Chronogesic (sufentanil) / Durect - LARVOL DELTA

Comparison between lumbar plexus block and fascia iliaca block in hip surgery: A systematic review and meta-analysis. (PubMed, Medicine (Baltimore)) - "LPB significantly reduced intraoperative and postoperative opioid doses, and provided more stable hemodynamics at the end of surgery. FIB showed higher efficiency and shortened hospital stay. Anesthesiologists should select appropriate block techniques based on the unique advantages of different nerve blocks and patients' specific conditions."

Clinical • Journal • Retrospective data • Review • Addiction (Opioid and Alcohol) • Anesthesia

The application of paravertebral block for open cholecystectomy in a high-risk patient with an implantable cardioverter-defibrillator: a case report. (PubMed, Croat Med J) - "Using ultrasound, we identified the thoracic (Th) paravertebral spaces on the right side at four levels (from Th6 to Th9) and administered 3.5 mL of 0.5% levobupivacaine per level, for a total of 14 mL...The pain was successfully treated with rescue analgesia of 10 µg of intravenous (IV) sufentanil and a sedation dose of 50 mg IV propofol...The patient was discharged on postoperative day six. In conclusion, the application of TPVB combined with remimazolam sedation could present a feasible anesthetic and analgesic technique for open cholecystectomy in high-risk cardiac patients."

Journal • Anesthesia • Cardiovascular • Congestive Heart Failure • Heart Failure • Pain

Intra-operative care in uterine transplantation: a case report of a living-donor procedure (Euroanaesthesia 2025) - "Spinal anesthesia was performed using morphine, fentanyl and sufentanil for postoperative analgesia, while general anesthesia induction included propofol, sufentanil and succinylcholine. Maintenance consisted of sevoflurane (2–3%, MAC 1–1.3), remifentanil infusion (0.1–0.3 μg/kg/min), and cisatracurium (0.1 μg/kg/min)...Before uterine implantation, basiliximab (20 mg) and methylprednisolone (500 mg) were administered, and 5,000 U of heparin was given before arterial and venous anastomoses were released...Ultrasonography confirmed adequate blood flow through uterine vessels. Experience with living donor uterine transplantation is limited in Latin America. Living donors offer advantages such as reduced cold ischemia time and better surgical planning but raise ethical concerns.This case demonstrated minimal hemodynamic fluctuations, absence of reperfusion syndrome and negligible bleeding, suggesting uterine transplantation may elicit unique physiological responses compared..."

Case report • Clinical • Anesthesia • Cardiovascular • Infertility • Sexual Disorders • Solid Organ Transplantation • Transplantation

Dexmedetomidine as a Ropivacaine Adjuvant in a Thoracic Paravertebral Block Combined With an Erector Spinae Plane Block for Improving Early Quality of Recovery After Transapical Transcatheter Aortic Valve Implantation. (PubMed, Kaohsiung J Med Sci) - "The postoperative sufentanil consumption was significantly less in the RD group than that in the RS group. A longer time to first use of flurbiprofen with less remedial doses of flurbiprofen consumption within 48 h postoperatively was required for the RD group than that for the RS group. The two groups did not differ in the incidence of side effects. The findings of the study suggest that adding Dex to ropivacaine in TPVB combined with ESPB is effective in improving early quality of recovery and alleviating postoperative pain for patients undergoing transapical TAVI under general anesthesia."

Journal • Anesthesia • Pain

Effects of general anesthesia combined with ultrasound-guided lumbosacral plexus block on hemodynamics and postoperative rehabilitation in geriatric patients with total hip arthroplasty. (PubMed, Afr Health Sci) - "Prior to anesthesia induction, MAP, HR, and SpO2 between them had significant differences (P>0.05); at skin-incision-time and implantation of the prosthesis, the MAP value of the experimental group was higher than that of the general anesthesia group, 30 minutes after surgery, the SpO2 was higher than the general anesthesia group, and had significant differences (P0.05); 2 hours after that, the values of Cor, CRP, and MDA in experimental group were lower than the general anesthesia group, and that of IL-6 and SOD were higher than those in the general anesthesia group, and had significant differences (P<0.05); the dosage of propofol, remifentanil, sufentanil in experimental group were lower than the general anesthesia group, while postoperative extubation time in experimental group was earlier than general anesthesia group, and had significant differences (P<0.05); the incidence of POD in experimental group was lower than the general anesthesia group at 1d, 2d,..."

