Xelpros (latanoprost ophthalmic emulsion) / China Medical System, Sun Pharma Advanced Research Company - LARVOL DELTA

A Comprehensive Review of the Clinical Evidence Comparing Benzalkonium Chloride-Preserved and Benzalkonium Chloride-Free Latanoprost in the Treatment of Primary Open-Angle Glaucoma and Ocular Hypertension. (PubMed, Clin Ophthalmol) - "Inclusion criteria were peer-reviewed clinical trials and meta-analyses comparing latanoprost with placebo or other treatments (eg. bimatoprost, travoprost, tafluprost, latanoprostene bunod)...Comparative studies indicate that latanoprost achieves a good balance between IOP reduction and tolerability compared to bimatoprost, travoprost, tafluprost, and unoprostone...Latanoprost remains a first-line therapy for POAG and OHT due to its efficacy, safety, and patient adherence. The availability of BAK-free formulations enhances its therapeutic profile, with reduced corneal toxicity making it a preferred choice for long-term glaucoma management."

Clinical • Journal • Review • Cardiovascular • Dermatology • Glaucoma • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension. (PubMed, Clin Ophthalmol) - P3 | "These findings support the chronic use of latanoprost BAK-free to treat OAG or OHT. NCT00945958."

Clinical • Cardiovascular • Conjunctivitis • Glaucoma • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain

Noninferiority Study Comparing Latanoprost 0.005% Without Versus With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension. (PubMed, Eye Contact Lens) - "Latanoprost without BAK did not meet two of three criteria for noninferiority and showed a similar safety profile relative to latanoprost with BAK."

Head-to-Head • Journal • Glaucoma • Ophthalmology

"I will be so happy when a generic version of Xelpros is available." (,@chrisagrissom)

"@n8radcliffe When can Xelpros go generic?" (,@chrisagrissom)

Blog: The scourge of preserved eye drops (Healio) - "In this day and age, why are we bathing the ocular surface with fluids that contain substances that produce inflammation on the cornea and the conjunctiva and, by extension, meibomian glands? Come on, folks, it's 2020 for heaven's sake. Do you know how benzalkonium chloride (BAK) is manufactured? It's basically re-esterified tears from the eye of a newt. I guess that's cooler than the original Healon (sodium hyaluronate, Johnson & Johnson Vision) being made from the cockscombs of roosters. Still, eye of newt is a basic ingredient in every evil witch's brew."

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