quetiapine / Generic mfg. - LARVOL DELTA

Second-generation antipsychotics - Cardiac ion channel modulation and QT interval disturbances: A review. (PubMed, Biomol Biomed) - "A narrative literature review was conducted using PubMed, Web of Science, and Google Scholar, without year restrictions, focusing on English-language experimental and clinical studies related to clozapine, olanzapine, risperidone, quetiapine, and ziprasidone. Notably, the observed variability in the ratio of half-maximal inhibitory concentration to maximum free plasma concentration (IC₅₀/Cmax,free) reflects its dependence on both the degree of hERG inhibition and the pharmacokinetic properties specific to each SGA. Additionally, several SGAs affect other potassium, sodium, and calcium currents, which may either mitigate or exacerbate the consequences of IKr inhibition. In conclusion, QT interval prolongation associated with SGAs is primarily driven by hERG potassium channel blockade, although the degree of this effect varies significantly among different agents. This variability highlights the necessity for electrocardiogram (ECG) monitoring and..."

Journal • Review • Cardiovascular • CNS Disorders • Psychiatry

DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Is More: A Rare Case of Acalculous Cholecystitis. (PubMed, ACG Case Rep J) - "We present the first case of acalculous cholecystitis due to quetiapine-induced drug reaction with eosinophilia and systemic symptoms. This case report emphasizes the need for high clinical suspicion to initiate appropriate treatment."

Journal • Eosinophilia • Gastroenterology • Hepatology

Comment: Olanzapine Versus Quetiapine: Corrected QT Changes in Critically Ill Patients. (PubMed, Ann Pharmacother) - No abstract available

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Reply: Olanzapine Versus Quetiapine: Corrected QT Changes in Critically Ill Patients. (PubMed, Ann Pharmacother) - No abstract available

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Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol. (PubMed, Prim Care Companion CNS Disord) - No abstract available

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Drug-induced polycystic ovary syndrome: a real-world pharmacovigilance study based on the FAERS database. (PubMed, Front Endocrinol (Lausanne)) - "The median time to onset for the top three drugs with the highest signal frequency was as follows: Olanzapine (155.5 days), Quetiapine (335 days), and Valproic acid (905 days). The drugs identified are primarily associated with the nervous system, followed by respiratory system medications and other types of drugs. These findings provide new warning evidence and references for clinical drug safety, suggesting that enhanced monitoring of female patients should be implemented when prescribing such drugs."

Adverse events • Journal • Real-world evidence • CNS Disorders • Polycystic Ovary Syndrome

Consultation-Liaison Case Conference: Stimulant-Induced Tardive Dyskinesia. (PubMed, J Acad Consult Liaison Psychiatry) - "We discuss treatment strategies, including VMAT2 inhibitors (e.g., valbenazine), antipsychotic switches (e.g., clozapine, quetiapine), and adjunctive therapies (e.g., vitamin E). The report advocates vigilant monitoring, early intervention, and individualized approaches for TD in high-risk patients."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Movement Disorders • Post-traumatic Stress Disorder • Psychiatry

What is your next step? A case of how a misleading diagnosis can mask avoidable serious adverse effects of quetiapine. (PubMed, Intern Emerg Med) - No abstract available

Adverse events • Journal

Prevalence of potentially inappropriate use of antiviral therapy with simnotrelvir-ritonavir versus nirmatrelvir-ritonavir in hospitalised patients: a retrospective study in Beijing, China. (PubMed, BMJ Open Respir Res) - "About half of the patients use simnotrelvir-ritonavir and nirmatrelvir-ritonavir that might potentially be inappropriate. More extensive research is required to supplement the empirical evidence supporting COVID-19 therapeutics. Additionally, appropriate therapy requires collaboration with pharmacists and education on the appropriate use of COVID-19 therapeutics among physicians and patients."

Clinical • Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Renal Disease

Transient Perioperative Aggressive Behavior during Subthalamic Nucleus Deep Brain Stimulation for Parkinson's disease. (PubMed, Asian J Neurosurg) - "The psychiatric symptoms were then controlled with quetiapine until the behavioral changes had resolved after 7 days. No recurrence was noted during follow-up consults.This case report confirms the importance of fundamental knowledge and understanding of the neuroanatomical structures affected in DBS of the STN, and their clinical implications. A thorough preoperative psychiatric evaluation is essential for comprehensive management and allows anticipation of possible adverse events."

Journal • CNS Disorders • Depression • Movement Disorders • Parkinson's Disease • Psychiatry

Do the pharmacokinetics of statins explain psychiatric symptom improvement from adjunctive statin prescribing in severe mental illness? Three target trial emulation studies. (PubMed, BMJ Ment Health) - "There is currently not enough evidence to guide the prescription of statins for psychiatric symptom improvement in patients with SMI. If there is an effect of statins, it may be through specific statin-antipsychotic combinations."

Journal • PK/PD data • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry • Schizophrenia

A deep representation learning algorithm on drug-target interaction to screen novel drug candidates for Alzheimer's disease. (PubMed, Artif Intell Med) - "Our results identified that several drugs could be promising for AD treatment, including human C1-esterase inhibitor, quetiapine, dasatinib, miconazole, aniracetam, chlorpromazine, hypericin, entrectinib, torcetrapib, bosutinib, sunitinib, aniracetam, rosiglitazone, tarenflurbil, milrinone, and MITO-4509. Results from this study also provided insights for understanding the molecular mechanisms underlying AD. As a systematic and versatile method, our approach can also be applied to identify efficacious therapies for other complex diseases."

Journal • Alzheimer's Disease • CNS Disorders

Phenobarbital for Refractory Behavioral Disturbances in Anti-NMDAR and HSV Encephalitis: A Case Report. (PubMed, J Pain Palliat Care Pharmacother) - "Disease-modifying therapies, including IV acyclovir, IV immunoglobulin, prednisone, and rituximab, were ineffective. Multiple psychotropic medications, including fluoxetine, quetiapine, olanzapine, and trazodone, failed to relieve behavioral symptoms...No adverse effects were reported. This case suggests that low-dose oral phenobarbital may be a viable option for managing refractory behavioral disturbances in patients and improving quality of life with anti-NMDAR and HSV encephalitis."

Journal • CNS Disorders • Herpes Simplex • Immunology • Insomnia • Mental Retardation • Palliative care • Psychiatry • Sleep Disorder

Posterior alien hand syndrome in a patient with parieto-occipital infarction: a presentation mimicking anterior variant features-a case report. (PubMed, J Med Case Rep) - "This case underscores the varied manifestations of alien hand syndrome variations, indicating a complicated interaction among anatomical regions. A multidisciplinary approach is crucial for the management of alien hand syndrome, especially in instances with overlapping features."

Journal • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Pulmonary Embolism • Respiratory Diseases

Fecal incontinence in hospitalized bipolar disorder patients: prevalence, gender disparities, and associations with demographic and pharmacological factors. (PubMed, BMC Psychiatry) - "This study reveals an exceptionally high prevalence of fecal incontinence in hospitalized bipolar disorder patients, with demographic factors proving more predictive than broad medication classes. The profound gender disparity and medication-specific risk profiles necessitate systematic continence screening protocols and individualized pharmacological selection strategies. These findings highlight the critical need for multidisciplinary care approaches integrating psychiatric treatment with specialized continence management to address this previously underrecognized complication affecting nearly half of hospitalized bipolar patients."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Quetiapine treatment corrects behavioral impairments and promotes neuroplasticity in a neurodevelopmental rat model of schizophrenia. (PubMed, Neuroscience) - "At the neuroplasticity level, QUET treatment partially reversed nVHL-induced deficits by restoring dendritic spine density and the proportion of mushroom spines in the basilar dendritic tree of PFC layer 3 pyramidal neurons, whereas PFC layer 5 neurons and nucleus accumbens spiny projection neurons remained unaffected. These findings provide new insights into the non-monoaminergic mechanisms underlying the clinical effects of atypical antipsychotics and may inform the development of novel pharmacotherapies."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Therapeutic efficacy of quetiapine combined with magnesium valproate in schizophrenia: Impact on serum BDNF and GFAP levels. (PubMed, Medicine (Baltimore)) - "Quetiapine combined with magnesium valproate offers superior clinical benefits over monotherapy in patients with schizophrenia. It significantly improves psychiatric symptoms, cognitive function, and quality of life, likely through modulation of neurotrophic and glial activity, with good tolerability and safety."