Journal • Anesthesia • CNS Disorders • Geriatric Disorders • Inflammation • Musculoskeletal Diseases • Orthopedics • IL6

Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized controlled trial. (PubMed, BMC Anesthesiol) - "Low-dose esketamine is used for its anti-inflammatory and analgesic effects in lumbar spine surgery of elderly patients. It is beneficial to hemodynamic stabilization and can reduce the incidence of postoperative respiratory depression in elderly patients. Among them, 0.2 mg/kg induction and 0.25 mg/(kg-h) infusion were more effective."

Journal • Anesthesia • CNS Disorders • Depression • Hypotension • Musculoskeletal Diseases • Oncology • Orthopedics • Pain • Psychiatry • IL10 • IL1B • IL6 • TCF21 • TNFA

Use of esketamine for tracheoscopic drug injection: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - "Sufentanil may induce hypotensive bradycardia and other adverse reactions in elderly patients during anesthesia, while esketamine exhibits sedative and analgesic effects with minimal impact on respiration and circulation...The heart rate and oxygen saturation showed no significant differences between the two groups, nor did the amount of propofol administered during the procedure. The utilization of esketamine during the induction phase of bronchoscopy and lavage under general anesthesia can enhance hemodynamic stability and reduce the occurrence of hypotension, thereby facilitating postoperative anesthetic recovery."

Journal • Anesthesia • Cardiovascular • Hypotension • Pain

Study on the effective dose of cyclopofol combined with sufentanil for painless gastrointestinal endoscopy by age and gender factors (ChiCTR) - P4 | N=300 | Not yet recruiting | Sponsor: Huludao Central Hospital; Huludao Central Hospital

New P4 trial • Gastrointestinal Disorder • Pain

Effective dose of remazolam in inhibiting laryngeal mask implantation in children when combined with sufentanil (ChiCTR) - P4 | N=120 | Recruiting | Sponsor: Shanghai Children's Hospital; Shanghai Children‘s Hospital

New P4 trial • Anesthesia

Spinal anaesthesia in primigravida with long QT syndrome for urgent section delivery: a case report (Euroanaesthesia 2024) - "We performed a spinal anaesthesia (SA), in the sitting position, using a 27G pencil point needle at the L3 to L4 interspace with 10 mg of hyperbaric 0.5% bupivacaine and 10 µg of fentanyl...Several medications are strictly forbidden to administer, such as dexmedetomidine, ketamine, sufentanil, succinylcholine, pancuronium, atropine and epinephrine. 1 In our patient, we did not observe rapid onset hypotension following SA which could lead to a ventricular arrhythmia and cardiac arrest. Our case further supports safe usage of SA for urgent CS in parturient with LQTS."

Case report • Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Hypotension • Ventricular Tachycardia • KCNH2

Catheter Tip-Associated Mass With Continuous Infusion of Sufentanil for Persistent Spinal Pain Syndrome Type 2: A Case Report Including Histopathologic Examination and Review of the Associated Basic and Clinical Research. (PubMed, Neuromodulation) - "To our knowledge, this is the first published case report of sufentanil causing this complication. The science and mechanism of intrathecal catheter tip-associated mass formation and associated clinical research correlates are reviewed in detail, and explanations for this phenomenon are proposed based on histochemical analysis of the patient's pathology findings."

Journal • Review • Musculoskeletal Pain • Orthopedics • Pain

Characterizing neurons in anesthetized macaque V1 with multi-photon imaging via a chronically implanted window (Neuroscience 2023) - "After 26 days, during which two recovery imaging sessions were carried out to assess wide-field functional architecture (eye dominance and orientation domains), a multi-day, terminal 2-photon imaging session commenced under anesthesia (sufentanil, isoflurane), with paralysis to reduce eye movement...We aim to further test this with both multi-photon imaging and high-density electrode recording. In addition to reporting our clustering results, we will describe our novel chronic imaging window and wide-field imaging system."

