pethidine / Samaritan Pharma - LARVOL DELTA

Comparative efficacy and safety of dexmedetomidine and midazolam for conscious sedation in blind nasotracheal intubation: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - "Sixty patients undergoing oral and maxillofacial surgery were randomly divided into the dexmedetomidine (DEX) group (1.0 μg/kg, 15 min of infusion + pethidine 1.0 mg/kg) and the midazolam (MID) group (0.02 mg/kg + pethidine 1.0 mg/kg)...The intraoperative fentanyl dosage, end-tidal carbon dioxide partial pressure (PETCO2) were recorded, and postoperative numerical rating scale (NRS) score, satisfaction and adverse reaction incidence were evaluated...The dosage of sufentanil, the postoperative NRS score, and adverse reactions (nausea, vomiting, respiratory depression) were reduced in the DEX group (p  0.05). Dexmedetomidine used for blind nasotracheal intubation for oral and maxillofacial surgery can provide comprehensive anesthesia effects, significantly reduce the stress response of tracheal intubation and the dosage of intraoperative opioids, while maintaining good hemodynamic stability."

Intubation • Journal • Anesthesia • CNS Disorders • Depression • Otorhinolaryngology • Psychiatry

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Postspinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries: A Double-Blind Comparative Study. (PubMed, Anesthesiol Res Pract) - P=N/A | "A common and distressing consequence that may arise after spinal anesthesia (SA) is shivering. IV nefopam was more effective than DEX and pethidine in preventing shivering under SA, with fewer hemodynamic and sedative side effects. ClinicalTrials.gov identifier: NCT06627816."

Journal • Anesthesia

Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects (clinicaltrials.gov) - P=N/A | N=140 | Recruiting | Sponsor: Zohar Nachum

Adverse events • New trial • Pain

Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials. (PubMed, J Pain Res) - "SUCRA rankings identified combined physical intervention + analgesia/sedation, propofol, and water perfusion/CO2 as top overall interventions. Multimodal strategies that combine pharmacological agents, especially pethidine or propofol, with non-pharmacological techniques such as CO2 insufflation and water perfusion provide the most effective pain relief during colonoscopy."

HEOR • Journal • Retrospective data • Review • Anesthesia • Colorectal Cancer • Oncology • Pain • Solid Tumor

Comparison of the effect of preemptive pregabalin versus pethidine on postoperative pain after septorhinoplasty. (PubMed, JPRAS Open) - "This approach can improve patient satisfaction. Further research is needed to investigate the effects of different doses of pregabalin and pethidine."

Clinical • Journal • Pain

Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. (clinicaltrials.gov) - P=N/A | N=220 | Completed | Sponsor: Changhai Hospital | Enrolling by invitation ➔ Completed

Trial completion • Pancreatitis

Novel Approach: Radial Ebus Guided Bronchoscopic Transparenchymal Nodule Access (APSR 2025) - "Bronchoscopy was performed with IM pethidine 50 mg and lignocaine 1% for topical anaesthesia. Discussion : Peripheral pulmonary nodules < 2 cm in size without visible CT bronchus sign are known to be difficult to biopsy. For hospitals where technologies such as virtual bronchoscopy, electromagnetic navigation or robotic bronchoscopy are not available, bronchial branch tracing, radial ultrasound and fluoroscopy can be used to perform bronchoscopic transparenchymal nodule access."

Endobronchial ultrasound • Anesthesia • Anorexia • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

Single Centre Experience of Transbronchial Peripheral Lung Nodule Biopsy with Bronchial Branch Tracing, Radial Miniprobe and Fluoroscopy (APSR 2025) - "All patients underwent moderate sedation with midazolam, fentanyl or pethidine. Bronchoscopies were performed with Olympus 1TH1100 with K203 guide sheath and 20R radial ultrasound, or P190 with K201 and 17S radial ultrasound, or MP 190 with 17s radial ultrasound...The solitary patient without specific diagnosis is currently on follow up with repeat CT imaging. Conclusion : Bronchial branch tracing, radial endobronchial ultrasound and fluoroscopy remains a feasible technique with good diagnostic yield for evaluation of peripheral lung nodules."

Biopsy • Clinical • Anesthesia

OPIOID AVAILABILITY FOR PAIN IN PEDIATRIC ONCOLOGY POPULATIONS IN LOW- AND MIDDLE-INCOME COUNTRIES: A PAUCITY OF RESEARCH (SIOP 2025) - "The most frequently reported opioids were morphine and fentanyl, in 11 and 10 articles respectively, followed by tramadol (4), pethidine, methadone, and codeine (2 each), and tapentadol, remifentanil, alfentanil, and oxycodone (one each). Our finding of limited opioid research in pediatric oncology in LMICs highlights a significant research gap and possibly limited access to opioids for pain in LMICs in pediatric oncology. In the context in which opioid distribution is unequal and inequitable generally, this is especially concerning for the vulnerable pediatric oncology population."

Clinical • Pain • Palliative care • Pediatrics

High-dose Oral Vitamin C Supplementation and Acute Pain Control Following Laparoscopic Cholecystectomy: A Randomized Controlled Study. (PubMed, J Perianesth Nurs) - "This study showed that high-dose oral vitamin C was ineffective for pain reduction after LC."

Journal • Pain

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections (clinicaltrials.gov) - P4 | N=330 | Completed | Sponsor: Ain Shams University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia

Effect of virtual reality on perioperative anxiety, stress and pain in total hip arthroplasty: a randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "VR can reduce perioperative anxiety, stress, pain, and opioid requirements, and improve satisfaction in THA patients."

Clinical • Journal • Anesthesia • Mood Disorders • Orthopedics • Pain • Psychiatry

Comparative Effectiveness of Continuous Intra-Operative Suprascapular Nerve Block (CI-SSNB) with and Without Intravenous Patient-Controlled Analgesia (IV-PCA) on Acute Post-Arthroscopy Pain: A Retrospective Cohort Study. (PubMed, J Clin Med) - "This retrospective cohort study aimed to compare the analgesic efficacy and safety of continuous intra-operative suprascapular nerve block (CI-SSNB) alone versus CI-SSNB combined with fentanyl-based IV-PCA (CI-SSNB + IV-PCA)...The total number of rescue pethidine doses up to post-operative day 3 was 1.80 ± 2.02 vs. 0.95 ± 1.10, respectively (p = 0.108). However, adverse effects such as nausea and vomiting occurred only in the CI-SSNB + IV-PCA group. CI-SSNB provides comparable analgesia to CI-SSNB + IV-PCA, while avoiding IV-PCA-related side effects, suggesting that IV-PCA may not be necessary when CI-SSNB is employed for post-operative analgesia following ARCR."

HEOR • Journal • Retrospective data • Anesthesia • Orthopedics • Pain

Adverse Events of Single Balloon Enteroscopy-assisted Endoscopic Retrograde Cholangiopancreatography in the Elderly: A Propensity Score Matching Analysis. (PubMed, DEN Open) - "We retrospectively analyzed consecutive patients with surgically altered anatomy who underwent their initial BE-ERCP using midazolam and pethidine at our institution between January 2016 and December 2022. Cardiopulmonary complications and ERCP-related AEs were similar in elderly and non-elderly patients undergoing BE-ERCP. With careful monitoring, sedation during BE-ERCP appeared safe, even for elderly patients."

Adverse events • Journal • Anesthesia • Cardiovascular • CNS Disorders • Hypotension

Prevalence and types of medication errors in pro re nata medication orders among hospitalized patients: a cross-sectional study. (PubMed, J Pharm Health Care Sci) - "The high frequency of PRN prescribing errors underscores the urgent need for improved documentation and targeted training. Structured interventions such as electronic prescribing and focused medical education can help reduce errors and improve patient safety. Structured interventions such as electronic prescribing, regulatory enforcement, and focused medical education can help reduce errors and improve patient safety."

Journal • Observational data

Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample. (PubMed, BMC Chem) - "Furthermore, it enabled the simultaneous detection of pethidine and paracetamol in biological samples, with low detection limits of 980 pmol L⁻1 and 977 pmol L⁻1 for PTD and PCM, respectively. The sensor offers a promising tool for point of care diagnostics and routine analysis due to its sensitivity, simplicity, and cost-effectiveness."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Pain • Psychiatry

Simulated client study on the dispensing practices for narcotic and psychotropic medications in community drug outlets in Ethiopia. (PubMed, Drugs Context) - "A total of nine types of narcotic and psychotropic medications were dispensed without prescription, the most common of which were amitriptyline, followed by tramadol, carbamazepine, pethidine and haloperidol. This study revealed a high prevalence of non-prescription dispensing of narcotic and psychotropic medications, particularly in response to assertive client requests. Urgent regulatory measures are needed to ensure adherence to prescription-only policies, especially for frequently dispensed drugs such as amitriptyline, tramadol and chlorpromazine."

