ranitidine hydrochloride / Generic mfg. - LARVOL DELTA

Evaluation of the clinical application of histamine H2 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting based on the attribute hierarchy model method. (PubMed, Front Pharmacol) - "The clinical application of H2 RAs showed a preference for the higher-priced ranitidine (88.54%)...The rationality of H2 RAs use in oncology departments was lower than that in non-oncology departments, while the associated drug costs were higher. Strengthened management of H2 RAs application in CINV prevention is needed to improve the rationality of drug use and to ensure safety, efficacy, and cost-effectiveness for patients."

CINV • Journal • Chemotherapy-Induced Nausea and Vomiting • Oncology • HRH2

H2-antagonists in paclitaxel premedication: systematic review and meta-analysis. (PubMed, BMJ Support Palliat Care) - "Subgroup analysis showed minimal heterogeneity with all-grade reactions once prospective studies were excluded (I2=0.0%, p=0.689). This meta-analysis supports the safe omission of H2As, particularly ranitidine, from paclitaxel premedication protocols without compromising patient safety in terms of HSRs."

Journal • Retrospective data • Immunology • Oncology

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Gastroprotective Effects of Green Synthesised Silver Nanoparticles Using Artocarpus Lakoocha Leaves Improves Oxidative Stress and Control Inflammation Modulating Via Inflammatory Markers in Ethanol Induced Ulcer Model in Mice. (PubMed, Biol Trace Elem Res) - "ALAgNPs and ranitidine significantly reduced MDA, TNF-α, and IL-1β levels while restoring GSH, CAT, SOD, gastric mucus, and antioxidant potential. Histopathology confirmed mucosal protection, reinforcing A. lakoocha derived AgNPs as promising gastroprotective agents with antioxidative and anti-inflammatory properties for ulcer management and cancer cytotoxicity."

Journal • Preclinical • Inflammation • Lung Cancer • Oncology • Peptic Ulcer • Solid Tumor • IL1B • TNFA

Severe cutaneous adverse reactions linked to medications in children and adolescents: a pharmacovigilance study based on the FDA Adverse Event Reporting System database. (PubMed, Int J Clin Pharm) - "SCARs in children and adolescents show distinct patterns, high hospitalization and mortality, and strong links with antiepileptics and anti-infectives. Strengthening pediatric pharmacovigilance, implementing risk-alert systems, and promoting genotype-guided prescribing may help prevent these severe reactions."

Adverse events • Journal • Eosinophilia • Pediatrics • Steven-Johnson Syndrome

LemKids: A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT (clinicaltrials.gov) - P3 | N=16 | Terminated | Sponsor: Genzyme, a Sanofi Company | Active, not recruiting ➔ Terminated; Enrolment formally closed earlier than planned due to recruitment challenges.

Trial termination • CNS Disorders • Multiple Sclerosis • Pediatrics

VKT Pharma, an associate of SMS Pharmaceuticals, has received US FDA approval for reformulated Ranitidine tablets in 150mg and 300mg strengths. (Scanx) - "This marks the return of this acid-reducing medication to the US market after a five-year absence."

ANDA • Gastrointestinal Disorder

Dual Biologic Therapy In Eosinophilic Esophagitis: A Case Report (ACAAI 2025) - "Despite treatment with dexlansoprazole, ranitidine, montelukast, cetirizine, budesonide (swallowed), and multiple food elimination diets, she experienced persistent retrosternal chest pain, dysphagia, abdominal pain, nausea and recurrent oral sores...After unsuccessful trials of crisaborole and cyclosporine, dupilumab was started...Discussion The 2025 American College of Gastroenterology guidelines support dupilumab use in EoE, however no recommendation exists for or against benralizumab use. This case highlights the potential role of dual biologic use, particularly in patients with severe EoE and coexisting atopic disease, though further research is needed."

