BGP-15 / N-Gene - LARVOL DELTA

Lipid-Based Formulations Enhance the Apparent Intestinal Permeability of BGP-15: Physicochemical Characterization and Caco-2 Transport Studies. (PubMed, Eur J Pharm Sci) - "ATPase assays showed no consistent concentration-dependent interaction with MDR1, ABCG2, or MRP2. These findings demonstrate a formulation-associated increase in the apparent absorptive transport of BGP-15 and support further investigation of lipid-based delivery approaches."

Journal • ABCB1 • ABCG2 • CEACAM1

BGP-15 ameliorates sepsis-induced cardiomyopathy via SIRT3/SOD2-associated antioxidant signaling and suppression of myocardial inflammation. (PubMed, Inflamm Res) - "These findings support the involvement of SIRT3-related signaling in the cardioprotective effects associated with BGP-15 in experimental sepsis and support further preclinical investigation of BGP-15 for septic cardiomyopathy. SIRT3 and SOD2 enzymatic activities were not measured directly."

Journal • Cardiomyopathy • Cardiovascular • Infectious Disease • Inflammation • Septic Shock • CEACAM1 • SIRT3 • SOD2

'Weak by Structure'-Limb Muscle Fibre Cytoarchitecture Remodelling During Critical Illness and Effects of Chaperone Co-Inducer BGP-15 and Dissociative Glucocorticoid VBP-15. (PubMed, Cells) - "VBP-15 reversed atrophy at day 10 in soleus but not in EDL fibres. Our study is the first to quantify myofibrillar remodelling in limb muscle fibres during ICU intervention in 3D and provides exploratory assessment of BGP-15 and VBP-15 treatments on aberrant remodelling in CIM."

Journal • Critical care • Muscular Atrophy • Myositis • CEACAM1

BGP-15 Treatment Improves Follicle Growth and Alters Collagen Deposition in Mouse Transplanted Ovaries. (PubMed, Mol Reprod Dev) - "BGP-15 improves follicular growth and survival in ovarian grafts, coinciding with mitochondrial gene dysregulation and reduced collagen deposition. These findings suggest BGP-15 as a promising candidate for improving follicular outcomes after ovarian transplantation."

Journal • Preclinical • Metabolic Disorders • Transplantation • CEACAM1 • FOXO3 • NAMPT • PTEN • SIRT1 • SIRT3

Heat Shock Proteins in Schizophrenia: Integrating Stress Responses, Molecular Pathways, and Emerging Therapeutic Strategies. (PubMed, Neuroscientist) - "HSP autoantibodies are increased in individuals with schizophrenia, and levels correlate with symptom severity, blood-brain barrier dysfunction, and response to antipsychotics such as clozapine...Antipsychotics modulate HSP expression, indicating potential for precision medicine using HSP coinducers like BGP-15...Despite recent advancements, challenges remain in achieving consistent immune responses, ensuring genetic relevance across populations, and fully understanding the importance of CSPs, which calls for longitudinal multiomics studies, diverse cohort analyses, and advanced preclinical models. This review positions HSPs as central to the molecular framework of schizophrenia and CSPs as a largely unexplored area, advocating for integrated research to enhance mechanistic understanding and therapeutic approaches for this complex disorder."

Journal • Review • CNS Disorders • Mental Retardation • Psychiatry • Schizophrenia • CDC37 • CEACAM1 • HSP90AA1 • HSPA1A • HSPB1 • HSPD1

BGP-15 Mitigates Oxidative Stress and Mitochondrial Dysfunction in In Vitro Matured Oocytes From Type 1 Diabetic Mice. (PubMed, FASEB J) - "The beneficial effect of BGP-15 on diabetic oocytes is mediated by reducing DNA damage to oocytes and increasing mitochondrial fatty acid β-oxidation. Collectively, our findings demonstrate that BGP-15 supplementation can protect oocytes from maternal diabetes-related damage and provide a potential strategy to improve reproductive outcomes of women with diabetes."

Journal • Preclinical • Diabetes • Gestational Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus • CEACAM1

Impacts of PACAP 1-38 and BGP-15 on the Healing of Fasciocutaneous Groin Flaps Affected by Ischemia-Reperfusion in Rats. (PubMed, Biomedicines) - "The tensile strength increased in the areas of better perfusion. The anti-inflammatory effects of PACAP 1-38 and BPG-15, as well as the impact of PACAP 1-38 on collagen and elastic fiber composition, have been demonstrated."

