milrinone / Generic mfg. - LARVOL DELTA

RESCUE-CV: Endovascular Therapy for Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage (clinicaltrials.gov) - P=N/A | N=306 | Not yet recruiting | Sponsor: Beijing Tiantan Hospital | Initiation date: Jun 2026 ➔ Oct 2026

Trial initiation date • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Ain Shams University | Phase classification: P ➔ P4

Phase classification • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology

COMPACT: Cerebral Oximetry in Management of Post Cardiac Arrest (clinicaltrials.gov) - P=N/A | N=44 | Recruiting | Sponsor: University of Calgary

New trial • Cardiovascular • CNS Disorders • Vascular Neurology

Corrigendum to: The PDE3-specific inhibitor milrinone improves asthenozoospermic sperm function by regulating cAMP-PKA signaling pathway and energy metabolism. (PubMed, Reprod Fertil Dev) - No abstract available

Journal

Intravenous magnesium sulfate combined with targeted pulmonary vasodilators in preterm infants with bronchopulmonary dysplasia and associated pulmonary hypertension: a case series and literature review (ERS 2026) - "All received sildenafil; milrinone added in three cases due to right ventricular dysfunction (RVD) or suboptimal response. Adjunctive MgSO₄ combined with targeted pulmonary vasodilation was well tolerated and associated with respiratory and echocardiographic improvement. These data generate the hypothesis that combined bronchodilator and pulmonary vasodilator therapy could modify short-term cardiorespiratory trajectories in this high-risk neonatal population. Prospective controlled studies are needed to define efficacy, optimal dosing and safety."

Clinical • Prematurity • Review • Bronchopulmonary Dysplasia • Cardiovascular • Heart Failure • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

USE OF MILRINONE FOR INTRACARDIAC RIGHT TO LEFT SHUNTING REVERSAL IN A PATIENT WITH A CLOT IN TRANSIT AND A PFO (CHEST 2026) - No abstract available

Clinical • Cardiovascular

[Translated article] Milrinone in aneurysmal subarachnoid hemorrhage: A long way ahead. (PubMed, Farm Hosp) - No abstract available

Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

Catastrophic Embolization of a Left Ventricular Thrombus Following Initiation of Milrinone for Cardiorenal Syndrome. (PubMed, Am J Ther) - No abstract available

Journal • Cardiovascular • Nephrology • Thrombosis

Reversible cerebral vasoconstriction syndrome: a medical challenge in the peripartum period requiring a multimodal approach: a case report. (PubMed, AJOG Glob Rep) - "She was managed in a specialized maternal neurocritical care unit using a multimodal strategy that included continuous neuromonitoring with transcranial Doppler ultrasonography, cerebral oxygenation and metabolic monitoring, electroencephalography, intracranial pressure monitoring, serial cerebral angiography with selective intra-arterial milrinone infusion, and, ultimately, ultrasound-guided stellate ganglion block as rescue therapy...Early diagnosis, multidisciplinary management, and multimodal neuromonitoring may facilitate individualized treatment and timely therapeutic escalation in patients with refractory cerebral vasospasm. Further prospective studies are needed to better define the role of advanced neuromonitoring and rescue therapies in this rare condition."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Epilepsy • Gynecology • Hematological Disorders • Hypertension • Obstetrics • Pain • Subarachnoid Hemorrhage

Multicentre outbreak of Candida viswanathii bloodstream infections linked to contaminated milrinone, Italy, April to October 2025. (PubMed, Euro Surveill) - "Immediate control measures included withdrawal of the implicated product, notification of national authorities and active microbiological surveillance of exposed patients. This outbreak highlights the importance of clinician-led outbreak detection, hypothesis-driven epidemiology and pharmacovigilance in identifying rare, medicine-associated fungal infections."

Journal • Infectious Disease

Milrinone Challenge In Assessing Right Ventricle Reserve Prior To Left Ventricular Assist Device Implantation [Poster no. 293] (HFSA 2026) - No abstract available

Cardiovascular

Milrinone Challenge Can Reveal Pulmonary Vascular Reserve Associated With Pulmonary Hypertension Reversal After Left Heart Unloading [Poster no. 235] (HFSA 2026) - No abstract available

Cardiovascular • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

The association between documented right ventricular dysfunction and in-hospital mortality in mechanically ventilated critically ill patients receiving a noradrenaline infusion: A retrospective observational cohort study. (PubMed, Crit Care Resusc) - "A greater number of interventions were provided in those with RVD, including: inhaled nitric oxide (39.6% vs 7.8%, p < 0.001), epoprostenol (1.8% vs 0.1%, p < 0.001), milrinone infusion (77.3% vs 23.6%, p < 0.001), continuous renal replacement therapy (48.7% vs 25.8%, p < 0.001), and extracorporeal membrane oxygenation (33.7% vs 10.4%, p < 0.001). The median number of transthoracic (TTE) or transoesophageal echocardiography (TOE) was 3 (interquartile range [IQR]: 1-4) in those with RVD, compared to 1 (IQR: 1-2) in those without RVD (p < 0.001). Approximately 1 in 4 patients who were mechanically ventilated and receiving noradrenaline had documented RVD, which was associated with a higher risk-adjusted in-hospital mortality, longer LOS, and greater treatment intensity."

Journal • Observational data • Retrospective data • Cardiovascular • Critical care • Heart Failure

Outcomes of Milrinone vs. Dobutamine in Cardiogenic Shock with Acute Kidney Injury (AHA 2026) - "Abstract is embargoed at this time."

Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease

The PDE3-specific inhibitor milrinone improves asthenozoospermic sperm function by regulating cAMP-PKA signaling pathway and energy metabolism. (PubMed, Reprod Fertil Dev) - "The present study has gained new insight into the molecular basis of cAMP signaling regulation in human sperm and provides theoretical and experimental support for the potential application of milrinone for asthenozoospermic sperm activation."

Journal • PDE3A

Anesthetic Management of Delayed Primary Arterial Switch Operation in a Two-Month-Old Infant With Dextro-Transposition of the Great Arteries (d-TGA), Preserved Left Ventricular Mass, and Patent Ductus Arteriosus: A Case Report. (PubMed, Cureus) - "During separation from cardiopulmonary bypass, milrinone (0.5 mcg/kg/min) and low-dose epinephrine (0.05 mcg/kg/min) were administered to enhance myocardial contractility while optimizing the balance between systemic and pulmonary vascular resistances (SVR and PVR) to prevent low cardiac output syndrome and reactive pulmonary hypertensive crises. In this selected late-presenting infant, primary ASO was feasible alongside preserved LV mass and geometry in the presence of a large PDA. Comprehensive preoperative echocardiography and tailored anesthetic management focusing on biventricular loading and PVR/SVR balance are key to achieving favorable outcomes."

Journal • Anesthesia • Pediatrics

Ambulatory milrinone in advanced heart failure: a single-center comparison of continuous and intermittent infusion strategies (ESC 2026) - "Conclusion Long-term ambulatory milrinone is feasible and improves functional status in advanced heart failure, with benefits sustained at 1 year in selected continuous-infusion patients and low complication rates. Heart failure hospitalizations were lower in our cohort than in previously described advanced heart failure cohorts without ambulatory milrinone."

Clinical • Metastases • Cardiovascular • Congestive Heart Failure • Heart Failure

Right-Sided Ischemic Colitis From Severe Constipation in ATTR Amyloidosis: A Case Report (ACG 2026) - "Case Description/ A 66-year-old man with HFrEF (LVEF 40â45%) secondary to ATTR cardiac amyloidosis on home milrinone undergoing heart-kidney transplant evaluation presented with acute decompensated heart failure and encephalopathy...This case highlights severe constipation as a potentially underrecognized precipitating factor for right-sided ischemic colitis in patients with systemic amyloidosis. Figure: Severe constipation with suspected pneumatosis of the cecum (arrow) with concerns for extraluminal foci of gas Figure: Dilated bowel with increased stool burden, with arrow pointing towards concerns for air in the superior mesenteric vein"

Case report • Clinical • Amyloidosis • Cardiac Amyloidosis • Cardiovascular • CNS Disorders • Congestive Heart Failure • Constipation • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Immunology

Cerebral Vasospasm After Traumatic Subarachnoid Hemorrhage: A Narrative Review. (PubMed, Medicina (Kaunas)) - "This paper presents key characteristics and differences between tSAH and aSAH, available diagnostic approaches, and treatment options, including nimodipine, milrinone, and stellate ganglion block. Owing to the lack of specific clinical guidelines for tSAH, current management strategies often rely on recommendations and experiences from aSAH. Further research is needed to better define risk factors for vasospasm following tSAH, optimize diagnostic pathways, and evaluate targeted treatment strategies."

Journal • Review • Cardiovascular • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Preoperative Optimization for Heart Transplant in a Patient Declining Transfusions (ASA 2026) - "A 53 y/o female Jehovah's Witness with non-ischemic cardiomyopathy (EF 20-30% on IV milrinone) was admitted for optimization before heart transplant. Given the black box warning for thrombotic events with erythropoietin, a risk/benefit decision is being considered regarding thrombopoietin agonists (e.g. eltrombopag) to stimulate platelet production. She will be listed for transplant using all perioperative blood conservation measures."

Clinical • Cardiomyopathy • Cardiovascular • Hematological Disorders • Transplantation

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

Managing Neonatal Pulmonary Hypertension in Low-Resource Settings. (PubMed, J Paediatr Child Health) - "These limitations have led to increased use of accessible alternatives such as sildenafil, milrinone and other vasodilators, which offer vital options where iNO is not feasible. This review highlights regional variability in management, the impact of resource constraints, and the need for equitable care. Using India as an example, a 10-step approach for managing PPHN in low-resource settings is proposed, alongside a call for standardized protocols and further research into both established and emerging therapies."

Journal • Review • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Reconsidering milrinone: Time to revive the oral form for drug repurposing? (PubMed, Curr J Neurol) - No abstract available

Journal • Hematological Disorders • Subarachnoid Hemorrhage

Inhaled Milrinone Guided by Intraoperative Transesophageal Echocardiography for Severe Pulmonary Hypertension During Laparoscopic Cholecystectomy in a 95-Year-Old Patient (ASA 2026) - "During pneumoperitoneum, estimated pulmonary systolic pressure remained near 40 mmHg with stable right ventricular performance and preserved systemic hemodynamics. The procedure was completed without major events."

Clinical • Cardiovascular • Coronary Artery Disease • Heart Failure • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Managing the Failing Right Ventricle: Anesthetic Strategy for Cesarean Delivery in Severe Pulmonary Hypertension (ASA 2026) - "Invasive monitoring was established, and milrinone combined with norepinephrine optimized right ventricular function and ventriculo-arterial coupling. The procedure was completed without immediate complications, highlighting the importance of tailored anesthetic strategies in high-risk parturients with severe pulmonary hypertension."

Cardiovascular • Fibrosis • Hematological Disorders • Hepatology • Immunology • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Thrombocytopenia