pethidine / Samaritan Pharma - LARVOL DELTA

Perioperative management of a patient with Kennedy disease undergoing knee replacement: A case report (PubMed, Beijing Da Xue Xue Bao Yi Xue Ban) - "After sufficient preoperative consultation and evaluation, femoral nerve block was performed with 0.25% ropivacaine under guidance with ultrasound and nerve stimulator, followed by induction of general anesthesia with sufentanil, propofol, and etomidate...During the operation, propofol and remifentanil were used for total intravenous anesthesia...A postoperative analgesia combination of nerve block and oral nonsteroidal analgesics was performed, and emergency pain rescue with pethidine was administered if necessary. The analgesic effect was satisfactory. The patient was safely discharged in the end and recovered well."

Journal • Anesthesia • Cardiovascular • Coronary Artery Disease • Genetic Disorders • Heart Failure • Infectious Disease • Muscular Atrophy • Musculoskeletal Diseases • Orthopedics • Pain • Respiratory Diseases

Double-blind randomized noninferiority study of the effect of pharyngeal lidocaine anesthesia on EUS. (PubMed, Endosc Ultrasound) - "Secondary outcomes included endoscopist and patient satisfaction, midazolam/pethidine doses, number of gag events, number of esophageal insertion attempts, use of sedative/analgesic antagonists, interruptions due to body movements, throat symptoms after endoscopy, and sedation-related adverse events...These results suggest that pharyngeal anesthesia with lidocaine can be omitted when performing EUS under sedation with concomitant analgesics. Omitting pharyngeal anesthesia with lidocaine may prevent discomfort and complications caused by pharyngeal anesthesia, shorten examination times, and reduce medical costs."

Head-to-Head • Journal • Allergy • Anesthesia • Pain

Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances: Potential Drug Interactions and Substance Use Disorder Treatment Data. (PubMed, CNS Drugs) - "Suspected cases of serotonin toxicity have been reported for MAOIs in combination with amphetamine, dextromethorphan, 3,4-methylenedioxymethamphetamine (MDMA), meperidine (pethidine), methadone, and tramadol...Fatalities have been reported for MAOIs in combination with 5-MeO-DMT, amphetamine, dextroamphetamine, dextromethorphan (in overdose), MDMA, methamphetamine, meperidine, and tramadol (in overdose)...While there was initially hope MAOIs might effectively treat some SUDs, there are no robust human data to support their efficacy in this context. Given growing levels of substance use and an increasing number of novel illicit compounds being produced, more research on MAOI safety in patients with psychiatric conditions and comorbid psychoactive substance use/misuse is essential to determining their appropriateness in this complex patient population."

Journal • Review • Addiction (Opioid and Alcohol) • Anesthesia • Bipolar Disorder • Cerebral Hemorrhage • CNS Disorders • Depression • Hematological Disorders • Mood Disorders • Psychiatry

Effectiveness of maintaining oxygenation of a new high flow nasal cannula for endoscopic retrograde cholangiopancreatography during intravenous anesthesia. (PubMed, Trials) - "This study aims to generate evidence supporting the utility of HFNC as a potential therapeutic device for ERCP under sedation by determining whether the incidence rates of hypercapnia and hypoxemia are lower in the HFNC group than in the LFNC group. TRIAL REGISTRATION {2A,2B}: The study was registered as jRCTs072240096 on January 16, 2025."

Journal • Anesthesia • CNS Disorders • Depression • Pain • Psychiatry

Comparing the efficacy of pethidine and ketorolac in managing postoperative pain following orthopedic fracture surgery in addicts: a prospective clinical study. (PubMed, Ann Med Surg (Lond)) - "Both pethidine and ketorolac provided effective postoperative analgesia in patients with substance use disorder undergoing orthopedic fracture surgery, with comparable efficacy and safety profiles. The choice between these analgesics should consider individual patient characteristics and the potential for substance misuse."

Journal • CNS Disorders • Musculoskeletal Diseases • Orthopedics • Pain • Psychiatry

Ultrasound Guided TAPB vs Surgical TAPB With Bupivacaine in Cesarean Section (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Al-Azhar University | Trial completion date: Nov 2024 ➔ Dec 2026 | Trial primary completion date: Nov 2024 ➔ Dec 2026

Trial completion date • Trial primary completion date • Pain

Prophylactic Role of Ketamine and Dexmedetomidine on the Prevention of Shivering in Patients Undergoing Inguinal Herniorrhaphy by Spinal Anesthesia: A Randomized Clinical Trial. (PubMed, Anesth Pain Med) - "Due to the potential complications associated with the use of pethidine, such as respiratory failure, the exploration of alternative drugs for the prevention and treatment of postoperative shivering has been a key consideration. Throughout all time periods, patients in the dexmedetomidine group exhibited significantly lower heart rates. Both ketamine and dexmedetomidine proved effective in reducing post-herniorrhaphy shivering compared to the control group, with the effect being notably greater in the dexmedetomidine group."