Case report • Clinical • Allergic Rhinitis • Asthma • Contact Dermatitis • Dermatitis • Dermatology • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology • Inflammation • Respiratory Diseases • IL13 • IL4 • IL5

30-Minute Infusion of Isatuximab in Newly Diagnosed Multiple Myeloma (NDMM) Patients: Results of a Phase 1b Study (ASH 2023) - P1, P1/2 | "Introduction: The anti-CD38 antibody isatuximab (Isa) is approved in various countries with pomalidomide-dexamethasone for relapsed/refractory multiple myeloma (RRMM) patients (pts) with ≥2 prior therapies including lenalidomide and a proteasome inhibitor, based on the ICARIA-MM study, and with carfilzomib-dexamethasone for RRMM pts with ≥1 prior therapy, based on the IKEMA study...Results previously reported from this study showed efficacy of treatment with Isa in combination with bortezomib-cyclophosphamide-dexamethasone (VCd) or bortezomib-lenalidomide-dexamethasone (VRd), with manageable safety profiles...]), acetaminophen (paracetamol) 650 to 1000 mg PO; ranitidine 50 mg IV (or eq. ), diphenhydramine 25 to 50 mg IV (or eq. ), and montelukast 10 mg PO (or eq... These preliminary results show that 30-min infusion of Isa is a feasible, well-tolerated, and convenient administration method for pts with multiple myeloma on Isa treatment for several months. The..."

Clinical • P1 data • Hematological Malignancies • Leukemia • Multiple Myeloma • Oncology

Antioxidant and Gastroprotective Effect of Erica arborea Extract Against Diclofenac-Induced Gastric Ulcer in Mice: In Vivo and In Silico Molecular Docking Study. (PubMed, Chem Biodivers) - "Liquid chromatography analysis of EAHEx identified nine phenolic compounds (flavonoids and phenolic acids) that had in silico high binding energy to the gastric proton pump (H+/K+-ATPase), good membrane permeation, good distribution, and a good elimination profile due to their high solubility compared to omeprazole and ranitidine. E. arborea had antioxidant and anti-ulcer activity, and therefore it is a potential candidate for future drug development."

Journal • Preclinical • Peptic Ulcer

Asparaginase-Associated Toxicities and Hypersensitivity Reactions in Pediatric and Adolescent Down Syndrome Patients with Acute Lymphoblastic Leukemia or Lymphoma (ASH 2023) - "Pegaspargase (PEG) is integral in protocols for the treatment of pediatric ALL and lymphoblastic lymphoma (LBL), and full exposure to all doses of PEG can be limited by toxicities, including hypersensitivity reactions (HSR) due to the production of anti-asparaginase antibodies rendering PEG therapy ineffective...An H1 blocker (diphenhydramine) and H2 blocker (ranitidine, famotidine or cimetidine) were administered prior to PEG administration in consolidation and subsequent cycles...Most toxicity occurred during the consolidation phase and no grade 4 or 5 toxicities were observed. Given the PEG-associated toxicity observed in DS ALL/LBL, we are conducting pharmacokinetic analysis to propose a lower dose of PEG which may minimize toxicity while maintaining therapeutic efficacy."

Clinical • Acute Lymphocytic Leukemia • Developmental Disorders • Genetic Disorders • Hematological Malignancies • Hepatology • Immunology • Leukemia • Lymphoma • Obesity • Oncology • Pediatrics

Successful Management of D816V Mutated c-KIT Systemic Mastocytosis with Chronic Imatinib: A Case Report (ASH 2023) - "When reactions did occur, she treated them at one point with a cocktail of an histamine-2 blocker (ranitidine), histamine-1 blocker (diphenhydramine), and a mast cell stabilizer (cromolyn) and without requiring the use of epinephrine...After the most recent BMB the patient altered her daily regimen due to gastric upset and found she could take of her histamine-1 blocker (diphenhydramine) once daily along with a twice daily regimen of her imatinib (split into two smaller daily doses), histamine-1 antagonist (cetirizine), her histamine-2 antagonist (famotidine), and citalopram (selective serotonin reuptake inhibitor or SSRI) with improved symptomatic control to this day. This case serves to illustrate the diagnostic and therapeutic challenges associated with SM, as well as the potential therapeutic use of imatinib in patients with D816V outside of its original FDA indication. Further characterization of the effect of imatinib on D816V mutated SM may warrant the..."

