bupivacaine/dextrose / Generic mfg. - LARVOL DELTA

OB Hypotension: Spinal Dose after Epidural (ASA 2025) - "Forty-five minutes after the last dose of the epidural medication with 9 mL of 0.0625% bupivacaine plus 2 mcg/mL fentanyl, an intrathecal injection was performed with 12 mg of 0.75% bupivacaine with dextrose. Despite immediate intravenous phenylephrine infusion after spinal, the patient experienced severe hypotension (BP 60s/40s), leading to prolonged fetal decelerations and emergent delivery. Patient and newborn recovered without morbidity."

Anesthesia • Hypotension

Successful ultrasound-guided epidural anaesthesia following failed spinal anaesthesia in a patient with neurofibromatosis 1. (PubMed, BMJ Case Rep) - "Spinal anaesthesia was attempted using 3 mL of 0.5% hyperbaric bupivacaine (dextrose 8%), resulting in a unilateral block...The next day, ultrasound-guided epidural anaesthesia at T10-T11 was performed successfully with placement of an epidural catheter in situ for postoperative pain control. This is a rare phenomenon underlining the complexity of anaesthetic management in patients with NF1 and significant spinal abnormalities."

Journal • Anesthesia • Genetic Disorders • Musculoskeletal Diseases • Neurofibromatosis • Pain • Rheumatology • Solid Tumor • NF1

Robotic-Assisted Total Hip Arthroplasty Through the Posterior Approach. (PubMed, JBJS Essent Surg Tech) - "If there is concern for an error in component placement, intraoperative radiographs should be obtained. THA = total hip arthroplastyCT = computed tomographyDVT = deep vein thrombosisIT = iliotibial."

Journal • Cardiovascular • Hematological Disorders • Immunology • Orthopedics • Pain • Rheumatology • Thrombosis

A Prospective Nonrandomized Comparison of Wet Needling Versus Prolotherapy in Myofascial Pain. (PubMed, Cureus) - "Both modalities are effective at one month. At three and 24 months, the DPT was significantly more effective in improving the VAS and ODI."

Journal • Fibromyalgia • Musculoskeletal Pain • Pain

T-Cell Lymphoblastic Lymphoma with Anterior Mediastinal Mass in Pregnancy (ASA 2024) - "Spinal technique included 1.4 ml bupivacaine 0.75% with dextrose 8.25%, fentanyl 15mcg, and morphine 0.15mcg. Advanced airway equipment was readily available in the event of failed neuraxial in the setting of anterior mediastinal mass. Cesarean delivery was uneventful."

CNS Disorders • Hematological Malignancies • Lymphoma • Oncology • Respiratory Diseases

High Spinal Anesthesia and the Incidence of Delirium After Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=50 | Active, not recruiting | Sponsor: University of Manitoba | Recruiting ➔ Active, not recruiting | Trial completion date: Dec 2023 ➔ Jun 2024 | Trial primary completion date: May 2023 ➔ Jun 2024

Enrollment closed • Surgery • Trial completion date • Trial primary completion date • Anesthesia • Cardiovascular • CNS Disorders

Evaluation of the Typical Spinal Block During Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=250 | Enrolling by invitation | Sponsor: Oregon Health and Science University | Initiation date: Jan 2024 ➔ Jun 2024

Trial initiation date • Anesthesia • Obstetrics

Evaluation of the Typical Spinal Block During Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=250 | Enrolling by invitation | Sponsor: Oregon Health and Science University

New trial • Anesthesia • Obstetrics

SAFER-L: Spinal Anesthesia For Enhanced Recovery After Liver Surgery (clinicaltrials.gov) - P=N/A | N=128 | Recruiting | Sponsor: University of Manitoba | Unknown status ➔ Recruiting | Trial completion date: Dec 2019 ➔ Jan 2026 | Trial primary completion date: Nov 2019 ➔ Dec 2025

Enrollment open • Surgery • Trial completion date • Trial primary completion date • Anesthesia • Gastrointestinal Cancer • Liver Cancer • Oncology • Pain • Solid Tumor

Effect of Subarachnoid Hyperbaric Bupivacaine in Obese Pregnant Patients Undergoing Cesarean Section (clinicaltrials.gov) - P4 | N=106 | Recruiting | Sponsor: Hospital Civil de Guadalajara

New P4 trial • Anesthesia • Obesity • Obstetrics

The effect of anesthesia type on the outcomes of percutaneous nephrolithotomy in elderly males. (PubMed, Ann Med) - "Patients who underwent percutaneous nephrolithotomy under CSEA needed less analgesic injection during the postoperative period. CSEA can shorten the time a patient spends in the operating room and PACU, which provides more effective use of operation room working hours."