Journal • CNS Disorders • Depression • Psychiatry

Inadequate pain management in prehospital emergency care: a retrospective study from Krapina-Zagorje County. (PubMed, Croat Med J) - "Despite wide accessibility of analgesics, pain is still not treated adequately in the Emergency Department of Krapina-Zagorje County."

Journal • Retrospective data • Pain • Palliative care

Comparative efficacy of memantine and vitamin C in postoperative pain management: a randomized clinical trial. (PubMed, Pain Manag) - "Pain was assessed using the visual analogue scale (VAS) at 0, 6, 12, and 24 hours postoperatively, with pethidine rescue analgesia (VAS >V). Further multicenter trials with larger cohorts and extended observation are warranted to confirm these results and optimize dosing strategies. https://irct.behdasht.gov.ir/trial/80349 is: IRCTID: IRCT20240120060739N1)."

Clinical • Journal • Pain

Comparison of hypnosis plus sedoanalgesia and sedoanalgesia alone methods used in the ERCP procedure: A prospective randomized study. (PubMed, Medicine (Baltimore)) - "Both groups were administered 0.5 to 0.6 mg/kg intravenous pethidine hydrochloride (HCl), 1 to 3 mg intravenous midazolam, and 1 to 2 mg/kg intravenous propofol. The use of hypnosis during ERCP enhances the efficacy of sedoanalgesia. Hypnotic anesthesia may be employed as an alternative method in cases where high-dose administration of these agents is contraindicated."

Clinical • Journal • Anesthesia • Hepatology

Efficacy and Safety of G Protein-Biased μ-Opioid Receptor Agonists in the Treatment of Moderate-to-Severe Pain Following Off-Pump Coronary Artery Bypass Grafting: A Randomized Blinded Study (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Qilu Hospital of Shandong University Dezhou Hospital; Qilu Hospital of Shandong University Dezhou Hospital

New trial • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Heart Failure • Pain

Comparison of analgesic efficacy of tramadol, petidine and morphine in the treatment of pain after elective thoracic surgery under the Erector Spina Plan (ESP) block: preliminary results (Euroanaesthesia 2025) - "Effective pain management reduces complications and accelerates recovery.The aim of this study is to compare the analgesic efficacy of tramadol (T), pethidine (P), morphine (M) under ESP block and to monitor their effectiveness using the Analgesic Nociceptor Index (ANI).Materials and A single-center, prospective,RCT was conducted between 10/ 2023-11/2024, involving 50 patients who underwent elective thoracic surgery.After obtaining informed consent,patients were randomly assigned to 3 opioid groups.In OR,ASA monitoring was applied and ESP block was applied for pain management.Group T received 1 mg/kg loading dose followed by T-PCA.Group M received 0.1 mg/kg loading dose followed by M-PCA.Group P received 1 mg/kg loading dose followed by P-PCA. No significant differences in RASS 1-2 scores between 3 groups.Conclusion(s): This study is the first to compare 3 opioid groups under ESP block in thoracic surgery. While ANI is more commonly used in intubated patients,there are..."

Clinical • Surgery • Anesthesia • CNS Disorders • Constipation • Depression • Gastroenterology • Gastrointestinal Disorder • Musculoskeletal Pain • Pain • Psychiatry • Respiratory Diseases

Validity of Bronchoscopist Assessment of Patient Discomfort During Flexible Bronchoscopy: An Observational Study. (PubMed, Cureus) - "Bronchoscopists may underestimate patient discomfort during bronchoscopy under intravenous sedation. The use of midazolam was an important factor affecting the patient's discomfort during bronchoscopy."

Journal • Observational data • Anesthesia

Differences in Clinical Characteristics Between Missed and Detected Laryngopharyngeal Cancers. (PubMed, J Gastroenterol Hepatol) - "This study highlights the importance of precisely observing the laryngopharynx, facilitated by the use of pethidine hydrochloride and narrow-band imaging. In addition, epiglottic lesions are frequently missed. Comprehensive observation of the laryngopharynx using narrow-band imaging and premedication may reduce the frequency of missed cancers."

Journal • Esophageal Cancer • Gastric Cancer • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma

Anaesthesia for castration of 2 - 8 day old piglets using dexmedetomidine--alfaxalone with or without butorphanol or pethidine. (PubMed, Schweiz Arch Tierheilkd) - "Current intramuscular anaesthesia for piglet castration, involving azaperone and ketamine, is unsatisfactory in terms of anaesthesia and recovery. No further testing was conducted. In conclusion, none of the tested combinations of alfaxalone and dexmedetomidine, whether with or without an opioid, provided satisfactory anaesthesia for surgical castration in piglets aged between two and eight days."

Journal • Anesthesia