amantadine / Generic mfg. - LARVOL DELTA

10d, a Pyridoquinoxaline-Based P-Glycoprotein Inhibitor, Exacerbates MPTP-Induced Neurotoxicity in PC12 Cells. (PubMed, Curr Issues Mol Biol) - "In addition, the ability of 10d to modulate MPTP-induced neurotoxicity was assessed, alone and in combination with amantadine (AMA), a known antiparkinsonian drug...Furthermore, 10d altered dopaminergic homeostasis by decreasing intracellular DA levels and modifying DA metabolite profiles, with more pronounced effects following co-treatment with MPTP. The combined administration of 10d, MPTP and AMA produced a stronger disruption of DA metabolism compared with individual treatments or 10d/MPTP co-exposure."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Occurrence of influenza antivirals and resistance development in influenza A viruses in aquatic environments: A risk assessment. (PubMed, PLoS One) - "This study aimed to assess the environmental risk posed by four IAs-oseltamivir carboxylate (OC), zanamivir (ZA), peramivir (PE), and amantadine (AM)-based on their potential for environmental release, environmental stability, and induction of antiviral resistance...However, in uncomplicated influenza among otherwise healthy individuals, the clinical benefit is limited, and the risk of resistance development should be carefully considered. Among the evaluated antivirals, ZA showed the lowest environmental risk and should be preferred when feasible."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Improvement of Pseudobulbar Affect in Progressive Supranuclear Palsy with Amantadine: A Case Report (MDS Congress 2026) - No abstract available

Case report • Clinical • CNS Disorders • Movement Disorders • Progressive Supranuclear Palsy

A Case Report: Successful Management of Mixed Tardive Syndrome With Combination Pharmacotherapy in a 19-Year-Old Female With Schizophrenia. (PubMed, Clin Case Rep) - "A 19-year-old female with schizophrenia developed severe mixed tardive syndrome (choreoathetoid dyskinesia with prominent tardive dystonia) after antipsychotic treatment, which remained debilitating despite deutetrabenazine, benzodiazepines, baclofen, and amantadine. Over a 39-day inpatient stay, switching the antipsychotic to clozapine and adding botulinum toxin injections plus the central muscle relaxant eperisone led to dramatic improvement, with the Abnormal Involuntary Movement Scale (AIMS) score falling from 32 to 8...This case illustrates that a multimodal strategy-combining a low-D2-affinity antipsychotic, a VMAT2 inhibitor, and targeted muscle relaxation-was associated with marked improvement in this patient with refractory mixed tardive syndrome. However, given the near-simultaneous implementation of multiple interventions, the relative contribution of each component cannot be definitively determined, and controlled studies are needed to establish the efficacy..."

Journal • CNS Disorders • Dystonia • Movement Disorders • Psychiatry • Schizophrenia

A transdiagnostic approach to non-motor symptoms in Parkinson's disease: exploring internalizing, bipolar spectrum, and impulsive compulsive behavior profiles via cluster analysis. (PubMed, Front Aging Neurosci) - "The Severe Internalizing-Impulsive cluster showed the highest psychiatric burden, motor severity, disease stage, dopaminergic treatment load, and amantadine use...These findings support a transdiagnostic model in PD in which affective dysregulation and impulsivity interact with disease-related factors to form distinct neuropsychiatric phenotypes. Recognizing these profiles may facilitate earlier identification of vulnerable patients and more individualized neuropsychiatric management strategies beyond a solely dopaminergic framework."

Journal • Alzheimer's Disease • Bipolar Disorder • CNS Disorders • Dementia • Depression • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Delusional infestation in Parkinson disease: a case report of medication-induced psychosis. (PubMed, Neurocase) - "The patient's symptoms resolved following discontinuation of amantadine, supporting an iatrogenic etiology. Previous case reports have consistently described a link between DI and dopaminergic overstimulation, although DI has been observed across a broad range of cognitive functioning. This case highlights the diagnostic utility of formal neuropsychological assessment and underscores the importance of recognizing DI as a potentially reversible, iatrogenic phenomenon within the spectrum of PD psychosis."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation. (PubMed, CNS Neurosci Ther) - "Future strategies should adopt multi-target, multi-level approaches grounded in individualized network profiling. Priorities include large-scale RCTs for DBS and stratified protocols based on etiology and consciousness level."

Journal • Review

Ekbom's Delusional Parasitosis Related to Pramipexole and Amantadine Use: A Case Report. (PubMed, J Pharm Pract) - "Delusional parasitosis can occur in patients receiving concomitant treatment with pramipexole and amantadine. Patients receiving high doses of these agents in combination with other risk factors such as advanced age and impaired renal function should be monitored for symptoms of delusional parasitosis."

