prochlorperazine maleate / Generic mfg. - LARVOL DELTA

Drugs for acute treatment of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

A Fizzy Solution: Coca-Cola Dissolution of Gastric Bezoar to Facilitate Hemostatic Intervention (ACG 2026) - "Chronic nausea and emesis were partially controlled with prochlorperazine and promethazine; symptoms acutely worsened two days prior...Metoclopramide and continuous PPI infusion were initiated, but despite treatment, recurrent hematemesis persisted (hemoglobin nadir 6.5 g/dL)...A third EGD showed substantial bezoar clearance, revealing a single oozing cratered ulcer with active hemorrhage (Forrest Class Ib) along the lesser curvature, treated with epinephrine injection...Figure: Pre-intervention EGD showing undigested food bezoar in the gastric body prior to Coca-Cola dissolution. Figure: Post-Coca-Cola dissolution EGD revealing clearance of the gastric bezoar with residual actively oozing gastric ulcer in the setting of upper GI bleed."

Diabetes • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Metabolic Disorders • Peptic Ulcer • Type 2 Diabetes Mellitus

Gastrointestinal Manifestations of 7-Hydroxymitragynine Withdrawal (ACG 2026) - "7OHMZ is the more active narcotic metabolite that is 4.5 times more potent in inducing respiratory depression than morphine...The patient was treated with prochlorperazine, pain control, and IVF...Upon abrupt cessation after chronic use of 7OHMZ, severe GI symptoms can manifest. Clinicians should be aware of the GI manifestations of 7OHMZ withdrawal, as illustrated by this case report."

Addiction (Opioid and Alcohol) • Bipolar Disorder • CNS Disorders • Depression • Endometriosis • Gastroenterology • Gastrointestinal Disorder • Gynecology • Immunology • Mood Disorders • Polyendocrine Metabolic Ovarian Syndrome • Post-traumatic Stress Disorder • Women's Health

Pan-Enteric Dysmotility and Small Bowel Malabsorption: A Multidisciplinary Challenge in a Patient With LADA and Hashimoto's (ACG 2026) - "Despite extensive medical therapy which included prokinetics (prucalopride, erythromycin, azithromycin) , intestinal secretagogues (lubiprostone, plecanatide), antiemetics (ondansetron, prochlorperazine) and antispasmodics (dicyclomine), (proton pump inhibitors and H2 blockers), symptoms persisted . An integrated neuro-immuno-gastroenterological approach is essential in such complex presentations. Figure: Smallbowel Figure: Autoimmune"

Clinical • Constipation • Crohn's disease • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Secondary Hyperparathyroidism • IL13 • IL6

Robust changes in brain function require high D2 receptor occupancy by prochlorperazine: an imaging correlate for the antipsychotic therapeutic window. (PubMed, Neuropsychopharmacology) - "In both human subjects and NHP, functional MRI responses showed a rapidly escalating response at occupancies larger than about 60%, a response consistent with autoreceptor-mediated dopamine release. These results provide a functional correlate for the lower edge of the antipsychotic therapeutic occupancy window and confirm that D2 receptor antagonism is ineffective at attenuating post-synaptic function at low occupancies."

Journal • CNS Disorders • Psychiatry • Schizophrenia • DRD2

RAPID ONSET OF NEUROLEPTIC MALIGNANT SYNDROME FOLLOWING PROCHLORPERAZINE ADMINISTRATION (CHEST 2026) - No abstract available

2026 Taiwan guidelines for the acute pharmacologic treatment of migraine in adults. (PubMed, J Chin Med Assoc) - "Non-specific agents include acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs: diclofenac, ibuprofen, naproxen). Injectable prochlorperazine is also strongly recommended. Ergotamine/caffeine combinations are less effective and are second-line agents, while high-dose aspirin is limited by gastrointestinal risk. Considering the potential risk of dependency, tramadol or tramadol/paracetamol combinations should be reserved until all other agents fail, and should be limited to oral forms. Other opioids, such as morphine, butorphanol, etc., lack evidence and are not recommended...Acetaminophen remains first-line for children and pregnant women. To prevent medication-overuse headache, acute treatments, including NSAIDs, acetaminophen, triptans, ergot derivatives, and combination analgesics, should not exceed two days per week, probably with the exception of rimegepant."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Migraine • Pain

