quinine/doxycycline / Generic mfg. - LARVOL DELTA

Travel-Related Malaria Diagnosis on Karius Test Despite Negative Blood Smear. (PubMed, Trop Med Infect Dis) - "The patient needed several treatment regimens for the recurrent attacks, including chloroquine and primaquine, artemether-lumefantrine, and eventually a combination of quinine and doxycycline together with a prolonged course of primaquine. This case demonstrates the limitations of smear microscopy diagnosis in P. vivax infections, highlights the role of molecular diagnostics like the Karius test, and stresses the importance of preventing relapses with adequate hypnozoite clearance. It further highlights the importance of clinician awareness and diligent follow-up in cases of travel-related Malaria, especially those with unusual presentations or recurrent symptoms."

Journal • Hematological Disorders • Infectious Disease • Leukopenia • Malaria • Musculoskeletal Pain • Pain • Thrombocytopenia

Missed Until Critical: Unravelling the Mystery of Persistent Hemolysis With a Definitive Diagnosis of Babesiosis. (PubMed, Cureus) - "From these tests, we were able to diagnose her with a malarial infection that was treated with quinine and doxycycline, then atovaquone/proguanil following worsening infection...Clinically, she improved after the transition to atovaquone and azithromycin, but unfortunately, she was readmitted due to persistent hemolysis and pneumonia requiring extended antibiotic therapy and supportive care...It raises awareness among clinicians regarding tick-borne illnesses in endemic regions, as in this case, to minimize delays in diagnosis and treatment. This case also shows how early recognition and treatment are crucial to prevent severe complications of babesiosis, including septic shock, especially in the immunocompromised and elderly population."

Journal • Cardiovascular • Critical care • Dyslipidemia • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Malaria • Pneumonia • Respiratory Diseases • Septic Shock • Thrombocytopenia

A RARE CASE OF SINUS NODE DYSFUNCTION SECONDARY TO QUININE TOXICITY DURING TREATMENT OF MALARIA - Vincent K. Le (ACC 2025) - "Investigations confirmed that she had falciparum malaria, and she was started on treatment with quinine and doxycycline... It is important that physicians know the potential cardiovascular side effects of quinine so that patients are monitored to reduce the risk of cardiac complications."

Clinical • Cardiovascular • Infectious Disease • Malaria • Nephrology • Renal Disease

Artemisinin resistance-associated gene mutations in Plasmodium falciparum: A case study of severe malaria from Mozambique. (PubMed, Travel Med Infect Dis) - "This case highlights the emergence of P. falciparum strains carrying mutations in artemisinin resistance-associated genes in Mozambique, couple with a reduction in ex vivo susceptibility to ACT drugs. Continuous surveillance of mutations linked to drug resistance and regular monitoring of drug susceptibility are imperative to anticipate the spread of potential resistant strains emerging in Mozambique and to maintain effective malaria control strategies."

Journal • Cough • Infectious Disease • Malaria • Musculoskeletal Pain • Pain • Respiratory Diseases • Targeted Protein Degradation • FUBP1