SYSTANE HYDRATION PF (polyethylene glycol/propylene glycol) / Alcon - LARVOL DELTA

Impact of lower temperatures on the squeezability behavior of preservative-free multidose ocular lubricant bottles (ARVO 2025) - "Methods Six new commercial presentations of PFMDBs were evaluated: Refresh Relieva PF, Eyestil Plus, Nanodrop PF, Systane Complete PF, Systane Ultra PF, and Systane Hydration PF.SF was measured by a digital dynamometer...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Dry Eye Disease • Ocular Inflammation • Ophthalmology

Evaluation of the Squeezability Behavior of Multi-Dose, Preservative-Free Ocular Lubricant (ARVO 2025) - "Methods Six new commercial presentations of preservative-free, multi-dose bottles were measured: Refresh Relieva PF and Eyestil Plus (both with Ophthalmic Squeeze Dispenser technology (OSD)), as well as Nanodrop PF, Systane Complete PF, Systane Ultra PF, and Systane Hydration PF (with Pureflow Technology)...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Dry Eye Disease • Ocular Inflammation • Ophthalmology

Alcon Announces U.S. Launch of New SYSTANE PRO Preservative-Free, Revolutionizing Dry Eye Relief With Its Longest Lasting Formula Yet (Businesswire) - "Alcon...today announced the U.S. launch of SYSTANE PRO Preservative-Free (PF) as the latest over-the-counter eye drop in the company’s dry eye portfolio. SYSTANE PRO PF is the longest lasting eye drop in the SYSTANE portfolio with a unique triple action, preservative-free formula for the temporary relief of burning and irritation due to dryness of the eye...The launch begins in the U.S. this month and will extend to additional markets in 2026."

Launch • Dry Eye Disease • Ophthalmology

Excipients of concern in the package inserts of human medicines prescribed in veterinary pharmacotherapy: frequency and implications for animal health. (PubMed, An Acad Bras Cienc) - "The identified excipients include ethyl alcohol, benzyl alcohol, benzalkonium chloride, mannitol, sodium metabisulfite, sodium lauryl sulfate, propylene glycol, polyethylene glycol, polysorbate, and ethoxylated castor oil. Although off-label use of human medicines in veterinary practice is permitted, the study suggests that regulatory agencies and professional councils should raise awareness among veterinary prescribers and pharmacists regarding these excipients. This unprecedented study highlights the urgent need to address this issue, aiming to encourage research on excipient safety in animal populations and strengthen veterinary pharmacovigilance services."

Journal

Systane® Hydration PF and Systane® Hydration Preserved (clinicaltrials.gov) - P=N/A | N=137 | Completed | Sponsor: Alcon Research | Active, not recruiting ➔ Completed

Trial completion • Dry Eye Disease • Ophthalmology

Systane® Hydration PF and Systane® Hydration Preserved (clinicaltrials.gov) - P=N/A | N=137 | Active, not recruiting | Sponsor: Alcon Research | Recruiting ➔ Active, not recruiting

Enrollment closed • Dry Eye Disease • Ophthalmology

Role of the Soft and Hard Segments Structure in Modifying the Performance of Acrylic Adhesives Modified by Polyurethane Macromonomers. (PubMed, ACS Omega) - "In this paper, PU macromonomers were prepared by a two-step synthesis method, using polypropylene glycol or polyethylene glycol with different molecular weights as soft segments and different types of diisocyanates: isophorone diisocyanate, hexamethylene diisocyanate, dicyclohexylmethylmethane diisocyanate (HMDI), 2,4-toluene diisocyanate (TDI), and 4,4'-diphenylmethane diisocyanate (MDI) and chain extenders as hard segments...Diols with a molecular weight of 600 have the best effect. Diisocyanates containing benzene rings can better improve the thermal performance of adhesives, where P MDI containing a biphenyl ring is the best, while aliphatic isocyanate groups have a greater improvement in adhesion performance, and the adhesion performance of P HDI with a long carbon chain is the best."

Journal

Effects of vehicles on the physical properties and biocompatibility of premixed calcium silicate cements. (PubMed, Dent Mater J) - "The extract of CSC-PG induced the highest expressions of osteogenic markers along with the greatest calcium deposites. When implanted in rat femurs, CSC-PEG was absorbed considerably, whereas CSC-PG remained relatively unaltered inside the femur."