Treating Intractable Nausea and Vomiting in Cerebellar and Medullary Stroke. (PubMed, Cureus) - "Ondansetron and metoclopramide provided only limited or temporary relief. Symptoms improved after sequential escalation to ondansetron, chlorpromazine, prochlorperazine, and amitriptyline; transdermal scopolamine was included in the discharge regimen...Because multiple medications were introduced over a short interval and natural neurologic recovery may have contributed, the effect of any individual agent or combination cannot be determined. This case suggests that receptor-diverse pharmacotherapy may be considered when initial treatment fails while underscoring the need for further study of efficacy, safety, and medication sequencing."

Journal • Cardiovascular • Diabetes • Gastrointestinal Disorder • Metabolic Disorders

Identifying candidate therapeutic targets in amyotrophic lateral sclerosis through a transcriptome-wide machine-learning consensus approach for drug repurposing. (PubMed, Neuroscience) - "Deferoxamine and disulfiram showed the clearest reversal-compatible profiles in motor cortex, whereas yohimbic acid and atovaquone showed reversal-compatible profiles in blood. Ciprofloxacin, prochlorperazine, and a compound group led by androsterone instead showed concordant connectivity. The results provide transparent, hypothesis-generating gene, pathway, and compound priorities, but they do not establish biomarkers, therapeutic efficacy, or clinical suitability and require validation in independent cohorts and experimental ALS models."

Journal • Amyotrophic Lateral Sclerosis • CNS Disorders

Prochlorperazine dimaleate elicits antiproliferative activity of gastric cancer cells via inhibiting the PI3K/AKT/mTOR signaling pathway. (PubMed, Genes Dis) - No abstract available

Journal • Gastric Cancer • Oncology • Solid Tumor

Pre-hospital healthcare for hyperemesis gravidarum: a cross-sectional analysis of baseline data from the SUKK-P study. (PubMed, BMC Pregnancy Childbirth) - "Women with hyperemesis gravidarum describe high level of distress, still there is a delay in being provided antiemetics as 42% reported provision of sick leave as first healthcare measure."

Journal • Constipation • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Pain • Rare Diseases

Medication-Induced Catecholamine Release in Undiagnosed Pheochromocytoma (ENDO 2026) - "Her metoprolol dose had recently been increased for elevated blood pressure despite being on hydrochlorothiazide...Shortly after receiving IV fluids, prochlorperazine, and diphenhydramine, her systolic blood pressure acutely increased to 160-260 mmHg. She received Dilaudid, Zofran, hydralazine, and labetalol but developed sudden dyspnea. Imaging was concerning for pulmonary edema, prompting treatment with Lasix, nitroglycerin, and BiPAP... This case highlights that pheochromocytoma can present in uncommon ways and should be considered when patients develop new or unusual headaches, especially with abrupt blood pressure changes. When it is suspected, medications such as prochlorperazine and beta-blockers should be avoided, and alpha-blockers should be given as the first-line treatment."

Cardiomyopathy • Cardiovascular • CNS Disorders • Hypertension • Migraine • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Pharmaceutical policy and off-label prescribing in pregnancy: A population-based historical cohort study analyzing inequality in access to antiemetics within Australia's Pharmaceutical Benefits Scheme. (PubMed, Acta Obstet Gynecol Scand) - "Off-label ondansetron access accounted for the majority of public expenditure on antiemetics dispensed during pregnancy, revealing a disconnect between health policy, clinical practice, public expenditure, and pregnant women's needs. While pro-poor access and public subsidies for antiemetics align with the equity elements embedded in the design of the Pharmaceutical Benefits Scheme, they may also be reflective of inequitable access to other unsubsidized, guideline-recommended pharmacotherapies for nausea and vomiting in pregnancy."

