HH102007 / HaiHe Biopharma - LARVOL DELTA

HH102007 is a highly selective and potent PARP1 inhibitor and trapper (AACR 2024) - "HH102007 achieved tumor regression in MDA-MB-436 xenografts at a lower dose than AZD9574, and showed synergistic efficacy in combination with carboplatin in SUM149PT, which was insensitive to AZD9574. As for hematological toxicity, HH102007 up to 25 mg/kg did not reduce reticulocyte in rat while AZD5305 at 1 mg/kg caused reticulocyte reduction in a head-to-head comparison. In summary, HH102007 is a potent PARP1 inhibitor and trapper, with better selectivity and therapeutic window than both AZ compounds."

Late-breaking abstract • Oncology • DRD • PARP2