ranitidine hydrochloride / Generic mfg. - LARVOL DELTA

Efficient determination of ranitidine, famotidine, and cimetidine in environmental and biological matrices using a NH₂-bimetallic MIL-88(Fe/Ni)@SiO₂/Fe₃O₄ composite and dispersive micro solid-phase extraction. (PubMed, Anal Bioanal Chem) - "The method was successfully applied to tap, river, and well water, as well as human urine samples, achieving excellent relative recovery rates (89.8-95.3%), even in samples from individuals who had ingested the drugs. The adsorbent could be reused for three cycles without significant loss in performance."

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Proton Pump Inhibitors and H2-Receptor Blockers as Culprit Agents in Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis: A Systematic Review of Case Reports (ACG 2026) - "While antibiotics, anticonvulsants, and allopurinol are well-established culprits, proton pump inhibitors (PPIs) and H2-receptor blockers (H2RBs), among the most widely prescribed drug classes globally, are underrecognized triggers...PPIs were implicated in 62% of cases; lansoprazole, omeprazole, and pantoprazole were most frequent. H2RBs accounted for 38%, with ranitidine and cimetidine most common... Twenty studies met inclusion criteria, including one two-patient case series, yielding 21 cases (10 TEN, 11 SJS). Median age was 50 years; 62% were female. Median latency to onset was 10 days."

Case report • Clinical • Review • Acute Respiratory Distress Syndrome • Cardiovascular • Infectious Disease • Renal Disease • Respiratory Diseases • Septic Shock • Steven-Johnson Syndrome

Proton Pump Inhibitors Versus Famotidine and Infection or Hepatic Encephalopathy in Cirrhosis (ACG 2026) - " In the TriNetX US Collaborative Network, adults with cirrhosis and an acid-suppression indication who newly initiated a PPI or famotidine on or after January 1, 2021 (postdating the 2020 ranitidine withdrawal), following a 365-day washout of both to define new use, were propensity-score matched 1:1 on 30 baseline covariates (maximum standardized mean difference 0.075). The primary outcome was a 1-year composite of infection (SBP, Clostridioides difficile, or pneumonia) or medication-anchored hepatic encephalopathy (a diagnosis code plus lactulose or rifaximin, to improve coding validity)... Among 14,785 matched pairs, the primary infection/HE composite was null (HR 0.99, 95% CI 0.95-1.03), stable from 30 to 730 days, and also null in a broader within-platform network. Pneumonia, C. difficile, all-cause death, and liver transplant were null. Incident SBP was elevated (HR 1.33, 95% CI 1.09-1.61), persisted with the first 30 days excluded (1.33, 1.05-1.69), and remained..."

CNS Disorders • Fibrosis • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases

Polyphenol-rich Dactyloctenium aegyptium extract protects against aspirin or ethanol-induced gastric ulcers via antioxidant, anti-inflammatory, and anti-apoptotic pathways. (PubMed, Tissue Cell) - "Additionally, quercetin (1), naringenin (2), catechin (3), gallic acid (4), and chlorogenic acid (5), were also isolated and identified...Pretreatment with D. aegyptium extract (400 mg/kg b.w.), similar to ranitidine, dramatically decreased the number and severity of ulcers in both AS- or EtOH-induced ulcers...COX-1 expression was restored and caspase-3 and COX-2 were downregulated, according to immunohistochemistry. These results show that D. aegyptium uses anti-inflammatory, anti-apoptotic, antioxidant, and mucosal defense-preserving pathways to produce strong gastroprotective effects."

Journal • Gastroenterology • Gastrointestinal Disorder • Peptic Ulcer • CASP3

Ranitidine attenuates myocardial fibrosis by suppressing histamine/H2 receptor signaling and FAK/Src activation. (PubMed, Front Pharmacol) - "Our findings demonstrate that ranitidine ameliorates pressure overload-induced myocardial fibrosis, likely in association with attenuation of histamine/H2 receptor-related inflammatory responses and reduced FAK/Src activation. This study suggests the repurposing potential of ranitidine for treating MF."

Journal • Fibrosis • Immunology • Inflammation • HRH2 • TGFB1

Assessment of Drug Utilization Pattern of Antimicrobials Prescribed in the Orthopedic Department of a Tertiary Care Hospital. (PubMed, Cureus) - "Antimicrobial use was dominated by broad-spectrum agents, particularly ceftriaxone (43.4%), ciprofloxacin (47.5%), and metronidazole (54.5%), with moderate use of aminoglycosides (35.4%). Fixed-dose combinations were led by Cefuroxime + Sulbactam (25.2%). Supportive therapy was extensive, including ranitidine (62.6%), tramadol (59.6%), antihypertensives, insulin, and nutraceuticals. Combination therapies such as Bromelain + Trypsin + Rutoside (37.4%) were frequently used. Conclusion This study reflects a pattern of polypharmacy characterized by extensive use of broad-spectrum antimicrobials and adjunctive therapies, emphasizing the need for rational prescribing practices and antimicrobial stewardship to optimize clinical outcomes and minimize resistance."

Journal • Musculoskeletal Diseases • Orthopedics

Huangjin Shuangshen decoction alleviates chronic atrophic gastritis by suppressing TNF/NF-κB signaling and promoting CFTR-associated gastric mucosal barrier repair. (PubMed, Front Immunol) - "CAG was induced in mice by MNNG combined with ranitidine and irregular feeding, followed by treatment with different doses of HJSS, with folic acid as a positive control...HJSS alleviates MNNG-induced CAG by attenuating inflammatory injury and promoting the recovery of gastric mucosal barrier-associated molecular features. Its protective effects are associated with suppression of TNF/NF-κB signaling and involvement of CFTR-associated regulation, supporting an inflammation-barrier mechanism underlying the action of HJSS in CAG."

Journal • Gastric Cancer • Gastrointestinal Disorder • Inflammation • Oncology • CLDN1 • MUC5AC • OCLN • TJP1

Managing medicine shortages in community pharmacies: a simulated patient mixed-method study. (PubMed, Int J Pharm Pract) - "Pharmacists adhered to some key elements of the practice standard when managing shortages, but gaps in patient-centered communication and consistent implementation remain. Strengthening awareness of the standard and improved communication are essential to ensure safe, equitable, and patient-focused care during shortages."

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Comment on "Anaphylactic shock following intravenous ranitidine in rural Nepal: a case report". (PubMed, Int J Emerg Med) - "Moreover, while ranitidine has been withdrawn in many high-income countries, it remains in use across numerous low- and middle-income countries, including Nepal. We therefore argue that for such a report to make a meaningful scientific contribution, its discussion should more explicitly address regional pharmacovigilance gaps, disparities in drug regulation, and the responsibility of national regulatory authorities regarding the continued availability of this agent."

Journal • Immunology

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride. (PubMed, J Pharm Sci) - "Cryoground ranitidine hydrochloride samples exhibited minimal reactivity under vacuum or nitrogen, elevated reactivity in air (∼21% oxygen), and the highest nitrosamine formation in an oxygen-rich environment. These results suggest that well-controlled crystallization producing high-quality crystals may be an extremely effective method to inhibit nitrosamine formation, as SSRS are needed to promote reactivity, and could be an alternative and/or complementary approach to the current strategy of adding antioxidants and/or pH modification to formulations to minimize nitrosamine formation."

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A Robust and Universal LC-MS/MS Method for Determination of N-Nitrosodimethylamine in Pharmaceuticals Using a C30 Column. (PubMed, J Sep Sci) - "Since the 2018 valsartan recall, the genotoxic impurity N-nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals...Notably, NDMA was quantified in historical batches of ranitidine (164.83 ± 5.68 ng/mL), nizatidine (10.25 ± 0.52 ng/mL), and amitriptyline (2.28 ± 0.19 ng/mL)...These findings highlight the method's effectiveness for real-world surveillance and the critical risk of post-manufacturing NDMA generation during prolonged storage. This universal C30-based method provides a practical, reliable tool for routine screening, facilitating regulatory compliance and improved patient safety without drugspecific method development."

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Continued use of ranitidine in Pakistan despite global withdrawal: A call for regulatory action. (PubMed, J Pak Med Assoc) - No abstract available

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Traditional Herbal Medicine Hyangsapyeongwi-san Inhibits Alcohol-Induced Gastric Injury in Mice by Regulating NLRP3 Inflammasome Signaling. (PubMed, J Ethnopharmacol) - "HPS protects against acute gastric injury through NLRP3 inflammasome inhibition via the AKT/NF-κB pathway, providing molecular evidence that supports its traditional use for digestive disorders."

