gentamicin sulfate / Generic mfg. - LARVOL DELTA

First Report of Intra-Procedural Cone-Beam CT Guiding Management of a Paraesophageal Sinus Tract (ACG 2026) - "Endoscopic closure was deferred, and the tract was irrigated with dilute gentamicin followed by a 14-day course of amoxicillin-clavulanate. Figure: Figure 1. Intra-procedural cone-beam CT evaluation of the proximal paraesophageal sinus tract, Cone-beam CT images obtained during advanced endoscopic evaluation demonstrate opacification of a proximal esophageal, paraesophageal tract extending posteriorly into the paraesophageal mediastinal space."

Atrial Fibrillation • Cardiovascular • Gastrointestinal Disorder • Infectious Disease

Gut phages are linked to off-target antimicrobial resistance genes in orthopedic patients receiving peri-surgical antibiotics. (PubMed, Front Microbiol) - "This study investigates the effects of predominantly flucloxacillin- and gentamicin-based perioperative antibiotic prophylaxis on phage and ARG dynamics in orthopedic trauma patients. Our findings suggest perioperative antibiotics may contribute to phage-associated dissemination of off-target ARGs. Understanding how ARGs spread in the gut microbiome is important for improving antibiotic stewardship and protecting vulnerable patients from difficult to treat infections."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

In vitro effects of apigenin, curcumin, and fumaric acid on intracellular ROS and TNF-α responses in Escherichia coli-stimulated canine PBMCs. (PubMed, Front Vet Sci) - "Minimum inhibitory concentration (MIC), mutant prevention concentration (MPC), and fractional inhibitory concentration (FIC) indices were determined to evaluate antimicrobial activity and interactions with enrofloxacin, amoxicillin-clavulanic acid, and gentamicin. 863, whereas fumaric acid exhibited concentration-dependent antagonism with enrofloxacin. Overall, the findings demonstrate compound- and stimulus-dependent modulation of oxidative and inflammatory responses in canine PBMCs and support further investigation of these compounds in disease-relevant models of endotoxemia and canine CIE."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Inflammation • TNFA

Localized Multidrug-Resistant Morganella morganii Urinary Tract Infection in a Dapagliflozin-Treated Man with Bladder Outlet Obstruction and Incomplete Ureteral Duplication: A Case Report. (PubMed, Reports (MDPI)) - "Antimicrobial susceptibility (VITEK® 2 Compact, EUCAST v14.0, 2024) demonstrated resistance to ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, ceftriaxone, ceftazidime, gentamicin and trimethoprim-sulfamethoxazole, with susceptibility (S) retained only to piperacillin-tazobactam, levofloxacin/norfloxacin, cefepime and carbapenems (ertapenem, meropenem)...Transurethral resection of the prostate (TUR-P) was performed 18 days after completing antibiotics (28 days after presentation) for bladder outlet obstruction refractory to tamsulosin 0.4 mg daily, with complete resolution of symptoms, normalization of inflammatory markers and PVR 0 mL...The narrative is hypothesis-generating; urinary stasis was the dominant modifiable factor. Culture-guided therapy, individualized decisions on SGLT2 continuation, and definitive correction of outlet obstruction are the practical takeaways."

Journal • Benign Prostatic Hyperplasia • Cardiovascular • Infectious Disease • Nephrology • Pain • Urology

Ignatzschineria indica bacteremia in a fatal case of accidental wound myiasis. (PubMed, Folia Microbiol (Praha)) - "Antimicrobial susceptibility tests using gradient diffusion demonstrated susceptibility to all tested antibiotics (cefotaxime, cefepime, meropenem, piperacillin/tazobactam, ciprofloxacin, trimethoprim-sulfamethoxazole and gentamicin). This is unique in Central Europe, where no report on lethal infection with I. indica has been reported so far. Hence, this paper can serve as a valuable piece of knowledge on the treatment of maggot-infested wounds, particularly where I. indica infections are concerned."