Journal • Anesthesia • Nephrology • Pain • Renal Calculi

The Effect of Intrathecal Bupivacaine Plus Dextrose 5% and Fentanyl Compared with Bupivacaine Alone on the Onset and Duration of Analgesia in Patients Undergoing Lower-Limb Orthopedic Surgery. (PubMed, Adv Orthop) - "The mean duration of anesthesia and analgesia was significantly longer in patients receiving bupivacaine plus fentanyl than in those receiving bupivacaine alone. However, concerning hemodynamic parameters, it cannot be concluded that the bupivacaine plus fentanyl receiving group was generally superior to the bupivacaine receiving group."

Journal • Surgery • Anesthesia • Orthopedics • Pain

A Comparative Preliminary Randomized Clinical Study to Evaluate Heavy Bupivacaine Dextrose Prolotherapy (HDP) and Autologous Blood Injection (ABI) for Symptomatic Temporomandibular Joint Hypermobility Disorder. (PubMed, J Maxillofac Oral Surg) - "HDP is a safe and simple modality for treating symptomatic sub-luxation with predictable clinical outcome. Heavy bupivacaine-dextrose can be considered as a prolotherapeutic agent for symptomatic chronic temporomandibular joint sub-luxation with the pharmacological benefit of local anaesthesia and proliferent delivery through the same injection."

Journal • Anesthesia • Pain

Use of Spinal Anesthesia in Lower Thoracic Spine Surgery: A Case Series. (PubMed, Oper Neurosurg (Hagerstown)) - "Spinal anesthesia is feasible for thoracic-level spine procedures, even in elderly patients with comorbidities. We describe our cases and technique for safely achieving a thoracic level of analgesia, as well as discuss recommendations, adverse events, and considerations for the use of spinal anesthesia during lower thoracic-level spine operations."

Journal • Anesthesia • Musculoskeletal Diseases • Orthopedics

Anesthesia Type on Percutaneous Nephrolithotomy in Aging Male (clinicaltrials.gov) - P=N/A | N=184 | Completed | Sponsor: Sedat Önen

New trial • Anesthesia • Renal Calculi

High Spinal Anesthesia and the Incidence of Delirium After Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: University of Manitoba

New trial • Anesthesia • Cardiovascular • CNS Disorders

Management Of Suboptimal Spinal Anesthesia During Cesarean Section (ASA 2021) - "Spinal anesthesia with 1.4 mL of 0.75% bupivacaine and 8.25% dextrose was administered, and testing was performed with Allis clamp without reported pain...The patient was offered general anesthesia, but she declined and agreed to proceed with the procedure, throughout which she continued to experience pain and discomfort. Here, we discuss the intraoperative management options for suboptimal spinal anesthesia during Cesarean section."

Anesthesia • Pain

[VIRTUAL] High-Resolution Epidural spinal cord stimulation (HR-SCS) evokes selective micturition and continence reflexes through a frequency-dependent effect governed by distinct neural circuits. (AUA 2021) - " Three male and three female cats (n=6) were anesthetized with a-chloralose after initial surgical preparations under isoflurane anesthesia... HR-SCS can selectively evoke continence and micturition reflexes through a unique frequency-dependent effect."

Anesthesia • CNS Disorders

Investigation into spinal anesthetic failure with hyperbaric bupivacaine: the role of cold exposure on bupivacaine degradation. (PubMed, Can J Anaesth) - "Canadian clinical practice and handling of hyperbaric bupivacaine is consistent. Most respondents indicated an interest in a formal reporting and collection process. Cold exposure did not degrade bupivacaine. A complex and possibly inconsistent reaction involving dextrose was identified that requires further analysis of a larger sample size to elucidate the mechanisms."

Journal • Anesthesia • Obstetrics

VICON-SPINE: Study of Spino-pelvic Sagittal Balance by Vicon® Optoelectronic System (clinicaltrials.gov) - P=N/A; N=36; Completed; Sponsor: University Hospital, Rouen; Recruiting ➔ Completed

Trial completion

Comparing the Effects of Levobupivacaine and Bupivacaine in Saddle Spinal Anesthesia (clinicaltrials.gov) - P4; N=60; Completed; Sponsor: Gazi University

New P4 trial

Subarachnoid Bupivacaine in Obese Patients Undergoing Cesarean Delivery (clinicaltrials.gov) - P4; N=40; Completed; Sponsor: Hospital Civil de Guadalajara

Clinical • New P4 trial

VICON-SPINE: Study of Spino-pelvic Sagittal Balance by Vicon® Optoelectronic System (clinicaltrials.gov) - P=N/A; N=35; Recruiting; Sponsor: University Hospital, Rouen; Not yet recruiting ➔ Recruiting

Enrollment open