Netildex (netilmicin/dexamethasone) / Knight Therap, SIFI - LARVOL DELTA

Alcohol delamination and topical mitomycin-C 0.02% for the treatment of corneal intraepithelial neoplasia. (PubMed, Eur J Ophthalmol) - "At the end of the procedure, a bandage contact lens was applied, and the eye was started on a topical treatment with Netilmicin 3% and Dexamethasone 1% 4 times daily for 15 days and mitomycin-C 0.02% drops four times a day, on alternate weeks for 4 weeks.ResultsPatient's symptoms improved and BCVA was restored to 20/20 over 1-month period. The ocular surface showed a significant regularization, clinically and both at the AS-OCT and corneal topography. Three years after the procedure patient's BCVA and refraction were stable without any sign of recurrence.ConclusionsALD is a safe and inexpensive procedure when dealing with CIN allowing both clinical improvements and a definitive histopathological diagnosis."

Journal • Oncology

The efficacy of a netilmicin/dexamethasone gel combination in the treatment of posterior blepharitis in moderate-severe dry eye patients. (PubMed, Eur J Ophthalmol) - "Netilmicin/dexamethasone combination is effective and safe to treat MGD-associated posterior blepharitis improving both symptoms and ocular surface signs."

Journal • Dry Eye Disease • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology

Validated spectrofluorimetric method for the determination of netilmicin based on its interaction with o-phthalaldehyde/mercaptoethanol: Evaluation of the method's greenness. (PubMed, Luminescence) - "Finally, multicriteria greenness and whiteness metrics were used to evaluate the sustainability, greenness, and whiteness of the approach. The applied tools were the AGREE algorithm, the RGB 12 algorithm, and HEXAGON."

Journal • Ophthalmology

Post Cataract Surgery Dry Eye Disease, Effectiveness Of Semifluorinated Alkanes (Perfluorohexyloctane) Eye Drops . (ESCRS 2023) - "Purpose: To evaluate the effectiveness of Semifluorinated Alkanes (perfluorohexyloctane) eye drops for the treatment of post operative cataract Dry eye disease Setting: Massa Marittima Hospital, Department of Ophthalmology 60 patients 30 controls mean age 69.8 years +- 9.4 years M/F ratio 1:3 Affected by dry eye disease INCLUSION CRITERIA: preoperative subjective indicating dry eye disease OSDI TBUT and EXCLUSION CRITERIA: dry eye due to systemic disease or concomitant therapy, preoperative glaucoma therapy, use of contact lenses Each patient was treated with pre-operative therapy 3 days before and 28 days post-op with steroid antibiotic fixed association (0.3% Dexamethasone 0.1% netilmicin without preservatives) 3 times daily to reduce... PERFLUOROHEXYLOCTANE proved to be an effective molecule in reducing the symptoms of ocular discomfort in post operative DED."

Surgery • Cataract • Dry Eye Disease • Glaucoma • Ophthalmology

Reduced Posology of an Ophthalmic Hydrogel Containing Dexamethasone/Netilmicin to Prevent and Treat Ocular Inflammation After Cataract Surgery: Efficacy and Tolerability. (PubMed, Adv Ther) - "Efficacy of the gel reduced posology (twice a day) is not inferior to four times a day eye drops. Both treatments were well tolerated and efficacious. The new reduced posology hydrogel formulation may improve patient compliance and quality of life."

Journal • Cataract • Immunology • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology

The efficacy of a netilmicin/dexamethasone gel combination in the treatment of posterior blepharitis in moderate-severe dry eye patients. (ARVO 2022) - "Netilmicin/dexamethasone combination is effective and safe to treat MGD-associated posterior blepharitis improving both symptoms, and ocular surface signs."

Clinical • Dry Eye Disease • Ocular Inflammation • Ophthalmology

Antimicrobial efficacy of netilmicin against Staphylococci administered two or four times a day. (ARVO 2022) - "Marketed formulations with netilmicin and dexamethasone have a dosing schedule of 4 administrations per day... Interestingly, pulsed protocol demonstrated that bactericidal effect of netilmicin against Staphylococci is maintained unchanged when administered 2 or 4 times a day. Therefore, in order to reduce the antibiotic resistance and improve the patient’s compliance, the hypothesis to reduce the posology of marketed products containing netilmicin could be taken into account. Images:"

Clinical • Ocular Infections • Ophthalmology

In vitro safety evaluation of two eye drops solutions containing a combination of corticosteroid and antibiotic. (ARVO 2022) - "Netildex and Betabioptal, both preservative-free solutions, when used diluted according to Takahashi et. al, 2011, showed no cytotoxic concerns on corneal epithelium. On the contrary, when tested undiluted Betabioptal was found cytotoxic, while Netildex was found to be endowed with an advantageous cytocompatibility profile even at the concentration used in clinical ophthalmological practice."