Journal • Preclinical • Cardiovascular • Hematological Disorders • Reperfusion Injury • ADCYAP1 • CEACAM1

Bioactive specialized metabolites of Trochila sp., an endophytic fungus of Lilium carniolicum. (PubMed, Phytochemistry) - "BGP15P7IS3, an undescribed endophytic fungus from Lilium carniolicum, resulted in isolation and identification of eleven specialized metabolites, of which four pyridone alkaloid derivatives (1, 2, 4, and 5) and a biphenyl derivative (8) were identified as previously undescribed natural products...Compound 3 displayed antifungal activity only against C. neoformans with an MIC value of 12.5 μg/mL, and compound 6 exhibited promising antifungal activity with MIC values of 0.39-3.25 μg/mL against all the aforementioned fungal pathogens, and a concentration-dependent growth inhibitory property against T. vaginalis. Based on the identification of derivatives, a revised biosynthetic pathway for pyridone-type alkaloids was proposed."

Journal • CEACAM1

Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females. (PubMed, BMC Cancer) - "Promoting mitochondrial fusion via OPA1 induction improved cachectic outcomes in mice. Targeting OPA1providing provides a promising therapeutic approach for CC treatment."

Journal • Cachexia • Lung Cancer • Muscular Atrophy • Oncology • Solid Tumor • CEACAM1 • FOXO3

Biochemical Insights into the Effects of a Small Molecule Drug Candidate on Imatinib-Induced Cardiac Inflammation. (PubMed, Int J Mol Sci) - "BGP-15, a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor exerts cardioprotective effects; however, the underlying mechanisms remain unclear. The immunohistochemical staining further supported these biochemical changes. Our study provides new and comprehensive biochemical insight for managing Imtb-induced inflammatory responses via BGP-15-induced PARP1 inhibition."

Journal • Inflammation • CEACAM1 • HMGB1 • HMOX1 • IL18 • IL1B • IL6 • MPO

OPA1 Enhances Microglial Amyloid-β Clearance and Alleviates Cognitive Impairments in an Alzheimer's Disease Model. (PubMed, Aging Dis) - "Next, we utilized an OPA1 activator BGP-15, an OPA1 inhibitor myls22 and an OPA1 overexpression virus to investigate the role of OPA1 in AD...This may relate to down-regulation of hexokinase-2 (HK2) expression. These results suggest a critical role for OPA1 in Aβ clearance by microglia and a promising new direction for therapeutic approaches in AD."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Ocular Inflammation • CEACAM1 • HK2 • OPA1

BGP-15 improves quality of goat sperm by mitigating oxidative stress during cryopreservation. (PubMed, Cryobiology) - "Moreover, the apoptosis rate of freeze-thawed spermatozoa significantly decreased in the 100 μM BGP-15 treatment group compared to the control (P < 0.05), while the MMP of freeze-thawed spermatozoa significantly enhanced in the 100 μM BGP-15 treatment group (P < 0.05). In conclusion, BGP-15 enhances cryo-protective effects on goat spermatozoa, and 100 μM BGP-15 addition to the extender during cryopreservation is beneficial to the goat breeding industry."

Journal • CEACAM1 • ROMO1 • SOD2

Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization. (PubMed, Nat Commun) - "We further demonstrate that telomere elongation during ICM formation is controlled by mitochondrial-nuclear communication at fertilization. Using mitochondrially-targeted therapeutics (BGP-15, MitoQ, SS-31, metformin) we demonstrate that it is possible to modulate the preimplantation telomere resetting process and restore deficiencies in neonatal telomere length."

Journal • Genetic Disorders • Obesity • CEACAM1

Sperm oxidative damage acquired during seminal plasma removal for assisted reproductive technology is reduced by BGP-15. (PubMed, J Assist Reprod Genet) - "The inclusion of BGP-15 during semen preparation can protect sperm quality and, in the future, may be used clinically to improve sperm selection methods."

Journal • CEACAM1

Systemic infection of cowpea aphid-borne mosaic virus in Passiflora spp. occurs at the initial stage regardless of the species' resistance. (PubMed, Arch Virol) - "(BRS Pérola do Cerrado, resistant), and P. suberosa L. (BGP152, resistant) were used...This pioneering study provides information for the selection of time intervals for future molecular research into the interaction between Passiflora spp. and CABMV."

Journal • Infectious Disease • CEACAM1

Mitochondrial activator BGP-15 protects sperm quality against oxidative damage and improves embryo developmental competence. (PubMed, F S Sci) - "BGP-15 protects sperm against cellular damage and has the potential to improve ART outcomes."