Journal

Safe and Effective Management of Dry Eye Symptoms with Hydroxypropyl Guar and Hyaluronic Acid Dual-Polymer Lubricating Eye Drops: A Review of Preclinical and Clinical Studies. (PubMed, Clin Ophthalmol) - "The dual-polymer eye drops consist of dual demulcents (propylene glycol and polyethylene glycol 400) and the polymers hydroxypropyl guar (HPG) and hyaluronic acid (HA)...Clinical scientific evidence demonstrates that HPG HA dual-polymer lubricant eye drops are safe and effective in the management of DED. Specifically, they reduce the signs and symptoms of DED, reduce dry eye symptoms post-cataract surgery, and improve tear film quality in healthy eyes."

Journal • Preclinical • Review • Cataract • Dry Eye Disease • Ophthalmology

Quatramer™ encapsulation of dual-targeted PI3-Kδ/HDAC6 inhibitor, HSB-510, suppresses growth of breast cancer. (PubMed, Bioeng Transl Med) - "The present study investigates the encapsulation of a PI3-Kδ/HDAC6 dual inhibitor into hybrid block copolymers (polylactic acid-methoxy polyethylene glycol; polylactic acid-polyethylene glycol-polypropylene glycol-polyethylene glycol-polylactic acid) (HSB-510) as a delivery system to target PI3-Kδ and HDAC6 pathways in breast cancer cells. The treatment with HSB-510 was without any significant effect on the body weights of the mice. These results demonstrate that a novel Quatramer encapsulation of a PI3-Kδ/HDAC6 dual inhibitor (HSB-510) represents an approach for the successful targeting of breast cancer and potentially other cancer types."

Journal • Breast Cancer • Oncology • Solid Tumor • MYC

Modulation of mucin secretion using combined polyethylene glycol-propylene glycol topical formulation in a hyperosmotic stress-based explant model. (PubMed, Indian J Ophthalmol) - "The corneoscleral rim tissues showed induction of MUC5AC and MUC16 expression upon treatment with PEG-PG topical formulation but did not show significant changes in the presence of hyperosmolar treatments. Our findings showed that PEG-PG-based topical formulation slightly alleviated hyperosmolar stress-induced decrease in MUC5AC and MUC16 gene expression that is encountered in DED."

Journal • Dry Eye Disease • Ophthalmology • Transplantation • MUC16 • MUC5AC

Quality of Life in Digital Device Users Who are Treated with Systane Hydration PF. (PubMed, Clin Optom (Auckl)) - "Digital device users with dry eye symptoms had meaningful improvements in eye comfort and quality of life scores after being treated with Systane Hydration PF for 2 weeks. Participants did not have a clear dispensing system preference suggesting that the best dispensing system may depend on the patient."

HEOR • Journal • Dry Eye Disease • Ophthalmology

Preparation and in vitro-in vivo evaluation of QbD based acemetacin loaded transdermal patch formulations for rheumatic diseases. (PubMed, Pharm Dev Technol) - "Patches were successfully created by solvent casting method using hydroxypropyl methylcellulose, propylene glycol, polyethylene glycol 400, tween 80, and dimethyl sulfoxide...F1-ACM patch significantly (p < 0.001) inhibited paw edema formation at 1, 2, 3, 4, and 5 h after induction of inflammation as compared to the control group. Therefore, this formulation can be employed more efficiently for rheumatic disease."

Journal • Preclinical • Immunology • Inflammation • Pain • Rheumatology

Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide. (PubMed, Pharmaceuticals (Basel)) - "After the preparation of DADS, its solubility was investigated in different liquid excipients (propylene glycol, polyethylene glycol, silicone oil) and its membrane diffusivity was assessed in silicone matrices of different compositions...The 8-day-old patch showed a significantly lower, but better-regulated, drug release over time than the 4-day-old one. In conclusion, the silicone-based polymer matrix developed in this study is suitable for stable storage and optimal release of DADS, providing a good basis for a TTS applied in chronic pain."

Journal • Pain

Digital Device Users Who Are Treated With Systane Hydration PF (clinicaltrials.gov) - P4 | N=30 | Completed | Sponsor: University of Alabama at Birmingham | Phase classification: P=N/A ➔ P4

HEOR • Phase classification • Dry Eye Disease • Ophthalmology

Glycolysis of semi-interpenetrated polymer network foam based on poly(vinyl chloride) for recovery and reuse of the individual components. (PubMed, Waste Manag) - "The parameters studied were reaction time (8 min to 3 h), temperature (155 to 200 °C), catalyst (potassium acetate or dibutyl tin dilaurate (DBTL)), glycol (ethylene glycol, 1,4 butanediol, diethylene glycol, dipropylene glycol, polyethylene glycol), as well as the effect of PVC thermal stabilizers such as hindered phenols and organo-phosphites...The greatest part of the crosslinked portion (≥90 %) was depolymerized and the result were mainly hydroxyl- and in minor amount amine- terminated oligomers. The recovered PVC (purity roughly 90 %) had a low degree of degradation and a viscosity suitable for its processing as thermoplastic material, i.e. by injection moulding."

Journal

Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction. (PubMed, Front Bioeng Biotechnol) - "In details, an injectable selenium-containing polymeric hydrogel, namely, poly[di-(1-hydroxylyndecyl) selenide/polypropylene glycol/polyethylene glycol urethane] [poly(DH-SE/PEG/PPG urethane)], was synthesised by combining a thermosensitive PPG block, DH-Se (which has oxidation-reduction properties), and hydrophilic PEG segments...At the same time, we confirmed by enzyme-linked immunosorbent assay, Masson staining and Western blotting that this formulation could inhibit inflammation and fibrosis, so as to significantly improve left ventricular remodelling. In summary, a selenium-containing polymeric hydrogel formulation analysed in the current study could be a promising therapeutic formulation, which can provide new strategies towards the effective treatment of myocardial infarction or even other inflammatory diseases."

Journal • Cardiovascular • Fibrosis • Immunology • Inflammation • Myocardial Infarction

Efficacy of chitosan paste as intracanal medication against Enterococcus faecalis and Candida albicans biofilm compared with calcium hydroxide in an in vitro root canal infection model. (PubMed, BMC Oral Health) - "Chitosan paste showed better efficacy in reducing viable E. faecalis biofilm when compared to Ca(OH) after 7-day intracanal medication in this in vitro root canal model. It could also significantly reduce viable C. albicans, but was not significantly different from Ca(OH)."

Journal • Preclinical • Gastrointestinal Disorder • Infectious Disease

Treating Symptomatic Heavy Digital Device Users with Systane Hydration PF (ARVO 2022) - "Consistently treating symptomatic heavy digital devices users with Systane Hydration PF for 2 weeks significantly improved dryness symptoms and patient quality of life. Participants were overall equivocal with regards to drop dosing systems suggesting that practitioners should discuss both options with patients."

Dry Eye Disease • Ophthalmology

Development of Antifouling Polysulfone Membranes by Synergistic Modification with Two Different Additives in Casting Solution and Coagulation Bath: Synperonic F108 and Polyacrylic Acid. (PubMed, Materials (Basel)) - "The efficient simple and reproducible technique of PSF membrane modification to increase antifouling performance by simultaneous addition of triblock copolymer polyethylene glycol-polypropylene glycol-polyethylene glycol (Synperonic F108, M =14 × 10 g mol) to the casting solution and addition of polyacrylic acid (PAA, M = 250 × 10 g mol) to the coagulation bath is proposed for the first time...Membrane modification with PAA results in higher ThMP process water flux, fouling recovery ratio, and hemicellulose and total lignin rejection compared to the reference PSF/Synperonic F108 membrane. This suggests the possibility of applying the developed membranes for hemicellulose concentration and purification."

Journal

Digital Device Users Who Are Treated With Systane Hydration PF (clinicaltrials.gov) - P=N/A; N=30; Completed; Sponsor: University of Alabama at Birmingham; Recruiting ➔ Completed

HEOR • Trial completion • Dry Eye Disease • Ophthalmology

On the Biocompatibility and Teat Retention of In Situ Gelling Intramammary Formulations: Cattle Mastitis Prevention and Treatment. (PubMed, Pharmaceutics) - "Concentration-dependent cytotoxicity was observed for glycerin, propylene glycol, polyethylene glycol 400, ethanol, N-methyl-2-pyrrolidone and 2-pyrrolidone, with the 2-pyrrolidone solvents showing higher cytotoxic effects (p < 0.05). In situ gelling formulations comprising hydroxypropyl methylcellulose or carboxymethyl cellulose and solvents in specific ratios were biocompatible at higher concentrations with MAC-T cells compared to alginates. All investigated formulations could undergo in situ sol-to-gel phase transformation, forming non-toxic gels with good biocompatibility in excised cow teats hence, showing potential for use as intramammary carriers for sustained drug delivery."

Journal

Digital Device Users Who Are Treated With Systane Hydration PF (clinicaltrials.gov) - P=N/A; N=30; Recruiting; Sponsor: University of Alabama at Birmingham; Not yet recruiting ➔ Recruiting

Enrollment open • HEOR • Dry Eye Disease • Ophthalmology

ASCRS 2021 Surgical Lunch Symposium (eyetube) - https://eyetube.net/spotlight/zeiss-professional-education/ascrs-2021-surgical-lunch-symposium

Video

Quicksand Chronicles Ep #2| CATHLEEN MCCABE: Runaway Rhexis (YouTube) - "Watch and join us for the second episode of Ophthalmology Quicksand Chronicles with our guest..."

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