quetiapine / Generic mfg. - LARVOL DELTA

Potential Impact of Childhood Abuse on Quality of Life During Mood-Stabilising Treatment in Individuals Living With Bipolar Disorder. (PubMed, Bipolar Disord) - P4 | "This study comprehensively investigated the relationships between a history of childhood abuse and QoL among people with bipolar disorder who were receiving pharmacotherapy. Although the present findings need to be replicated, they suggest significant impairment in several domains of QoL associated with childhood abuse, which has service and treatment implications for trauma-informed care."

HEOR • Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Neuropsychiatric Manifestations in Myhre Syndrome: Expanding the Phenotype to Guide Early Diagnosis and Monitoring (ACMG 2026) - "While he still experiences psychotic episodes, his overall functional capacity has improved while taking a 5 mg daily dose of olanzapine...She is currently on quetiapine and divalproex, with stable symptom control for 1.5 years... Myhre syndrome is characterized by neurocognitive symptoms of variable severity, with developmental delay being the most common feature, followed by autism spectrum disorder. Psychosis, although infrequently documented, is increasingly being recognized as a potential component of Myhre syndrome. Its underlying mechanism is not yet well understood but may involve disruptions in the TGF-β signaling pathway, which includes interactions among TGF-β family members and SMAD proteins, including SMAD4."

Anorexia • Autism Spectrum Disorder • Bipolar Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Insomnia • Mental Retardation • Mood Disorders • Otorhinolaryngology • Psychiatry • Schizophrenia • Sleep Disorder • SMAD4 • TGFB1

Antipsychotic treatment patterns and cardiometabolic medicine use: current real-world evidence. (PubMed, Epidemiol Psychiatr Sci) - "Use of cardiometabolic medicines is increased among people on long-term antipsychotic treatment. These results highlight the need for active monitoring for cardiometabolic adverse effects, with antipsychotic cessation where possible, or timely interventions to limit morbidity."

HEOR • Journal • Real-world evidence • Retrospective data • Cardiovascular • CNS Disorders • Metabolic Disorders

PSYCHOTIC FEATURES IN MYHRE SYNDROME: EVIDENCE FOR BROADER NEUROPSYCHIATRIC SURVEILLANCE (WRMC 2026) - "Presently, she lives in a group home due to her complex needs but has been asymptomatic while taking olanzapine...She is currently on quetiapine and divalproex, with stable symptom control for 1.5 years...TGF-β signaling not only influences neurodevelopment but also plays a role in immune regulation, which is thought to contribute to the pathophysiology of psychosis and schizophrenia. Although additional cases are needed to confirm our observations, psychosis may be a component of the neurodevelopmental phenotype of Myhre syndrome, underscoring the importance of prompt psychiatric evaluation and intervention."

Anorexia • Autism Spectrum Disorder • Bipolar Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Insomnia • Mental Retardation • Otorhinolaryngology • Psychiatry • Schizophrenia • Sleep Disorder • SMAD4 • TGFB1

Trends in Atypical Antipsychotic Use Among Children and Adolescents With Depressive Disorders in Korea. (PubMed, J Korean Med Sci) - "The use of AAPs has progressively increased among Korean children and adolescents with depressive disorders, particularly among those with psychiatric comorbidities. Further studies are needed to establish safer and more evidence-based AAP treatments for depressive disorders in children and adolescents."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

Persistent Tremor in Bipolar Disorder: A Case Report of Idiopathic Parkinson's Disease Superimposed on Lithium and Antipsychotic Effects. (PubMed, Case Rep Psychiatry) - "Management included discontinuing lithium, switching aripiprazole to quetiapine to limit motor worsening, and starting carbidopa-levodopa...When parkinsonian signs are atypical or persist after medication changes, consider idiopathic PD rather than attributing symptoms to side effects. Care is best delivered through close collaboration between psychiatry and neurology to balance dopaminergic therapy with mood stabilization."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Use of antipsychotics in children and adolescents in Spain, 2015-2023: a real-world, population-based study. (PubMed, Span J Psychiatry Ment Health) - "AP prescriptions and patients treated among Spanish youth increased significantly between 2015 and 2023, with notable differences by age and sex. While total CED rose, treatment intensity per patient remained relatively stable. Future studies should investigate the clinical indications for these prescriptions as well as the outcomes associated with AP use in children and adolescents."

Journal • Real-world evidence • CNS Disorders

Sertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report. (PubMed, BMC Psychiatry) - No abstract available

Journal

Prevalence and predictors of high-dose antipsychotic therapy among adult psychiatric inpatients in Baghdad, Iraq. (PubMed, S Afr J Psychiatr) - "Predictors of high-dose antipsychotics were polypharmacy (adjusted odd ratio [AOR]:12.61; 95% confidence interval [CI]: 1.78, 89.50), first-generation antipsychotics (AOR: 7.049; 95% CI 1.33, 37.44), quetiapine (AOR: 5.66; 95% CI 1.16, 27.53), procyclidine (AOR: 0.17; 95% CI 0.05, 0.55), and antidepressants (AOR: 0.19; 95% CI 0.05, 0.76)...Targeted educational interventions are warranted to enhance guideline adherence and promote safe and appropriate use of antipsychotics. This is the first study to assess the magnitude and factors associated with high-dose antipsychotic prescription in Iraq."

Journal • CNS Disorders • Psychiatry

Sleep-Related Eating Disorder and Sexsomnia; Two Rare Parasomnias? A Mini-Review with Illustrative Case-Reports. (PubMed, Int J Sex Health) - "One of our cases (sex without consent of the partner) points to the potential forensic consequence of sexsomnia; and two cases highlight the side-effect of Quetiapine and Zolpidem (alike several additional psychoactive drugs) provoking sleep-related eating-episodes...Regular sleep-schedule and other lifestyle-improvements help managing these conditions treated by Melatonin, certain antidepressants and, sedatives. Understanding their mechanism may provide meaningful data on reward-seeking during sleep."

Journal • CNS Disorders • Sleep Disorder

Pragmatic trial design enhances diversity and retention among research participants with Lewy body diseases. (PubMed, NPJ Dement) - P4 | "An ongoing pragmatic, randomized, unblinded clinical trial compares pimavanserin and quetiapine for psychosis in Lewy body diseases over 6 months (n = 60). Embedding pragmatic trials within routine care can enhance retention and diversity, thereby improving representativeness and real-world applicability of clinical research. Registry: ClinicalTrials.gov, TRN: NCT05590637; Registration Date: 18 October 2022."

Journal • CNS Disorders • Lewy Body Disease • Psychiatry

Advancing Torsades de pointes risk prediction: unveiling the role of drug metabolites through molecular docking. (PubMed, Toxicol Res (Camb)) - "Using a dual-strategy molecular docking approach with AutoDock Vina and PatchDock, we analyzed clinically relevant ligand pairs: astemizole/desmethylastemizole, terfenadine/fexofenadine, and quetiapine/norquetiapine. These findings highlight the importance of focusing not only on the parent drug but also on metabolites for TdP risk assessment in new drug development. We advocate for an integrated computational framework combining binding energy, geometric complementarity, and physicochemical profiling to enhance the accuracy of early cardiac safety screenings."

Journal • Cardiovascular

PEGylated flexosomes as a novel intranasal carrier for quetiapine: formulation, characterization, and in vivo studies. (PubMed, J Liposome Res) - "Histopathological evaluation confirmed the formulation's safety. PFs present a promising platform for enhanced intranasal QTP delivery."

Journal • Preclinical

Drug-related suicidal events in children and teenagers: Age-stratified insights from FAERS. (PubMed, Leg Med (Tokyo)) - "Across FAERS youth suicide reports, drug-associated fatality risk varies markedly by drug, surges in mid- to late adolescence, diverges by sex and shifts at both age extremes. These heterogeneities underscore the need for age-appropriate pharmacovigilance and trial strategies rather than direct extrapolation from adult data, particularly regarding the safety of drugs associated with suicide."

Journal • Pediatrics

An observational study on the effects of as-needed use of various antipsychotic drugs for agitation due to psychotic disorders. (PubMed, Int Clin Psychopharmacol) - "Kaplan-Meier estimates showed mean onset times (minutes) for oral/sublingual drugs as follows: asenapine sublingual, 30.0; olanzapine orally disintegrating tablet, 31.9; quetiapine, 46.6; and risperidone oral solution, 34.5...For injectable antipsychotics, mean onset times were: olanzapine intramuscular, 36.3; haloperidol intramuscular, 47.5; and haloperidol intravenous, 45.0, with no significant differences among them. No serious adverse events were observed. The findings suggest that asenapine sublingual may offer faster calming in patients without refusal, and that future studies with shorter assessment intervals are warranted."

Journal • Observational data • CNS Disorders • Psychiatry

Perinatal Safety of Quetiapine During Pregnancy: A Systematic Review, Meta-Analysis, ‎‎and ‎Evidence Gaps. (PubMed, J Clin Psychopharmacol) - "QTP is not associated with an increased risk of major malformations and does not significantly raise adverse perinatal outcomes compared with controls. The dose-related metabolic risks of QTP underscore the importance of minimizing dosage and closely monitoring metabolism during pregnancy."

