pethidine / Samaritan Pharma - LARVOL DELTA

Respiratory Support With Nasal High Flow Reduces Opioid Requirements During Endoscopic Retrograde Cholangiopancreatography. (PubMed, DEN Open) - "Sedation used dexmedetomidine, midazolam and pethidine with a standardized protocol. The ability of NHF to provide respiratory support, ensure adequate oxygenation, and allow monitoring of breathing makes it a promising modality during procedural sedation; however, further multi-center studies are needed. 072210047 [jRCTs]."

Journal • Anesthesia • CNS Disorders • Depression • Psychiatry

CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery) (clinicaltrials.gov) - P2/3 | N=881 | Active, not recruiting | Sponsor: KK Women's and Children's Hospital | Trial completion date: Dec 2026 ➔ Dec 2027

Trial completion date • Anesthesia • CNS Disorders • Depression • Mood Disorders • Obstetrics • Pain • Postpartum Depression • Psychiatry

Prophylactic Efficacy of Intravenous Nefopam Versus Ondansetron in Preventing Post-Spinal Shivering in Parturients Undergoing Elective Caesarean Section: A Double-Blind Randomised Controlled Trial. (PubMed, Niger Med J) - "Group N received intravenous nefopam (0.15 mg/kg), Group O received intravenous ondansetron (0.1 mg/kg), and Group P received 10 mL of normal saline as a placebo...Side effects and the need for rescue medication (intravenous pethidine 0.5 mg/kg) were also recorded...Intravenous nefopam and ondansetron are similarly effective in preventing post-spinal shivering and reducing rescue analgesia requirements during caesarean section under spinal anaesthesia. Ondansetron showed better antiemetic effect, while nefopam was associated with mild injection-site discomfort."

Journal • Review • Anesthesia • Obstetrics • Pain

Opioid prescribing trends in pain management clinics in Taiwan: 2008-2018: A population-based retrospective study. (PubMed, Medicine (Baltimore)) - "Morphine was the most prescribed opioid, while pethidine declined markedly; oxycodone, introduced in 2016, surged to 4024 prescriptions by 2018. Opioid prescribing in Taiwanese PMCs was stable overall, with a shift from traditional agents toward newer high-potency opioids. The predominance of non-cancer pain indications and the centralization of prescribing within medical centers highlight the need for targeted stewardship policies and post-market surveillance of newly introduced opioids."

Journal • Retrospective data • Head and Neck Cancer • Neuralgia • Oncology • Oral Cancer • Pain • Pancreatic Cancer • Pancreatitis • Solid Tumor

Ultrasound guided external oblique intercostal plane block versus posterior transversus abdominis plane block for postoperative analgesia in adult patients undergoing open nephrectomy: a randomized trial. (PubMed, BMC Anesthesiol) - P=N/A | "In adults undergoing OPN, EOIPB provided superior early postoperative analgesia compared to TAPB during the first 18 h after surgery, as evidenced by lower pain scores, reduced opioid requirements, delayed time first to rescue analgesia, and higher patient satisfaction. Both blocks demonstrated comparable safety profiles."

Clinical • Journal • Anesthesia • Pain

Comparison between ultrasound guided pericapsular nerve group (PENG) block and interscalene brachial plexus block for postoperative analgesia following shoulder arthroscopy: a randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "The present study concludes that the ultrasound-guided PENG block can provide effective management of postoperative pain following shoulder arthroscopy. Importantly, the PENG block offers this benefit with adequate safety profile."

Clinical • Journal • Anesthesia • Orthopedics • Pain

Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia Surgery (clinicaltrials.gov) - P2 | N=50 | Completed | Sponsor: Kasr El Aini Hospital | Recruiting ➔ Completed

Trial completion • Gastroenterology

On pethidine: The 'accidental' opioid that became a 'model' analgesic agent. (PubMed, Anaesth Intensive Care) - "A 1939 German publication on a search for novel synthetic atropine substitutes reported that 'Substanz III', named Dolantin (now generically known as pethidine and meperidine), was found coincidentally to also have morphine-like, albeit markedly weaker, analgesic properties. The 1970s' discovery of spinal opioid receptors and mechanisms led to neuraxial pethidine administration being investigated and subsequently integrated into standard clinical practice. Although pethidine has now been superseded in many countries, it served as an important 'model' drug to investigate how to improve the use of opioid analgesic agents for the management of severe pain."

Journal • Pain

Nationwide trends in intravenous sedative and analgesic drug use in Korean dental institutions: a big data analysis using the Narcotics Information Management System from 2020 to 2024. (PubMed, J Dent Anesth Pain Med) - "The drugs analyzed included midazolam, propofol, ketamine, and remimazolam (used for intravenous sedation), as well as fentanyl, remifentanil, and pethidine (used as analgesic adjuncts). The use of IV sedation in Korean dentistry is consistently increasing. Safe IV sedation methods, primarily involving midazolam, are being widely implemented for adults in dental clinic settings."

