MI-2 / University of Michigan - LARVOL DELTA

Novel lanthanide(iii)/gallium(iii) metallacrowns with appended visible-absorbing organic sensitizers for molecular near-infrared imaging of living cells. (PubMed, Chem Sci) - "Taking advantage of the maleimide moieties in the [Ln2Ga8(shi)8(mip)4]2- metallacrowns (MCs; shi3- = salicylhydroximate; mip2- = 5-maleimido-isophthalate; Ln = NdIII, GdIII, ErIII, YbIII and YIII), we appended visible-absorbing thiol-coumarin (C) sensitizers through a thiol-Michael addition click reaction, affording the functionalized [Ln2Ga8(shi)8(C-mip)4]2- MCs...NIR epifluorescence microscopy of living HeLa cells incubated with the NdIII derivative confirmed unambiguous detection of the signal arising from the 4F3/2 → 4I11/2 electronic transition in the range of 1050-1080 nm in the cells. These results demonstrate that the [Ln2Ga8(shi)8(mip)4]2- MC can be used as a versatile molecule for tuning the chemical and photophysical properties of the [Ln2Ga8] MC family."

Journal • MIP-2

Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation. (PubMed, Nat Plants) - "This N-glycan-mediated receptor and co-receptor heterodimerization occurs in both Arabidopsis and Brassica napus. Our findings elucidate the molecular basis of SCOOP perception by the MIK2-BAK1 immune complex and underscore the crucial role of N-glycans in plant receptor-coreceptor interactions and signalling activation, shaping immune responses."

Journal • BAK1

The histone methyltransferase mixed-lineage-leukemia-1 drives T cell phenotype via notch signaling in diabetic tissue repair. (PubMed, JCI Insight) - "Treatment of diabetic wound CD4T cells with a small molecule inhibitor of MLL1 (MI-2) yielded a significant reduction in CD4+TH17 cells and IL17A. This is the first study to identify the MLL1-mediated mechanisms responsible for regulating the TH17/Treg balance in normal and diabetic wounds and define the complex role of Notch signaling in CD4+T cells in wounds, where increased or decreased Notch signaling both result in pathologic wound repair. Therapeutic targeting of MLL1 in diabetic CD4+TH cells may decrease pathologic inflammation through regulation of CD4+T cell differentiation."

Epigenetic controller • Journal • Diabetes • Hematological Malignancies • Inflammation • Leukemia • Metabolic Disorders • Oncology • CD4 • IL17A

Differences in Nailfold Capillary Morphology Distinguish Juvenile Dermatomyositis Patients That Are Myositis-Specific Autoantibody Positive (ACR Convergence 2023) - "Interestingly, we found that all JDM patients with presence of a positive MSA (TIF-1?, MDA5, NXP2, Mi-2, Ku) were assigned to C2, while those with negative MSAs were spread between C1, 2 and 3 ( Figure 2B )... We demonstrate 3 distinct groupings of NFC patterns that align with clinical diagnosis and MSA positivity. A predominant pattern of tortuosity and ramification is most pronounced in JDM as compared to MCTD, SLE and control patients. Further investigation into NFC morphology and patterns within a larger JDM cohort may hold the potential to assist in diagnosis, disease subtyping, monitoring and prognostication."

Clinical • Dermatology • Dermatomyositis • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Myositis • Pediatrics • Rheumatology • Systemic Lupus Erythematosus • IFIH1