Journal • Obstetrics

Migrainous cardialgia: When the headache hurts the heart—A multicenter, retrospective case series (AHS 2026) - "Chest pain resolved with prochlorperazine (n = 8), or rizatriptan (n = 2). We propose the term, Migrainous Cardialgia/Thoracalgia to describe chest discomfort temporally linked to migraine attacks but without evidence of structural or ischemic heart disease. This series of 11 subjects underscores the need to systematically study the incidence and attributes of chest pain in larger populations of people with migraine with and without aura. A note of caution, however, although cardiac assessments did not disclose ischemia evidence in any of our cases, this should be pursued vigorously to rule out coronary insufficiency till such time more data accumulates."

Retrospective data • CNS Disorders • Migraine • Pain

The development of a just in time teaching module to rapidly and effectively educate health care providers on updated American Headache Society evidence for acute management of migraine in the emergency room (AHS 2026) - "Secondly, it reviews how Prochlorperazine IV and GONB could be offered to adults while hydromorphone IV should not. Potential treatments include ketorolac IV, metoclopramide IV, sumatriptan SC, and SONB. Chlorpromazine IV, dexamethasone IV, and valproate IV may be offered. In general, acetaminophen IV should not be offered, and additional evidence is needed for caffeine, granisetron, ibuprofen, ketamine, lidocaine and others... Many health care providers in the emergency room setting provide idiosyncratic and non-evidence based parenteral care. Our educational piece was developed in order to rapidly educate providers on essential aspects of recognizing migraine in the emergency room and what evidence based recommendations are suggested by the American Headache Society. Once the educational piece is accepted for inclusion in the app, it can be used to help standardize education and ensure a rapid, meaningful guide to care for acute treatment of migraine in the emergency..."

CNS Disorders • Migraine • Pain

Preparation and evaluation of Prochlorperazine Maleate loaded nanostructured lipid carrier for the treatment of schizophrenia. (PubMed, Ther Deliv) - "The optimized NLCs exhibited a particle size of 213.40 ± 46.53 nm, zeta potential of -32.7 mV, and entrapment efficiency of approximately 72%. This approach has strong potential for enhancing therapeutic outcomes in schizophrenia."

Journal • CNS Disorders • Psychiatry • Schizophrenia • DRD2

Successful use of intravenous droperidol in hyperemesis following failure of sequential antiemetic therapy. (PubMed, Am J Emerg Med) - "Additional treatment with ondansetron, prochlorperazine, and metoclopramide via IV administration as well as fluid administration resulted in minimal improvement in her symptoms in the emergency department. This adds to the evidence supporting consideration of droperidol for refractory cases of nausea and vomiting and hyperemesis gravidarum in pregnancy. The purpose of this case report is to describe the safety and efficacy of droperidol in the treatment in refractory nausea and vomiting in pregnancy."

Journal • Rare Diseases

Prochlorperazine inhibits the proliferation of hepatocellular carcinoma cells by promoting phosphorylation of β-catenin. (PubMed, Anticancer Drugs) - "This novel finding sheds light on the potential molecular mechanisms of PCZ as a therapeutic strategy for HCC. In summary, our study provides fresh insights into the utility of PCZ as a therapeutic option for HCC and elucidates its molecular mechanisms."

Journal • CNS Disorders • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor • CTNNB1

Efficacy of Nasal Migraine Cocktail used in Pediatric Emergency Department: A Clinical Trial (PAS 2026) - "Exclusion criteria included allergies or other contraindications to ketorolac, intranasal obstruction, inability to self-report pain, and concurrent conditions that could affect study outcomes.Participants were randomized to receive either intranasal (IN) ketorolac (1 mg/kg) with oral prochlorperazine (0.1mg/kg, max 10mg) and diphenhydramine (1mg/kg, max 50mg) (Group A) or IV ketorolac (0.5 mg/kg, max 30 mg) with the same oral adjuncts (Group B). Our primary outcome was the pain assessment 60 minutes after receiving study medication. Secondary outcomes include time to onset of clinically meaningful decrease in pain; ancillary emergency department outcomes (e.g. receipt of rescue medications, headache relief, headache freedom, percentage improvement); 24- hour follow-up outcomes; and adverse events."