Journal • Anesthesia • Mood Disorders • Pain • Psychiatry

The Effect of Multimodal Analgesia on Postoperative Pain Management: A Study From a Pain-Free Hospital Project. (PubMed, Pain Physician) - "Our study demonstrates that implementing a structured perioperative protocol emphasizing preemptive analgesia and multimodal analgesia resulted in pain management effects, including decreased incidences of severe postoperative pain and reduced analgesic opioid consumption."

Journal • Observational data • Infectious Disease • Novel Coronavirus Disease • Pain

Ultrasound-Guided Erector Spinae Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Adult Patients Undergoing Laparoscopic Appendectomy. (PubMed, Anesthesiol Res Pract) - P=N/A | "Secondary outcomes included time to first rescue analgesia, total 24 h pethidine consumption, intraoperative fentanyl requirements, and adverse events. The erector spinae plane block provides superior postoperative analgesia after laparoscopic appendectomy and supports its inclusion in multimodal analgesic pathways. Trial Registration: ClinicalTrials.gov: NCT06220513."

Clinical • Journal • Anesthesia • Pain

Efficacy and safety of nalbuphine vs. pethidine in oocyte retrieval: a non-inferiority, double-blinded, randomized controlled trial. (PubMed, Front Reprod Health) - "The intervention group received 10 mg intravenous Nalbuphine combined with 5 mg of Midazolam, while the control group received 50 mg intravenous Pethidine with 5 mg of Midazolam. Its impact on long-term reproductive outcomes and clinical superiority warrants further investigation. https://www.thaiclinicaltrials.org/show/TCTR20240406003, identifier TCTR20240406003."

Clinical • Head-to-Head • Journal • Cardiovascular • Pain

Pre-surgical medical interventions for treatment of pediatric post-tonsillectomy pain: A Systematic Review and Meta-Analysis (COSM 2026) - "IV and PO acetaminophen, IM diclofenac, INF ketamine, IV lidocaine, PO midazolam, IM papaveretum, IV parecoxib, IM and IV pethidine, INF ropivacaine, IM tenoxicam, and IV and INF tramadol showed no difference from placebo in percentage of patients requiring rescue analgesia. A total of 2,952 articles were screened, and 75 RCTs met inclusion criteria. Patients receiving IV or INF dexmedetomidine had the longest time to request additional analgesia post-surgically (µ = 583.45 minutes, 95% CI [524.9, 641.2] and µ = 537.6 minutes, 95% CI [498.3, 576.9], respectively), followed by INF levobupivacaine (µ = 460.98 min, 95% CI [281.9, 640.0]). IV ketamine or INF levobupivacaine demonstrated the shortest time to resumption of oral intake (µ = 127.452 minutes, 95% CI [41.1, 213.8], and µ = 126.2 minutes, 95% CI [108.4, 143.9] respectively)."

Retrospective data • Review • Pain • Pediatrics

Effectiveness of Magnesium Sulfate for Post-Cesarean Pain Control: A Double-blind Clinical Trial : Magnesium Sulfate for Post-cesarean Pain. (PubMed, Galen Med J) - "Although there was a difference in pain scores between the intervention and control groups up to 24 hours after surgery, this difference was not statistically significant (P0.05). This study showed that the administration or non-administration of magnesium sulfate has no effect on increasing the time of postpartum analgesia and reducing the need for pethidine."

Journal • Anesthesia • Pain

Labour pain management practices in a teaching tertiary hospital in Botswana: a cross-sectional study. (PubMed, Pan Afr Med J) - "Common analgesics included pethidine (98.2%), paracetamol (50.0%), and morphine (19.6%), while deep breathing (82.1%), massaging (78.6%), and reassurance (69.6%) were common non-pharmacological methods. key barriers to labour pain management were inadequate training and a shortage of equipment and supplies. Enhancing capacity building, ensuring resource availability, and developing locally appropriate protocols could significantly improve labour analgesia service and its effective application."

Journal • Observational data • CNS Disorders • Depression • Mood Disorders • Obstetrics • Pain • Psychiatry

A Clinical Study on the Analgesic Effect of Acupuncture at Zulinqi (GB41) Based on the Theory of "Eight Confluent Points" for Acute Ureteral Stone Pain (ChiCTR) - P=N/A | N=56 | Completed | Sponsor: Beijing University of Chinese Medicine Fangshan Hospital; Beijing University of Chinese Medicine Fangshan Hospital

New trial • Pain • Renal Calculi

Pre-surgical medical interventions for treatment of pediatric post-tonsillectomy pain: A Systematic Review and Meta-Analysis (COSM 2026) - "IV and PO acetaminophen, IM diclofenac, INF ketamine, IV lidocaine, PO midazolam, IM papaveretum, IV parecoxib, IM and IV pethidine, INF ropivacaine, IM tenoxicam, and IV and INF tramadol showed no difference from placebo in percentage of patients requiring rescue analgesia. A total of 2,952 articles were screened, and 75 RCTs met inclusion criteria. Patients receiving IV or INF dexmedetomidine had the longest time to request additional analgesia post-surgically (µ = 583.45 minutes, 95% CI [524.9, 641.2] and µ = 537.6 minutes, 95% CI [498.3, 576.9], respectively), followed by INF levobupivacaine (µ = 460.98 min, 95% CI [281.9, 640.0]). IV ketamine or INF levobupivacaine demonstrated the shortest time to resumption of oral intake (µ = 127.452 minutes, 95% CI [41.1, 213.8], and µ = 126.2 minutes, 95% CI [108.4, 143.9] respectively)."

