lignocaine / Generic mfg. - LARVOL DELTA

CORRELATION OF HISTOMORPHOMETRIC PARAMETERS OF VENOUS WALL WITH AVF NON-MATURATION IN NON-DIABETIC CHRONIC KIDNEY DISEASE (ISN-WCN 2026) - "The ABI was calculated as the mean of three ankle systolic pressures divided by the mean of three brachial systolic pressures.Surgical Procedure and Tissue CollectionAVF creation was performed under 2% lignocaine using a standard side-to-side anastomosis technique at either the radio-cephalic or brachiocephalic site, depending on vessel suitability...Integrating venous morphometry with hemodynamic evaluation could enable individualized AVF planning and early risk stratification. Future work should explore rapid tissue evaluation techniques and targeted therapies against intimal hyperplasia and fibrosis to improve AVF success rates."

Cardiovascular • Chronic Kidney Disease • Fibrosis • Hypertension • Hypotension • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Peripheral Arterial Disease • Renal Disease • Thrombosis • Type 1 Diabetes Mellitus • VIM

A Prospective Randomized Controlled Study Comparing Intravenous and Nebulised Dexmedetomidine for Awake Fibreoptic Nasotracheal Intubation. (PubMed, Cureus) - "When combined with standardized nebulized lignocaine airway topicalization, intravenous dexmedetomidine 1 μg/kg provided superior sedation quality, better intubating conditions, reduced adjunct use, and shorter intubation time compared with nebulized dexmedetomidine, with comparable safety. Intravenous administration may therefore be preferred for sedation during AFOI."

Clinical • Intubation • Journal • Anesthesia • Cough • Hypotension • Respiratory Diseases

Comprehensive Analysis of Frozen Shoulder Management. (PubMed, J Nepal Health Res Counc) - "Conservative treatments proved effective in most cases (89.3%), while ultrasound-guided hydrodistension was beneficial for resistant cases (83.3%)."

Journal • Retrospective data • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Pain

Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Cairo University | Trial completion date: Nov 2025 ➔ Jun 2026 | Trial primary completion date: Oct 2025 ➔ May 2026

Trial completion date • Trial primary completion date • Lung Cancer • Oncology • Pain • Solid Tumor

N/A: An 18-participant study in depressed patients collecting CSF (Cerebrospinal fluid) to study the pharmacodynamic biomarkers of EVX-301 (L-5 Hydroxytryptophan in Saline) over a 24 hour infusion period. (ANZCTR) - P1/2 | N=18 | Recruiting | Sponsor: Evecxia Therapeutics, Inc. | Not yet recruiting ➔ Recruiting | Initiation date: Jan 2026

Biomarker • Enrollment open • Trial initiation date • CNS Disorders • Depression • Mood Disorders • Psychiatry

Blood biomarkers of inflammation and brain-derived neurotrophic factor can not be used to assess the effectiveness of collagen mesotherapy in chronic cervical myofascial pain syndrome. A pilot single-blind randomized study. (PubMed, Rheumatol Int) - P | "The study comprised 23 subjects, who were randomly assigned either to the collagen mesotherapy group (n = 11) or the lignocaine mesotherapy group (n = 12)...Trial registration: NCT06807177. https//clinicaltrials.gov/study/NCT06807177."

Biomarker • Journal • CNS Disorders • Fibromyalgia • Inflammation • Musculoskeletal Pain • Pain • BDNF • IL1B • IL6 • TNFA

Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach (clinicaltrials.gov) - P=N/A | N=142 | Not yet recruiting | Sponsor: Mayo Hospital Lahore

New trial • Anesthesia • Pain

Lignocaine and phenylephrine spray prior to brachycephalic obstructive airway syndrome surgery in dogs reduces postoperative regurgitation: a prospective, randomized, controlled trial. (PubMed, J Am Vet Med Assoc) - "Intraoperative and postoperative methadone requirements did not differ significantly between treatment groups. Intraoral lignocaine and phenylephrine spray did not reduce intraoperative opioid requirements but did decrease postoperative regurgitation. To reduce gastrointestinal complications, locoregional vasoconstrictive anesthesia techniques should be considered as part of a multimodal anesthesia plan for dogs undergoing corrective surgery for brachycephalic obstructive airway syndrome."

