beta-escin (MAM-06.301) / Marinomed Biotech - LARVOL DELTA

Battling COVID-19 leveraging nanobiotechnology: Gold and silver nanoparticle-B-escin conjugates as SARS-CoV-2 inhibitors. (PubMed, Open Life Sci) - "This study investigates the molecular interactions between the receptor binding domains of five SARS-CoV-2 spike protein variants (Alpha, Beta, Delta, Omicron, and Gamma) and the angiotensin-converting enzyme 2 (ACE2) receptor, followed by the docking of AuNPs and AgNPs and the natural compound Beta-escin onto these complexes. Subsequent docking of AuNPs and AgNPs revealed strong interactions with all ACE2-spike complexes, with AuNPs showing slightly higher affinities. The findings contribute to a deeper understanding of the interactions between NPs and viral proteins, shedding light on their mechanisms of action and their potential to offer innovative solutions for combating infectious diseases, particularly those caused by SARS-CoV-2."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

ISCOM-type matrix from beta-escin and glycyrrhizin saponins. (PubMed, Heliyon) - "These particles are successful included into isolated mouse macrophages. Among the variety of generated nanoparticles, the E3-M2 particles demonstrated properties of safe and efficient devices for future vaccine design and antigen targeting to immune system."

Journal • Hematological Disorders

GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury. (PubMed, Int J Mol Sci) - "Candidate drugs that target GADD45A and GADD45B include beta-escin, sertraline, primaquine, pimozide, and azacyclonol. The dysregulation of GADD45A and GADD45B is related to renal IRI and the infiltration of pDCs, and drugs that target GADD45A and GADD45B may have therapeutic potential for renal IRI."

Biomarker • Journal • Cardiovascular • Reperfusion Injury • DUSP1 • GADD45A • GADD45B • GADD45G • HSPA1A

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles. (PubMed, Front Pharmacol) - "At present, antitumor drugs derived from natural products mainly include 1) apoptosis inducers such as curcumin, gallic acid, resveratrol, Theranekron D6, and gaillardin; 2) topoisomerase inhibitors such as camptothecins, scaffold-hopped flavones, podophyllotoxin, oxocrebanine, and evodiamine derivatives; 3) telomerase inhibitors such as camptothecin and isoquinoline alkaloids of Chelidonium majus, amentoflavone, and emodin; 4) microtubule inhibitors such as kolaflavanone, tanshinone IIA analog, eugenol, and millepachine; 5) immunomodulators such as fucoidan, myricetin, bergapten, and atractylenolide I; 6) tumor microenvironment regulators such as beta-escin and icaritin; 7) multidrug resistance reversal agents such as berberine, quercetin, and dihydromyricetin; and 8) antiangiogenic and antimetastatic agents such as epigallocatechin-3-gallate, lupeol, ononin, and saikosaponin A. Anticancer natural product technology was introduced earlier, but the later development..."

Review • Immune Modulation • Inflammation • Oncology

Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca sensitization force of smooth muscle. (PubMed, J Smooth Muscle Res) - "Recombinant CPI-17 proteins at a physiologic level (10 µM) were doped into beta-escin-permeabilized smooth muscle strips for Ca sensitization force measurement. The N-terminal deletion dampened phosphorylation at Thr38 by protein kinase C (PKC), and the C-terminal truncation lowered the affinity to the myosin phosphatase. Under the physiologic conditions, PKC and myosin phosphatase may recognize CPI-17 N-/C-terminal unstructured tails inducing Ca sensitization force in smooth muscle cells."

Journal

Datasets for calcium dynamics comparison between the whole-cell and a β-escin based perforated patch configuration in brain slices from adult mice. (PubMed, Data Brief) - "These data can be used to compare the two methods or to draw comparisons with the Ca handling properties of other neuron types. Further details and an in-depth analysis of the new combination of the 'added buffer approach' with the β-escin based perforated patch clamp configuration can be found in our companion manuscripts "Analysis of neuronal Ca handling properties by combining perforated patch clamp recordings and the added buffer approach" [2] and "A Simple Method for Getting Standard Error on the Ratiometric Calcium Estimator" [3]."

Journal • Preclinical • Immunology