DEL-30 / NGM Biopharma - LARVOL DELTA

GENETIC ANALYSIS OF GLUT10 (SLC2A10) GENE IN PAKISTANI PATIENTS WITH DIABETES MELLITUS (ADPD 2025) - "Six single nucleotide variations were detected in 5 of the patients in which two similar deletio n variations (c.T>del24, c.A>del31) were found within the region of Exon 3 (111bp) in three diabetic individuals whereas the other four variations (c.T>del23, c.A>del30, c.T>del30, c.A>del37) were detected in two affected individuals. To conclude, our research emphasizes the importance of finding DNA variations using DNA sequencing in the molecular diagnosis of diverse genetic diseases."

Clinical • Diabetes • Genetic Disorders • Metabolic Disorders

"7 días en 7 noticias, 1 cifra y 1 frase: lo imperdible del 30 de junio al 7 de julio de 2023 https://t.co/uZEPJLuez1 vía @medscape" (@carolyn_doctor)

"primer tractament de radioterapia a la nova Seu Granollers de Oncologia RT ⁦@hospitalclinic⁩ prevista abans del 30 Setembre! #JornadaC17mama ⁦@MeritxellMolla⁩" (@prat_aleix)

Clinical

Epstein-Barr virus variation in people living with human immunodeficiency virus in southeastern China. (PubMed, Virol J) - "In southeastern China, EBV in HIV-infected patients had higher active virus replication; EBV infection was mainly EBV-1, and EBV-2 infection has higher EBV virus load; hotspot mutations of LMP-1 C-ter were different between HIV-infected patients and non-HIV-infected patients."

Journal • Epstein-Barr Virus Infections • Human Immunodeficiency Virus • Infectious Disease

"Un programma di formazione e accesso alle terapie oncologiche transfrontaliere ha migliorato del 30% la sopravvivenza a 5 anni dei bambini affetti da #leucemia linfoblastica acuta #ASCO23 https://t.co/6NQQQJVuus" (@Oncoinfo_it)

"Ni compren el #DIABETESSINPIQUETES DE #MasterloyaltyGroup sus #sensoresabbot @AbbottNews NO ENVIAN FACTURA y en mi 5ta. Llamada me tienen esperando más de 30 min. Pork el "sistema" no ha generado la factura del 30 marzo" (@c700504)

Diabetes • Metabolic Disorders

"Qui in Italia la mortalità dei giovani è aumentata del 30%. Persone vaccinate con 3 dosi!!" (@nadiafrancy)

Clinical

Discrepancia de miembros inferiores en artroplastia total de rodilla. ¿Es realmente un problema? (PubMed, Rev Fac Cien Med Univ Nac Cordoba) - "Conclusiones: La incidencia de discrepancia de longitud de miembro inferior tras el RTR fue del 30%. No se requirió  intervención como consecuencia de dicha discrepancia. Los resultados funcionales y dolor al seguimiento alejado no demostraron diferencias entre ambos grupos."

Journal

Spatial Dispersal of Epstein-Barr Virus in South America Reveals an African American Variant in Brazilian Lymphomas. (PubMed, Viruses) - "The Raji/Argentine clade was associated with polymorphisms I124V/I152L, del30 bp, and ins15 bp (p < 0.0001, to all clades) and with a high haplotype diversity related to EBV type and Zp variants...Although no LMP1 variant has been directly associated with disease, the Raji/Argentine clade was predominantly clustered with lymphomas (61%) and the Mediterranean clade with non-malignant cases (59%) (p = 0.1). These data highlight the high genetic diversity of EBV circulating in Brazil, calling attention to a Raji-related variant with great recombination potential in Brazilian lymphomas."