Journal • Cardiovascular • Critical care • Fibrosis • Gastroenterology • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Cirrhosis • Musculoskeletal Diseases • Orthopedics • Pulmonary Arterial Hypertension • Septic Shock

Impact of mGFR Versus eGFR on the Pharmacokinetics of a Renally Excreted Model Drug in Older Medical Patients: A Proof-of-Concept Trial. (PubMed, Kidney Int Rep) - "Creatinine-only eGFR equations may be suboptimal proxies for gentamicin clearance in this patient population. If measuring GFR is unfeasible, estimating GFR on the basis of a combination of creatinine and cystatin C is the best alternative."

Journal • PK/PD data • B2M • CST3

Ceftriaxone versus cefazolin plus gentamicin for antibiotic prophylaxis in Gustilo-Anderson type III open lower extremity fractures. (PubMed, J Orthop Trauma) - "Ceftriaxone monotherapy demonstrated similar rate of FRI and complications compared to cefazolin plus gentamicin for Gustilo-Anderson type III open lower extremity fractures. Severity of the open fracture and time to antibiotics were independently associated with higher infection risk regardless of antibiotic regimen."

Journal • Acute Kidney Injury • Infectious Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease

Hybrid PVA filaments with combined release-based and contact-active antimicrobial functionality: Structure, release, and performance. (PubMed, Biomater Adv) - "In this study, hybrid poly(vinyl alcohol) (PVA) filaments combining gentamicin sulfate (GES) as the drug-loaded phase and zinc oxide (ZnO) nanoparticles as the inorganic antimicrobial phase were developed via melt extrusion as a scalable and shapeable platform (PVA-ZnO-GES), and their key structural, mechanical, release, antimicrobial, and biological properties were comparatively evaluated against single-phase counterparts (PVA-GES and PVA-ZnO)...Cytocompatibility studies demonstrated high cell viability, supporting the suitability of the developed filaments for biomedical applications. Overall, these findings demonstrate that hybrid PVA-ZnO-GES filaments provide a versatile platform for combining controlled drug release with sustained antimicrobial functionality for biomedical applications."

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Microbiological safety and antimicrobial resistance in cashew-based plant-based cheese analogues. (PubMed, Braz J Microbiol) - "Resistance was detected in a limited number of isolates, mainly to ciprofloxacin, tetracycline, and gentamicin, whereas C. malonaticus exhibited resistance to penicillin. A total of eight antimicrobial resistance genes were identified, four of which were located on plasmids in C. malonaticus and L. brevis. These findings suggest that microorganisms associated with plant-based cheese analogues may act as reservoirs of antimicrobial resistance determinants, highlighting the importance of safety assessment and microbiological surveillance of strains intended for technological or probiotic applications."

Journal

Development and In Vitro/In Vivo Characterization of Surface-Modified Nintedanib-Loaded Nanoparticles for Enhanced Bioavailability in Chronic Kidney Disease. (PubMed, ACS Omega) - "Chronic kidney disease (CKD), a heterogeneous disorder with limited therapeutic options, is often complicated by drug-induced nephrotoxicity from aminoglycosides, such as gentamicin (GM). Immunohistochemical analysis further revealed downregulation of fibronectin, α-SMA, Smad3, and collagen III expression, and histopathology showed a reduction in tubular degeneration, extracellular matrix accumulation, and fibrosis. Collectively, these findings demonstrate that NTD-PNPs enhance the therapeutic index of nintedanib, offering a promising sustained-release nano formulation to mitigate CKD progression."

Journal • Preclinical • Chronic Kidney Disease • Fibrosis • Immunology • Nephrology • Renal Disease • FN1 • SMAD3

Antibiotic residues and antimicrobial resistance patterns of bacteria isolated from beef at Ruti Rufura Slaughterhouse, southwestern Uganda. (PubMed, Front Microbiol) - "Among 75 viable isolates, resistance was highest to ampicillin (97.3%), chloramphenicol (86.7%), tetracycline (82.7%), ceftriaxone (57.3%), and ciprofloxacin (54.7%), while gentamicin showed the highest susceptibility (86.7%). Beef marketed in southwestern Uganda frequently contains antimicrobial residues and antimicrobial-resistant bacteria, posing a potential food safety risk. Strengthened antimicrobial stewardship, enforcement of withdrawal periods, and integrated surveillance of antimicrobial residues and resistance in foods of animal origin are needed to support One Health efforts against antimicrobial resistance."