Case report • Clinical • Atrial Fibrillation • Endocrine Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Hematological Disorders • Metabolic Disorders • Myeloproliferative Neoplasm • Oncology • Rare Diseases • FLT3 • IDH1 • IDH2 • KIT • NPM1

Efficacy and Tolerance of Isatuximab, Cyclophosphamide, Bortezomib, and Dexamethasone (Isa-CBD) Induction Chemotherapy in Newly Diagnosed, Transplant Eligible Multiple Myeloma: Report of the Phase 2 Multi-Centre, Open Label Canadian Myeloma Research Group (CMRG)-008 Prospective Clinical Trial (ASH 2023) - "In an effort to improve outcomes, the current Canadian Myeloma Research Group (CMRG)--008 trial aimed to assess the efficacy and tolerance of a regimen of isatuximab-CyBorD (Isa-CyBorD) induction, stem cell mobilization/collection, high-dose melphalan with ASCT, followed by continuous maintenance with isatuximab and lenalidomide in newly diagnosed multiple myeloma (NDMM) patients eligible for transplant...Isatuximab premedication also included acetaminophen, H2-antagonist (ranitidine) or proton pump inhibitor and montelukast...SC mobilization utilized cyclophosphamide in 10 (15.4%) and plerixafor in 12 (18.5%) patients; mobilization was successful in all 65 patients mobilized so far with 1-3 apheresis (median 2)... Isa-CyBorD with weekly bortezomib is an effective induction therapy in patients with NDMM (93% ≥ PR with no progression and no mobilization failures). The treatment was well-tolerated with a side-effect profile comparable to our Canadian prior experience with..."

Clinical • P2 data • Anemia • CNS Disorders • Constipation • Fatigue • Febrile Neutropenia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Insomnia • Multiple Myeloma • Neutropenia • Oncology • Sleep Disorder • Transplantation • CD34

Drug-Diarrhea Associations Among Common Prescription Medications: An Analysis of the 2005-2010 NHANES Data (ACG 2025) - "Three medications were found to have an FDR-adjusted p-value (q) less than 0.05: metformin, ranitidine, and pantoprazole. The final sample size was 13,722 participants. 50 medications were taken by at least 200 participants and included in the analysis. The estimated prevalence of diarrhea as defined by self-reported Bristol Stool Scale 6 or 7 was 6.6% (95% CI 6.1-7.1%)."

Robotic and On-Flow Solid Phase Extraction Coupled with LC-MS/MS for Simultaneous Determination of 16 PPCPs: Real-Time Monitoring of Wastewater Effluent in Korea. (PubMed, Toxics) - "Among the 16 PPCPs monitored at a municipal wastewater treatment plant in South Korea, only sulfamethazine and ranitidine were not detected. Compounds such as iopromide, caffeine, and paraxanthine were detected at high concentrations, and seasonal variation patterns were also observed This study demonstrates the feasibility of a fully automated and on-site SPE pretreatment system for ultra-trace environmental analysis and presents a practical solution for the real-time monitoring of contaminants in remote areas."

Journal

Comparative evaluation of pregnancy-related adverse events associated with proton pump inhibitors using the FDA adverse event reporting system database. (PubMed, Int J Clin Pharm) - "This study detected potential disproportionality signals, suggesting an association between PPIs use during pregnancy and reported AEs. Certain signals appeared to be drug-specific rather than class-specific, such as omeprazole for postpartum hemorrhage and preeclampsia, lansoprazole for pregnancy on contraceptives, and pantoprazole for morning sickness. However, these findings should be regarded as exploratory and hypothesis generating, warranting cautious interpretation and confirmation through rigorously designed epidemiological and clinical studies."

Adverse events • Journal • Gynecology • Hematological Disorders • Postpartum Hemorrhage

Effect of ranitidine hydrochloride on water activity in ternary aqueous solutions containing drug and ionic liquid based on vapor liquid equilibria at 298.15 K. (PubMed, Sci Rep) - "The drugs examined alongside Rani-HCl included diphenhydramine hydrochloride (DPH-HCl), guaifenesin (GFN), and naproxen sodium (NS), while the selected ILs were 1-butyl-3-methylimidazolium chloride ([BMIm]Cl), 1-butyl-3-methylimidazolium bromide ([BMIm]Br), and 1-butyl-1-methylpyrrolidinium trifluoromethanesulfonate ([BMP][TfO]). To analyze the data, several local composition models-TNRF-mNRTL, NRTL, NRF-NRTL, mNRTL, and Wilson-were employed to compute key VLE parameters such as activity coefficients and vapor pressures for both binary and ternary systems. The resulting data, together with their thermodynamic interpretations, provided valuable insights into the nature and extent of solute-solvent interactions within the studied mixtures."

