PRX-5 / Sawai Pharma - LARVOL DELTA

Reduced peroxisomal import triggers peroxisomal retrograde signaling. (PubMed, Cell Rep) - "Specifically, we show that peroxisomal import stress caused by knockdown of the peroxisomal matrix import receptor prx-5/PEX5 triggers NHR-49/peroxisome proliferator activated receptor alpha (PPARα)- and MDT-15/MED15-dependent upregulation of the peroxisomal Lon protease lonp-2/LONP2 and the peroxisomal catalase ctl-2/CAT...While the PRS can be triggered by perturbation of peroxisomal β-oxidation, we also observed hallmarks of PRS activation upon infection with Pseudomonas aeruginosa. We propose that the PRS, in addition to a role in lipid metabolism homeostasis, may act as a surveillance mechanism to protect against pathogens."

Journal • Metabolic Disorders • CAT

Round Table 7: The history of levodopa and dopamine agonists, benefits and myths (WPC 2019) - No abstract available.

Talk 1: The history of levodopa and dopamine agonists - Benefits and myths (WPC 2019) - No abstract available.