Journal • CNS Disorders • Movement Disorders • Multiple Sclerosis • Parkinson's Disease • Psychiatry • Restless Legs Syndrome • Sleep Disorder

Levodopa exacerbated tremor in Parkinson's disease. (PubMed, Front Neurol) - "No benefit from biperiden or amantadine was observed for levodopa-exacerbated tremor in any of the cases. Patients with levodopa-exacerbated tremor were very reluctant to take more than a small dose of levodopa or any dose at all, hampering potential benefits for other parkinsonian features such as rigidity, bradykinesia, and parkinsonian gait. Tremor exacerbated by levodopa is an uncommon side effect in patients with PD that limits the benefit of this therapy."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Mechanism-Targeted Therapeutic Strategies for Traumatic Brain Injury: From Molecular Pathways to Functional Recovery. (PubMed, Front Biosci (Landmark Ed)) - "Central to this synthesis is the Dual-Axis Theory, which posits that successful emerging modalities, including repurposed agents such as glibenclamide, amantadine, and statins, alongside cell-free biologics and neuromodulation, converge on two shared pathological targets: the Inflammatory Axis (M1-to-M2 microglial polarization) and the Metabolic Axis (restoration of mitochondrial bioenergetics). By integrating these biological signals with bioengineered delivery systems and artificial intelligence (AI)-driven precision phenotyping, the field can transition from acute neuroprotection toward genuine circuit-level regeneration. We conclude with a blueprint for the next generation of TBI trials, emphasizing biomarker-based stratification and multidimensional endpoints to bridge the translational gap."

Journal • Review • CNS Disorders • Inflammation • Vascular Neurology

Neurostimulants for disorders of consciousness in the intensive care unit: A systematic review. (PubMed, Gen Hosp Psychiatry) - "Neurostimulants were associated with short-term improvements in measures of arousal and recovery, although evidence remains heterogeneous and largely observational. Amantadine has the largest ICU evidence base; methylphenidate has been studied as monotherapy and augmentation; modafinil has primarily been evaluated for hypersomnolence. Further placebo-controlled trials are needed to establish efficacy across different causes of DoC; head-to-head studies are needed to clarify comparative effectiveness among available neurostimulants."

Journal • Review • Critical care

An Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review. (PubMed, J Korean Neurosurg Soc) - "Glibenclamide/glyburide and hypertonic sodium lactate produced preliminary imaging or physiological signals without demonstrated functional benefit. Riluzole was neutral in an adult randomized trial, whereas a small study in chronic TBI found that minocycline reduced a neuroinflammatory imaging signal but increased plasma neurofilament light. Metformin and N-acetylcysteine plus probenecid provided exploratory pharmacokinetic, biomarker, or safety data. Amantadine provided phenotype-specific clinical proof of principle in traumatic disorders of consciousness. Cerebrolysin showed mixed human evidence, including a favorable day-90 multidimensional ensemble signal that requires independent replication. Deferoxamine and clemastine remain preclinical...Module activation should require optimized foundational care, a matching phenotype, measurable target activation or engagement, and acceptable systemic safety. This framework prioritizes phenotype-enriched, single-module..."

Journal • CNS Disorders • Vascular Neurology • Plasma NfL

Neuromodulation to Promote Recovery Following Traumatic Brain Injury: A Narrative Review of Current Pharmacologic and Non-Pharmacologic Approaches. (PubMed, Brain Sci) - "This narrative review summarizes current evidence supporting pharmacologic neuromodulatory therapies, including central nervous system stimulants (methylphenidate and modafinil), dopaminergic agents (amantadine and bromocriptine), acetylcholinesterase inhibitors (donepezil and rivastigmine), and selective serotonin reuptake inhibitors (sertraline and fluoxetine). However, current evidence is limited by heterogeneous study populations, small sample sizes, inconsistent outcome measures, and a paucity of long-term randomized controlled trials. Future research should prioritize adequately powered comparative studies, standardized outcome measures, biomarker-guided patient selection, and multimodal treatment strategies to optimize neurological recovery following TBI."

Journal • Review • CNS Disorders • Fatigue • Vascular Neurology

Neuroleptic Malignant Syndrome (PubMed, Medicina (B Aires)) - "Management relies on immediate discontinuation of the offending agent, intensive supportive care, and, in moderate to severe cases, pharmacological treatment with benzodiazepines, dopaminergic agents such as bromocriptine or amantadine, and muscle relaxants such as dantrolene. Early recognition and timely treatment are crucial to ensure favorable outcomes and reduce morbidity and mortality."

Journal • Review • CNS Disorders • DRD2

Modulating glutamate neurotransmission in in vivo models of Multiple Sclerosis: a narrative review. (PubMed, Front Immunol) - "Collectively, these data indicate that pharmacological modulation of glutamatergic signaling can engage multiple facets of EAE pathophysiology. However, completed clinical trials of repurposed glutamatergic drugs (riluzole, amantadine, memantine, lamotrigine) have so far failed to demonstrate disease-modifying efficacy in MS, underscoring a marked translational gap."

Journal • Preclinical • Review • CNS Disorders • Immune Modulation • Immunology • Inflammation • Multiple Sclerosis • TNFA

Suspected amantadine-induced hypoglycaemia in a dog treated for chronic lumbosacral pain. (PubMed, Vet Anaesth Analg) - "The dog was being administered gabapentin, paracetamol, and amantadine for chronic lumbosacral pain. A temporal association between amantadine administration and hypoglycaemia, together with resolution following drug discontinuation, suggests a potential causal relationship. This case represents the first report of suspected amantadine-associated hypoglycaemia in a dog and highlights the need to consider this drug as a possible cause of hypoglycaemia in dogs."

