Cirrhosis Secondary to Sickle Cell Hepatopathy (SCH) Managed With Orthotopic Liver Transplantation (OLT) Followed by Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) (ACG 2025) - "Despite treatment of SCD with transfusions and hydroxyurea, his cirrhosis progressed with refractory ascites, spontaneous bacterial peritonitis, and hepatic encephalopathy. With a MELD score of 36, he underwent successful OLT with the institution's immunosuppression protocol of basiliximab induction, steroid taper, mycophenolate modafinil and maintenance tacrolimus...Complications included cutaneous reaction to ampicillin requiring IV methylprednisolone and ruxolitinib due to initial concern for early GVHD which was later felt less likely based on timing and presentation characteristics. Sirolimus, used for immunosuppression/GVHD prophylaxis, was switched to tacrolimus due to possible cutaneous adverse reaction and was continued to prevent OLT rejection...Patients with SCD who have undergone liver transplantation can have significant risk of graft loss, with studies showing up to 22% requiring re-transplantation due to SCD complications. Our approach addresses both..."

Clinical • Bone Marrow Transplantation • CNS Disorders • Fibrosis • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Immunology • Liver Cirrhosis • Sickle Cell Disease • Transplantation

Double Whammy Toxicity: A Case of Simultaneous Immune Mediated Colitis and Hepatitis After Pembrolizumab Therapy in Metastatic Bladder Cancer (ACG 2025) - "Given significant abdominal symptoms and markedly elevated LFTs, pembrolizumab was discontinued by oncology team and he was started on IV methylprednisolone with subsequent symptomatic improvement and mild reduction in LFTs. This case highlights the potential nuances of diagnosing and managing ICI colitis (ICIC) and ICI hepatitis (ICIH). For both ICIC and ICIH, severity is graded is based on using the Common Terminology Criteria for Adverse Events (CTCAE) which dictates whether immunotherapy can be continued, held, or stopped and whether steroid therapy is warranted to reverse effects. Although managing both ICIC and ICIH may be challenging, it is important to consider multidisciplinary shared decisions between hepatology, gastroenterology, and oncology to develop an appropriate management plan for such patients."

Clinical • IO biomarker • Metastases • Bladder Cancer • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Hepatology • Immunology • Mucositis • Oncology • Solid Tumor