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A Population Pharmacokinetic Model of Gentamicin in Hospitalized Neonatal Foals. (PubMed, J Vet Pharmacol Ther) - "A simulated hypothetical dose of 15 mg/kg q36h demonstrated promising PTA with mean trough values ≤ 2 mg/L. Despite substantial interindividual variability, the model provides a rational basis for selecting a dosing regimen in hospitalized neonatal foals."

Journal • PK/PD data • Infectious Disease

In vitro Biofilm-forming Ability and Antiseptic and Antimicrobial Susceptibility of Bacterial Strains Derived from Surgical-site Infections in Equine Orthopedic Surgery. (PubMed, J Equine Vet Sci) - "Biofilm formation at surgical sites should be considered following equine orthopedic surgery. In this in vitro study, povidone-iodine had greater activity than other agents against established biofilms, suggesting its potential usefulness for biofilm-associated surgical site disinfection."

Journal • Preclinical • Infectious Disease • Orthopedics

Clinical Characteristics and Outcomes of Invasive Listeria Monocytogenes Infection: A 45-Year Retrospective Study at a US Tertiary Center. (PubMed, Open Forum Infect Dis) - "Most patients received a beta-lactam-based regimen, 46% aminopenicillin monotherapy, and 30% received combination therapy with gentamicin...Host factors and severity of illness at presentation appear to be key drivers of unfavorable outcomes. Larger multicenter studies are needed to define optimal management strategies."

Journal • Retrospective data • Critical care • Infectious Disease

Biogenic E. coli EPS-capped Ag/ZrO2 nanocomposites (Ag/ZrO2 NCs): synthesis, characterization, and multitarget biomedical activity. (PubMed, RSC Adv) - "COX-1 and COX-2 inhibition IC50 values were 7.43 ± 0.2 and 10.5 ± 0.1 µg mL-1 relative to celecoxib, while BSA denaturation inhibition recorded an IC50 of 2.46 ± 0.112 µg mL-1, closely approaching diclofenac sodium at 1.72 ± 0.022 µg mL-1. Antimicrobial screening by agar well diffusion showed inhibition zones of 34, 26, and 18 mm against Bacillus subtilis, Staphylococcus aureus, and MRSA, respectively, each exceeding those of gentamicin (29, 24, and 14 mm). Against Candida albicans, a zone of 30 mm was recorded against fluconazole at 29 mm...Broth microdilution yielded the lowest MIC of 7.8 µg mL-1 against both B. subtilis and C. albicans, with MBC/MIC and MFC/MIC ratios of 2 across most strains and a tightest bactericidal ratio of 1 against E. coli, keeping every strain within the ≤4 bactericidal/fungicidal cutoff. These results demonstrate that E. coli EPS03-mediated synthesis yields a physicochemically stable Ag/ZrO2 NC system..."

Journal • Infectious Disease

Topical gentamicin 0.1% as a targeted therapy in hereditary epidermolysis bullosa: A prospective open-label study (EADV 2026) - No abstract available

Clinical • Dermatology

Clinical Outcomes of Gentamicin Therapy in Dystrophic Epidermolysis Bullosa: A Case-Based Literature Review (EADV 2026) - No abstract available

Clinical • Clinical data • Review

Ultrasound Cavitation From Low-Boiling Point Perfluorocarbon Phase Change Contrast Agents Correlates With Bacterial Burden Reduction in Antibiotic Treatment of Biofilm-Infected Murine Wounds. (PubMed, Ultrasound Med Biol) - "This study provides the first in vivo evidence correlating cavitation dose to bacterial reduction in MRSA biofilm-infected wounds. These findings support cavitation monitoring as a valuable feedback tool for optimizing ultrasound-enhanced antimicrobial therapies."