Journal • Hematological Disorders • Hypoglycemia • Pain • Solid Tumor

Amantadine-based coordination systems with Co(II) and Zn(II) chlorides. (PubMed, Dalton Trans) - "DC conductivity follows Arrhenius behavior in both compounds, with changes in activation energy across the transition reflecting modified proton-transfer pathways. These results demonstrate that the nature of the metal center tunes hydrogen-bond dynamics, dipolar relaxation, and charge transport, highlighting amantadine-based halometalates as promising candidates for switchable dielectric and proton-conducting hybrid materials."

Journal

Probable pregabalin and amantadine-containing cold medication intoxication in an adolescent with rhabdomyolysis: Case report. (PubMed, J Taibah Univ Med Sci) - "A limited qualitative urine toxicology screen was negative, but the panel did not include pregabalin, amantadine, acetaminophen, caffeine, or chlorpheniramine. Creatine kinase decreased to 495 U/L by day 15. This case highlights the need for collateral medication histories and expanded toxicological testing when routine screening is negative."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Myocardial Infarction • Psychiatry • Respiratory Diseases • MB

Emergence From Minimally Conscious State Following Addition of Zolpidem to Amantadine Therapy in a Patient With Preserved Cortical Metabolism After Subarachnoid Hemorrhage: A Case Report. (PubMed, Brain Neurorehabil) - "After initiating zolpidem 10 mg and escalating amantadine to 200 mg/day, the patient's CRS-R score increased from 12 to 19 within three days, corresponding to emergence from a minimally conscious state. This case suggests that preserved cortical metabolic activity may be associated with the additive or synergistic effects of pharmacological arousal therapy in disorders of consciousness in non-Traumatic Brain Injury patients."

Journal • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Amantadine-Responsive, Benzodiazepine-Resistant Catatonia in an Adolescent With Autism Spectrum Disorder. (PubMed, J Child Adolesc Psychopharmacol) - "Amantadine may be a viable adjunctive treatment for benzodiazepine-insufficient catatonia in adolescents with ASD when lorazepam is insufficient or poorly tolerated and ECT is unavailable. Further research is needed."

Journal • Autism Spectrum Disorder • Genetic Disorders • Pediatrics • Psychiatry

Add-on safinamide and amantadine in Filipino Parkinson's disease patients with motor fluctuations: a retrospective exploratory cohort study. (PubMed, J Neural Transm (Vienna)) - "However, baseline imbalances, small sample size, non-randomized treatment allocation, and limitations in outcome assessment preclude conclusions regarding comparative treatment efficacy. These findings should be interpreted as preliminary and hypothesis-generating."

Journal • Retrospective data • CNS Disorders • Movement Disorders • Parkinson's Disease

The Redesign of the Molecular Scaffold of Viral Ion Channel Blockers. (PubMed, Comput Struct Biotechnol J) - "Extending the antiviral amantadine led to new compounds that better match the alternating hydrophobic and hydrophilic patterns of the inner walls of ion channels-a common feature across many viruses...SARS-CoV-2 variants served as test systems in laboratory experiments. The new molecular scaffolds presented here provide a strong foundation for designing potent viral ion channel blockers, helping to fill the drug pipeline."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Amantadine Use in Severe Traumatic Brain Injury. (PubMed, Am Surg) - "Despite demonstrated benefits and generally favorable safety profile, significant heterogeneity exists in patient selection, dosing and treatment duration, and the standardization of treatment algorithms. This review serves to consolidate the current evidence base, clarify the mechanistic rationale for amantadine use in TBI, and provide a clinically grounded framework to guide its responsible and effective application within the context of neurological rehabilitation."

Journal • Review • CNS Disorders • Infectious Disease • Influenza • Movement Disorders • Respiratory Diseases • Vascular Neurology

A novel approach to the management of levodopa-induced dyskinesia using deep transcranial magnetic stimulation: A case report. (PubMed, J Int Med Res) - "Although levodopa-induced dyskinesia can substantially impair the quality of life, therapeutic strategies are often limited to levodopa dose adjustment, amantadine, or deep brain stimulation...However, this is a two-patient case report without sham stimulation or extended follow-up; therefore, the findings should be interpreted as preliminary and hypothesis-generating. Larger controlled studies with objective outcome measures and longer follow-up are needed to determine the efficacy, durability, and optimal stimulation parameters."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Amantadine Modulates Action-Specific Neural Ensembles in Hypokinetic and Hyperkinetic Conditions. (PubMed, Mov Disord) - "Levodopa and amantadine may act through distinct mechanisms, with levodopa normalizing pathway balance and amantadine modulating action-specific neural ensembles. These findings support the importance of action-coding disruptions during hypokinetic and hyperkinetic conditions and suggest that correcting them can restore motor function."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease