lignocaine / Generic mfg. - LARVOL DELTA

Computed Tomography-Guided Versus Fluoroscopy-Guided Celiac Plexus Neurolysis for Pancreatic Cancer Pain: A Novel Comparative Study Integrating Pain Phenotyping and Functional Outcomes. (PubMed, Indian J Palliat Care) - "Neurolysis was achieved using absolute alcohol (6-10 mL) mixed with 2% lignocaine (2-3 mL). Pain scores (VAS and LANSS), opioid use (in morphine equivalents) and functional outcomes (karnofsky performance status [KPS] and short form 36 health survey questionnaire [SF-36]) were recorded at baseline, immediate post-procedure, 1 week, 1 month and 3 months...However, CT-guided CPN is associated with significantly greater pain reduction, especially in patients with neuropathic pain features, lower complication rates and better functional outcomes. Pain phenotyping using LANSS enhances procedural decision-making and supports a personalised approach to palliative care in pancreatic malignancy."

Journal • Hypotension • Neuralgia • Oncology • Pain • Palliative care • Pancreatic Adenocarcinoma • Pancreatic Cancer • Solid Tumor

Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery. (clinicaltrials.gov) - P4 | N=104 | Recruiting | Sponsor: Instituto Mexicano del Seguro Social | Trial primary completion date: Feb 2026 ➔ May 2027 | Not yet recruiting ➔ Recruiting

Enrollment open • Trial primary completion date • Genetic Disorders • Inflammation • Obesity • Pain

Does Tramadol Match Lignocaine for Maxillary Tooth Extraction Under Supra-Periosteal Injection?-A Prospective Clinical Study. (PubMed, J Maxillofac Oral Surg) - "Consumption of analgesic tablets was more in lignocaine group, p = 0.022. Tramadol can be safely employed as an alternative to conventional local anaesthetic agents through supra-periosteal injection due to its dual local anaesthetic and analgesic action."

Journal • Anesthesia • Pain

Comparing ethyl chloride and 10% lignocaine spray for pediatric intravenous cannulation pain relief. (PubMed, Clin Exp Pediatr) - "Ethyl chloride vapocoolant spray provides significantly superior dermal analgesia, faster onset, and improved ease of IVC compared to 10% lignocaine spray in children aged 8-17 years. Its rapid action and safety profile make it a valuable alternative in pediatric anesthesia practice, particularly in time-sensitive clinical settings."

Clinical • Journal • Anesthesia • Pain • Pediatrics • Psychiatry

Novel Approach: Radial Ebus Guided Bronchoscopic Transparenchymal Nodule Access (APSR 2025) - "Bronchoscopy was performed with IM pethidine 50 mg and lignocaine 1% for topical anaesthesia. Discussion : Peripheral pulmonary nodules < 2 cm in size without visible CT bronchus sign are known to be difficult to biopsy. For hospitals where technologies such as virtual bronchoscopy, electromagnetic navigation or robotic bronchoscopy are not available, bronchial branch tracing, radial ultrasound and fluoroscopy can be used to perform bronchoscopic transparenchymal nodule access."

Endobronchial ultrasound • Anesthesia • Anorexia • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

Bronchial Foreign Body Retrieval: Insights from a Tertiary Care Hospital in Pakistan (APSR 2025) - "Most of the procedures with flexible bronchoscopy were conducted under topical anesthesia using 2% lignocaine, along with intravenous midazolam and fentanyl for procedural sedation and analgesia. If the foreign body persisted for weeks to months, it resulted in non- resolving pneumonia and lung abscesses. Conclusion : Bronchoscopy is useful and safe procedure for the diagnosis and retrieval of endobronchial foreign bodies."

Clinical • Anesthesia • Infectious Disease • Mood Disorders • Pneumonia • Psychiatry • Pulmonary Disease • Respiratory Diseases

Comparative Effects of 4% Articaine and 2% Lignocaine on Salivary Biomarkers of Pain and Stress in Surgical Extraction of Impacted Mandibular Third Molars: A Prospective Observational Study. (PubMed, Cureus) - "Compared to 2% lignocaine, 4% articaine demonstrated superior modulation of pain and stress biomarkers, supporting its preferential use in impacted mandibular third molar extraction."

Biomarker • Journal • Observational data • Anesthesia • Pain • Psychiatry

Comparative Evaluation of Pain Reduction with Vibration Using Speech Stimulator vs 2% Lignocaine Topical Gel Application Prior to Greater Palatine Nerve Block in 7-12-year-old Children: A Randomized Controlled Trial. (PubMed, Int J Clin Pediatr Dent) - "Comparative Evaluation of Pain Reduction with Vibration Using Speech Stimulator vs 2% Lignocaine Topical Gel Application Prior to Greater Palatine Nerve Block in 7-12-year-old Children: A Randomized Controlled Trial. Int J Clin Pediatr Dent 2025;18(10):1278-1282."