Clinical • Journal • Anesthesia • Respiratory Diseases

Nitrous oxide in labor and neonatal hyperbilirubinemia: a retrospective propensity score-matched study (2012-2023). (PubMed, Int J Obstet Anesth) - "Intrapartum nitrous oxide analgesia was not associated with increased neonatal hyperbilirubinemia compared with other labor analgesic modalities. However, the NICU admission rate after nitrous oxide exposure was significantly higher."

Journal • Retrospective data • Critical care • Hypoglycemia • Pain

Evaluating the role of preemptive intravenous ketorolac in preventing post-operative pain in patients undergoing hemorrhoidectomy: A randomized clinical trial. (PubMed, Surgeon) - "We found that NSAIDs, particularly ketorolac, can be used as preemptive medication to reduce postoperative pain and decrease the use of opioids. This might lead to a decrease in the side effects of opioids. However, further evaluations with larger populations and longer follow-up periods are essential. This randomized clinical trial registration code is IRCT20240808062692N1."

Clinical • Journal • Gastroenterology • Gastrointestinal Disorder • Pain

Comparative efficacy and safety of dexmedetomidine and midazolam for conscious sedation in blind nasotracheal intubation: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - "Sixty patients undergoing oral and maxillofacial surgery were randomly divided into the dexmedetomidine (DEX) group (1.0 μg/kg, 15 min of infusion + pethidine 1.0 mg/kg) and the midazolam (MID) group (0.02 mg/kg + pethidine 1.0 mg/kg)...The intraoperative fentanyl dosage, end-tidal carbon dioxide partial pressure (PETCO2) were recorded, and postoperative numerical rating scale (NRS) score, satisfaction and adverse reaction incidence were evaluated...The dosage of sufentanil, the postoperative NRS score, and adverse reactions (nausea, vomiting, respiratory depression) were reduced in the DEX group (p  0.05). Dexmedetomidine used for blind nasotracheal intubation for oral and maxillofacial surgery can provide comprehensive anesthesia effects, significantly reduce the stress response of tracheal intubation and the dosage of intraoperative opioids, while maintaining good hemodynamic stability."

Intubation • Journal • Anesthesia • CNS Disorders • Depression • Otorhinolaryngology • Psychiatry

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Postspinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries: A Double-Blind Comparative Study. (PubMed, Anesthesiol Res Pract) - P=N/A | "A common and distressing consequence that may arise after spinal anesthesia (SA) is shivering. IV nefopam was more effective than DEX and pethidine in preventing shivering under SA, with fewer hemodynamic and sedative side effects. ClinicalTrials.gov identifier: NCT06627816."

Journal • Anesthesia

Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects (clinicaltrials.gov) - P=N/A | N=140 | Recruiting | Sponsor: Zohar Nachum

Adverse events • New trial • Pain

Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials. (PubMed, J Pain Res) - "SUCRA rankings identified combined physical intervention + analgesia/sedation, propofol, and water perfusion/CO2 as top overall interventions. Multimodal strategies that combine pharmacological agents, especially pethidine or propofol, with non-pharmacological techniques such as CO2 insufflation and water perfusion provide the most effective pain relief during colonoscopy."

HEOR • Journal • Retrospective data • Review • Anesthesia • Colorectal Cancer • Oncology • Pain • Solid Tumor

Comparison of the effect of preemptive pregabalin versus pethidine on postoperative pain after septorhinoplasty. (PubMed, JPRAS Open) - "This approach can improve patient satisfaction. Further research is needed to investigate the effects of different doses of pregabalin and pethidine."

Clinical • Journal • Pain

Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. (clinicaltrials.gov) - P=N/A | N=220 | Completed | Sponsor: Changhai Hospital | Enrolling by invitation ➔ Completed

Trial completion • Pancreatitis

Novel Approach: Radial Ebus Guided Bronchoscopic Transparenchymal Nodule Access (APSR 2025) - "Bronchoscopy was performed with IM pethidine 50 mg and lignocaine 1% for topical anaesthesia. Discussion : Peripheral pulmonary nodules < 2 cm in size without visible CT bronchus sign are known to be difficult to biopsy. For hospitals where technologies such as virtual bronchoscopy, electromagnetic navigation or robotic bronchoscopy are not available, bronchial branch tracing, radial ultrasound and fluoroscopy can be used to perform bronchoscopic transparenchymal nodule access."

