milrinone / Generic mfg. - LARVOL DELTA

Association Between Ionized Calcium Concentrations During Weaning From Cardiopulmonary Bypass and Postoperative Low Cardiac Output Syndrome: A Retrospective Cohort Study. (PubMed, Anesth Analg) - "Both low and high iCa levels at CPB weaning were associated with an increased risk of postoperative LCOS in patients undergoing cardiovascular surgery."

Journal • Retrospective data • Cardiovascular • Endocrine Disorders

Inotropic therapy in outpatients with worsening or advanced heart failure: literature evidence and comparison of Italian management models (PubMed, G Ital Cardiol (Rome)) - "In this review, we explore the role of home-administered inotropes, specifically dobutamine, milrinone, dopamine, and levosimendan, in the management of AdvHF patients through a summary of current literature and the presentation of management models adopted in selected Italian centers. Reported experiences suggest improved quality of life, reduced hospital admissions, and enhanced clinical stability in patients with AdvHF. These models may serve as practical examples for organizing care pathways in a clinical context that remains poorly defined by current guidelines."

Clinical • Journal • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • Palliative care • Transplantation

Uncovering a multi-centre outbreak of Candida viswanathii candidaemia caused by contaminated milrinone in Italy (ESCMID Global 2026) - No abstract available

Clinical • Late-breaking abstract

Immune Checkpoint Inhibitor-Induced Myocarditis: A Late Presentation. (PubMed, Ochsner J) - "We present a case of cardiogenic shock secondary to ICI-associated myocarditis with onset 13 months after administration of pembrolizumab for triple-negative breast cancer...The patient was diagnosed with acute decompensated heart failure (stage C cardiogenic shock), started on milrinone and vasopressin, and transferred to our institution for a higher level of care...A presumptive diagnosis of ICI-associated myocarditis was made within 12 hours, and treatment with high-dose intravenous methylprednisolone was initiated. Despite the high mortality associated with ICI-associated myocarditis, the patient improved and was discharged 9 weeks after admission. This case highlights the importance of considering ICI myocarditis in the differential diagnosis of cardiogenic symptoms, even in delayed presentations, and supports the lifesaving potential of early recognition and treatment."

Checkpoint inhibition • Journal • Breast Cancer • Cardiovascular • Congestive Heart Failure • Cough • Heart Failure • Inflammation • Lung Cancer • Melanoma • Oncology • Pulmonary Disease • Respiratory Diseases • Small Cell Lung Cancer • Solid Tumor • Triple Negative Breast Cancer

Early Milrinone and effects on Oxygenation in Congenital Diaphragmatic Hernia: A Randomized Controlled Trial (PAS 2026) - No abstract available

Clinical • Gastroenterology

Effect of Inotropes in Patients with Advanced Heart Failure: A Meta-Analysis of Randomized Trials. (PubMed, Tunis Med) - "Inotropic agents showed a non-significant trend toward reduced mortality in AHF patients. Heterogeneity limits firm conclusions. Larger RCTs are needed to identify subgroups that may benefit."

Clinical • Journal • Retrospective data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology

Arrhythmias and Cardiac Dysfunction: What Drives What? (SCCM 2026) - "Treatment included IV milrinone, Lasix, high dose steroids and IVIG without improvement...IV amiodarone was initiated after EP consultation...We hypothesize that viral illness and catecholamine surge acutely accelerated his arrhythmia, precipitating cardiogenic shock. This case highlights the impact of unrecognized atrial tachyarrhythmias and the reversibility of TIC with appropriate management."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases

Balancing Hemorrhage and Thrombosis: Management of Massive PE With Concurrent Massive Hemoptysis (SCCM 2026) - "He received inhaled tranexamic acid and was prepared for intubation. Pre-intubation RV optimization with milrinone may mitigate peri-intubation risk of RV collapse. Survival in this high-mortality scenario underscores the importance of coordinated multidisciplinary care."