Clinical • CNS Disorders • Immunology • Migraine • Pain • Pediatrics

Comparing Second-Line Intravenous Medication Management of Acute Migraine Headache in the Pediatric Emergency Department: Magnesium vs. Methylprednisolone (PAS 2026) - "Commonly used and better reviewed IV medications for pediatric migraine include NSAIDs (ketorolac) and dopamine receptor antagonists (metoclopramide, prochlorperazine), often given in combination with fluids as a first-line IV "migraine cocktail". Secondary outcome data included disposition from the PED, adverse medication events, need for additional migraine medications following second-line treatment, and re-visit to PED within 72 hours for migraine. Statistical analysis will be carried out using Chi-Square tests, Wilcoxon rank sum tests, and logistic regression, as appropriate."

Clinical • CNS Disorders • Migraine • Pain • Pediatrics

Impact of Haloperidol on Emergency Department Outcomes in Pediatric Cannabis Hyperemesis Syndrome (PAS 2026) - "Commonly used antiemetics such as ondansetron and prochlorperazine are ineffective in the treatment of this condition. There were 21 pre-pathway and 71 post-pathway CHS encounters. In the pre-pathway cohort, 11/21 (52.4%) patients improved with haloperidol, compared with 55/71 (77.5%) in the post-pathway group, a significantly higher proportion (z = -2.24, p = 0.025). 14/21 (66.6%) of pre-pathway patients were admitted to the hospital, which was significantly higher than that of post-pathway encounters, 22/71 (32.4%) (z=2.81, p=0.005)."

Clinical • Pediatrics

Exploring Risk Drugs and Mechanisms in Dystonia: Insights from Pharmacovigilance and Proteogenomics. (PubMed, Curr Neuropharmacol) - "Our study highlights risk drugs for dystonia and their molecular mechanisms and provides evidence for the safer and more individualized use of antipsychotics, antidepressants, and other drugs related to dystonia."

Adverse events • Journal • CNS Disorders • Dystonia • Essential Tremor • Movement Disorders • Parkinson's Disease

Identifying High-Risk Medications for Drug-Induced Dystonia: A 20-Year Retrospective Real-World Pharmacovigilance Study Based on FAERS. (PubMed, Health Sci Rep) - "Among the top 50 drugs, metoclopramide showed the strongest disproportionality signal, followed by prochlorperazine and haloperidol...The combination of aripiprazole and risperidone was frequently reported and showed notable interaction signals. Metoclopramide and several antipsychotics were strongly associated with reported drug-induced dystonia. These findings highlight the need for cautious prescribing and close monitoring, particularly with antipsychotic combinations, and may support improved risk awareness and labeling."

Adverse events • Journal • Real-world evidence • Retrospective data • CNS Disorders • Dystonia • Movement Disorders • Parkinson's Disease

Congenital malformation risk following prenatal antipsychotic exposure: a systematic safety surveillance approach. (PubMed, BMJ Ment Health) - "The potential risk increase observed for some less-severe malformations and some antipsychotics needs to be weighed against the high potential for relapse and mental health deterioration following treatment discontinuation. While no consistent patterns suggesting a strong teratogenic effect have emerged thus far for newer antipsychotics, continued monitoring of these medications is important."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry • Schizophrenia

Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs. (PubMed, Drugs Aging) - "NSAID and antihypertensive-induced ADRs such as dizziness or nausea may contribute to subsequent prochlorperazine initiation among adults who are older, representing a potential prescribing cascade. Further research examining data that include clinical indications for prescribing is needed to confirm whether these signals represent true prescribing cascades or prescribing for another reason. ADRs should be included in the differential diagnosis for people who are older presenting with new symptoms in primary care."

Journal