Journal • Gynecology • Infertility • Sexual Disorders • CEACAM1

The Impact of YabG Mutations on Clostridioides difficile Spore Germination and Processing of Spore Substrates. (PubMed, Mol Microbiol) - "Spores derived from C. difficile yabGC207A (a catalytically inactive allele), C. difficile yabGA46D, C. difficile yabGG37E, and C. difficile yabGP153L strains germinated in response to taurocholic acid alone...Finally, changes in yabG expression under the mutant promoters were analyzed using a SNAP-tag and revealed expression differences at early and late stages of sporulation. Overall, our results support and expand upon the hypothesis that YabG is important for germination and spore assembly and, upon mutation of the processing site, can shift where it cleaves substrates."

Journal • CEACAM1

REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice. (PubMed, Reproduction) - "BGP-15 treatment for 3 weeks prior to conception improved on-time pre-implantation embryo development and fetal viability and increased fetal size in pregnancies sired by old males. These results validate that ageing negatively affects male fertility and offspring physiology and indicates that pre-conception treatment with BGP-15 has the potential to improve sperm quality as well as early embryo development and post-natal health."

Journal • Preclinical • CEACAM1

Response to comment on: BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy. (PubMed, Brain Behav Immun) - No abstract available

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry • CEACAM1

CAS3D: 3D quantitative morphometry on Second Harmonic Generation image volumes from single skeletal muscle fibers. (PubMed, Comput Biol Med) - "The software was applied to a previously published data set of single skeletal muscle fiber volumetric SHG image data from a rat intensive care unit (ICU) model of ventilator-induced diaphragm dysfunction (VIDD) with treatment regimens involving the small anti-inflammatory molecules BGP-15, vamorolone, or prednisolone. Our method reliably reproduced the results of the previous work and improved the standard deviation of the cosine angle sum detection in all sample groups from a mean of 0.03 to 0.008. This improvement is achieved by applying analysis algorithms to the whole volumetric images in 3D in contrast to the previously common method of slice-wise XY analysis."

Journal • Critical care • CEACAM1

Commentary on the Article "BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy". (PubMed, Brain Behav Immun) - No abstract available

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry • CEACAM1

Altered Autophagic Flux in GNE mutant cells of Indian Origin: potential drug target for GNE Myopathy. (PubMed, Exp Cell Res) - "Interestingly, treatment of GNE mutant cells with HSP70 activator, BGP-15, restored the expression and refolding activity of HSP70 along with autophagosome formation. Treatment with calcium chelator, BAPTA-AM restored the cytoplasmic calcium levels and autophagosome formation but not LC3II/I ratio significantly. Our study provides insights towards GNE mutation specific response for autophagy regulation and opens up a therapeutic advancement area in calcium signalling and HSP70 function for GNE related Myopathy."

Journal • CNS Disorders • Genetic Disorders • Myositis • CEACAM1

BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy. (PubMed, Brain Behav Immun) - "Based on the research findings, it can be inferred that the antidepressant properties of BGP-15 in LPS-induced depressive-like behaviors could potentially be attributed to the involvement of the mitophagy pathway. These findings offer a potential novel therapeutic strategy for managing MDD."

Journal • CNS Disorders • Depression • Inflammation • Major Depressive Disorder • Metabolic Disorders • Psychiatry • CEACAM1 • IL1B • IL6 • NLRP3 • PINK1 • TNFA

Potential small effector molecules restoring cellular defects due to sialic acid biosynthetic enzyme deficiency: Pathological relevance to GNE myopathy. (PubMed, Biochem Pharmacol) - "In the present study, we analyzed the effect of small molecules like BGP-15 (HSP70 modulator), IGF-1 (IGF-1R ligand) and CGA (cofilin activator) on cellular phenotypes of GNE heterozygous knock out L6 rat skeletal muscle cell line (SKM‑GNEHz)...Treatment with CGA recovered epimerase activity by 49 %, F-actin assembly by 132 % and cell migration upto 41 % (24 h) in SKM‑GNEHz. Our study shows that treatment with these small effector molecules reduces the detrimental phenotype observed in SKM‑GNEHz, thereby, providing insights into potential therapeutic targets for GNEM."

Journal • CNS Disorders • Gene Therapies • Metabolic Disorders • Myositis • CEACAM1 • IGF1

Promoting mitochondrial dynamics by inhibiting the PINK1/PRKN pathway to relieve diabetic nephropathy. (PubMed, Dis Model Mech) - "Regulating mitochondrial dynamics by either genetic modification of the Pink1/Park (mammalian PINK1/PRKN) pathway or treatment with BGP-15, mitigated the mitochondrial defects and nephrocyte functional decline. These findings support a role for Pink1/Park-mediated mitophagy and associated control of mitochondrial dynamics, essential for function, in diabetic nephropathy; and demonstrate that targeting this pathway might provide therapeutic benefits in type 2 diabetic nephropathy."

Journal • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus • CEACAM1