fucoidan (BAX 513) / Takeda - LARVOL DELTA

Fucoidan-rich Ecklonia radiata supplementation improves growth performance, immune responsiveness, and gut health in pigs. (PubMed, Sci Rep) - "In summary, E. radiata supplementation improved pig growth performance and cellular immune responsiveness, potentially mediated by enhanced intestinal morphology and modulated gut microbiota. These findings highlight the potential of Australian brown seaweeds as functional feed additives to support sustainable animal nutrition and health."

Journal

Nutritional strategies in supporting immune checkpoint inhibitor, PI3K inhibitor, and tyrosine kinase inhibitor cancer therapies. (PubMed, Front Nutr) - "Optimizing PI3K treatment tolerance requires close attention to monitoring and managing glycemic control through nutrition, lifestyle and pharmacological intervention as necessary, and in supporting patients with EGFR-TKIs both nutritional prehabilitation and close attention to managing gastrointestinal toxicities is paramount. Rational individualized approaches based on detailed and dynamic clinical assessment of patient-, cancer- and treatment-related factors, using validated prognostic scores and biomarkers, are needed to maximize the potential of precision nutrition now and in future trials in this arena."

Checkpoint inhibition • IO biomarker • Journal • Review • Oncology

Anti-Inflammatory, Antidiabetic, and Antioxidant Properties of Extracts Prepared from Pinot Noir Grape Marc, Free and Incorporated in Porous Silica-Based Supports. (PubMed, Molecules) - "The anti-inflammatory potential against COX and LOX enzymes of selected samples was evaluated and compared with that of Indomethacin and Zileuton, respectively. The best anti-inflammatory activity was observed when PN extract was loaded on MCM-NH2-Fuc support."

Journal • Infectious Disease • Inflammation

Treatment of Cachexia in Gastric Cancer: Exploring the Use of Anti-Inflammatory Natural Products and Their Derivatives. (PubMed, Nutrients) - "(3) Natural anti-inflammatory products represent a potential adjunctive therapy for gastric cancer cachexia. Further research, particularly well-designed clinical trials, is needed to elucidate their optimal role, dosing and safety profiles in the management of gastric cancer cachexia."

Journal • Review • Cachexia • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

The Antioxidant and Anti-Inflammatory Properties of Wild Bilberry Fruit Extracts Embedded in Mesoporous Silica-Type Supports: A Stability Study. (PubMed, Antioxidants (Basel)) - "For the extract encapsulated in an MCM-SH support, a lower IC50 value (0.69 μg/mL) towards COX-2 was obtained, comparable with that of Indomethacin (0.6 μg/mL). Also, this sample showed a higher selectivity index (2.71) for COX-2 than the reference anti-inflammatory drug (0.98). The developed formulations with antioxidant and anti-inflammatory properties could be further used in nutraceuticals."

Journal

[PREPRINT] Unveiling the anti-glioma potential of a marine derivative, Fucoidan: its synergistic cytotoxicity with Temozolomide-an in vitro and in silico experimental study (bioRxiv) - "The dual-drug combination significantly reduced the cell viability and migration of glioma cells in a synergistic dose-dependent manner. At the molecular level, the dual-drug combination significantly down-regulated inflammatory genes with a concomitant upregulation of pro-apoptotic marker. In consensus with our in vitro findings, molecular docking and simulation studies revealed that the anti-tumor ligands: Temozolomide, Fucoidan with 5-(3-Methy1-trizeno)-imidazole-4-carboxamide (MTIC), and 4-amino-5-imidazole-carboxamide (AIC) had the potency to bind to the inflammatory proteins at their active sites, mediated by H-bonds and other non-covalent interactions."

Preclinical • Preprint • Glioma • Oncology

Mode of action for anticoagulant activities of non-anticoagulant sulphated polysaccharides (WFH 2012) - U.p. fucoidan increased clotting time by 50% at 4lg/mL, which represents a two-fold higher anticoagulant effect than the other fucoidans; All fucoidans clearly increased HCII-mediated thrombin inhibition at concentrations below 1 lg/mL

MOA • Hemophilia

Determination of the active transport of fucoidan derived from Okinawa Mozuku across the human intestinal Caco-2 cells as assessed by size-exclusion chromatography. (PubMed) - "We firstly report that the active transport occurs for such a high molecular-weight sulphated-polyfucose of fucoidan in vitro using Caco-2 cells."

Journal • Biosimilar