Journal • Retrospective data • Diabetes • Gestational Diabetes • Metabolic Disorders • Psychiatry

Optimizing antipsychotic dosing for relapse prevention in cannabis-induced psychosis: A nationwide cohort study. (PubMed, Psychiatry Res) - "Findings indicate dose-dependent real-world effectiveness of antipsychotics in CIP, with most agents performing best at 0.6-<1.4 DDDs/day. These results support optimizing dosing of oral antipsychotic medications for relapse prevention after CIP to balance efficacy and adverse effects."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Three cases of drug-related death during treatment for stimulant-induced psychosis. (PubMed, Leg Med (Tokyo)) - "Two deaths were directly due to drug overdose (Case 1, chlorpromazine and quetiapine poisoning; Case 2, zotepine and tramadol poisoning). In the third case, the direct cause of death was hanging, but markedly elevated blood concentrations of quetiapine and trazodone suggested that drug intoxication may have contributed to death. Elucidating the pathophysiology of stimulant-induced psychosis and selecting and developing effective treatments are essential, and long-term mental health care and social support to prevent isolation are crucial for preventing unfortunate deaths."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Construction of multi-component covalent organic framework coated stainless steel fiber for efficient microextraction of psychiatric drugs: experiments and clinical applications. (PubMed, Anal Chim Acta) - "Quetiapine (QTP) and clozapine (CLZ) are widely used antipsychotic drugs to treat psychotic symptoms. This novel self-fabricated COF-based SPME fiber can effectively extract QTP and CLZ from complex human plasma samples, eliminating interfering substances, mitigating matrix effects, enhancing detection sensitivity, and reducing the risk of instrument contamination. Our research has facilitated the application of SPME technology from laboratory settings to clinical practice, further confirming its applicability in the clinical monitoring of psychiatric drugs."

Journal • CNS Disorders • Psychiatry

Lumateperone (Caplyta) for adjunctive treatment of depression. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Beyond first-line antidepressants: lithium, quetiapine, or esketamine? Integrating meta-analyses and preliminary head-to-head evidence. (PubMed, World J Biol Psychiatry) - "A systematic review of databases was conducted for randomised and naturalistic head-to-head studies comparing augmentation with lithium, quetiapine, or (es)ketamine in adults with TRD was included...The results generally argue for a re-evaluation of existing treatment algorithms in guidelines. However, since all three are fundamentally different molecules with different pharmacokinetic and pharmacodynamic properties and differ in (1) side effects and contraindications as well as (2) profile focus, embedding them in a comprehensive clinical context is important."

Head-to-Head • Journal • Review • CNS Disorders • Depression • Psychiatry

Analysis of drug-drug interactions between psychiatric drugs in spontaneous adverse drug reaction reports from EudraVigilance. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Mirtazapine-quetiapine (26.3%, 10/48) was the interacting drug pair most commonly associated with tachycardia and QT prolongation. Checks for interactions and tight monitoring after initiating drug therapy can help to avoid serious DDI. Special attention should be paid to older patients taking more than one QT-interval prolonging drug."

Adverse drug reaction • Journal • Anesthesia • Cardiovascular • CNS Disorders • Epilepsy • Psychiatry

Depressive and anxiety disorders in Polish children across the COVID-19 pandemic: a nationwide registry-based time-trend analysis. (PubMed, Front Psychiatry) - "Only sertraline shows no clear peak, but rather a steady increase over the analyzed period. Statistical analysis revealed strong upward trends for specific medications, such as escitalopram and quetiapine, and highlighted the pandemic's distorting effect on prescribing patterns. These findings underscore the long-term impact of COVID-19 on youth mental health and emphasize the need for enhanced early intervention, expanded access to psychiatric care, and robust public health strategies tailored to children and adolescents."

Journal • CNS Disorders • Depression • Infectious Disease • Mood Disorders • Novel Coronavirus Disease • Psychiatry

Bipolar major depression: A comprehensive review of pharmacotherapy. (PubMed, Nurse Pract) - "Effective options include quetiapine, lurasidone, and olanzapine-fluoxetine...Antidepressant monotherapy is discouraged. A patient-centered approach optimizing efficacy, safety, and stability is essential."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Patient and Physician Perspectives on Pharmacotherapy in Parkinson's Disease Psychosis: A Mixed-Methods Exploratory Study. (PubMed, Pharmacy (Basel)) - "Clozapine and quetiapine are widely used in the treatment of Parkinson's disease psychosis (PDP). Overall, patient priorities centered on symptom control and independence, whereas physician decisions emphasized feasibility and safety. Facilitating clozapine monitoring and incorporating patient-reported outcomes into routine care may improve patient-centered PDP management."

Journal • Agranulocytosis • Anesthesia • CNS Disorders • Granulocytopenia • Movement Disorders • Parkinson's Disease • Psychiatry