HMN-176
/ Nippon Shinyaku
- LARVOL DELTA
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May 30, 2022
Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth.
(PubMed, Pharmaceuticals (Basel))
- "HMN-214 is a prodrug of HMN-176 and is known to selectively interfere with PLK1 function. In the NB 3D spheroid tumor model, HMN-214 significantly and in a dose-dependent manner inhibits spheroid tumor mass and growth. Overall, our study highlights that targeting PLK1 using HMN-214 is a novel therapeutic approach for NB."
Journal • Neuroblastoma • Oncology • Pediatrics • Solid Tumor • CCNB1 • CDK1 • CDK2 • CHEK1 • CHEK2 • MYCN • PLK1
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