Journal • Anesthesia • Mood Disorders • Pain • Pediatrics • Psychiatry

Local Anaesthetic Practices in Mohs Micrographic Surgery: An Australasian Cross-Sectional Survey. (PubMed, Australas J Dermatol) - No abstract available

Journal • Anesthesia

The efficacy and safety of lignocaine-embedded dissolvable microneedle versus EMLA for topical analgesia in adults undergoing venepuncture: A single-centre, parallel-group, double-blind randomised clinical trial protocol in a tertiary care setting. (PubMed, PLoS One) - P1/2 | "All trial participants will provide written informed consent, which the trial investigators will obtain before trial enrollment and randomisation. The trial findings will be disseminated via peer-reviewed publications and presentations at international conferences and shared with participants via the web-based trial notification system.."

Clinical protocol • Journal • Ophthalmology • Pain

Comparative Evaluation of the Effectiveness of 2% Lignocaine Mixed With Dexamethasone 4 mg vs. 2% Lignocaine (1:200,000 Epinephrine) for Pain Control During the Removal of Orthodontically Indicated Mandibular Premolars: A Randomized Controlled Trial. (PubMed, Cureus) - "These findings align with prior studies showing that dexamethasone added to lignocaine accelerates the onset, prolongs anesthesia, and reduces pain and analgesic consumption. Conclusion The twin mix enhanced anesthesia by reducing injection pain, accelerating onset, prolonging the duration of action, and decreasing postoperative analgesic use, supporting its value as a superior, patient-centered option for minor oral surgery."

Journal • Anesthesia • Pain

The effect of topical flavanoid cream on post-operative excisional haemorrhoidectomy pain; a randomised controlled trial (ANZCTR) - P2 | N=120 | Not yet recruiting | Sponsor: University of Auckland

New P2 trial • Pain

To Compare Opioid Based versus Opioid-Free Anesthesia (Integrating with Erector Spinae Plane Block) in Laparoscopic Surgeries - A Prospective Study. (PubMed, J Pharm Bioallied Sci) - "Group A received OFA with lignocaine, magnesium sulfate, paracetamol, and bilateral ESPB. Group B received OBA with fentanyl...Adverse events were more common in Group B but not statistically significant. OFA with ESPB provides superior postoperative analgesia, better hemodynamic stability, and reduces opioid consumption and related side effects in laparoscopic surgeries."

Journal • Anesthesia • Pain

Comparative Study of Local Anesthesia Techniques for Pain Management in Mandibular Third Molar Extractions. (PubMed, J Pharm Bioallied Sci) - "Statistical analysis confirmed significant differences among the groups. Ropivacaine is more effective in managing postoperative pain and offers a longer duration of anesthesia than lignocaine making it the preferable agent for mandibular third molar extractions."

Journal • Anesthesia • Pain

Safety and efficacy of intrauterine lidocaine compared to warm isotonic sodium chloride solution for the control of pain during office hysteroscopy: a randomized controlled trial. (PubMed, Obstet Gynecol Sci) - "Regarding side effects, significantly fewer patients in the lidocaine group experienced lower abdominal pain, nausea, and headache compared with those in the isotonic sodium chloride solution group. The addition of lidocaine to isotonic sodium chloride solution as the distension medium during office hysteroscopy was associated with low pain scores during and after the procedure, short procedure time, reduced need for additional analgesia, high patient satisfaction, and low procedural difficulty scores."

Journal • Anesthesia • Gynecology • Pain

Efficacy of Lignocaine Jelly Versus Water-Based Lubricant in Preventing Postoperative Airway Morbidity After Endotracheal Intubation: A Prospective Comparative Study. (PubMed, Cureus) - "Water-based lubricating jelly applied over the ETT is more effective than lignocaine jelly in reducing the incidence and severity of postoperative sore throat, cough, and hoarseness of voice. Being inexpensive, widely available, and devoid of potential systemic side effects of lignocaine, it may be recommended as a safer alternative for routine clinical practice."

Intubation • Journal • Anesthesia • Cough • Otorhinolaryngology • Respiratory Diseases

Does lignocaine effect growth of nontuberculous mycobacteria? (WBC 2025) - "Lignocaine MICs for reference strains of NTM were greater than the concentrations measured in routine bronchoalveolar lavage samples suggesting topical lignocaine is unlikely to affect BAL yield for NTM. Further investigation of the effect of lignocaine on growth of clinical NTM isolates to verify these findings is warranted."

Nontuberculous mycobacteria • Anesthesia • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers (clinicaltrials.gov) - P=N/A | N=230 | Active, not recruiting | Sponsor: Vanderbilt University Medical Center | Enrolling by invitation ➔ Active, not recruiting | Trial completion date: Dec 2027 ➔ Dec 2029 | Trial primary completion date: Dec 2027 ➔ Dec 2029

Enrollment closed • Trial completion date • Trial primary completion date • Anesthesia • Genetic Disorders

Comparison of Efficacy of Autologous Blood Injection versus Steroid Injection in Treatment of Lateral Epicondylitis: A Comparative Study. (PubMed, J Orthop Case Rep) - "Using simple randomization, patients were assigned to Group A (methylprednisolone acetate 40 mg with 1 mL 2% lignocaine) or Group B (2 mL autologous venous blood from the opposite arm). Pain relief stratified by age, sex, symptom duration, and baseline VAS score showed significant improvement in both groups, with greater improvement in Group B. No acute or late complications were observed. AB injection provides superior and more sustained pain relief than steroid injection in patients with lateral epicondylitis."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Comparison of Efficacy of 0.5% Ropivacaine Versus 2% Lignocaine Hydrochloride with Adrenaline (1:80,000) in Surgical Removal of Impacted Mandibular Third Molars with Emphasis on Depth of Anesthesia- Prospective, Randomized, Split Mouth Study. (PubMed, J Maxillofac Oral Surg) - "It also provides an added benefit of greater depth of penetration into the bone along with a postoperative analgesic effect, thereby increasing the patient comfort. However, further study on a larger sample size is necessary to determine the overall effectiveness and practicality of using Ropivacine as an alternative to lignocaine in minor oral surgical procedures."

Journal • Anesthesia • Cardiovascular • Pain

The effect of intravenous lignocaine infusion on intraoperative desflurane requirement: A randomised controlled trial. (PubMed, Medicine (Baltimore)) - "Intravenous lignocaine infusion reduces the Et-Des concentration, amount, and cost required to maintain the BIS value at 40 to 60 without significant hemodynamic changes or side effects in laparoscopic abdominal surgery. The usage of intravenous lignocaine infusion as adjunct to anesthesia is feasible to reduce anesthetic agent requirement."

Clinical • Journal • Anesthesia

COMPARISON OF INTRAVENOUS ANAESTHESIA WITH PROPOFOL AND LIGNOCAINE VS INHALATIONAL ANAESTHESIA ON VEGF AND T CELL LEVELS IN OVARIAN CANCER PATIENTS: RANDOMISED CONTROLLED TRIAL (FIGO 2025) - "The study shows that TIVA and IA produce similar effects on perioperative immune markers (VEGF, CD4, CD8) in ovarian cancer patients. No significant difference was observed in systemic inflammation, DOD or RIOT.This study suggests that anaesthetic technique does not influence immunosuppression or angiogenesis. Anaesthesia technique can be chosen based on patient profile, comorbidities, and surgical requirements, as both groups demonstrated a comparable profile."

Clinical • Anesthesia • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Ovarian Cancer • Solid Tumor • CD4 • CD8

OUTPATIENT HYSTEROSCOPY FOR EVERYONE-EVALUATION OF SAFETY AND TOLERABILITY USING LOCAL ANAESTHETIC OINTMENT (FIGO 2025) - " Women were advised to take either paracetamol (1 gm) or Ibuprofen (400 mg) 1 hour before the procedure. The procedure involves the use of miniaturised endoscopic equipment to directly visualise the uterine cavity by using the Lignocaine 25% and Tetracaine 6% (LTP) ointment applied inside the vagina... This study demonstrates that outpatient hysteroscopy is an acceptable, safe procedure that is well tolerated by patients. In this study it was found that LTP ointment was found cost-effective alternative to the expensive hysteroscopy under GA as an inpatient."

Clinical • Anesthesia • Gynecology • Infertility • Solid Tumor • Uterine Leiomyoma • Women's Health

Comparative Evaluation of Pain Control Using 4% Articaine Buccal Infiltration and 2% Lignocaine Inferior Alveolar Nerve Block for Pulpectomy in Primary Mandibular Second Molars in the Children of Age-group 6-10 Years: A Split-mouth Randomized Controlled Clinical Trial. (PubMed, Int J Clin Pediatr Dent) - "Comparative Evaluation of Pain Control Using 4% Articaine Buccal Infiltration and 2% Lignocaine Inferior Alveolar Nerve Block for Pulpectomy in Primary Mandibular Second Molars in the Children of Age-group 6-10 Years: A Split-mouth Randomized Controlled Clinical Trial. Int J Clin Pediatr Dent 2025;18(5):491-499."

Clinical • Journal • Anesthesia • Mood Disorders • Pain • Pediatrics • Psychiatry

Assessment of efficacy of lignocaine patch in pain management post third molar extraction: A prospective, split mouth study. (PubMed, J Oral Biol Craniofac Res) - "These findings suggest that 5 % lignocaine patches offer an effective alternative to oral analgesics for managing postoperative pain after third molar extractions. Further research, however, is recommended to explore their potential in reducing opioid use and their effectiveness in other minor oral surgical procedures."

Journal • Pain