vipadenant (V2006) / BMS, HitGen - LARVOL DELTA

CFD simulation of CVD reactors in the CHSiCl(MTS)/H system using a two-step MTS decomposition and one-step SiC growth models. (PubMed, Heliyon) - "An in-house version of reactingFoam, a reactive flow solver within OpenFOAM v2006, was used as the simulation tool...Then, the MTS decomposition model was coupled with the SiC growth model, and the coupled model was applied to the SiC deposition data. The model could reproduce multiple datasets through validation studies."

Journal

Second Near-Infrared Light-Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy. (PubMed, Adv Mater) - "ASPA backbone is obtained by conjugating vipadenant, an antagonist to adenosine A2A receptor, onto NIR-II light-absorbing semiconducting polymer via an azo-based thermolabile linker...Such a remotely controlled immunometabolic regulation potentiates cytotoxic T cell functions while suppresses regulatory T cell activities, leading to efficient primary tumor inhibition, pulmonary metastasis prevention, and long-term immunological memory. Thereby, this work provides a generic polymeric approach for precise spatiotemporal regulation of cancer immunometabolism."

Journal • Immune Modulation • Immunology • Inflammation • Oncology • ADORA2A

Development of F-Labeled Radiotracers for PET Imaging of the Adenosine A Receptor: Synthesis, Radiolabeling and Preliminary Biological Evaluation. (PubMed, Int J Mol Sci) - "Specific binding of [F]PPY2 on mice brain slices was demonstrated by in vitro autoradiography. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance."

Journal • CNS Disorders • MRI