Journal

Meckel's Scan Revisited (EANM 2025) - "Materials and Methods Medical file, 99m Tc-PS images and radiological report of patients imaged between 2014 and 2024 were reviewed: The absence (no-PP) or presence (PP+) of a pharmacological preparation with intravenous (iv) or per os (po) Ranitidine (R) and Famotidine (F), po proton pump inhibitors (PPI) was compiled. Elution occured later during the acquistion with F iv. In conclusion, recommendation is made to perform 99m Tc-PS with Famotidine iv preparation."

Pediatrics

Dose-dependent antiulcerogenic effect of bacterial levans on indomethacin-induced gastric lesions through modulation of NF-κB/TNF-α expression and apoptotic pathways. (PubMed, Int J Biol Macromol) - "Notably, LevAE-Low showed superior gastroprotective effects, surpassing Ranitidine in reducing the ulcer burden, normalizing gastric inflammatory cytokines, alleviating oxidative stress, and preserving the mucosal structure. Although P. aeruginosa HI1 alone achieved comparable or superior cytokine and redox modulation, its combination with LevAE-Low showed weaker effects at some endpoints. These findings highlight the treatment- and dose-specific benefits of bacterial levans and probiotics in NSAID-induced gastric injury, emphasizing careful dose optimization to avoid undesirable outcomes."

IO biomarker • Journal • Immunology • Peptic Ulcer • BAX • BCL2 • NFKB1 • TNFA

Simple and economical photoelectrode modification for efficient ranitidine removal: Improved surface reactivity and switchable radical/non-radical pathways. (PubMed, J Hazard Mater) - "This capability enables the tailored design of PEC processes to adapt flexibly to complex real-world operating conditions. This work offers a simple yet highly effective new insight into the design of high-performance photoelectrodes that can effectively utilize both radical and non-radical processes."

Journal

Recombinant IL-1β induces striatal dopamine depletion in aged rats: Involvement of histamine H1 receptors. (PubMed, Brain Res) - "The observed rrIL-1β effects were reversed by H1 antagonist mepyramine whereas H2 and H3/H4 antagonists ranitidine and thioperamide were ineffective...Apparently, there exists a certain IL-1β-histamine mechanism exerting depletion of dopamine in the dorsal striatum and initiating catalepsy; the mechanism is mediated by H1 receptors. Our data suggest that the IL-1β-histamine interaction might contribute to the PD development, and be potential target for the treatment of parkinsonism."

Journal • Preclinical • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • IL1B

: Vascular Function in Health and Disease (clinicaltrials.gov) - P1 | N=420 | Recruiting | Sponsor: Russell Richardson | Trial completion date: Aug 2025 ➔ Aug 2026 | Trial primary completion date: Aug 2025 ➔ Aug 2026

Trial completion date • Trial primary completion date • Cardiovascular • Chronic Obstructive Pulmonary Disease • Heart Failure • Hypertension • Immunology • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Antiulcer activity of Prosopis farcta L. fruits extract in rats. (PubMed, Open Vet J) - "fruits extract against indomethacin-induced ulcers in rats, comparing it to the standard drug, ranitidine. Statistical analysis was performed to determine significant differences between groups. Prosopis farcta L. fruit extract special (400 mg /kg) showed potential as a natural treatment for gastric ulcers and can provide cytoprotective effects."

Journal • Preclinical • Review • Gastroenterology • Inflammation • Peptic Ulcer

Safety, Pharmacokinetics, and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation (clinicaltrials.gov) - P1/2 | N=23 | Terminated | Sponsor: Sanofi | Phase classification: P1b/2 ➔ P1/2

Phase classification • Transplantation

Dynamic myocardial injury and variable hallucination latency in Psilocybe keralensis poisoning: a molecularly confirmed case series from China. (PubMed, Clin Toxicol (Phila)) - "Supportive treatment (gastric lavage, intravenous ranitidine, and fluid therapy) led to full recovery without sequelae...Future clinical research on psilocybin should prioritize cardiovascular comorbidity screening and implement cardiac monitoring for high-risk patients. We believe that public health education should emphasize that both traditional morphological identification methods and folk-based toxicity testing lack scientific basis; it must advocate avoidance of wild mushroom foraging, which is the most reliable prevention strategy."

Journal • Cardiovascular • Hypertension • MB