lignocaine / Generic mfg. - LARVOL DELTA

Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy (clinicaltrials.gov) - P=N/A | N=160 | Completed | Sponsor: Beni-Suef University | Recruiting ➔ Completed

Trial completion • Cardiovascular • Pain

Postoperative Analgesic Efficacy of Extended Opioid-free Anesthesia Regimen with Intravenous Lignocaine versus Morphine Following Major Head and Neck Surgeries. (PubMed, Ann Afr Med) - "Intravenous lignocaine significantly reduced inadequate analgesia and need for rescue medications with optimal hemodynamics in the immediate postoperative period following major head and neck surgeries. Further large-scale, prospective, randomized controlled trials are warranted."

Clinical • Journal • Observational data • Retrospective data • Anesthesia • Critical care • Oncology • Otorhinolaryngology • Pain

Aspiration-Assisted Catheter-Directed Foam Sclerotherapy Using the Sclerosafe Device for Anterior Saphenous Vein Insufficiency: A Retrospective Study. (PubMed, Healthcare (Basel)) - "All procedures were performed in an outpatient setting under local anaesthesia (2 mL of 1% lignocaine at the puncture site) without tumescent infiltration...Polidocanol 2% foam (5 mL per session, Tessari technique) was administered and a standardised compression regimen was applied...In the absence of a control group and clinical outcome measures, the technique cannot be presented as an established alternative to thermal or non-thermal ablation, but it may be a technically attractive option in patients with clinical CEAP class C2-C4 disease. Prospective comparative studies are warranted to confirm these findings."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hematological Disorders • Pain • Pulmonary Embolism • Respiratory Diseases • Varicose Veins

Effect of ultrasound-guided superior laryngeal nerve block on intubation-induced haemodynamic changes in hypertensive patients: A randomised clinical trial. (PubMed, Indian J Anaesth) - "The iSLNB group received ultrasound-guided bilateral iSLNB using lignocaine following intravenous induction, while the control group received standard intravenous induction...The postoperative sore throat was significantly lower in the iSLNB group (P = 0.01), and no block-related adverse events were observed. Ultrasound-guided iSLNB as an adjunct to GA effectively attenuates the haemodynamic response to endotracheal intubation."

Intubation • Journal • Anesthesia • Cardiovascular • Hypertension • Otorhinolaryngology

Clinical Outcomes of Clinico-radiologically Predetermined Patient Specific Multi-site Steroid Injection in Primary Frozen Shoulder: A Prospective Case Series. (PubMed, J Orthop Case Rep) - "The steroid preparation consisted of 8 mg of betamethasone (4 mg/mL vial) diluted with 8 mL of 2% plain lignocaine...The mean ASES score improved from 28.8 to 88.9 (P = 0.001), the mean VAS score decreased from 6.7 to 0.7, while the mean internal rotation improved by 3.5 vertebral levels during the same timelines. The results of our study demonstrate that intra-articular combined with clinico-radiologically predetermined patient-specific landmark-based multisite steroid infiltration using betamethasone leads to a remarkable reduction in pain as well as significant improvement in ROM and clinical outcomes in FS."

Clinical data • Journal • Inflammation • Musculoskeletal Pain • Pain

Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Cairo University | Trial completion date: Jun 2026 ➔ Jan 2027 | Trial primary completion date: May 2026 ➔ Jan 2027

Trial completion date • Trial primary completion date • Lung Cancer • Oncology • Solid Tumor

Intravenous Magnesium Sulphate Versus Lignocaine for Attenuating Hemodynamic Responses to Laryngoscopy and Endotracheal Intubation (clinicaltrials.gov) - P=N/A | N=78 | Not yet recruiting | Sponsor: Lady Reading Hospital, Pakistan

Intubation • New trial

N/A: An 18-participant study in depressed patients collecting CSF (Cerebrospinal fluid) to study the pharmacodynamic biomarkers of EVX-301 (L-5 Hydroxytryptophan in Saline) over a 24 hour infusion period. (ANZCTR) - P1/2 | N=18 | Completed | Sponsor: Evecxia Therapeutics, Inc. | Recruiting ➔ Completed

Biomarker • Trial completion • CNS Disorders • Depression • Mood Disorders • Psychiatry

Popliteal Sciatic Block as a Safe Anesthetic Alternative for High-risk Below-knee Surgeries. (PubMed, Ann Afr Med) - "Combined ultrasound-guided popliteal sciatic and femoral nerve blocks may provide a reliable anesthetic alternative for high-risk patients undergoing urgent below-knee surgery. They can provide satisfactory surgical anesthesia, effective postoperative analgesia, and perioperative hemodynamic stability when conventional neuraxial or general anesthesia may be associated with increased risk."

Journal • Anesthesia • Cardiovascular • Coronary Artery Disease • Diabetes • Heart Failure • Hepatology • Liver Failure • Metabolic Disorders

A comparative study of the effectiveness of cooled versus room temperature lignocaine gel for relieving pain during optical internal urethrotomy. (PubMed, Urologia) - "Cooled lignocaine gel offers superior pain control for OIU without additional complications. Its use can make OIU a less painful, more cost-effective procedure with short hospital stay, especially in resource-limited setting. These findings should be validated in larger multicentre trials that incorporate formal Patient-Reported Outcome Measures (PROMs) to effectively evaluate patient satisfaction."

Journal • Anesthesia • Pain • Urology

Comparison of 4 ml of 1% Lignocaine Versus 2 ml of 2% Lignocaine for Landmark-Guided Superior Laryngeal Nerve Block During Awake Fiberoptic Intubation. (PubMed, Cureus) - "For landmark-guided superior laryngeal nerve block, 4 mL of 1% lignocaine per side was associated with more completely relaxed vocal cords and shorter fiberoptic intubation time than 2 mL of 2% lignocaine per side. The findings support further multicenter confirmation using validated airway-anesthesia scales and fully blinded injectate preparation where feasible."

Intubation • Journal • Anesthesia

Intravenous Lignocaine for Acute Migraine (ANZCTR) - P3 | N=33 | Recruiting | Sponsor: Wide Bay Hospital and Health Service | Not yet recruiting ➔ Recruiting | Initiation date: Jun 2026

Enrollment open • Trial initiation date • CNS Disorders • Migraine

Ultrasound-Guided Posteromedial Fascial-Periarticular Injection for Mild-to-Moderate Knee Osteoarthritis: Twelve-Month WOMAC Outcomes in a Retrospective Pilot Case Series. (PubMed, Diagnostics (Basel)) - "Each patient received three monthly ultrasound-guided posteromedial injections using 30 mL of 5% dextrose with 0.1% lidocaine (lignocaine)...These findings are preliminary and hypothesis-generating; non-specific effects including placebo, regression to the mean, and natural symptomatic fluctuation cannot be excluded. Prospective controlled trials are required to establish safety, reproducibility, mechanism, and comparative effectiveness."

Journal • Retrospective data • Immunology • Musculoskeletal Diseases • Osteoarthritis • Pain • Rheumatology

Anesthetic Efficacy of Lignocaine Added with Magnesium Sulfate during Pulpectomy in Children with Irreversible Pulpitis: A Prospective, Split-mouth, Randomized Controlled Trial. (PubMed, Int J Clin Pediatr Dent) - "Magnesium sulfate, when added to lignocaine local anesthesia (LA), was successful in enhancing the depth of pulpal anesthesia. Addition of magnesium sulfate enhances the depth of local anesthesia while treating primary teeth with chronic irreversible pulpitis."

Journal • Anesthesia • Dental Disorders • Pain • Pediatrics

Comparative Evaluation of Pain Perception Following Topical Application of Clove Oil, EMLA 5%, and Lignocaine Hydrochloride Gel 2% as a Pre-anesthetic Agent in Children Aged 7-10 Years: A Randomized Controlled Study. (PubMed, Int J Clin Pediatr Dent) - "Clove oil can serve as a viable herbal alternative. Clove oil demonstrates comparable efficacy to conventional topical anesthetics, offering a safe, natural, and cost-effective alternative for pain reduction in pediatric dentistry."

Journal • Anesthesia • Pain • Pediatrics

Enhanced Analgesic Outcomes with Low-dose Dexmedetomidine and Lignocaine-Adrenaline in Pediatric Inferior Alveolar Nerve Block: A Randomized Trial. (PubMed, Int J Clin Pediatr Dent) - "Incorporating low-dose dexmedetomidine with lignocaine in pediatric pulpectomies enhances local anesthetic efficacy by reducing pain, shortening onset, and prolonging duration of anesthesia. This combination offers a safer and more comfortable treatment experience for young children."

Journal • Anesthesia • Pain • Pediatrics

Analgesia for Awake Internal Jugular Vein Cannulation in Trauma Emergency Bay: A Randomized Comparison of Ultrasound-Guided Superficial Cervical Plexus Block With Local Infiltration. (PubMed, J Emerg Med) - "Ultrasound-guided SCPB may be a useful alternative to local infiltration for IJV cannulation in selected awake trauma patients, when performed by clinicians experienced in ultrasound-guided regional anesthesia. By providing comprehensive sensory coverage, the technique significantly reduces procedural time and enhances patient cooperation without need for systemic sedation."

Journal • Anesthesia • Mood Disorders • Pain

Comparative Evaluation of the Properties of Irreversible Hydrocolloid Materials Following the Addition of Two Different Local Anesthetic Agents: An In Vitro Study. (PubMed, Cureus) - "This in vitro study, within its limitations, found that adding local anesthetic agents to irreversible hydrocolloid impression materials may reduce the gag reflex without affecting their compressive strength, tear strength, or chemical properties."

Journal • Preclinical • Anesthesia

Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes (clinicaltrials.gov) - P3 | N=80 | Not yet recruiting | Sponsor: Prince of Wales Hospital, Shatin, Hong Kong

New P3 trial • Aesthetic Medicine • Anesthesia • Pain

Tramadol hydrochloride vs. lignocaine hydrochloride in the extraction of anterior teeth: a randomised comparative study. (PubMed, J Maxillofac Oral Surg) - "Tramadol has less potent, higher dose is required for the desired anesthetic property which cannot be recommended as a first-line anesthetic. However, it can be considered as alternative drug for patients who are allergic to lignocaine or other conventional local anesthetics."

Clinical • Journal • Anesthesia • Pain

Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars (clinicaltrials.gov) - P=N/A | N=330 | Recruiting | Sponsor: Armed Forces Institute of Dentistry, Pakistan | Not yet recruiting ➔ Recruiting | Trial completion date: Feb 2027 ➔ Aug 2026

Enrollment open • Trial completion date • Anesthesia • Dental Disorders

Local Anaesthetic Systemic Toxicity in Dental and Oral and Maxillofacial Surgery: Safe Dosing, Combination Agents, and Emergency Management-A Narrative Review. (PubMed, Dent J (Basel)) - "Three amide agents are commonly used in the UK: lignocaine (lidocaine) 2% with adrenaline 1:80,000; articaine 4% with adrenaline 1:100,000 (2.2 mL cartridges); and bupivacaine 0.5%...Patient-specific factors substantially lower the effective toxic threshold. Safe LA administration in oral surgery requires systematic MRD calculation, application of the fractional dose rule for combined-agent appointments, attention to patient-specific risk factors, setting-appropriate emergency preparedness, and structured differential diagnosis to distinguish LAST from more common dental emergencies."

Journal • Review • Anesthesia • Cardiovascular • Immunology • Pain

Informing scale-up of Kenya’s advanced HIV disease package of care: an assessment of early implementation (AIDS 2026) - "Oral electrolyte supplementation was available in 2/9 facilities, and while LP needles (5/9) and lignocaine (8/9) were stocked, they were not routinely available outside of surgical theatre...Flucytosine was available at all facilities, but insufficient stocks of L-AmB (5/9) and fluconazole (5/9) were observed... Focused AHD care implementation has improved coverage of CD4 testing for identification and use of WHO-recommended treatment for CM, though CD4 coverage remains low in individuals returning to care. Additional support is needed for commodity availability and linkage to care using EMR systems."

Metastases • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • CD4

Tumescent anaesthesia for endovenous interventions - a survey of medical practitioners. (PubMed, Phlebology) - "The vast majority of survey participants use lignocaine (92.5%), adrenaline (55%), sodium bicarbonate (67.1%) in a base fluid of sterile normal saline (90.8%) in the preparation of TA...Two thirds recorded the anaesthetic dose, as mg/kg (23.5%), or total dose (45.6%) Only 40.6% of participants reported storing intralipid. 7.9% of respondents in this survey had experienced Local Anaesthetic Systemic Toxicity, with one death reported.ConclusionsThe survey identified some variability in the volume of components used, and considerable variability in consenting practices, documentation, patient observations, the storage of Intralipid and the re-use of single use intravenous fluid bags between patients."

Journal • Anesthesia • Varicose Veins

Neisseria gonorrhoeae notifications, resistance and management in the Pilbara Region, Western Australia, July 2023 - June 2024. (PubMed, Commun Dis Intell (2018)) - "In October 2024, Pilbara treatment guidance for uncomplicated urogenital gonorrhoea shifted from routine ZAP pack (amoxicillin 3 g and probenecid 1 g and azithromycin 1 g oral as a single treatment) to ceftriaxone-based LAC pack (ceftriaxone 500 mg in 2 mL 1% lignocaine intramuscularly and azithromycin 1 g oral, as a single treatment) in response to rising penicillinase-producing N. gonorrhoeae (PPNG) and the threat of imported ciprofloxacin resistance. Reinforcing treatment consistent with the updated treatment guidelines of October 2024 for the Pilbara region will reduce the risk of ineffective treatment. Improving the rate of test of cure and test for reinfection (33%) would improve the likelihood of detecting treatment failure and detecting resistance."

Journal • Retrospective data • Infectious Disease