Biomarker • Clinical • Journal • CNS Disorders • Psychiatry • Schizophrenia • BDNF • GFAP

Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine and Risperidone in Alzheimer's Disease: A Real□World Cohort Study with Treatment Effect Heterogeneity Analysis. (PubMed, medRxiv) - "Aripiprazole and quetiapine were associated with lower mortality compared to olanzapine and risperidone. Treatment effect heterogeneity suggests the need for individualized prescribing based on patient characteristics such as comorbid T2DM."

Heterogeneity • Journal • Real-world evidence • Alzheimer's Disease • CNS Disorders • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Magnetic Seizure Therapy for Psychotic Disorders (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Shanghai Jiao Tong University School of Medicine | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Epilepsy • Psychiatry

Sodium bicarbonate to the ROSCue: a case report on how sodium bicarbonate successfully resuscitated a patient in cardiac arrest from suspected quetiapine and trazodone overdose. (PubMed, Eur Heart J Case Rep) - "Although the role of SB in cardiac arrest remains limited, SB in SCB toxicity in TCA overdose and in other drug toxicities can be life-saving. SB should be considered in patients with wide QRS and suspected drug overdose."

Journal • Cardiovascular • CNS Disorders • Metabolic Disorders

Pattern of Pharmaceutical Poisoning in the Perak Population with Special Reference to the Age and Poisoning Mode Impact. (PubMed, Risk Manag Healthc Policy) - "Quetiapine (2.9%) and calamine lotion (2.3%) were marked as the most common causes. Female sex (p < 0.001), working age (p < 0.001), and psychiatric agents (p < 0.001) were significantly associated with intentional poisoning, whereas male sex (p < 0.001), young age (p < 0.001), and topical agents (p < 0.001) were significantly associated with accidental poisoning. The exposure to pharmaceutical poisoning was associated with age, sex, psychiatric agents, and topical agents."

Journal • Psychiatry

Comparative Efficacy and Tolerability of Multiple Antipsychotics Across Varying Doses for Neuropsychiatric Symptoms of Dementia Including Alzheimer's Disease: A Dose-Response Model-Based Network Meta-Analysis. (PubMed, Acta Psychiatr Scand) - "Aripiprazole 10 mg, brexpiprazole 1-2.5 mg, risperidone 1 mg, and olanzapine 2.5 mg were both effective and well tolerated, indicating their potential as favorable treatment options. As the present model incorporates several sources of uncertainty, its findings should be interpreted with caution and regarded as a provisional framework to support clinical decision-making."

Journal • Retrospective data • Review • Alzheimer's Disease • CNS Disorders • Dementia • Psychiatry

Automated R workflow for Batman peak fitting using unified equation and stochastic modeling. (PubMed, J Chromatogr A) - "Quetiapine chromatograms were analyzed over a wide range of flow rates (0.1mL/minto3.0mL/min) and temperatures (10°C to 40°C)...By combining the unified equation with stochastic modeling, it delivers reliable results across diverse chromatographic conditions. This framework is readily adaptable for routine analysis of dynamic enantiomerization in pharmaceutical and analytical chemistry applications."

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Valproate sodium-associated acute pancreatitis: a case report and systematic analysis of antiepileptic drug adverse events in FAERS. (PubMed, Am J Transl Res) - "This study reinforces the association between VPA and AP while providing a broader pharmacovigilance assessment of AED-induced pancreatitis. Clinicians should remain vigilant when prescribing AEDs, particularly to high-risk patients, given the potential of serious pancreatic toxicity."

Adverse events • Journal • CNS Disorders • Epilepsy • Pancreatitis

QT interval prolongation in acute antipsychotic poisoning: systematic review and recommendations. (PubMed, Clin Toxicol (Phila)) - "Individual medication recommendations were made for amisulpride (15 articles), thioridazine (11 articles), ziprasidone (eight articles) and quetiapine (13 articles), whilst consensus statements based on limited data were made for acute ingestions of clozapine, haloperidol, iloperidone, pimozide, pipamperone, olanzapine and risperidone (14 articles in total). The QT Interval Prolongation in Clinical Toxicology Workgroup suggests the same approach for patients with overdoses of haloperidol, iloperidone, pipamperone and pimozide. The risk of torsade de pointes is likely overstated for acute antipsychotic medication overdose as a general class group, and concern should rather focus on a few specific medications."

Journal • CNS Disorders