Cardiovascular • Hypotension • Lung Cancer • Pulmonary Embolism • Respiratory Diseases • Solid Tumor • Thrombosis

Association of New-Onset Arrhythmias Between Milrinone and Renal Impairment (SCCM 2026) - "Patients were excluded if they received antiarrhythmic agents while hospitalized prior to receiving milrinone, received dobutamine within 1 hour prior to initiating milrinone, or received concurrent dobutamine and milrinone infusions. Based on the data from this study, there was no association of new-onset arrhythmias between milrinone and renal impairment."

Cardiovascular • Hypotension • Renal Disease

Evaluation of Milrinone Versus Dobutamine Use in Cardiogenic Shock (SCCM 2026) - "Choice of initial inotrope in cardiogenic shock was significantly influenced by the degree of hypotension and ventricular arrhythmia history. Patients requiring bridging with inotropes to advanced therapies were more likely to initially receive milrinone, contributing to the longer median inotrope therapy duration and LOS seen in the milrinone group overall. Similar to prior studies, no significant differences were seen in inpatient mortality, cardiac arrest, or RRT, though further research is needed given the rate of dobutamine use in both groups during admission."

Cardiovascular • Hypotension

NORMOTENSIVE CARDIOGENIC SHOCK: A DIAGNOSTIC PITFALL MIMICKING ACUTE LIVER FAILURE (ACC 2026) - "This prompted initiation of intravenous low-dose Milrinone to improve cardiac output and tissue perfusion, resulting in rapid improvement in lactate, renal function, and liver enzymes. N-acetylcysteine was discontinued as liver injury was attributed to hypoperfusion rather than intrinsic hepatic disease... This case highlights the diagnostic pitfall of normotensive cardiogenic shock, particularly in patients with severe multi-organ dysfunction. Despite normal BP, profound hypoperfusion can cause striking lab abnormalities, leading to misdiagnosis. Clinicians should maintain a high index of suspicion for cardiac causes when unexplained lactic acidosis or organ dysfunction persists."

Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Hematological Disorders • Hepatology • Immunology • Liver Failure • Metabolic Disorders • Thrombosis

THE TRABECULATED TRAP: A RARE CASE OF NONCOMPACTION CARDIOMYOPATHY IN A YOUNG FEMALE WITH HEART FAILURE (ACC 2026) - "Decision-Making: Given her low cardiac output state, characterized by reduced CO and CI along with elevated filling pressures, she was initiated on milrinone and furosemide drips. LVNC is a rare form of nonischemic cardiomyopathy. While its classification as a distinct cardiomyopathy remains controversial, early recognition is essential to initiate appropriate medical therapy and, when necessary, escalate to advanced interventions such as heart transplantation."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Disease

HEART FAILURE IN AN INFANT WITH AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE (ACC 2026) - "Despite triple therapy with enalapril, labetalol, and amlodipine, her blood pressure remained elevated...She managed milrinone infusion for poor systolic function and nicardipine infusion for blood pressure control and later transitioned to oral medications... Cardiovascular involvement in autosomal recessive polycystic kidney disease is increasingly recognized as an early complication. The literature on ARPKD has shown that systemic hypertension and left-ventricular remodeling can occur in infancy and childhood, often before overt renal failure develops. Incorporating routine echocardiogram surveillance into standard ARPKD care may help prevent irreversible myocardial remodeling and improve long-term cardiovascular outcomes."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Hypertension • Nephrology • Polycystic Kidney Disease • Renal Disease

ECPELLA SUPPORT IN FULMINANT VIRAL MYOCARDITIS: A BRIDGE IN CARDIOGENIC SHOCK (ACC 2026) - "Case: A 34-year-old previously healthy male was diagnosed with viral pericarditis after coxsackievirus infection and treated with ibuprofen and colchicine...Despite inotropic support with milrinone, he progressed to advanced cardiogenic shock...He developed sustained ventricular tachycardia (VT) requiring intravenous amiodarone, lidocaine, and temporary transvenous pacing at 90 bpm for overdrive suppression. He also received pulse intravenous methylprednisolone for 3 days and intravenous immunoglobulin (IVIG)... This case underscores the rapid progression from outpatient viral myocarditis to fulminant myocarditis with cardiogenic shock requiring VA-ECMO and Impella support. EMB excluded acute inflammatory myocarditis, highlighting the role of biopsy, vigilance in follow-up, and multidisciplinary coordination to bridge young patients toward recovery or advanced heart failure therapies."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Infectious Disease • Inflammation • Pulmonary Disease • Sarcoidosis • Ventricular Tachycardia

CLINICAL OUTCOMES OF MILRINONE VERSUS DOBUTAMINE IN ISCHEMIC CARDIOGENIC SHOCK: A 30-DAY PROPENSITY-MATCHED ANALYSIS (ACC 2026) - "In this large, contemporary real-world cohort of ischemic cardiogenic shock patients, milrinone use was associated with a lower risk of 30-day mortality compared with dobutamine, without an increased risk of arrhythmia. These observational findings contrast with recent randomized trial evidence, highlighting the critical need for further research to reconcile outcomes between trial populations and routine clinical practice."

Clinical • Clinical data • Cardiovascular • Myocardial Infarction

IMPELLA ASSOCIATED ENDOCARDITIS IN A TRANSPLANT CANDIDATE WITH ADVANCED HEART FAILURE (ACC 2026) - "Case: A 56-year-old man with HFrEF on home milrinone, Bi-Ventricular ICD, Atrial fibrillation, pulmonary hypertension, presented with acute decompensated heart failure and recent ICD shock...Bivalirudin was held due to the severe anemia, increasing device risk... Impella can be life-saving in advanced heart failure, but device-related endocarditis with septic shock underscores the extreme complexity of managing transplant candidates on MCS."

Metastases • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Immunology • Infectious Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • Transplantation

CLOT IT FROM MY MAMA: A CASE OF NEONATAL MYOCARDIAL INFARCTION WITH MATERNAL THROMBOPHILIA (ACC 2026) - "Case: A male term infant was born to a mother with Protein S deficiency and Antiphospholipid Antibody Syndrome (APS) on enoxaparin...Milrinone and epinephrine were started...On day 9, he was discharged on aspirin and clopidogrel... This case highlights the importance of suspecting MI in neonates of mothers with thrombophilia. It also shows the value of early diagnosis with aggressive multimodal intervention for rapid recovery."

Clinical • Cardiomyopathy • Cardiovascular • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Myocardial Infarction • PROS1

IMPACT OF IDEAL BODY WEIGHT VERSUS ACTUAL BODY WEIGHT DOSING OF INOTROPES IN ADVANCED HEART FAILURE PATIENTS AWAITING HEART TRANSPLANTATION OR DURABLE LVAD (ACC 2026) - " This retrospective study included hospitalized adults who received continuous intravenous inotropic therapy (dobutamine or milrinone) prior to heart transplant or left ventricular assistant device (LVAD) implantation. This study may provide guidance on the appropriate weight-based dosing strategy in advanced heart failure patients that may lead to minimization of drug toxicity, while maintaining efficacy and safety."

Clinical • Metastases • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Obesity • Transplantation

THE BREAKING POINT: RIGHT HEART FAILURE IN SEVERE SYSTEMIC SCLEROSIS-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION (ACC 2026) - "The initiation of epoprostenol (a gold standard parenteral prostacyclin), along with sildenafil and aggressive inotropic support (milrinone) and pulmonary vasodilation (iNO), stabilized the patient. Severe SSc-associated PAH presenting with cardiogenic shock requires rapid, multi-modal intervention with a parenteral prostacyclin and hemodynamic monitoring. These presentations with extreme PAH severity and critical CI necessitate urgent advanced therapy evaluation, reflecting the current shift toward aggressive, goal-directed treatment for highest-risk PAH populations."