Journal • Preclinical • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • CXCL8 • IL1B • IL6 • NLRP3 • TNFA

Shengyang Xiehuo formula regulates lipid droplet-mitochondrial interaction via TNF-α/PPARγ axis to treat chronic atrophic gastritis. (PubMed, J Ethnopharmacol) - "SYXHF inhibits the interaction between PLIN2 and ACSL1 via the TNF-PPARG pathway, regulating lipid droplet-mitochondrial interaction to promote lipid droplet lipolysis, which may represent a novel approach to halt the progression of CAG."

Journal • Gastrointestinal Disorder • Inflammation • ACSL1 • AKT1 • IL6 • PLIN2 • PPARG • STAT3 • TNFA • TP53

Decontamination from water pollutants and pathogens by electrospun nanofibers doped with heavy-atom-free borafluorene-BODIPY photosensitizers. (PubMed, Beilstein J Nanotechnol) - "Optimization of the material composition revealed that polycaprolactone (PCL), an FDA- and EMA-approved, biodegradable, easily accessible, and cost-efficient polymer, doped with BODIPY at a concentration of only 0.15 wt %, is an efficient photocatalyst for the degradation of the pharmaceutical agents ranitidine, propranolol, and cimetidine, selected as model water pollutants. Furthermore, the materials showed significant photoinactivation of Staphylococcus aureus under white light irradiation compared to the control experiment performed without irradiation. These findings highlight the potential of the electrospun PCL nanofibers as optimal matrix for the immobilization with singlet oxygen photosensitizers and subsequent application in the decontamination of water from pollutants and pathogens."

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Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System. (PubMed, Mar Drugs) - "Drug dissolution profiles using cefradine and ranitidine hydrochloride showed over 85% cumulative release within 30 min, with similarity factors higher than 50 relative to commercial gelatin capsules under the tested conditions. This work provides a feasible and low-cost strategy for the industrial production of plant-based capsules and promotes the high-value utilization of polysaccharide-based capsule materials."

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Computational fluid dynamics and machine learning modeling of drug delivery by hydroxypropyl methylcellulose. (PubMed, Int J Pharm) - "The CFD-generated data, combined with experimental measurements from the literature for eight model drugs (ribavirin, ranitidine hydrochloride, isoniazid, diltiazem hydrochloride, theophylline, tinidazole, sulfamethoxazole, and propylthiouracil), were used to train the machine learning techniques. This LS-SVR model, configured with the Gaussian kernel function, successfully predicts the overall dataset with an R-squared of 0.99850, an average absolute relative deviation of 1.27%, and a root mean squared error of 0.833. This hybrid CFD-ML approach provides a powerful tool for the rational design of HPMC-based drug formulations with targeted release profiles."

Journal • Inflammatory Arthritis

A flavour of death: perindopril induced thick melanoma and bcc of the back: the special link to the drug mediated nitroso photo carcinogenicity (EADV-Sp 2026) - "Following alert checks confirming their post-existence in diabetes drugs, anti- smoking drugs, a number of antibiotics, ACE inhibitors, Sartans, thiazide diuretics, ranitidine, but probably a number of others, the decision has been taken to give the green light to their permissible availability...Initial ten courses of immunotherapy with pembrolizumab were started...Conclusions The potential pro-carcinogenic effects of both nitrosamines and the generic substance of perindopril are discussed. Special attention is drawn to the Nitroso Photocarcinogenicity, triggered via the permanent drug intake."

Basal Cell Carcinoma • Diabetes • Melanoma • Metabolic Disorders • Non-melanoma Skin Cancer • Skin Cancer • Skin Nodular Basal Cell Carcinoma • Solid Tumor • BRAF

Comparative Efficacy and Acceptability of Pharmacological Treatments for Ischaemic Optic Neuropathy: A Multiple-Treatment Meta-Analysis. (PubMed, J Coll Physicians Surg Pak) - "This systematic review of nine randomised controlled trials (1,012 participants) from April 1994 to May 2022 compared the efficacy of placebo (PLA), ranibizumab (RAN), dexamethasone (DEX), prednisolone (PRE), oxygen (OX), troxerutin (TRO), RPh201, erythropoietin (ERY), levodopa + carbidopa (LEV+CAR), and prednisolone + ranitidine (PRE+RA) for the treatment of ION. Therefore, these results should be considered in clinical practice. Key Words: Ischaemic optic neuropathy, Meta-analysis, Treatment."

Clinical • Journal • Retrospective data • Review • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Association between ranitidine use and thyroid cancer based on FAERS and VigiAccess databases. (PubMed, Discov Oncol) - "Despite certain limitations, our findings indicate a disproportionality signal suggesting a potential association between ranitidine use and thyroid cancer reporting in pharmacovigilance databases. In light of these findings, the disproportionality signal suggests a potential risk requiring confirmation through prospective studies; pending such validation, clinicians should exercise caution when prescribing ranitidine for extended periods, with attention to thyroid monitoring."

Journal • Oncology • Solid Tumor • Thyroid Gland Carcinoma

The Nitrosamine contamination in Beta blockers , ACE inhibitors , thiazides diuretics , calcium channel blockers, sartans and the subsequent skin cancer development and progression: Apocalypse now (EADV-Sp 2026) - "In practice, mankind faces the problem of certainly over 1 billion patients taking nitrosamine-contaminated drugs: 280 million patients with depression (antidepressants), over 1 billion patients with arterial hypertension (antihypertensive drugs), over half a billion patients with type 2 diabetes mellitus (oral antidiabetic drugs/metformin/ sitagliptin), over 4 billion patients with gastritis (ranitidine), over 5 million with tuberculosis (rifampicin), and probably a number of others...Figure.1a-e: 1a: 4 patients 1a: Drug-induced basal cell carcinoma (Bisoprolol/ Lisinopril) in the area under the left eyelid and immediately above the nasolabial fold. 1b: Drug-induced (Hydrochlorothiazide/ Felodipine) basal cell carcinoma in the medial orbital angle...Nitrosamine contamination in beta blockers seems to have the same procarcionogenic effect as Perindopril and Candesartan preparations. Results For the first time in the scientific literature, the contributory..."

Acute Lymphocytic Leukemia • Basal Cell Carcinoma • Brain Cancer • CNS Disorders • Colorectal Cancer • Depression • Diabetes • Gastrointestinal Cancer • Gastrointestinal Disorder • Genetic Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Melanoma • Metabolic Disorders • Neuroblastoma • Non-melanoma Skin Cancer • Oncology • Pulmonary Arterial Hypertension • Rectal Cancer • Respiratory Diseases • Skin Cancer • Solid Tumor • Tuberculosis • Type 2 Diabetes Mellitus

Identifying Key Pathogenic Mechanisms in Recurrent Glioblastoma Through Bioinformatics Analysis. (PubMed, Curr Med Chem) - "Collectively, this study offers valuable insights into the regulatory landscape of recurrent glioblastoma and lays the groundwork for more targeted and personalized therapeutic approaches."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Genetic diversity and camphor profiling of Curcuma caesia roxb.: identification of elite genotypes and in silico prediction of gastroprotective mechanisms. (PubMed, Front Pharmacol) - "Molecular docking studies against ulcer-associated targets predicted camphor's superior binding affinity for MMP9 (-7.8 kcal/mol) compared to ranitidine (-6.3 kcal/mol), with stable hydrogen bonding interactions involving TYR A:111 and TYR A:458...While in silico predictions suggest plausible mechanisms aligning with traditional ethnomedicinal use, these computational findings require experimental validation through in vitro enzyme inhibition assays and in vivo gastric ulcer models. This study provides a phytochemical and computational foundation for hypothesis-driven investigation of camphor's potential gastroprotective properties, identifying elite C. caesia genotypes (GTE-18, GMR-2, GMN-10) for breeding programs targeting enhanced camphor content and subsequent biological validation."

Journal • Gastroenterology • Gastrointestinal Disorder • Peptic Ulcer • MMP9

PPI use: How many of you treat it for limited periods or replace it with ranitidine (ERA 2026) - No abstract available

Cardiovascular • Chronic Kidney Disease

Covalently bound Eosin Y on chitosan as a removable photosensitizer for ranitidine degradation. (PubMed, Chemosphere) - "LC-QToF/MS analysis identified five major transformation products, enabling the proposal of an environmentally relevant degradation route involving both Type I and Type II photosensitized pathways. Overall, this work highlights CTS-EOY as a sustainable biopolymer-supported photosensitizer for visible-light degradation of pharmaceutical pollutants combining efficient photodegradation with low toxicity and post-treatment recoverability, offering an energy-efficient alternative to conventional oxidation approaches."

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