ranitidine hydrochloride / Generic mfg. - LARVOL DELTA

PPI use: How many of you treat it for limited periods or replace it with ranitidine (ERA 2026) - No abstract available

Cardiovascular • Chronic Kidney Disease

Drug-Induced Thrombocytopenia from Proton Pump Inhibitors and H₂ Blockers: A Systematic Review and Comparative Analysis of Published Case Reports (THSNA 2026) - "Representative PPI reports (pantoprazole, lansoprazole, omeprazole/esomeprazole) and classical H₂RA reports (cimetidine, ranitidine, famotidine) were abstracted for onset (days), recovery (days), bleeding and ICU status. Case-level evidence indicates both PPIs and H₂RAs can cause abrupt, reversible thrombocytopenia with onset within days and recovery within 1–2 weeks; PPI reports show a trend toward earlier onset and higher bleeding documentation. Findings are limited by reporting bias and small numbers; prospective pharmacovigilance and mechanistic testing are needed to confirm class-specific risks. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author."

Case report • Clinical • Review • Hematological Disorders • Thrombocytopenia

Mechanism of Shuangshen Yiwei Granules in regulating gastric acid secretion and blocking malignant progression of chronic atrophic gastritis with gastric intestinal metaplasia (PubMed, Zhongguo Zhong Yao Za Zhi) - "GIM model rats were established by a four-factor GIM induction protocol involving "N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), ranitidine, irregular feeding, and sodium salicylate"...Compared with the model group, the Shuangshen Yiwei Granules group exhibited alleviated mental state, general conditions, and pathological features of the gastric mucosa, significantly upregulated PGⅠ, PGⅠ/PGⅡ ratio, and G-17(P<0.05, P<0.01), significantly downregulated PGⅡ(P<0.01), ameliorated parietal cell ultrastructure to varying degrees, significantly reduced gastric glandular apoptosis(P<0.01), significantly lowered gastric pH(P<0.01), significantly decreased expression of p-JAK2/JAK2, p-STAT3/STAT3, Bax/Bcl-2, TNFR1, TRADD, FADD, and cleaved caspase-8/caspase-8(P<0.05, P<0.01), and significantly increased expression of HRH_2, CDK5, STX3, and SNAP25(P<0.05). To sum up, Shuangshen Yiwei Granules potentially inhibit JAK2/STAT3 and TNFR1/caspase-8..."

IO biomarker • Journal • B Cell Lymphoma • Gastrointestinal Disorder • Lymphoma • Oncology • BAX • BCL2 • CASP8 • CDK5 • FADD • STAT3 • TNFA • TNFRSF1A • TRADD

Evaluation of the safety, gastroprotective activity and possible mechanisms of action of Ziziphora hispanica L. methanol extract. (PubMed, Fitoterapia) - "Rats were pre-treated with ZME (50, 250, or 500 mg/kg) or ranitidine (50 mg/kg) as a reference control...ZME exhibits strong gastroprotective properties by reinforcing the gastric mucus barrier. These findings validate the traditional use of Z. hispanica for gastrointestinal relief and suggest its potential as a natural therapeutic agent for the management of gastric ulcers."

Journal • Peptic Ulcer

Unraveling the ranitidine removal mechanism in a novel riboflavin-mediated ultraviolet/peracetic acid system: An integrated density functional theory-machine learning framework. (PubMed, J Hazard Mater) - "In addition, SHAP-based interaction analysis revealed that electron-rich sites facilitate ·OH attack, conjugated π-systems promote 1O2 reactivity, and molecular polarization drives R-C· reactions. Our study provides not only an effective technology for ranitidine removal but also a quantitative, interpretable framework for predicting reactivity and guiding the design of photo-assisted advanced oxidation processes."

Journal

Widespread bioaccumulation of contaminants of emerging concern in Red Sea coral reefs: Evidence from Pocillopora favosa. (PubMed, Mar Pollut Bull) - "Bioaccumulation factors indicated uptake of most compounds except caffeine, tramadol, and ranitidine throughout the regions. Unexpectedly, some CECs exhibited higher concentrations offshore than neashore, suggesting complex transport and bioaccumulation dynamics. Results reveal widespread presence of CECs in Red Sea corals and the need for pollution mitigation strategies."

Journal

Management of Drug-induced Dyspepsia in Children: Current Evidence and Clinical Approach. (PubMed, Euroasian J Hepatogastroenterol) - "Management of Drug-induced Dyspepsia in Children: Current Evidence and Clinical Approach. Euroasian J Hepato-Gastroenterol 2025;15(2):190-197."

Journal • Review • Dyspepsia • Gastroenterology • Gastroesophageal Reflux Disease • Pediatrics

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response. (PubMed, Adv Sci (Weinh)) - "Using deep learning-based screening, we find that H2 receptor antagonists (ebrotidine, ranitidine and famotidine) can act as dual inhibitors of MCR and YqgB proteins, thus exhibiting excellent synergistic activity with colistin against mcr-positive bacteria under both neutral and acidic conditions. In animal models infected with mcr-positive pathogens, the co-administration of ranitidine and colistin demonstrates superior therapeutic outcomes against both systemic and intestinal infections. Our findings highlight the potential of targeting the bacterial acid stress response system to counteract mcr-mediated colistin resistance and offer a promising therapeutic strategy for the treatment of MDR bacterial infections."

Journal • Infectious Disease

Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transportome (CBLIF/TCN2) and CHRNA7 Nodes. (PubMed, Mol Nutr Food Res) - "Together, these in vivo and in silico results suggest that omeprazole-induced cognitive decline may involve B12 depletion and other mechanisms, whereas ranitidine likely acts via alternative pathways. This study provides novel mechanistic insights into differential cognitive risks associated with chronic acid-suppressing therapy, with implications for long-term management in populations vulnerable to neurodegeneration."

Journal • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • CHRNA7

Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies (clinicaltrials.gov) - P1 | N=13 | Completed | Sponsor: City of Hope Medical Center | Active, not recruiting ➔ Completed | Trial completion date: May 2026 ➔ Aug 2025 | Trial primary completion date: May 2026 ➔ Aug 2025

Trial completion • Trial completion date • Trial primary completion date • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • B Acute Lymphoblastic Leukemia • Chronic Myeloid Leukemia • Hairy Cell Leukemia • Hematological Malignancies • Hodgkin Lymphoma • Leukemia • Lymphoma • Myelodysplastic Syndrome • Oncology • T Acute Lymphoblastic Leukemia • IL3RA • PD-L1

Electrostatically reinforced acid-stable polysaccharide hydrogels for promoting gastric ulcer repair. (PubMed, J Mater Chem B) - "The system integrated a dynamic Schiff base network formed by dopamine-modified oxidized hyaluronic acid (HD) and carboxymethyl chitosan (CMCS) with polydopamine nanoparticles encapsulating ranitidine hydrochloride (PDR)...In vivo evaluation in an ethanol-induced rat gastric injury model confirmed that HDSCP significantly accelerated mucosal repair and regeneration. Overall, the HDSCP hydrogel offers a strategy for improving gastric mucosal integrity through its physical barrier function and ROS scavenging ability."

Journal • Inflammation • Peptic Ulcer

Naeso-san, a traditional herbal formula, attenuates HCl/ethanol-induced gastric injury via MAPK and NF-κB pathway modulation in mice. (PubMed, Front Pharmacol) - "We evaluated the gastroprotective effects of NSS (75, 300, 1200 mg/kg) in 7-week-old male ICR mice using a hydrochloric acid/ethanol (HCl/EtOH)-induced gastric injury model, with ranitidine (40 mg/kg) as positive control...NSS exhibits gastroprotective effects through multi-target anti-inflammatory mechanisms. These mechanistic advantages over conventional acid-suppressive therapies suggest NSS as a promising candidate for preclinical and translational studies evaluating its clinical applicability in inflammatory gastric conditions."

Journal • Preclinical • Gastric Adenocarcinoma • Gastric Cancer • Oncology • Peptic Ulcer • Solid Tumor • CXCL8 • IL1B • IL6 • TNFA

Association Between Long-term Use of H2 Receptor Antagonists and Prostate Cancer Risk: A Case-Control Study in Taiwan. (PubMed, J Cancer) - " These findings suggest that long-term use of cimetidine and ranitidine may increase prostate cancer risk in older men, while famotidine was not associated with prostate cancer risk. Risk varies by age and drug type, highlighting the need for drug-specific evaluation in cancer pharmacoepidemiology."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Ranitidine protects Müller cells against ferroptosis in diabetic retinopathy by regulating the AKT1/GSK3β pathway. (PubMed, Indian J Ophthalmol) - "The study highlighted that the mechanism of DR is closely associated with ferroptosis and demonstrated that Ra inhibits HG-induced ferroptosis of rMC-1 cells by regulating the AKT1/GSK3β signaling pathway, thereby providing a theoretical basis for using Ra in managing DR."

Journal • Diabetes • Diabetic Retinopathy • Retinal Disorders • AKT1 • GPX4

Esophageal Acid Suppression Unmasks Latent Esophageal Acid-Symptom Phenotypes in GERD. (PubMed, Dig Dis Sci) - "Post-prandial suppression of esophageal acid unmasks latent esophageal acid-symptom phenotypes in gastroesophageal reflux disease. Recognition of these patterns may improve the understanding of treatment response variability and guide individualized therapy."

Journal • Cognitive Disorders • Gastroenterology • Gastroesophageal Reflux Disease

Drug-Related Halitosis: A Narrative Review. (PubMed, Int Dent J) - "Multiple groups of medications can act as an underlying cause for halitosis. However, more research is needed to monitor halitosis as an independent side effect and to investigate the mechanism by which each medication causes halitosis."

Journal • Dental Disorders • Xerostomia

Dosage adjustments in renal impairment among medical ward patients: ChatGPT® and DeepSeek® models' effectiveness in assessing those adjustments. (PubMed, Explor Res Clin Soc Pharm) - "Piperacillin/tazobactam (66.7 %), levofloxacin (83.33 %), and ranitidine (89.1 %) were most frequently inappropriately dosed. Inappropriate renal dosing is prevalent among hospitalized patients with renal impairment. While AI models show promise as clinical decision support tools, their accuracy limitations require further optimization via evidence-based database training, prompt refinement, and integration of clinical expertise for reliable implementation."

Journal • Renal Calculi • Renal Disease

Oral Ranitidine as an Immunomodulatory Agent in the Treatment of Molluscum Contagiosum: A Pediatric Case Report. (PubMed, Cureus) - "No recurrence was observed over a six-month follow-up. Given its favorable safety profile and immunostimulatory potential, ranitidine may represent a viable, non-invasive therapeutic option for extensive or recurrent MC in immunocompetent pediatric patients."

Journal • Dermatology • Infectious Disease • Pain • Pediatrics

Anaphylactic shock following intravenous ranitidine in rural Nepal: a case report. (PubMed, Int J Emerg Med) - "This case highlights that ranitidine, although commonly used, can rarely trigger severe anaphylactic shock even in patients without prior exposure or known allergies. Early recognition of the reaction and timely administration of intramuscular epinephrine were key to the patient's rapid recovery. Awareness of this potential adverse reaction is important for all clinicians who administer H2-receptor antagonists."

Journal • Allergy • Dermatology • Hypotension • Immunology • Urticaria

Enhanced adsorption of ranitidine onto activated carbon‑modified zeolite composite and investigation of the removal mechanism. (PubMed, Sci Rep) - "Equilibrium studies demonstrate a strong alignment with the Langmuir isotherm, exhibiting a correlation coefficient of 0.9993, which suggests monolayer and homogeneous adsorption characteristics. The maximum adsorption capacity (qₘ) and RL values were calculated as 463.0 mg g⁻¹ and 0.0162, respectively."

Journal

Evaluation of the clinical application of histamine H2 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting based on the attribute hierarchy model method. (PubMed, Front Pharmacol) - "The clinical application of H2 RAs showed a preference for the higher-priced ranitidine (88.54%)...The rationality of H2 RAs use in oncology departments was lower than that in non-oncology departments, while the associated drug costs were higher. Strengthened management of H2 RAs application in CINV prevention is needed to improve the rationality of drug use and to ensure safety, efficacy, and cost-effectiveness for patients."

CINV • Journal • Chemotherapy-Induced Nausea and Vomiting • Oncology • HRH2

H2-antagonists in paclitaxel premedication: systematic review and meta-analysis. (PubMed, BMJ Support Palliat Care) - "Subgroup analysis showed minimal heterogeneity with all-grade reactions once prospective studies were excluded (I2=0.0%, p=0.689). This meta-analysis supports the safe omission of H2As, particularly ranitidine, from paclitaxel premedication protocols without compromising patient safety in terms of HSRs."

Journal • Retrospective data • Immunology • Oncology

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Gastroprotective Effects of Green Synthesised Silver Nanoparticles Using Artocarpus Lakoocha Leaves Improves Oxidative Stress and Control Inflammation Modulating Via Inflammatory Markers in Ethanol Induced Ulcer Model in Mice. (PubMed, Biol Trace Elem Res) - "ALAgNPs and ranitidine significantly reduced MDA, TNF-α, and IL-1β levels while restoring GSH, CAT, SOD, gastric mucus, and antioxidant potential. Histopathology confirmed mucosal protection, reinforcing A. lakoocha derived AgNPs as promising gastroprotective agents with antioxidative and anti-inflammatory properties for ulcer management and cancer cytotoxicity."

Journal • Preclinical • Inflammation • Lung Cancer • Oncology • Peptic Ulcer • Solid Tumor • IL1B • TNFA

Severe cutaneous adverse reactions linked to medications in children and adolescents: a pharmacovigilance study based on the FDA Adverse Event Reporting System database. (PubMed, Int J Clin Pharm) - "SCARs in children and adolescents show distinct patterns, high hospitalization and mortality, and strong links with antiepileptics and anti-infectives. Strengthening pediatric pharmacovigilance, implementing risk-alert systems, and promoting genotype-guided prescribing may help prevent these severe reactions."

Adverse events • Journal • Eosinophilia • Pediatrics • Steven-Johnson Syndrome