Clinical • Journal • Anesthesia

Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (clinicaltrials.gov) - P=N/A | N=25 | Completed | Sponsor: Postgraduate Institute of Dental Sciences Rohtak

New trial

A comparative clinical study to evaluate the efficacy of lignocaine 2% and articaine 4% for anesthesia of mandibular first molars with irreversible pulpitis. (PubMed, J Conserv Dent Endod) - "There was no significant difference between the EPT scores for both the groups, and pain was of mild intensity. Articaine is an efficient alternative for effective pain management in patients with IP."

Journal • Allergy • Anesthesia • Dental Disorders • Immunology • Pain

Suspected Lignocaine Allergy: Safe Conduct of Spinal Anesthesia with Bupivacaine. (PubMed, Ann Afr Med) - "Based on this, spinal anesthesia was planned with bupivacaine heavy and fentanyl, along with prophylactic corticosteroids and antihistamines. This case highlights the critical role of intradermal sensitivity testing with the intended local anesthetic drug in preventing allergic reactions and guiding safe anesthetic management. Individualized assessment, careful interpretation of test results, and preparedness are key to ensuring patient safety in cases of suspected LA hypersensitivity."

Journal • Allergy • Anesthesia • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Comparison of sensory-motor block dynamics after an ultrasound-guided single-point subfascial injection, supraclavicular versus costoclavicular brachial plexus block - A randomised clinical trial. (PubMed, Indian J Anaesth) - "Following institutional ethics approval, 50 patients undergoing upper limb surgery at or below the elbow were randomised to receive a single-point injection of 20 mL of a 1:1 mixture of 2% lignocaine (with 1:200,000 epinephrine) and 0.5% bupivacaine in either the supraclavicular fossa (Gp-SC) or the costoclavicular space (Gp-CC). Incomplete blockade was largely due to sparing of the ulnar (4% vs 36%, P = 0.004), median (8% vs 36%, P = 0.019), and radial nerves (0% vs 20%, P = 0.025). A single-point subfascial injection of local anaesthetic at the costoclavicular space produces a more complete sensory-motor blockade of all four major terminal nerves of the brachial plexus than at the supraclavicular fossa."

Journal • Anesthesia

Thoracic Spinal Anesthesia With Erector Spinae Plane Block Versus Conscious Sedation for Medical Thoracoscopy: A Comparative Pilot Study. (PubMed, Cureus) - "Conscious sedation was administered with fentanyl and midazolam in graded doses with local instillation of lignocaine 2%. TSA was administered at the T6-T7 level with 25 mcg of fentanyl and 0.5% levobupivacaine (1.5 ml), followed by ESPB with 0.25% levobupivacaine (10 ml). No block/anesthesia-related complications were reported in either group. Conclusion The combination of TSA with ESPB can be a novel, effective, and safe anesthetic technique for MT, offering better quality of recovery, improved postoperative analgesia, shorter procedure duration, and reduced perioperative morbidity."

Journal • Anesthesia • Pain

NCI-2018-01152: MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma (clinicaltrials.gov) - P=N/A | N=100 | Active, not recruiting | Sponsor: OHSU Knight Cancer Institute | Recruiting ➔ Active, not recruiting

Enrollment closed • Cutaneous Melanoma • Melanoma • Oncology • Skin Cancer • Solid Tumor

IANB SIP EPT: Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars (clinicaltrials.gov) - P=N/A | N=330 | Not yet recruiting | Sponsor: Armed Forces Institute of Dentistry, Pakistan

New trial • Anesthesia • Dental Disorders

Outcomes of Clinico-radiologically Predetermined Patient-specific Multi-site Steroid Injection in Primary Frozen Shoulder: A Prospective Study. (PubMed, J Orthop Case Rep) - "In this prospective study, 94 patients with primary FS, confirmed via ultrasound and X-ray, received intra-articular and multisite betamethasone injections (8 mg diluted in 8 mL of 2% lignocaine)...The mean ASES score improved from 28.8 to 92.5 (P = 0.001), VAS decreased from 6.7 to 0.4, and internal rotation improved by 4 vertebral levels. The results of our study demonstrate that patient-specific multi-site steroid infiltration significantly reduces pain and improves ROM and clinical outcomes in FS patients."

Journal • Inflammation • Musculoskeletal Pain • Pain

A comparative evaluation of efficacy of lignocaine and dexmedetomidine to attenuate hemodynamic and airway responses to endotracheal extubation in elective coronary artery bypass graft surgery: a prospective randomized double-blind clinical study. (PubMed, Anesth Pain Med (Seoul)) - "A single dose of dexmedetomidine (0.5 µg/kg) given 5 min prior to extubation significantly reduced post-extubation HR and improved extubation quality compared with lignocaine (1.5 mg/kg) in patients undergoing on-pump CABG surgeries."

Journal • Anesthesia

EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (clinicaltrials.gov) - P2 | N=80 | Active, not recruiting | Sponsor: M.D. Anderson Cancer Center | Recruiting ➔ Active, not recruiting

Enrollment closed • Anesthesia • Oncology

Comparative Evaluation of Efficacy of Buccal Infiltration and Intraligamentary Injection with 4% Articaine in Primary Molars: In Vivo Study. (PubMed, Int J Clin Pediatr Dent) - "Both IL and BI techniques using 4% articaine serve as an alternative to the inferior alveolar nerve block (IANB) with lignocaine...Comparative Evaluation of Efficacy of Buccal Infiltration and Intraligamentary Injection with 4% Articaine in Primary Molars: In Vivo Study. Int J Clin Pediatr Dent 2026;19(1):8-12."

Journal • Preclinical • Anesthesia • Pain

INFILTRATE trial : Does the use of sodium bicarbonate buffering of lignocaine reduce the pain associated with perineal infiltration prior to repair? (ANZCTR) - P3 | N=100 | Recruiting | Sponsor: University of Queensland | Not yet recruiting ➔ Recruiting | Initiation date: Dec 2025

Enrollment open • Trial initiation date • Pain

Effect of Local Anesthesia with and without Adrenaline on Blood Glucose Concentration, Blood Pressure, and Pulse Rate in Patients Undergoing Tooth Extractions: A Comparative Study. (PubMed, Ann Afr Med) - "The present study demonstrates that the use of adrenaline-containing local anesthesia during tooth extractions should have a cautious approach when dealing with patients. While the technique is effective for achieving hemostasis and prolonged anesthetic action, caution is advised, particularly in elderly or medically compromised patients. Careful patient selection and continuous monitoring are essential to minimize potential complications."

Journal • Anesthesia • Cardiovascular

IP LIGNO: Analgesic Effect of IntraPeritoneal LIGNOcaine in Gynaecological Open Surgery (clinicaltrials.gov) - P=N/A | N=112 | Completed | Sponsor: University of Malaya | Recruiting ➔ Completed

Trial completion • Anesthesia • Gynecology • Pain • Women's Health

To Study Efficacy of Dry Needling after Lignocaine Infiltration versus Local Steroid Injection for Management of Patients with Lateral Epicondylitis (Tennis Elbow). (PubMed, Ann Afr Med) - "Dry needling after lignocaine infiltration is superior to steroid injection in lateral epicondylitis, with better clinical outcomes and lower recurrence at 3-month follow-up."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

A comparative study on airway morbidity with air, saline, and alkalinized lidocaine used for inflation of tracheal tube cuffs. (PubMed, Natl J Maxillofac Surg) - "The study showed that the post-extubation incidence of cough was higher in ETT cuffs filled with air or saline than in alkalinized lidocaine at 0 h. POST was statistically significant in ETT cuffs filled with air or saline as compared to alkalinized lidocaine at 1 h. Hoarseness and PONV were lowest in the alkalinized lidocaine group. Filling the tracheal tube cuff with alkalinized lidocaine resulted in a lesser incidence of undesirable events post-intubation, which contributed to overall airway morbidity."

Journal • Anesthesia • Asthma • Chronic Obstructive Pulmonary Disease • Cough • Gastroenterology • Gastroesophageal Reflux Disease • Immunology • Infectious Disease • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases

Dex/Lido/Fent: Opioid-Free vs Opioid-Based Anesthesia for Nasal Surgeries (clinicaltrials.gov) - P3 | N=60 | Completed | Sponsor: Benha University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia • Otorhinolaryngology • Pain