Sinofuan (fluorouracil implants) / Simcere - LARVOL DELTA

Enhancing postoperative recurrence assessment in gastric and colorectal cancer patients with intraperitoneal fluorouracil implants: overcoming the diagnostic challenge of fluorouracil implant-related tumor-like lesions. (PubMed, Quant Imaging Med Surg) - "When surgical information was available, the diagnostic accuracy and confidence of the radiologists were improved in stage 3 (accuracy: 100%; confidence most often classified as high) compared to stage 2 (accuracy: P=0.007; confidence: P<0.001). The diagnostic accuracy and confidence of radiologists can be improved by providing them with training on implant imaging characteristics and precise surgical record documentation on the implant location and quantity."

Journal • Colorectal Cancer • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Clinical analysis of sustained-release 5-fluorouracil implants during surgery for advanced gastric cancer. (PubMed, Curr Probl Surg) - No abstract available

Journal • Gastric Cancer • Oncology • Solid Tumor

Gastrointestinal tumor-related perihepatic fluorouracil encapsulated lesions and liver metastases: a diagnostic imaging study based on contrast-enhanced computed tomography and magnetic resonance imaging. (PubMed, Quant Imaging Med Surg) - "FELs are typically non-enhancing lesions. In our study, two junior residents could best distinguish FELs from liver metastases using CECT with all MRI sequences."

Journal • MRI • Gastrointestinal Cancer • Gastrointestinal Disorder • Oncology • Solid Tumor

PROSPECT Trial: Pelvic Radiation Therapy Avoided for Most Patients With Intermediate-Risk, Locally Advanced Rectal Cancer (THE ASCO POST) - "Julie R. Gralow, MD...said the approach featured reliable patient selection and enabled treatment optimization. Investigators were able to de-escalate therapy in 91% of patients and identify the 9% who needed treatment escalation, she emphasized during a press briefing."

Media quote

3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma. (PubMed, J Pharm Pharmacol) - "The PCL-CS-5-FU implant was biocompatible and degradable with a significant effect in suppressing fibroblast contractility. The PCL-CS-5-FU implant could be used as a sustained release drug implant, replacing the need for repeated 5-FU injections in clinic, to prevent conjunctival fibrosis after glaucoma surgery."

Journal • Fibrosis • Glaucoma • Immunology • Liver Cirrhosis • Ophthalmology

No long-term survival benefit with sustained-release 5-fluorouracil implants in patients with stages II and III gastric cancer. (PubMed, World J Gastroenterol) - "Intraoperative sustained-release chemotherapy usage with 5-FU, did not improve the survival of patients who underwent an R0 radical resection in locally advanced stage of gastric cancer."

Journal • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Antineoplastic agents aggravate the damages caused by nicotine on the peri-implant bone: an in vivo histomorphometric and immunohistochemical study in rats. (PubMed, Clin Oral Investig) - "Assessing the interaction between chemotherapy and normal tissues is critical to assure quality of life during and after the cancer treatment."

Journal • Preclinical • Nicotine Addiction • Oncology

Intraperitoneal Chemotherapy Using Fluorouracil Implants Combined With Radical Resection and Postoperative Adjuvant Chemotherapy for Stage III Gastric Cancer: A Multi-Center, Randomized, Open-Label, Controlled Clinical Study. (PubMed, Front Oncol) - P3 | "There were neither significant differences between the groups in the incidence of hematogenous metastasis, lymph node metastasis, nor local metastasis. For cTNM stage III gastric cancer, intraoperative sustained-release fluorouracil implants after radical resection combined with postoperative adjuvant chemotherapy, could significantly reduce the risk of peritoneal recurrence and prolong PFS.Clinical Trial Registration: https://clinicaltrials.gov/, identifier (NCT02269904)."

Clinical • Journal • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Retrospective Cohort Study of Intraoperative Administration of Sustained-Release 5-Fluorouracil Implants in Advanced Gastric Cancer Patients. (PubMed, Front Pharmacol) - "Both the 5-years OS and PFS rates in 5-FU group were better than control group without significant side effect. 5-FU implants may improve 5-years OS and PFS rates after surgery in gastric cancer patients, while good safety profile suggests it could be reliable."

Journal • Retrospective data • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Does Intraperitoneal Chemotherapy Increase the Incidence of Anastomotic Leakage after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis. (PubMed, Gastroenterol Res Pract) - "This meta-analysis provides some evidence to suggest IC may increase the incidence of postoperative AL in colorectal cancer. However, fluorouracil implantation for IC does not increase the risk of AL, which seems to be a relatively safe method of IC."

Journal • Retrospective data • Review • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor