BLX 0631 / Biolexis Therap - LARVOL DELTA

Development of highly selective, potent, orally available PIM1 inhibitor BLX0631 shows a therapeutics potential in multiple myeloma models (AACR 2024) - "The present study demonstrates that PIM1 plays a vital role in the proliferation and survival of Multiple Myeloma. BLX-0631 induces full inhibition of all MM cell lines, suppresses cancer cell proliferation in vitro, and exhibits promising efficacy in MM tumor models. BLX-0631, a nominated IND candidate can serve as a novel targeted agent for treating Multiple Myeloma patients."

Hematological Malignancies • Multiple Myeloma • Oncology

Biolexis Therapeutics to Present Late-Breaking Poster at the American Association of Immunologists (AAI) Annual Meeting 2024 (PRNewswire) - "Biolexis Therapeutics...today announced it will present a late-breaking poster at the 2024 American Association of Immunologists (AAI), taking place May 3-7, 2024, in Chicago, IL....Biolexis' scientific team will be presenting pre-clinical data demonstrating the efficacy of the company's novel PIM1-inhibitor, BLX-0631."

Late-breaking abstract • Preclinical • Systemic Lupus Erythematosus

Development of highly selective, potent, orally available PIM1 inhibitor BLX-0631 shows a therapeutics potential in Systemic Lupus Erythematosus (SLE) models (IMMUNOLOGY 2024) - "Ex vivo SLE patient samples and NZBWF1/J mouse model data support our selection of BLX-0631 as a candidate for IND-enabling studies."

Late-breaking abstract • Immunology • Inflammatory Arthritis • Lupus • Oncology • Systemic Lupus Erythematosus • IL1B • PIM1 • TNFA

Biolexis Therapeutics to Present Five Posters at the American Association for Cancer Research (AACR) Annual Meeting 2024 (PRNewswire) - "Biolexis Therapeutics, Inc...today announced it will present five posters at the 2024 American Association for Cancer Research (AACR), taking place April 5-10, 2024, in San Diego, CA."

Preclinical • Genito-urinary Cancer • Hematological Malignancies • Multiple Myeloma • Oncology • Prostate Cancer • Solid Tumor