Retrospective data • Review • Pain • Pediatrics

Perioperative hypersensitivity reactions: a retrospective study (2018-2023) in a Lebanese tertiary clinic. (PubMed, Front Pharmacol) - "We assessed co-sensitization within the same drug class, identifying rocuronium and cisatracurium as the NMBAs with the highest co-sensitization, while morphine and pethidine showed the highest co-sensitization among opioids. Among the 124 patients with a history of POH reactions, SPTs results identified the causative agent, primarily morphine, fentanyl or rocuronium, in 38 patients. This study provides valuable insights into the clinical characteristics of POH reactions in Lebanon and highlights the role of SPTs in identifying causative agents thus allowing to suggest alternative perioperative options."

Journal • Retrospective data • Allergy • Anesthesia • Food Hypersensitivity • Immunology

LC-MS/MS methods for synthetic opioids in urine: analytical and clinical evaluation. (PubMed, Clin Chim Acta) - "This review critically evaluates liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the determination of buprenorphine, methadone, tramadol, fentanyl, and pethidine in urine. Overall, LC-MS/MS remains the most reliable confirmatory approach for urinary opioid analysis; however, challenges persist in the harmonization of analytical protocols, differentiation of structurally similar analogs, and standardization of matrix-effect evaluation. Future developments should focus on harmonization and integration of advanced analytical strategies to enhance clinical and forensic applicability."

Journal • Review • Pain

Association between Examination Time and Discomfort in Unsedated Esophagogastroduodenoscopy: A Prospective Observational Study. (PubMed, GE Port J Gastroenterol) - "Explanatory variables included age, sex, pethidine use, butylscopolamine use, current smoking status, alcohol intake, endoscopist, and examination time (minutes)...Therefore, the clinical impact of heightened discomfort due to longer examination times is considered to be minimal. Endoscopists should prioritize adequate examination time to ensure the most accurate esophagogastroduodenoscopy."

Journal • Observational data • Addiction (Opioid and Alcohol) • Anesthesia • Pain

Intravenous Tranexamic Acid-Induced Anaphylaxis. (PubMed, J Dermatol) - No abstract available

Journal • Immunology

Effects of Caudal Epidural Pethidine on Pain Control and Early Mobilization after Posterior Spinal Instrumentation: A Randomized Controlled Trial. (PubMed, Turk Neurosurg) - "Administering pethidine via a caudal epidural block before awakening at the conclusion of PLI surgery may provide benefits in postoperative pain controlandearlymobilization."

Journal • Anesthesia • Pain

Comparison of intravenous pethidine and sublingual buprenorphine on postoperative pain severity in patients with vertebral fracture surgery: a randomized multicenter, double-blind controlled trial. (PubMed, Ann Med Surg (Lond)) - "Sublingual buprenorphine does not differ from intravenous pethidine regarding pain intensity following vertebral fracture surgery; however, it is considered safer with fewer side effects. Furthermore, the trend of pain changes in both treatment groups did not show significant differences."

Clinical • Journal • Musculoskeletal Diseases • Orthopedics • Pain

Perioperative management of a patient with Kennedy disease undergoing knee replacement: A case report (PubMed, Beijing Da Xue Xue Bao Yi Xue Ban) - "After sufficient preoperative consultation and evaluation, femoral nerve block was performed with 0.25% ropivacaine under guidance with ultrasound and nerve stimulator, followed by induction of general anesthesia with sufentanil, propofol, and etomidate...During the operation, propofol and remifentanil were used for total intravenous anesthesia...A postoperative analgesia combination of nerve block and oral nonsteroidal analgesics was performed, and emergency pain rescue with pethidine was administered if necessary. The analgesic effect was satisfactory. The patient was safely discharged in the end and recovered well."

Journal • Anesthesia • Cardiovascular • Coronary Artery Disease • Genetic Disorders • Heart Failure • Infectious Disease • Muscular Atrophy • Musculoskeletal Diseases • Orthopedics • Pain • Respiratory Diseases

Double-blind randomized noninferiority study of the effect of pharyngeal lidocaine anesthesia on EUS. (PubMed, Endosc Ultrasound) - "Secondary outcomes included endoscopist and patient satisfaction, midazolam/pethidine doses, number of gag events, number of esophageal insertion attempts, use of sedative/analgesic antagonists, interruptions due to body movements, throat symptoms after endoscopy, and sedation-related adverse events...These results suggest that pharyngeal anesthesia with lidocaine can be omitted when performing EUS under sedation with concomitant analgesics. Omitting pharyngeal anesthesia with lidocaine may prevent discomfort and complications caused by pharyngeal anesthesia, shorten examination times, and reduce medical costs."

Head-to-Head • Journal • Allergy • Anesthesia • Pain