CNS Disorders

Continuous spinal anaesthesia in a patient with heart failure with reduced ejection fraction: a case report (Euroanaesthesia 2023) - "An initial dose of 2,5mg of 0,1% levobupivacaine and 2,5µg of sufentanil was given through the catheter. While the evidence is scarce, CSA has been reported to provide adequate sensory and motor block and hemodynamic stability. Although underutilized, CSA is a safe and effective anesthetic technique for the management of patients with HFrEF."

Clinical • Anesthesia • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Critical care • Diabetes • Dyslipidemia • Heart Failure • Hypertension • Hypotension • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease • Type 2 Diabetes Mellitus

Spinal Bupivacaine in a Pregnant Brugada Patient with SARS-COV-2 infection: an unnecessary or a calculated risk? (Euroanaesthesia 2023) - "Due to the urgency of the procedure, all options were quickly reviewed with the patient, and spinal anesthesia was performed with 2ml of hyperbaric bupivacaine 0,5% and 2,5 μg of sufentanil with lower limb motor block and T4 sensory level block...The patient was discharged 3 days later. Bupivacaine is a local anesthetic with a distinct affinity for cardiac sodium channels that is thought to potentiate arrhythmias in BrS patients, although there are no studies that undoubtedly demonstrate the risk, particularly in spinal anesthesia.2 Because of conflicting evidence on the matter, this case aims to report the uneventful use of spinal bupivacaine in a patient with BrS."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Diabetes • Endocrine Disorders • Genetic Disorders • Gestational Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases

Stability of Morphine Sulfate-Clonidine and Sufentanil-Clonidine Mixtures. (PubMed, Neuromodulation) - "This study shows the stability of the morphine-clonidine mixtures in syringes stored at 5 °C for five days and in implantable pumps stored at 37 °C for 28 days. For the sufentanil-clonidine mixtures, the results show stability in syringes for seven days at 5 °C. Pump results show stability of seven days for low concentrations and 28 days for high concentrations."

Journal • Oncology • Pain

Anesthetic management of a patient with catecholaminergic polymorphic ventricular tachycardia for a caesarean section (Euroanaesthesia 2022) - "Medicated with nadolol and flecainide...A combined spinal-epidural anaeshtesia was performed and 8 mg of bupivacaine and 2 mcg of sufentanil were injected in the subarachnoid space.Throughout the surgery the cardiac rhythm remained sinus...If required, an α-adrenergic agonist such as phenylephrine can be used. After the procedure an adequate pain management is important."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry • Ventricular Tachycardia

Breast augmentation under local anesthesia with intercostal blocks and light sedation. (PubMed, J Plast Surg Hand Surg) - "The anesthetic protocol consisted of an initial intravenous bolus of 1 mg midazolam and 0.25 mg alfentanil preoperatively. In 2017, this was changed to 2-4 mg midazolam intramuscularly, 1 mg midazolam intravenously, and 2.5 µg sufentanil intravenously...The change in anesthetic regime was associated with a significantly (p < 0.0001) decreased need for supplementary medication with no increased risk of complications. Breast augmentations in local anesthesia with intercostal blocks and light sedation can be performed safely and can serve as an alternative to procedures in general anesthesia."

Journal • Aesthetic Medicine • Anesthesia

[VIRTUAL] Anesthetic Consideration For SEEG Placement (ASA 2021) - "Volatile aesthetic with sevoflurane or isoflurane was used in all cases and the most common adjunct was sufentanil infusion (52, 78.8%), followed by propofol (32, 48.5%), then Fentanyl (1, 1.5%). Our preliminary data represents the largest cohort of pediatric patients with DRE who had SEEG for surgical planning with respect to (1) perioperative management and (2) outcomes. Retrospective analyses show that patients recover well, requiring minimal time in the ICU. There is low risk of inducing seizures during placement as only 3 patients required rescue AEDs."

