RVX 297 / Resverlogix, Zenith Epigenetics - LARVOL DELTA

Pharmacological Modulation of BET Family in Sepsis. (PubMed, Front Pharmacol) - "Small-molecule BET inhibitors (BETis) for different BDs, such as I-BET, JQ1, I-BET151, apabetalone, RVX-297, and dBET1 have shown promising therapeutic effects in experimental sepsis models. This mini-review summarizes the emerging roles of BETs and the applications of BETis in sepsis, discusses the existing shortcomings of BETis, and introduces possible future research directions in this area."

Journal • Review • Immunology • Infectious Disease • Inflammation • Septic Shock • BRD4 • CDK9