Preclinical • Ocular Infections • Ophthalmology

PHARMACOLOGICAL AND SAFETY PROFILE OF TWO NEW BETAMETHASONE/CHLORAMPHENICOL GEL OPHTHALMIC FORMULATIONS (ARVO 2022) - "Cells were exposed to: ZiclorP gel [0.1% betamethasone (BET)/0.25% chloramphenicol (CHL) with parabens; Alfa Intes], Betabioptal gel (0.1% BET/0.25% CHL with thiomersal; Thea), Netildex eye-drops [0.1% dexamethasone (DEX)/0.3% netilmicin with benzalkonium chloride (BAK); SIFI] and Ducressa eye-drops (0.1% DEX/0.5% levofloxacin; with BAK; Santen)... The new ophthalmic gel formulations have a good pharmacological and safety profile. PK study showed higher levels of steroid in anterior chamber with ZiclorPF, suggesting a longer pre-corneal residence time compared to Ducressa eye drops. Cells treated with ZiclorP showed a better viability and wound healing compared to the other formulations, preserving cell barrier connections, and suggesting that ZiclorP has a minimum impact on cell repair process."

Clinical • Ophthalmology

Short-Term Use of Dexamethasone/Netilmicin Fixed Combination in Controlling Ocular Inflammation After Uncomplicated Cataract Surgery. (PubMed, Clin Ophthalmol) - "Two cases of allergic conjunctivitis were considered adverse events and were both related to dexa/net. Short-term use of dexa/net fixed combination is safe and effective in the control of post-operative inflammation following uncomplicated cataract surgery."

Clinical • Cataract • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Dexamethasone/Netilmicin Eye Drops and Eye Gel for the Treatment of Ocular Inflammation After Micro-Incisional Vitreoretinal Surgery. (PubMed, Clin Ophthalmol) - "The combination dexa/net is safe and effective in the treatment of post-operative inflammation following sutureless MIVS. In particular, the use of eye gel formulation is characterized by a great tolerability."

Clinical • Immunology • Inflammation • Ocular Infections • Ocular Inflammation

Efficacy and safety of a reduced posology of Netilmicin/Dexamethasone ophthalmic gel versus the eye drops in the treatment of inflammation conditions following cataract surgery (ARVO 2020) - "Purpose To demonstrate the twice a day (BID) efficacy and safety of Netilmicin/Dexamethasone ophthalmic hydrogel containing Xanthan gum, versus Netilmicin/Dexamethasone eye drops four times a day (QID), in the treatment of inflammatory conditions after cataract surgery in the presence or at risk of microbial infection.Methods Phase III international multicenter (n=5) double-blind, non-inferiority study: a total of 168 patients, male and female, aged >40 years, were randomized to receive the Netilmicin/Dexamethasone ophthalmic hydrogel BID (N=85) or the eye drops QID (N=83) from the day of phaco-emulsification cataract extraction (Day0) until Day15. No microbial load and no safety issues were observed.Conclusions The current study demonstrated that hydrogel reduced posology (BID) is not inferior to the approved eye drops posology (QID) for the clinical response obtained after 7 days. Both treatments were very well tolerated and efficacious."

Clinical

Antimicrobial efficacy of netilmicin against Staphylococci administered two or four times a day (ARVO 2020) - "Marketed formulations with netilmicin and dexamethasone have a dosing schedule of 4 administrations per day...within 12h (6 log10 decrease) and also at 24h, i.e. after 12h washout.Conclusions Interestingly, pulsed protocol demonstrated that bactericidal effect of netilmicin against Staphylococci is maintained unchanged when administered 2 or 4 times a day. Therefore, in order to reduce the antibiotic resistance and improve the patient’s compliance, the hypothesis to reduce the posology of marketed products containing netilmicin could be taken into account."

Clinical

Cenegermin in Pediatric Neurotrophic Keratopathy. (PubMed, Cornea) - "Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK."

Clinical • Journal

Acute dacryocystitis with giant lacrimal abscess: a case report. (PubMed, Ital J Pediatr) - "Pediatric acute dacryocystitis is a potentially serious condition, which must be treated with intravenous antibiotic therapy followed by surgery tailored to the clinical history. Even if probing and dacryocystorhinostomy are the most used surgery in adults and children, open dacryocystectomy is a safe and successful option, mainly in severe cases where imaging studies are not available."

Clinical • Journal