Anesthesia • Cerebral Hemorrhage • CNS Disorders • Epilepsy • Hematological Disorders • Immunology • Infectious Disease • Pediatrics

Comparison of single-injection ultrasound-guided thoracic paravertebral block with transversus abdominis plane block in peritoneal dialysis catheter implantation: a randomized controlled trial. (PubMed, Trials) - "Single-injection US-TPVB provided a better pain relief at catheter exit site. The quality and reliability of anesthesia after a single-injection US-TPVB was comparable to that of LAI, but not better than that of an oblique subcostal TAP block for PDC implantation."

Clinical • Journal • Anesthesia • Chronic Kidney Disease • Nephrology • Pain • Renal Disease

Analgesic Efficacy of Regional Anesthesia of the Hemithorax in Patients Undergoing Subcutaneous Implantable Cardioverter-Defibrillator Placement. (PubMed, J Cardiothorac Vasc Anesth) - "Ultrasound-guided transversus thoracic muscle plane block and serratus anterior plane block resulted in lower intraoperative Critical-Care Pain Observation Tool scores and the need for less adjunctive pain medication and sedation compared with local anesthesia in patients undergoing S-ICD placement."

Clinical • Journal • Anesthesia • Critical care • Pain

Sufentanil postoperative analgesia reduce the increase of T helper 17 (Th17) cells and FoxP3 regulatory T (Treg) cells in rat hepatocellular carcinoma surgical model: A randomised animal study. (PubMed, BMC Anesthesiol) - "Sufentanil and morphine postoperative analgesia in HCC rats accepted hepatectomy could relieve postoperative pain, promote the recovery of liver function after surgery, alleviate the immunosuppressive effect of pain. Furthermore, Compared to morphine, sufentanil might have a slighter effect on CD4/CD8 ratio and Treg frequencies. Therefore, sufentanil postoperative analgesia is better than morphine in HCC hepatectomy rats."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Oncology • Pain • Solid Tumor • FOXP3

Dynamic changes in rhythmic and arrhythmic neural signatures in the subthalamic nucleus induced by anaesthesia and tracheal intubation. (PubMed, Br J Anaesth) - "Apart from similar activity changes in both STN and cortex associated with anaesthesia-induced unresponsiveness, we observed specific neuronal activity changes in the STN in response to the anaesthesia and tracheal intubation. We also show that the power-law exponent in the power spectra in the STN was modulated by tracheal intubation in anaesthesia. Our results support the hypothesis that subcortical nuclei may play an important role in the loss and return of responsiveness."

Journal • Anesthesia • CNS Disorders • Gene Therapies • Movement Disorders • Parkinson's Disease

Patient-controlled subcutaneous analgesia using sufentainil or morphine in home care treatment in patients with stage III-IV cancer: A multi-center randomized controlled clinical trial. (PubMed, Cancer Med) - "PCSA with sufentanil achieves better pain control and life quality as well as fewer adverse reactions in stage III-IV cancer patients with pain and may be a promising pain management in these patients."

Clinical • Journal • Oncology • Pain • Psychiatry

Analgesia Effects of Nalbuphine vs Sulfentanil (clinicaltrials.gov) - P=N/A; N=80; Not yet recruiting; Sponsor: Fudan University

New trial • Biosimilar • Pain

Combined paravertebral and intrathecal vs thoracic epidural analgesia for post-thoracotomy pain relief (Br J Anaesth) - P4, N=84; NCT00493909 ; PMID: 23151421; “TEA (ropivacaine 0.2%+sufentanil) or the PVB (ropivacaine 0.5%)+ITO (sufentanil+morphine) group…mean and maximal VAS scores were lower in the TEA (n=43) than in the PVB+ITO group (n=37) at several time points at rest (P<0.026) and during coughing/movement (P<0.021). However, in the PVB+ITO group, the mean VAS scores never exceeded 1.9 and 3.5 at rest and during coughing/movement, respectively; and the maximal differences between the groups (TEA vs PVB+ITO) in the maximal VAS scores were only 1.2 (3.4 vs 4.6) at rest, and 1.3 (4.4 vs 5.7) during coughing/movement”

P4 data • Pain