Endobronchial ultrasound • Anesthesia • Anorexia • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

Single Centre Experience of Transbronchial Peripheral Lung Nodule Biopsy with Bronchial Branch Tracing, Radial Miniprobe and Fluoroscopy (APSR 2025) - "All patients underwent moderate sedation with midazolam, fentanyl or pethidine. Bronchoscopies were performed with Olympus 1TH1100 with K203 guide sheath and 20R radial ultrasound, or P190 with K201 and 17S radial ultrasound, or MP 190 with 17s radial ultrasound...The solitary patient without specific diagnosis is currently on follow up with repeat CT imaging. Conclusion : Bronchial branch tracing, radial endobronchial ultrasound and fluoroscopy remains a feasible technique with good diagnostic yield for evaluation of peripheral lung nodules."

Biopsy • Clinical • Anesthesia

OPIOID AVAILABILITY FOR PAIN IN PEDIATRIC ONCOLOGY POPULATIONS IN LOW- AND MIDDLE-INCOME COUNTRIES: A PAUCITY OF RESEARCH (SIOP 2025) - "The most frequently reported opioids were morphine and fentanyl, in 11 and 10 articles respectively, followed by tramadol (4), pethidine, methadone, and codeine (2 each), and tapentadol, remifentanil, alfentanil, and oxycodone (one each). Our finding of limited opioid research in pediatric oncology in LMICs highlights a significant research gap and possibly limited access to opioids for pain in LMICs in pediatric oncology. In the context in which opioid distribution is unequal and inequitable generally, this is especially concerning for the vulnerable pediatric oncology population."

Clinical • Pain • Palliative care • Pediatrics

High-dose Oral Vitamin C Supplementation and Acute Pain Control Following Laparoscopic Cholecystectomy: A Randomized Controlled Study. (PubMed, J Perianesth Nurs) - "This study showed that high-dose oral vitamin C was ineffective for pain reduction after LC."

Journal • Pain

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections (clinicaltrials.gov) - P4 | N=330 | Completed | Sponsor: Ain Shams University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia

Effect of virtual reality on perioperative anxiety, stress and pain in total hip arthroplasty: a randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "VR can reduce perioperative anxiety, stress, pain, and opioid requirements, and improve satisfaction in THA patients."

Clinical • Journal • Anesthesia • Mood Disorders • Orthopedics • Pain • Psychiatry

Comparative Effectiveness of Continuous Intra-Operative Suprascapular Nerve Block (CI-SSNB) with and Without Intravenous Patient-Controlled Analgesia (IV-PCA) on Acute Post-Arthroscopy Pain: A Retrospective Cohort Study. (PubMed, J Clin Med) - "This retrospective cohort study aimed to compare the analgesic efficacy and safety of continuous intra-operative suprascapular nerve block (CI-SSNB) alone versus CI-SSNB combined with fentanyl-based IV-PCA (CI-SSNB + IV-PCA)...The total number of rescue pethidine doses up to post-operative day 3 was 1.80 ± 2.02 vs. 0.95 ± 1.10, respectively (p = 0.108). However, adverse effects such as nausea and vomiting occurred only in the CI-SSNB + IV-PCA group. CI-SSNB provides comparable analgesia to CI-SSNB + IV-PCA, while avoiding IV-PCA-related side effects, suggesting that IV-PCA may not be necessary when CI-SSNB is employed for post-operative analgesia following ARCR."

HEOR • Journal • Retrospective data • Anesthesia • Orthopedics • Pain

Adverse Events of Single Balloon Enteroscopy-assisted Endoscopic Retrograde Cholangiopancreatography in the Elderly: A Propensity Score Matching Analysis. (PubMed, DEN Open) - "We retrospectively analyzed consecutive patients with surgically altered anatomy who underwent their initial BE-ERCP using midazolam and pethidine at our institution between January 2016 and December 2022. Cardiopulmonary complications and ERCP-related AEs were similar in elderly and non-elderly patients undergoing BE-ERCP. With careful monitoring, sedation during BE-ERCP appeared safe, even for elderly patients."

Adverse events • Journal • Anesthesia • Cardiovascular • CNS Disorders • Hypotension

Prevalence and types of medication errors in pro re nata medication orders among hospitalized patients: a cross-sectional study. (PubMed, J Pharm Health Care Sci) - "The high frequency of PRN prescribing errors underscores the urgent need for improved documentation and targeted training. Structured interventions such as electronic prescribing and focused medical education can help reduce errors and improve patient safety. Structured interventions such as electronic prescribing, regulatory enforcement, and focused medical education can help reduce errors and improve patient safety."

Journal • Observational data

Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample. (PubMed, BMC Chem) - "Furthermore, it enabled the simultaneous detection of pethidine and paracetamol in biological samples, with low detection limits of 980 pmol L⁻1 and 977 pmol L⁻1 for PTD and PCM, respectively. The sensor offers a promising tool for point of care diagnostics and routine analysis due to its sensitivity, simplicity, and cost-effectiveness."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Pain • Psychiatry