levocetirizine / Generic mfg. - LARVOL DELTA

New Onset Pruritus Following Discontinuation of Cetirizine or Levocetirizine. (PubMed, J Allergy Clin Immunol Pract) - No abstract available

Journal • Dermatology • Pruritus

Marksans Pharma’s UK arm gets MHRA approval for anti-allergy oral solution (CNBC-TV18) - "The approval covers Cetirizine Dihydrochloride 1 mg/ml oral solution, expanding the firm’s allergy treatment portfolio. The oral solution is used to relieve a range of seasonal and year-round allergies, including hay fever and hives."

ANDA • Allergy

Comparative analysis of the effectiveness of treatment for exudative otitis media and eustachitis associated with concomitant allergic rhinitis (PubMed, Vestn Otorinolaringol) - "To assess the comparative effectiveness of different AR therapy regimens and their impact on middle ear and Eustachian tube pathology, the 168 affected patients were divided into four parallel groups: Main group (41 patients): treated with a fixed-dose combination of mometasone furoate and olopatadine hydrochloride (Rialtris); Control group 1 (45 patients): received intranasal monotherapy with mometasone furoate; Control group 2 (41 patients): treated with the oral antihistamine levocetirizine; Control group 3 (41 patients): received combination therapy of intranasal mometasone furoate and oral levocetirizine. Due to the accelerated recovery of Eustachian tube function and restoration of its drainage capabilities, the need for invasive middle ear drainage procedures (e.g., shunting, tympanostomy) was eliminated in the group receiving the fixed intranasal combination of mometasone furoate and olopatadine hydrochloride. This fixed-dose combination appears to be the optimal..."

Journal • Allergic Rhinitis • Immunology • Inflammation • Otorhinolaryngology

Generalized Bullous Fixed Drug Eruption Secondary to Levocetirizine: A Lesson Learned! (PubMed, Clin Case Rep) - "There are only two reports of levocetirizine-induced GBFDE in the literature to date. We hereby present a case of a 65-year-old male with GBFDE due to levocetirizine, which was misattributed to a more commonly implicated drug, that is, acetaminophen."

Journal • Immunology • CD8

Comparing Antihistamines for Chronic Urticaria: Systematic Review Dose Response and Network Meta-Analysis of Randomized Trials (ACAAI 2025) - "Sedation likely increases with higher doses, with first-generation agents among the most sedating; cetirizine, ketotifen, levocetirizine, and rupatadine among the intermediate sedating; and bilastine, desloratadine, fexofenadine, and loratadine among the least sedating. Cetirizine and loratadine are among the most effective for all components of urticaria activity, but cetirizine is intermediately sedating and loratadine has lower certainty on improving quality of life and sleep. Higher doses may have diminishing benefits and increased risks."

Retrospective data • Review • Anesthesia • Cardiovascular • CNS Disorders • Dermatology • Immunology • Pruritus • Sleep Disorder • Urticaria

Efficacy comparison of combined montelukast-antihistamine and montelukast monotherapy in allergic rhinitis: a meta-analysis of randomized controlled trials. (PubMed, Eur Ann Allergy Clin Immunol) - "In subgroup analysis, all combinations with loratadine, desloratadine, or levocetirizine showed greater efficacy than monotherapy in improving daytime symptoms. However, the effectiveness of each drug combination varied by symptom domain. These findings may assist clinicians in selecting appropriate combination regimens based on individual symptom patterns."

Journal • Monotherapy • Retrospective data • Review • Allergic Rhinitis • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

ANTITUBERCULAR THERAPY-INDUCED DRESS SYNDROME: A RARE BUT LIFE-THREATENING ADVERSE REACTION (CHEST 2025) - "Now ATT was stopped and patient is started on prednisolone (30 mg/day for 10 days), levocetirizine (5 mg/day for 10 days), atarax (10 mg/day for 5 days) and topical paraffin oil...The patient was then started on modified ATT regimen consisting isoniazid (300 mg), levofloxacin (750 mg), and linezolid (600 mg twice daily) for 6 months... Clinicians from high TB burden countries must be aware of DRESS associated with ATT. Timely management is vital as it is associated with 10% mortality and should be differentiated from other skin reactions.This case highlights the importance of recognizing DRESS syndrome as a rare but potentially life-threatening adverse reaction to ATT an emphasizes the need for early diagnosis and prompt intervention."

Dermatitis • Dermatology • Eosinophilia • Hepatology • Immunology • Inflammation • Nephrology • Pneumonia • Pruritus • Pulmonary Disease • Respiratory Diseases • Steven-Johnson Syndrome

Exploring the relationship and shared mechanisms of major depressive disorder and diabetic kidney disease: a comprehensive clinical and genetic analysis. (PubMed, Front Psychiatry) - "Furthermore, cMAP analysis and molecular docking suggested rucaparib and levocetirizine as candidate therapeutic agents. Our findings demonstrate a genetic and immunological link between MDD and DKD. CD163 and KLRB1 may serve as potential biomarkers and therapeutic targets, offering new insights into the shared mechanisms and treatment strategies for comorbid MDD and DKD."

