LY4170156
/ Eli Lilly
- LARVOL DELTA
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January 05, 2025
A First-In-Human Phase 1 Study Of LY4170156, An Antibody-Drug Conjugate Targeting Folate Receptor a (FRa)-Expressing Advanced Solid Tumors (Trial In Progress)
(ESGO 2025)
- P1 | "Mirvetuximab soravtansine-gynx, an FRα antibody-drug conjugate (ADC) with a DM4 payload, is approved for the treatment of platinum resistant ovarian cancer (PROC) with high FRα expression representing ~30% of PROC patients (pts). Key secondary objectives are to evaluate the pharmacokinetic profile and antitumor activity of LY4170156 per RECIST v1.1. The study is currently enrolling pts.Results NAConclusion NA"
Metastases • P1 data • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Solid Tumor • Triple Negative Breast Cancer • FOLR1 • PROC
July 19, 2024
A first-in-human phase I study of LY4170156, an antibody-drug conjugate targeting folate receptor α (FRα)-expressing advanced solid tumors
(ESMO 2024)
- P1 | "Mirvetuximab soravtansine-gynx, an FRα antibody-drug conjugate (ADC) with a DM4 payload, is approved for the treatment of platinum resistant ovarian cancer (PROC) with high FRα expression representing ∼30% of PROC patients (pts). Primary objectives are to determine the RP2D and assess the safety of LY4170156. Key secondary objectives are to evaluate the pharmacokinetic profile and antitumor activity of LY4170156 per RECIST v1.1."
Metastases • P1 data • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Solid Tumor • Triple Negative Breast Cancer • FOLR1 • PROC
May 16, 2024
A Study of LY4170156 in Participants With Selected Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=220 | Recruiting | Sponsor: Eli Lilly and Company | Not yet recruiting ➔ Recruiting
Enrollment open • Metastases • Tumor cell • Breast Cancer • Cervical Cancer • Colorectal Cancer • Endometrial Cancer • Gastrointestinal Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Pancreatic Cancer • Solid Tumor • Triple Negative Breast Cancer • Uterine Cancer
May 06, 2024
A Study of LY4170156 in Participants With Selected Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=220 | Not yet recruiting | Sponsor: Eli Lilly and Company
Metastases • New P1 trial • Tumor cell • Breast Cancer • Cervical Cancer • Colorectal Cancer • Endometrial Cancer • Gastrointestinal Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Pancreatic Cancer • Solid Tumor • Triple Negative Breast Cancer • Uterine Cancer
March 14, 2023
MBK-103, a potent novel conjugation platform-based antibody-drug conjugate, changing therapeutic options in folate receptor alpha positive cancer patients
(AACR 2023)
- "The compound was also very well tolerated in cynomolgus monkeys with HNSTD at 50 mg/kg and even when administered repeatedly. High conjugation yields along with 100% homogeneity are major drivers of the successful ongoing manufacturing process with planned IND submission in Q4/2023."
Clinical • Breast Cancer • Colorectal Cancer • Gastrointestinal Cancer • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • FOLR1
March 14, 2023
Mablink Bioscience to Present Promising Preclinical Data for Lead ADC Candidate MBK-103 at the AACR Annual Meeting 2023
(GlobeNewswire)
- "Mablink Bioscience...announced that preclinical efficacy and safety data on its lead ADC candidate, MBK-103, will be presented at the American Association for Cancer Research ('AACR') Meeting 2023 on April 17, 2023, in Orlando, Florida....The compound was also well tolerated in cynomolgus monkeys at the highest non-severely toxic dose (HNSTD) of 50 mg/kg administered repeatedly. These promising data are a significant differentiator in the ADC’s landscape."
Preclinical • Oncology • Solid Tumor
October 14, 2022
Mablink Bioscience Announces a €31 Million Series A Funding Round Led by Sofinnova Partners and Mérieux Equity Partners
(Issuer Direct)
- "Mablink Bioscience...announced today that it has raised a €31 million Series A funding round to advance its lead candidate to the clinic and to build a pipeline of ADCs using its proprietary platform technology....The proceeds of this financing round will enable Mablink to become a clinical-stage biotech by bringing its lead candidate, MBK-103, into clinical development for the treatment of solid tumors, notably ovarian cancer."
Financing • Oncology • Solid Tumor
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