Acute Respiratory Distress Syndrome • Cardiovascular • Congestive Heart Failure • Heart Failure • Hepatology • Immunology • Pulmonary Arterial Hypertension • Respiratory Diseases • Scleroderma • Systemic Sclerosis

CARDIOGENIC SHOCK COMPLICATED BY LYMPHOCYTIC MYOCARDITIS (ACC 2026) - "He received aspirin and a heparin drip for suspected NSTEMI...He was started on colchicine and ibuprofen...He was found to be in cardiogenic shock with worsened pericardial effusion and was started on milrinone and diuretics...He received an empiric dose of methylprednisolone 1 g IV... This case demonstrates fulminant myocarditis that improved with aggressive mechanical support and prompt diagnosis. Timely EMB is critical to establish definitive diagnosis and can help guide therapy."

Cardiomyopathy • Cardiovascular • CNS Disorders • Depression • Hypotension • Inflammation • Metabolic Disorders • IL6

NEW-ONSET STAGE D BIVENTRICULAR HEART FAILURE SECONDARY TO CHAGAS CARDIOMYOPATHY IN A U.S. IMMIGRANT (ACC 2026) - "He was managed with intravenous milrinone and diuresis... This case emphasizes the importance of evaluating for Chagas disease in immigrants from endemic areas who present with new onset nonischemic cardiomyopathy. Early recognition is crucial for proper management and prognosis."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Disease

TRENDS AND OUTCOMES OF VASOACTIVE AGENTS IN PATIENTS WITH PULMONARY HYPERTENSION AND RIGHT VENTRICULAR FAILURE: A RETROSPECTIVE COHORT STUDY (ACC 2026) - "The most commonly used medication was norepinephrine (25.5%), followed by epinephrine (22%), vasopressin (16%), phenylephrine (14.4%), dobutamine (8.0%), and milrinone (6.8%). This study highlights the significant variability in practice patterns and its potential impact on clinical outcomes in this patient population. Future studies are needed to identify optimal vasoactive medications in this patient population."

Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

COMPARISON OF DOBUTAMINE TO MILRINONE IN PATIENTS WITH PULMONARY HYPERTENSION AND RIGHT VENTRICULAR FAILURE: A RETROSPECTIVE COHORT STUDY (ACC 2026) - "These exploratory findings provide the hypothesis that in patients with PH who present with RV failure and hypoperfusion, milrinone may be associated with better survival. These findings need confirmation in a well-designed randomized control trial focused on this understudied population."

Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

MULTIFOCAL NEAR TRANSMURAL MYOCARDITIS MIMICKING ISCHEMIC CARDIOMYOPATHY TREATED WITH IMMUNOMODULATORY THERAPY SUPPORTED WITH COMBIED MECHANICAL AND INOTROPIC SUPPORT IN A YOUNG ADULT (ACC 2026) - "The patient's CS was managed with Impella CP support, milrinone, & intravenous diuresis... Multifocal near transmural myocarditis in young adults is rare & can mimic ICM. Prompt recognition of this atypical imaging pattern & timely initiation of multimodality therapy are crucial for stabilization & recovery."

Clinical • Immunomodulating • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Inflammation

CHALLENGING THE PARADIGM: EARLY RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITION WITH MECHANICAL CIRCULATORY SUPPORT PROMOTES DUAL ORGAN RECOVERY IN SEVERE CARDIORENAL SYNDROME, A CASE REPORT (ACC 2026) - "Once compensated, he was treated with milrinone and started on valsartan and spironolactone as part of his Impella weaning strategy...He was optimized with the addition of bisoprolol and empagliflozin... In select patients, MCS can create a stable hemodynamic bridge, enabling the safe and early initiation of RAAS inhibitors despite renal compromise from shock. This approach challenges the conventional practice of withholding these agents in cardiogenic shock-related AKI, offering a strategy to break the cardiorenal cycle and promote dual organ recovery"

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Nephrology