Journal • Preclinical • Infectious Disease

Computational Prioritization of Megalin-Aminoglycoside Recognition and Gentamicin-Associated Cellular Stress Responses. (PubMed, Arch Biochem Biophys) - "The experimental and computational findings support a sequential in silico-to-in vitro workflow in which cellular assays define a gentamicin-associated stress phenotype, while molecular modeling identifies megalin CR10 as a structurally plausible aminoglycoside-recognition region that may contribute to tissue uptake or retention in organs expressing LRP2/megalin."

Journal • Infectious Disease

Household fungal exposure across clinical phenotypes of pulmonary aspergillosis (ERS 2026) - "Cumulative indoor bioaerosol exposure was assessed using gentamicin–Sabouraud dextrose agar plates placed on desk surfaces with windows closed and analysed at 24 and 72 hours (CFU/plate)... Household fungal exposure patterns differed across pulmonary aspergillosis phenotypes. Standardised household sampling may provide complementary exposure information and support exposure-informed prevention strategies."

Clinical • Immunology • Respiratory Diseases

Treatments for Tinnitus: Current Evidence, Emerging Therapies, and the Role of Corticosteroids (AAO-HNSF 2026) - "Agents such as selurampanel, acamprosate, sulodexide, and select antidepressant combinations showed improvement in some patients...Additional interventions, including lidocaine, botulinum toxin, and gentamicin, yielded positive effects, though gentamicin was associated with hearing loss...Among corticosteroids, dexamethasone was largely ineffective, while methylprednisolone showed more consistent symptom improvement... Overall, no single therapy demonstrated consistent efficacy across populations. While select pharmacologic agents, neuromodulation, and methylprednisolone showed potential, treatment responses varied widely. These findings underscore the need for more rigorous, high-quality clinical trials to inform evidence-based management of tinnitus."

Infectious Disease • Otorhinolaryngology

Lateral line - evoked potentials (LLEPs): an effective tool for investigating ototoxicity. (PubMed, Toxicol Appl Pharmacol) - "Fish were subjected to 0.002% and 0.003% gentamicin solution. Differences in LLEP thresholds were observed in treated versus control animals. These data indicate that LLEPs are an effective physiological measure for assessing ototoxicity."

Journal • Brain Cancer

Isolation, Risk Factors, and Antimicrobial Resistance of Escherichia coli and Salmonella in Diarrheic Calves in Sebeta, Ethiopia. (PubMed, Vet Med Int) - "Most E. coli isolates were susceptible to sulphamethoxazole-trimethoprim (93.85%), polymyxin B (78.46%), gentamicin (76.92%), and ampicillin (73.85%), whereas tetracycline showed the highest resistance (58.46%). Improved calf management, appropriate colostrum feeding, adequate bedding, and prudent antimicrobial use are recommended. Further molecular characterization is warranted to determine the specific diarrheagenic E. coli pathotypes and clarify their contribution to calf diarrhea."

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Prevalence and antibiotic resistance pattern of Staphylococcus spp. isolated from acne, and disrupting their antimicrobial resistance: unveiling the potential of Ganoderma lucidum extract. (PubMed, J Genet Eng Biotechnol) - "Gentamicin and rifampin showed 100% susceptibility in both species...Docking and dynamic simulations revealed lucidenic acid D1 strongly and stably binding ermC, while ganoderlactone B and E showed dual binding to mecA and β-lactamase, suggesting inhibition of erythromycin and amoxicillin resistance. ADMET analysis confirmed favorable pharmacokinetics and low toxicity. The study highlights high prevalence of antibiotic-resistant staphylococci in acne and demonstrates the potential of G. lucidum as an effective natural antibacterial and resistance-modifying agent, offering a promising alternative to conventional antibiotics."

Journal • Acne Vulgaris

A liquid handling platform for standardized quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes. (PubMed, Synth Biol (Oxf)) - "After optimizing the pre-incubation time of ARGs and dispensing protocol, expression of aac(3)-IIa increased the half-maximal inhibition concentration (IC50) of gentamicin by over 150-fold, whilst arr-3 increased the IC50 of rifampicin by ~20-fold compared to controls. This methodology for rapid, semi-automated ARG characterization offers a strategy to combat AMR by assessing novel ARGs identified through genomic surveillance or profiling activity of new or derivative antibiotics."

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