Journal • Epstein-Barr Virus Infections • Hematological Malignancies • Lymphoma • Oncology

"Più del 30% dei soggetti oltre i 55 anni di età sviluppa Fibrillazione Atriale: un problema cardiaco che li espone a numerosi rischi. E, per questo, un problema da identificare precocemente. Un'interessante sintesi su questa condizione clinica: https://t.co/FwDRlcDbhG @NEJM" (@nursing_uniud)

Modelo SIR de la tendencia pandémica de COVID-19 en Perú. (PubMed, Rev Fac Cien Med Univ Nac Cordoba) - " Según el modelo SIR, el pico de infectados se produce poco después del 30 de Mayo desde el inicio de la epidemia (día 86) donde disminuye el número total de casos infectados a R0=1,5. Los resultados sugieren que las estrictas medidas actuales de Perú pueden prevenir eficazmente la propagación de COVID-19 y deben mantenerse aun obteniendo resultados eficientes."

Journal • Immunology • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

"Sei pronto per i #cardiofacts? Mentre ci prepariamo per l’#ESCCongress2021, parleremo di malattie cardiovascolari. FACTS 01 Lo sapevi che 150min di esercizio ogni settimana può ridurre il rischio di sviluppare una malattia cardiaca ischemica del 30%? https://t.co/EijnLWPIm2" (@DaiichiSankyoIT)

Cardiovascular • Myocardial Ischemia

"La tienen de antes. Desde febrero que se vacuna con esas vacunas. Y hoy cuantos paises estan vacunados con mas del 30% ??" (@walter_1966)

Anterolateral thigh versus radial forearm flap for cervical esophageal reconstruction in cancer patients: A retrospective cohort study in Colombia. (PubMed, Cir Cir) - "Functional outcomes of reconstruction with brachial-radial and ALT flap were satisfying. Our findings suggest that ALT has a lower incidence of post-operative complications than radial forearm flap. The choice of the type of flap will depend on the size and location of the defect. Small and partially covered defects benefit from the use of a radial flap, and for larger and circumferential pharyngeal reconstructions with possible radiotherapy requirements, they benefit from an ALT flap."

Journal • Retrospective data • Oncology

[VIRTUAL] IMB-1018792, A NOVEL FIRST-IN CLASS PARTIAL FATTY ACID OXIDATION INHIBITOR IMPROVES CARDIAC REMODELING AND FUNCTION POST-MYOCARDIAL INFARCTION (ACC 2021) - "IMB-1018972 improved LV systolic function while reducing LVEDP and myocardial fibrosis in a murine model of post-MI HF. The findings lend support to a therapeutic strategy of pFOX inhibition using the novel cardiac mitotrope IMB-101 to augment energetics in the context of myocardial ischemia and HF."

pFOX inhibitor • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • Myocardial Infarction • Myocardial Ischemia

Indel mutations of sheep PLAG1 gene and their associations with growth traits. (PubMed, Anim Biotechnol) - "Genotype ID and genotype II were dominant for the P2-del 30 bp and P4-del 45 bp loci, respectively. The above findings indicated that the two indel mutations in the ovine PLAG1 gene were suggested to become the molecular markers for the selection of economic traits in sheep."

Journal • PLAG

"Ti sei perso la puntata del programma "La casa della salute" del 30 gennaio? Guarda la replica qui: https://t.co/8vFyZXSMvO Tiziana Mele, AD @LudnbeckItalia ha affrontato il tema della leadership al femminile nel settore farmaceutico e della #saluteMentale in Italia." (@LundbeckItalia)

"Lo tienen fácil, dejar sin profesionales los hospitales en base al BOE del 30/09" (@PalomaCas2)

Clinical

"Estudio DAVINCI #eCongresoSEC20 via @JCosinSales Objetivo LDLc en 2039👥 con evento CV previo guias 2016 vs 2019⤵️ 📍44% solo con estatina moderada 📍9% combo con ezetimibe 📍⤵️en % de objetivo alcanzado: del 30% en LDL70 a 18% en LDL55 🩺Mucho trabajo por hacer @secardiologia" (@ValleAlfonso)

Cardiovascular

"El problema de las pruebas de antígenos... la sensibilidad, la cual tiene un rango variable del 30 al 90% #IDWeek2020" (@gabizambranoMD)

Infectious Disease

"A dire il vero, prima delle riviste, ne parlavamo da mesi: questo è uno screenshot del 30 marzo con un rianimatore di ferrara" (@DocWalls)