Journal • CNS Disorders • Depression • Diabetes • Diabetic Nephropathy • Inflammation • Major Depressive Disorder • Metabolic Disorders • Mood Disorders • Nephrology • Psychiatry • Renal Disease • CD163 • KLRB1

The influences of antihistamine on liver fibrosis, vasoresponsiveness and portosystemic shunting in bile duct-ligated cirrhotic rats. (PubMed, J Chin Med Assoc) - "Levocetirizine ameliorated liver fibrosis, portal hypertension and splanchnic hyperdynamic circulation in cirrhotic rats, possibly through the down-regulation of hepatic fibrogenesis factors. Antihistamines may be a therapeutic option to control portal hypertension. However, further investigations are required to clarify its clinical application."

Journal • Preclinical • Cardiovascular • Dermatology • Fibrosis • Gastroenterology • Hepatitis C • Hepatology • Hypertension • Immunology • Inflammation • Liver Cirrhosis • Portal Hypertension • Pruritus • MMP2 • SMAD2 • TGFB1 • TIMP1

Chronic spontaneous urticaria with overlapping type I/IIb endotypes in a patient with Graves disease (PubMed, Rev Alerg Mex) - "There are no specific statistics on the combined prevalence of hyperthyroidism and chronic urticaria worldwide. In this case, the patient presents elevated IgE, autoimmune disease, and positive autologous serum, leading to a diagnosis of type I/IIb overlap. Currently, there is no classification system for urticaria types that can be applied to any clinical setting, which impacts the patients therapeutic and prognostic decisions."

Journal • Cardiovascular • Chronic Spontaneous Urticaria • Dermatology • Endocrine Disorders • Grave’s Disease • Immunology • Pruritus • Urticaria

The First Report on Cat Flea (Ctenocephalides felis), a Zoonotic Haematophagous Insect Infestation in Humans in Bangladesh: A Case Report and Literature Review. (PubMed, Vet Med Sci) - "The flea was removed and identified as C. felis. The patient was advised to take levocetirizine once daily for five days, which led to satisfactory recovery from FBD."

Journal • Review • Dermatitis • Dermatology • Immunology • Pruritus • Urticaria

Efficacy, Safety, and Tolerability of Bilastine Versus Levocetirizine for Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (EADV 2025) - "A total of 5 RCTs involving 1,127 patients were included, comparing bilastine 20 mg (n = 462) to levocetirizine 5 mg (n = 449), with 216 patients assigned to placebo or fexofenadine in third-arm studies. The consistently lower risk of somnolence with bilastine reinforces its role as a better- tolerated alternative. High heterogeneity across efficacy outcomes limits certainty, highlighting the need for further high-quality, head-to-head trials."

Retrospective data • Review • Cardiovascular • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Wells syndrome: a case report (EADV 2025) - "Levocetirizine 10mg/hydroxyzine 50mg and Dapsone 100mg/d were ineffective. Prednisone 0.5 mg/kg/d led to a regression of the lesions with a localised recurrence in the form of scrotal pruritus... The particularity of our observation lies in the rarity of SW and of localisations to the scalp and scrotum. The association with a dysimmune disease such as vitiligo deserves to be reported and studied."

Case report • Clinical • Alopecia • Dermatitis • Dermatology • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Hypereosinophilic Syndrome • Inflammation • Pruritus • Urticaria • Vitiligo

Cross-regional University Migration Triggering Keratotic Eczema in an Adolescent—A Case Report (EADV 2025) - "When the patient took leave and returned to his warm, humid hometown, topical betamethasone-urea ointment, oral levocetirizine and avoidance of detergents resulted in complete clearance of lesions... This case indicates a definite association between keratotic eczema and regional environmental change. Hot, dry climate, hard water and frequent detergent use may impair the skin barrier, while psychological and lifestyle alterations caused by academic migration act as additional triggers. For susceptible students, personalised prevention strategies are recommended: environmental adaptation guidance with enhanced moisturising and reduced exposure to irritant cleansers before and after returning to campus; behavioural interventions to avoid mechanical injury such as picking of scales; and dynamic follow-up with timely adjustment of therapy during high- risk seasons or environmental transitions."

Case report • Clinical • Atopic Dermatitis • Dermatology • Dermatopathology • Immunology

Granulomatous Rosacea with Demodicosis in a 30-year old Filipino Male: A Case Report (EADV 2025) - "Patient was initially assessed with allergic contact dermatitis with secondary bacterial infection versus acneiform eruption and prescribed with cefalexin, cetirizine, mild cleanser, saline solution compress, mometasone and mupirocin ointment with noted flattening and drying of some lesions...Patient was treated with levocetirizine + betamethasone tab for 5 days then doxycycline 100mg twice a day for 8 weeks...Additionally, patient was instructed gentle skin care measures, sunscreen, and application of topical ivermectin 1% cream twice a day... Recent data highlights the significant role of Demodex in the pathogenesis of granulomatous rosacea by exaggerated stimulation of the immune system, rupture of hair follicles and formation of granulomas. This case report highlights a severe flare of rosacea with granulomatous features on histopathology. This emphasizes clinical and histopathological correlation with close regular follow up and evaluation of response to systemic..."

Case report • Clinical • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Ophthalmology • Pruritus • Rosacea

COURAGE: COrticosteroids in acUte uRticAria in emerGency dEpartment (clinicaltrials.gov) - P3 | N=137 | Completed | Sponsor: Assistance Publique - Hôpitaux de Paris | Trial primary completion date: Aug 2025 ➔ Feb 2025

Trial primary completion date • Dermatology • Immunology • Urticaria

Efficacy of levocetirizine in reducing albuminuria and inflammatory biomarkers in patients with diabetic kidney disease: A randomized controlled trial. (PubMed, J Diabetes Complications) - P2 | "Levocetirizine reduces albuminuria, inflammatory, and renal indicators, which makes it a potentially has albuminuria lowering effect and anti-inflammatory drug which decreases disease progression."

Biomarker • Journal • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Oncology • Renal Disease • CST3 • TNFA

Efficacy of Montelukast-Antihistamine Combination Therapy Compared with Antihistamine Monotherapy in Allergic Rhinitis: A Systematic Review and Meta-Analysis. (PubMed, Clin Exp Otorhinolaryngol) - "Combinations with desloratadine and levocetirizine showed greater benefits than those with loratadine or fexofenadine. Montelukast-antihistamine combination therapy improves overall symptoms and quality of life compared with antihistamine monotherapy. The magnitude of benefit appears to vary depending on the specific antihistamine used, highlighting the potential value of individualized treatment strategies in the management of AR."

Journal • Monotherapy • Retrospective data • Review • Allergic Rhinitis • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

COURAGE: COrticosteroids in acUte uRticAria in emerGency dEpartment (clinicaltrials.gov) - P3 | N=137 | Completed | Sponsor: Assistance Publique - Hôpitaux de Paris | Active, not recruiting ➔ Completed | N=240 ➔ 137

Enrollment change • Trial completion • Dermatology • Immunology • Urticaria

In brief: Pruritus following antihistamine discontinuation. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Dermatology • Immunology • Pruritus • Urticaria

Efficacy of Combined Oral Isotretinoin and Desloratadine or Levocetirizine vs. Isotretinoin Monotherapy in Treating Acne Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, Biomedicines) - "Overall, desloratadine improved tolerability and reduced mucocutaneous adverse events more than levocetirizine. Current evidence suggests that combining oral antihistamines with isotretinoin may offer therapeutic benefits in acne management, particularly in enhancing tolerability and potentially improving clinical outcomes, as reflected by significant reductions in GAGS scores and mucocutaneous adverse effects such as cheilitis, pruritus, and acne flare-ups."

Journal • Monotherapy • Retrospective data • Review • Acne Vulgaris • Dermatology • Pruritus

A comprehensive clinical evaluation of levocetirizine in the treatment of chronic urticaria in children. (PubMed, Front Pharmacol) - "The former is superior to the latter in terms of safety, effectiveness, suitability, innovation, and accessibility, whereas the latter is more cost-effective than the former. The comprehensive clinical value of levocetirizine is greater than that of loratadine in the treatment of chronic urticaria in children, which can provide evidence for the rational use of antiallergic drugs and drug catalog selection in medical institutions."

Journal • Dermatology • Immunology • Urticaria

Preparation and Evaluation of Long-Acting Injectable Levocetirizine Prodrug Formulation. (PubMed, Pharmaceutics) - " All formulations demonstrated potential for the long-acting delivery of LCZ, maintaining therapeutic plasma levels for over 30 days. Moreover, the release behavior and systemic exposure could be effectively modulated by excipient selection."

Journal • Allergic Rhinitis • Immunology • Inflammation • Pediatrics

Second-Generation H1-Receptor Antagonists, Mequitazine, Azelastine and Desloratadine Activate Caspase-8, Caspase-3, and Gasdermin E and Induce Cell Death Showing Pyroptotic-Like Features in Macrophages at Excessively High Concentrations. (PubMed, Biol Pharm Bull) - "Here, we examined the inflammation-modulating and cell death-inducing effects of 10 second-generation H1R antagonists on mouse intraperitoneal macrophages, which include ketotifen, mequitazine, azelastine, oxatomide, epinastine, bepotastine, fexofenadine, loratadine, levocetirizine, and desloratadine, to assess an anticipated adverse reaction. Western blotting analysis revealed that caspase-8, caspase-3, and gasdermin E (GSDME), but not gasdermin D, were cleaved and activated in the macrophages. These results suggest that second-generation H1R antagonists such as mequitazine, azelastine, and desloratadine induce pyroptotic-like cell death accompanied by caspase-8, caspase-3, and GSDME activation in macrophages."

Journal • Allergy • Immunology • Inflammation • CASP3 • CASP8 • GSDME • IL6

Efficacy of WuSheZhiYang Pills in Mild-to-Moderate Atopic Dermatitis: Protocol for a Double-Blind, Randomized, Placebo-Controlled Trial. (PubMed, JMIR Res Protoc) - "This study will evaluate the efficacy of WSZY pills for AD and provide additional evidence, suggest new therapeutic options for patients, and reduce their disease burden."

Clinical protocol • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus